Clinical trials: Endodontic Disease
Periapical Periodontitis
Evaluation of Three Irrigants, Sodium Hypochlorite, Chlorhexidine and Combination of CHX+H2O2 in Endodontic Treatment.
This study will evaluate the synergistic effect of CHX + H2O2 when used as an irrigant during biomechanical preparation.in root canal treatment on periapical healing and compared with Chlorhexidine( CHX) and Sodium Hypochlorite…
- Trial name
- NCT04373018
- Testing
- Sodium hypochlorite, Chlorhexidine, Chlorhexidine + Hydrogen peroxide
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Endodontic Disease, Pulp Disease, Dental
The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament
The goal of this randomized clinical trial is to evaluate the capability of the material to exert bacterial reduction of diclofenac sodium versus of that calcium hydroxide paste when these materials are used as intracanal…
- Conditions
- Endodontic Disease, Pulp Disease, Dental, Intracanal Medication
- Trial name
- NCT06207253
- Testing
- Diclofenac Sodium, Calcium hydroxide
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Endodontic Disease, Postoperative Pain
Postoperative Pain in Endodontic Therapy
The goal of this clinical trial is to evaluate the change in postoperative pain in mandibular premolar and first molar teeth with asymptomatic apical periodontitis when using EDDY and passive ultrasonic irrigation activation…
- Trial name
- NCT06741592
- Testing
- EDDY Group, PUI Group
- Where
- Turkey (Türkiye)
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Ordu University
Periapical Disease
Effect of Piezoelectric Surgery on Quality of Life and Periradicular Healing After Endodontic Surgery
This study will compare the effect of piezo Vs bur on quality of life and healing after endodontic surgery.
- Trial name
- NCT04358887
- Testing
- piezoelectric surgery, conventional bur
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Pulpitis
Use of Tramadol Intraligamentary Injections
Introduction: To achieve painless treatment in patients with a failed primary IANB, supplementary anaesthesia has been advised. The majority of the studies evaluating intraligamentary injections have been performed on…
- Trial name
- NCT05538052
- Testing
- Tramadol hydrochloride, Lidocaine Hydrochloride
- Where
- India
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Jamia Millia Islamia
Endodontically Treated Teeth, Post Operative Pain
Effect of Intra-Canal Cryotherapy on Postoperative Pain After Endodontic Procedures
The goal of this randomised clinical trial is to evaluate the effect of cryotherapy on postoperative pain after primary and secondary root canal treatment.
- Trial name
- NCT06134713
- Testing
- cryotherapy with sterile saline at 2.5ºC, control with sterile saline at room temperature
- Where
- United Arab Emirates
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ajman University
Endodontic Disease, Root Canal Infection
3D Analysis of Root Canal Conformation
Aim To evaluate in vivo the shaping ability of the canal with 3 different single-file systems: Reciproc Blue, WaveOne Gold and XP Endo-Shaper, using cone beam computed tomography and 3D reconstructions to measure canal volume…
- Trial name
- NCT03680534
- Testing
- Root canal preparation
- Where
- Colombia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Institucion Universitaria Colegios de Colombia
Pulpitis
Evaluation of Dentinal Fluid for the Presence of Matrix Metalloproteinase 9 (MMP-9) in Pulpal Inflammation
The purpose of this study is to determine whether dentinal fluid (tooth fluid) of teeth with or without a painful inflammatory condition in their nerve (pulp) contain inflammatory marker.
- Trial name
- NCT02967081
- Testing
- Collection of dentinal fluid using a cellulose membrane
- Where
- Switzerland
- Volunteers
- 67 people
- Sponsor
- University of Zurich
Teeth, Endodontically-Treated, Tooth, Nonvital
Comparison Between RCT in Single and Two Visits, With and Without Intracanal Dressing, in Apical Repair
This is a randomized, prospective, double-blind, controlled clinical trial designed to evaluate 3 distinct clinical approaches used during endodontic therapy: Group 1- Root canal treatment in single visit (RCT-SV); Group 2- Root…
- Conditions
- Teeth, Endodontically-Treated, Tooth, Nonvital, Periapical Periodontitis, Chronic Nonsuppurative, Periapical Granuloma
- Trial name
- NCT05256667
- Testing
- RCT-SV, RCT-TVWD, RCT-TVWOD
- Where
- Brazil
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- New York University
Teeth, Endodontically-Treated, Anterior Teeth
Clinical Evaluation of Laminate Veneers With Coronal Post Versus Post and Core Foundation Restoration With Single Crown for Restoration of Endodontically Treated Anterior Teeth (Randomized Controlled Trial) "In-vivo Study"
Clinical evaluation of Laminate veneers with coronal post versus post and core foundation restoration with single crown for restoration of endodontically treated anterior teeth (Randomized Controlled Trial) "In-vivo Study"
- Trial name
- NCT03314545
- Testing
- laminate veneer with coronal post, post,core and crown
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Cairo University
Endodontically Treated Teeth
Bite Force and Occlusal Force Distribution Following Root Canal Treatment.
