Clinical trials: Endodontic Inflammation, open to volunteers
Pulpal Inflammation
Characterization of Pulp Inflammation: an Observational Study Using Biological Samples Collected During Routine Dental Care
Background: Vital pulp therapy (VPT) is a cornerstone of minimally invasive dentistry and aims to preserve pulp vitality whenever clinically feasible.
- Trial name
- INFLAPULP (NCT07533396)
- Volunteers
- 1,200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Symptomatic Irreversible Pulpitis (SIP)
Short Term Comparative Assessment of MTA and Biodentine in Complete Pulpotomy for Symptomatic Irreversible Pulpitis
All Patients coming to the Operative Dentistry Department (DIDC-DUHS) with complain of pain in posterior teeth will be invited to participate. The treatment will be done by one dentist.
- Trial name
- NCT07483788
- Testing
- Biodentine pulpotomy
- Where
- 2 sites in Pakistan
- Volunteers
- 60 people
- Sponsor
- Dow University of Health Sciences
Asymptomatic Irreversible Pulpitis
Comparing Post Operative Pain With and Without Apical Patency Technique in Asymptomatic Irreversible Pulpitis Teeth
Primary Outcome - Measure Presence of postoperative pain Primary Outcome - Time Frame 24 hours post-treatment Primary Outcome - Description Postoperative pain assessed using the Numerical Rating Scale (NRS), categorized as…
- Trial name
- NCT07648862
- Testing
- Apical Patency Technique, Non-Patency Technique
- Where
- Pakistan
- Volunteers
- 150 people
- Sponsor
- Bolan Medical Complex Hospital Quetta Pakistan
Post Operative Pain, Acute, Irreversible Pulpitis
To Evaluate Post Operative Pain Using Two Different Kind of Sealers in Obturation of Teeth With Symptomatic Irreversible Pulpitis During Second Visit When the Patient is Painless
The goal of this randomized clinical trial is to evaluate pain after root canal treatment using two different kinds of sealers during obturation in 60 healthy , male and female patients ages between 18 to 40 years.
- Trial name
- NCT07266974
- Testing
- AH-Plus Epoxy Resin Sealer, bioceramic sealer
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Jaweria Gul Keyani
Pulpitis - Irreversible
Prognostic Biomarkers for Pulpotomy Outcome
This study will recruit 180 molars diagnosed with irreversible pulpitis. Full pulpotomy will be performed on 120 teeth, while RCT (root canal treatment) will be conducted on another cohort of 60 teeth as the control for assessing…
- Trial name
- NCT06514053
- Testing
- Full pulpotomy, Root canal treatment
- Where
- Hong Kong
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Extremely Deep Caries, Pulpitis
Effectiveness of Pulpotomy vs. Root Canal Treatment in Extremely Deep Caries
Recent clinical trials comparing pulpotomy versus root canal treatment (RCT) have shown promising outcomes; however, the current evidence lacks generalisability to general practitioners.
- Trial name
- NCT07242742
- Testing
- Full Pulpotomy, root canal treatment and intracanal medicament
- Where
- Singapore
- Volunteers
- 93 people
- Sponsor
- National University Hospital, Singapore
Pulpitis - Reversible, Pulpotomies on Primary Molars
Pelargonium Graveolens Essential Oil as a Pulpotomy Agent in Primary Teeth
The success of pulpotomy in primary teeth is critical for preserving function and arch integrity in children and depends largely on the biological properties of the medicament used.
- Trial name
- NCT07386925
- Testing
- pulpotomy, Radiation
- Where
- 2 sites in Egypt
- Volunteers
- 30 people
- Sponsor
- Tanta University
Symptomatic Irreversible Pulpitis
Postoperative Pain After Root Canal Obturation Using Bioceramic and Calcium Hydroxide Sealers
This study is designed to find out how different root canal sealers affect pain after root canal treatment. We are comparing two types of dental sealers: bioceramic sealer and calcium hydroxide sealer.
- Trial name
- BCvsCaOH (NCT07410780)
- Testing
- CeraSeal Bioceramic Sealer, Sealapex Calcium Hydroxide Sealer
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- HITEC-Institute of Medical Sciences
Periapical Periodontitis, Pulpitis
Clinical and Radiographic Evaluation of Primary Endodontic Treatment and Non-surgical Endodontic Retreatments
Background: Pulpitis and apical periodontitis are inflammatory conditions of the dental pulp and periapical tissues, primarily caused by microbial invasion.
- Trial name
- CR-ET (NCT07418840)
- Testing
- Root canal treatment and non surgical endodontic retreatment
- Volunteers
- 75 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Pulpitis, Pulpitis - Irreversible
Comparison of Aquaporin -4, -5, -9 and IL-8 Levels in GCF, Dentin Fluid and Pulp Samples
This study aimed to compare the changes in AQP -4, -5, -9, and IL-8 levels in pulp tissue, GCF, and dentin fluid samples routinely obtained during the treatment of healthy and symptomatic teeth diagnosed with irreversible…
- Conditions
- Pulpitis, Pulpitis - Irreversible, Pulp Inflammation, Healthy Pulp
- Trial name
- NCT06938191
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Pulpitis - Reversible, Pulpotomy
Clinical and Radiographic Evaluation of Chitosan Versus Formocresol After Vital Pulpotomy of Primary Molars
The goal of this clinical trial is to evaluate whether Chitosan liquid will show similar clinical and radiographical success rate compared to Formocresol when used in vital pulp therapy in primary molars.
