Clinical trials: Endodontic Inflammation
Post-operative Pain, Pulpitis - Irreversible
Evaluation of Post-operative Pain After Total Pulpotomy and Root Canal Treatment
The aim of this study was to compare post-operative pain following total pulpotomy (TP) and root canal treatment (RCT) in mature molar teeth with severe symptoms indicative of irreversible pulpitis.
- Trial name
- NCT05923619
- Testing
- Total pulpotomy, Root canal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Success of Inferior Alveolar Nerve Block
Effect of Magnesium Sulphate Added to Mepivacaine Hydrochloride on Inferior Alveolar Nerve Block Success in Patients With Symptomatic Irreversible Pulpitis in Mandibular Molars: A Randomized Clinical Trial.
the study is conducted to assess the effect of adding magnesium sulphate to mepivacaine HCl compared to mepivacaine HCl alone on the success of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis in…
- Trial name
- NCT04561921
- Testing
- Magnesium sulfate, Mepivacaine-Levonordefrin Hydrochloride
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Cairo University
Irreversible Pulpitis
Pulpotomy as a Treatment of Irreversible Pulpitis
The procedure currently recommended for the treatment of irreversible pulpitis is the endodontic treatment, i.e. the complete elimination of the pulp, disinfection and obturation of the whole root canal system.
- Trial name
- NCT02920606
- Testing
- Pulpotomy, Endodontic treatment
- Volunteers
- 100 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Symptomatic Irreversible Pulpitis (SIP), Symptomatic Apical Periodontitis
Comparison of Postoperative Pain After Root Canal Treatment Using Hand-Held vs Rotary ProTaper Files: A Randomized Controlled Trial
This randomized controlled trial aims to compare postoperative pain after root canal treatment using two different types of ProTaper file systems: manual (hand-held) and rotary (engine-driven).
- Conditions
- Symptomatic Irreversible Pulpitis (SIP), Symptomatic Apical Periodontitis, Postoperative Pain After Endodontic Treatment
- Trial name
- NCT07887087
- Testing
- ProTaper Manual Root Canal Instrumentation, ProTaper Rotary Root Canal Instrumentation
- Volunteers
- 200 people
- Sponsor
- College of Physicians and Surgeons Pakistan
Irreversible Pulpitis
Patient Perception Between Two Emergency Treatments of Symptomatic Irreversible Pulpitis.
To evaluate in a comparative way the perception of the patient who comes with pain due to irreversible pulpitis in a tooth and who receives two types of treatment: complete pulpectomy (or control group) or pulpotomy (or…
- Trial name
- NCT04654845
- Testing
- Pulpotomy, Pulpectomy
- Where
- 4 sites in Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Aula Dental Avanzada
Symptomatic Irreversible Pulpitis (SIP)
The Effect of Commercial and Medical Grade Sodium Hypochlorite on Post Endodontic Pain
the aim of the current study is to evaluate the effects of commercial and medical formulations of NaOCl on postoperative pain after endodontic treatment of mandibular posterior teeth with acute irreversible pulpitis.
- Trial name
- NCT07248189
- Testing
- commercially available Sodium Hypochlorite, Medical grade Sodium Hypochlorite
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Primary Teeth, Pulp Necrosis
Success of Lesion Sterilization and Tissue Repair Therapy
This study aimed to assess the clinical and radiographic success of lesion sterilization and tissue repair (LSTR) therapy with different antibiotic combinations, focusing on evaluating whether the alternative combination of…
- Conditions
- Primary Teeth, Pulp Necrosis, Pulpitis - Irreversible
- Trial name
- NCT06818578
- Testing
- Lesion Sterilization and Tissue Repair Therapy, Different Antibiotic Combinations
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Inonu University
Dental Pain, Pulpitis
Evaluation of Pulpal and Salivary Neuropeptides in Dental Pain
This observational cross-sectional study is designed to evaluate pulpal and salivary levels of Substance P (SP) and Calcitonin Gene-Related Peptide (CGRP) in individuals with and without dental pain.
- Conditions
- Dental Pain, Pulpitis, Pulpal Inflammation, Psychological Stress
- Trial name
- PAIN-SPCGRP (NCT07330024)
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Pulpitis
Efficacy of Pediatric Rotary File System Versus Hand Instrumentation for Root Canal Preparation in Primary Teeth
The teeth were randomly allocated in two equal groups : Control group (A):- included 20 mandibular primary molars in which pulpectomy were performed by hand instrumentation system using K- File from size 15 to size 35.