Understanding the changes in bite force and occlusal force distribution in ETT is clinically important, as it can directly influence tooth prognosis, guide restorative treatment planning, and impact the long-term survival of the…
- Trial name
- B-FORCE RCT (NCT07626372)
- Where
- Thailand
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Effects of; Cold
Role of Cryotherapy in Reduction of Post Operative Endodontic Pain Following Single Visit Root Canal Therapy
AIM : To determine the efficacy of cold saline irrigation in reduction of post operative pain following root canal therapy. METHODOLOGY : Forty patients requiring root canal treatment on permanent single rooted teeth were…
- Trial name
- NCT03044470
- Testing
- cryotherapy
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mamata Dental College
Endodontically Treated Teeth
Digital, Conventional, And Biomimetic Approaches for Restoring Endodontically Treated Teeth
Endocrowns are preferred over the post-retained crown, especially at a young age for many reasons; they allow better gingival health and care due to placement of the supragingival margin, have greater fracture resistance limiting…
- Trial name
- NCT06717230
- Testing
- EverX Posterior
- Where
- 2 sites in Egypt
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- October University for Modern Sciences and Arts
Tertiary Dentine, Indirect Pulp Capping
Silver Diamine Fluoride/ Potassium Iodide in Indirect Pulp Capping of Young Permanent Molars
The aim of this study is to evaluate and compare the clinical effectiveness of 38% silver diamine fluoride with and without potassium iodide with that of resin modified glass ionomer cement in indirect pulp capping of young…
- Trial name
- NCT04236830
- Testing
- Silver diamine fluoride/ potassium iodide, Silver diamine fluoride, Resin modified glass ionomer cement
- Where
- Egypt
- Volunteers
- 108 people
- Sponsor
- Nourhan M.Aly
Pulp Necrosis, Root Canal Infection
Comparison of Ultrasonic vs 980-nm Diode Laser Irrigant Activation for Reducing Residual Bacterial DNA in Necrotic Teeth
This randomized clinical trial aimed to compare residual oral bacterial DNA detection after ultrasonic irrigant activation and 980-nm diode laser irrigant activation during root canal treatment of necrotic single-rooted teeth.
- Trial name
- NCT07607028
- Testing
- Ultrasonic Activation, 980-nm Diode Laser Activation
- Where
- Indonesia
- Volunteers
- 16 people
- Sponsor
- Hasanuddin University
Endodontic Inflammation
Comparison Between the Vibringe and the Conventional Needle
The Vibringe is the first endodontic sonic irrigation system that enables delivery and activation of the irrigation solution in the root canal, in only one step.
- Trial name
- NCT03551587
- Testing
- Vibringe
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Cairo University
Inflammatory Pulp Diseases Related to Carious Teeth
Pulpotomy vs Pulpectomy Outcome.
Epidemiological data show a significant rate of failure of endodontic treatment of 20 to 50% worldwide, probably directly related to the difficulty of the procedure.
- Trial name
- PULPSAVE (NCT02727088)
- Testing
- Pulpotomy, Pulpectomy
- Where
- France
- Volunteers
- 226 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Deep Caries Lesion of Pemanent Teeth
Outcome of Selective Caries Removal Performed by Undergraduate Students
Deep tooth decay can sometimes reach very close to the nerve of a tooth. Traditionally, dentists may remove all of the decayed tooth tissue, but removing too much tissue can increase the risk of exposing or damaging the nerve.
- Trial name
- NCT07765810
- Testing
- Selective caries removal to soft dentine, Selective Caries Removal to Firm/Leathery Dentine
- Where
- Jordan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Pulpitis, Pulpotomy
Clinical and Radiographic Evaluation of Laser Photobiomodulation Pulpotomy of Primary Molars in Children
This study aimed to evaluate the clinical and radiographic outcomes of photobiomodulation pulpotomy compared to MTA pulpotomy in primary molars in children.
- Trial name
- NCT05850780
- Testing
- Photobiomodulation, MTA
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Aliaa Hamouda
Non-Vital Tooth
Turmeric Gel as Alternative Non-vital Pulpotomy Medicament in Primary Teeth
The purpose of this randomized controlled clinical trial is to use Turmeric gel as non-vital Pulpotomy medicament compared to Formocresol in primary teeth by evaluating its antibacterial effect against Streptococcus mutans and…
- Trial name
- NCT05801354
- Testing
- Turmeric Gel, Formocresol
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Health Sciences Lahore