- Trial name
- NCT06809478
- Testing
- Pulpotomy using Chitosan liquid, Pulpotomy using Formocresol
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pulpitis - Irreversible, Pulpitis - Reversible
Comparison of the Efficacy of Inferior Alveolar Nerve Block and Digital Anesthesia in Pulpectomy of Mandibular Permanent Molars in Children
This study aims to compare the effectiveness of inferior alveolar nerve block (IANB) and computer-controlled digital anesthesia in achieving adequate anesthesia in pediatric patients presenting with acute dental pain and…
- Trial name
- NCT07634900
- Testing
- Computer-Controlled Digital Anesthesia, Inferior Alveolar Nerve Block
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Inonu University
Pulpitis, Healthy
Measurement of Pro-resolving Inflammation Biomarkers in Saliva, Gingival Fluid, and Dental Pulp in Patients With Symptomatic Pulpitis and Healthy Controls
This observational study aims to better understand inflammation inside the dental pulp (the inner tissue of the tooth) in patients with symptomatic pulpitis compared with healthy individuals.
- Trial name
- SMART-PULP (NCT07450235)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Université de Nantes
Irreversible Pulpitis
Postoperative Pain After Pulpectomy in Primary Molars
To compare the post operative pain in pulpectomy of primary molars using a single rotary file system versus conventional manual instrumentation, through a Randomized Clinical Trial.
- Trial name
- NCT07427420
- Testing
- Fanta AF F one rotary files 20 taper 4, Manual files (k files ,Mani, Inc., Japan).
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Post Operative Pain After Root Canal Therapy
Postoperative Pain Comparison of Two Root Canal Sealers in Irreversible Pulpitis
This study, approved by the Institutional Ethics Review Committee, AFID (Annex "A"), will involve 62 eligible patients from the Operative Dentistry Department, Armed Forces Institute of Dentistry.
- Trial name
- NCT06975761
- Testing
- Resin Based sealer, ZnO eugenol based sealers
- Where
- Pakistan
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Armed Forces Institute of Dentistry, Pakistan
Irreversible Pulpitis, Primary Teeth
Comparison of 3Mixtatin Pulpotomy and Metapex Pulpectomy in Primary Molars With Irreversible Pulpitis
The present study aims to evaluate the clinical and radiographic success of pulpotomy using 3Mixtatin versus pulpectomy using Metapex in primary molars with irreversible pulpitis in children aged 4 to 9 years.
- Conditions
- Irreversible Pulpitis, Primary Teeth, Pulp Disease, Dental
- Trial name
- NCT06925490
- Testing
- Metapex, 3Mixtatin
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Type 2 Diabetes Mellitus (T2DM), Irreversible Pulpitis
Complete Pulpotomy and Root Canal Treatment Patients With Irreversible Pulpitis With Type 2 Diabetes Mellitus
there is limited endodontic research on the effects of DM on pulp tissues. Diabetic human and animal histological research have demonstrated decreased wound repair, chronic pulp inflammation and reduced dentin bridge formation.
- Trial name
- NCT07163975
- Testing
- complete pulpotomy, Root canal treatment
- Where
- India
- Volunteers
- 106 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Pulp Disease, Dental
Effect of Cavity Disinfectants on Post Operative Pain & Success of Partial Caries Removal
To investigate The Effect of Sodium hypochlorite and Chlorhexidine as cavity Disinfectants on the post operative pain and Success of Partial Caries Removal in deep carious lesion with moderate pulpitis in permanent teeth
- Trial name
- NCT06836882
- Testing
- Selective caries removal, Selective caries removal with NaOCl, Selective caries removal with CHX
- Where
- India
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Pulpitis Reversible, Pulp Exposure, Dental
Pomegranate Peel Extract for Primary Molar Pulpotomy
Pomegranate peel extract has demonstrated a range of potential uses in the biomedical industry in recent years because of its numerous benefits, which include anti-inflammatory, antibacterial, anti-apoptotic, antioxidant, and…
- Trial name
- NCT07108738
- Testing
- Pulpotomy, Radiation
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Tanta University
Pulpitis - Irreversible, Pulp Necrosis
Professional Practices Regarding Treatment of Non-vital Primary Teeth Among Dental Surgeons in France
When faced with primary teeth affected by irreversible pulpitis or pulp necrosis, extraction is often the preferred option for practitioners, although validated alternatives exist, notably pulpectomy, which has high success rates…
- Conditions
- Pulpitis - Irreversible, Pulp Necrosis, Apical Periodontitis
- Trial name
- DTNV (NCT07297836)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France