- Trial name
- NCT06152354
- Testing
- rotary system, Manual files
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Suez Canal University
Pulpitis - Irreversible
Cryoanalgesia for Irreversible Pulpitis
The aim of the present study was to evaluate the effectiveness of pulpal anesthesia in pain control during endodontic treatment by lowering the temperature of the injected plain 3% cold Mepivacaine (5ºC) compared to 3%…
- Trial name
- CryPain (NCT06268912)
- Testing
- Cold Mepivacaine, Mepivacaine at room temperature
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Universitat Internacional de Catalunya
Pulpitis - Irreversible
Postoperative Pain and Success Rate in Pulpotomy Versus Root Canal Treatment
Pulpotomy has been proposed in the last decade as a definitive treatment of mature permanent teeth with irreversible pulpitis due to the better understanding of the pulp biology and development of bioactive materials .
- Trial name
- NCT03916900
- Testing
- Pulpotomy, Root canal treatment
- Volunteers
- 52 people
- Sponsor
- Cairo University
Symptomatic Irreversible Pulpitis (SIP), Postoperative Pain After Endodontic Treatment
A Randomized Controlled Trial Evaluating Whether Pre-operative Trinase Reduces Post-operative Pain in Patients With Symptomatic Irreversible Pulpitis Compared to Placebo, Using VAS Scores and Analgesic Intake Over 48 Hours.
This study aims to determine whether Trinase, an enzyme-based anti-inflammatory medication, can reduce pain after root canal treatment in patients with symptomatic irreversible pulpitis.
- Conditions
- Symptomatic Irreversible Pulpitis (SIP), Postoperative Pain After Endodontic Treatment, Endodontic Disease, Dental Pain
- Trial name
- NCT07239505
- Testing
- Trinase
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Fayoum University
Pulpitis - Irreversible
Effect of Preoperative Diclofenac Potassium on Postoperative Endodontic Pain
The purpose of this study is to assess the effect of preoperative a single-dose of 50 mg diclofenac potassium on postoperative endodontic pain in mandibular molars with symptomatic irreversible pulpitis.
- Trial name
- NCT03341260
- Testing
- Diclofenac Potassium 50mg Tab.
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Cairo University
Irreversible Pulpitis (Toothache)
Laser Assisted Pulpotomy Versus MTA Pulpotomy in Permanent Teeth With Irreversible Pulpitis
This study compares two methods used during full pulpotomy, a treatment for teeth with deep tooth decay that has exposed the dental pulp.
- Trial name
- NCT07761962
- Testing
- Diode laser full pulpotomy, Sodium hypochlorite pulpotomy
- Where
- Jordan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Pulpitis - Irreversible
Clinical and Radiographic Evaluation of Turmeric, Thymus Vulgaris, Nigella Sativa and Aloe Vera as Pulpotomy Medicaments in Primary Teeth
when caries reaches the pulp of the tooth, it has to be removed and replaced with a material. In this study im examining the clinical and radiographic signs and symptoms after using different natural materials in pulpotomized…
- Trial name
- RCT (NCT04719247)
- Testing
- Pulpotomy
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Irreversible Pulpitis, Primary Teeth
Comparison of 3Mixtatin Pulpotomy and Metapex Pulpectomy in Primary Molars With Irreversible Pulpitis
The present study aims to evaluate the clinical and radiographic success of pulpotomy using 3Mixtatin versus pulpectomy using Metapex in primary molars with irreversible pulpitis in children aged 4 to 9 years.
- Conditions
- Irreversible Pulpitis, Primary Teeth, Pulp Disease, Dental
- Trial name
- NCT06925490
- Testing
- Metapex, 3Mixtatin
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pulpitis - Irreversible, Pulpitis
Vital Pulp Therapy vs. Root Canal Treatment in Mature Teeth With Irreversible Pulpitis
This study was designed as a prospective, randomized, controlled clinical trial with parallel groups and double blinding, following the principles of the Declaration of Helsinki for human experimentation and in accordance with…
- Conditions
- Pulpitis - Irreversible, Pulpitis, Pulpotomy, Root Canal Therapy
- Trial name
- NCT07355140
- Testing
- VPT Group and RCT Group
- Where
- Venezuela
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Universidad Central de Venezuela
Irreversible Pulpitis
Evaluation of Two Different Calcium Silicate Cements as a Treatment for Irreversible Pulpitis in Mature Molars
This randomized controlled clinical trial aims to evaluate the effect of two calcium silicate cements-Biodentine and EndoCem-on post-operative pain and treatment success in vital pulp therapy (VPT) for mature permanent mandibular…
- Trial name
- NCT07066410
- Testing
- intervention 1: endocem, Intervention 1: biodentine
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Symptomatic Irreversible Pulpitis
Effect of Inferior Alveolar and Gow-Gates Nerve Block Techniques for Symptomatic Mandibular Molars
Introduction: to evaluate the efficacy of inferior alveolar nerve block (IANB), Gow-Gates nerve block (GGNB), and their combination in patients with irreversible pulpitis.
- Trial name
- NCT03117491
- Testing
- GGNB injections, IANB injections, GGNB + IANB injections
- Where
- Iran
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences