Clinical trials: Endocrine System Diseases
Diabetes Mellitus, Type 2
Effectiveness and Safety of Two Approaches to the Management of Type 2 Diabetes Mellitus in Australian Primary Care
The primary objective is to demonstrate the improvement in glycosylated haemoglobin (HbA1c) levels after general practitioner (GP) initiation and management of type 2 diabetes mellitus (T2DM) with insulin glargine compared with…
- Trial name
- RELIANCE (NCT00950534)
- Testing
- INSULIN GLARGINE (HOE901), Oral Anti Diabetics (OAD)
- Where
- Australia
- Volunteers
- 25 people
- Sponsor
- Sanofi
Type 2 Diabetes Mellitus
Efficacy and Safety of Teneligliptin in Combination With Metformin in Chinese Patients With Type 2 Diabetes Mellitus
This study is designed as a prospective, multi-centre, parallel group, double-blind randomized, placebo-controlled, phase 3 clinical study to evaluate the efficacy and safety of MP-513 (Teneligliptin) in combination with…
- Trial name
- NCT02924064
- Testing
- Teneligliptin 20mg, Metformin ≥ 1000 mg
- Where
- China
- Volunteers
- 247 people
- Sponsor
- Tanabe Pharma Corporation
Gastric Cancer, Colorectal Cancer
Effect of Multi-modal Intervention Care on Cachexia in Patients With Advanced Cancer Compared to Conventional Management (MIRACLE)
Background Cancer Cachexia (CC) is a multi-factorial process characterized by progressive weight loss, muscle mass and fat tissue wasting, and adversely affecting their quality of life and survival in patients with advanced stage…
- Conditions
- Gastric Cancer, Colorectal Cancer, Pancreatic Cancer, Biliary Tract Cancer
- Trial name
- MIRACLE (NCT04907864)
- Testing
- Multi-modal intervention
- Where
- South Korea
- Volunteers
- 112 people
- Sponsor
- Kil Yeon Lee
Diabetes
Caspase Inhibition in Islet Transplantation
This is an Investigator Initiated, Phase I/II study, where Type 1 diabetic participants will receive a 14 day oral treatment of the investigational caspase inhibitor drug IDN-6556 following their first islet transplant.
- Trial name
- NCT01653899
- Testing
- IDN-6556
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Alberta
Recurrent Ovarian Cancer
Feasibility of the Combination of Chemotherapy (Carbo/Caelyx or Carbo/Doxorubicin) With Tocilizumab (mAb IL-6R) and Peg-Intron in Patients With Recurrent Ovarian Cancer
The purpose of this interventional study is to determine the feasibility to combine standard chemotherapy (Carbo/Caelyx or doxorubicin) for recurrent ovarian cancer with immunotherapy (Tocilizumab and Peg-Intron).
- Trial name
- PITCH (NCT01637532)
- Testing
- tocilizumab and interferon alpha 2-b, Carboplatin and Caelyx or doxorubicin
- Where
- Netherlands
- Volunteers
- 21 people
- Sponsor
- Leiden University Medical Center
Diabetic Ketoacidosis
Remote Glucose Monitoring System in Hospitalized Patients With Diabetic Ketoacidosis (DKA)
The purpose of this research study is to investigate the use of continuous glucose monitoring (CGM) device DEXCOM G6 in non-critically patients treated for diabetic emergency such as diabetic ketoacidosis (DKA).
- Trial name
- NCT05439928
- Testing
- DEXCOM G6 CGM
- Where
- United States
- Volunteers
- 163 people
- Sponsor
- Columbia University
Premature Ovarian Failure
Prevention of Chemotherapy-Induced Ovarian Failure With Goserelin in Premenopausal Lymphoma Patients
To Prevent Chemotherapy Induced Ovarian Failure with the gonadotropin-releasing hormone Agonist Goserelin in Young female Lymphoma Cancer patients Receiving Chemotherapy
- Trial name
- NCT04536467
- Testing
- Goserelin, Chemotherapy
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Beni-Suef University
Small Cell Carcinoma, Hypercalcaemic Type, Ovarian Cancer
Pembrolizumab in Small Cell Carcinoma of Ovary - Hypercalcemic Type Patient
This is a study of pembrolizumab as consolidation therapy for a patient with small cell carcinoma of the ovary, hypercalcemic type (SCCOHT).
- Trial name
- Pemb-HT (NCT05368207)
- Testing
- Pembrolizumab
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University Health Network, Toronto
Thyroid Cancer Stage I
Deciding on Active Surveillance or Surgery for Primary Management of Low Risk Papillary Thyroid Cancer
This is a prospective observational study. 1. In the first part of the study, consenting eligible adult patients with low risk papillary thyroid cancer that is confined to the thyroid, are provided verbal and written information…
- Trial name
- AS-PTC (NCT03271892)
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University Health Network, Toronto
Pancreas Cancer, Chemotherapy
The Survival Outcome of Adjuvant Chemotherapy for Stage I Pancreatic Cancer
This study aimed to evaluate the impact of adjuvant chemotherapy on survival in patients with Stage I pancreatic cancer stratified by pathologic risk factors.
- Trial name
- NCT06208436
- Testing
- Adjuvant chemotherapy
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Ovarian Cancer
Autophagy Maintenance (AUTOMAIN)
This is a single-institution, single-arm study with a safety lead-in to determine if previously established safe doses of autophagy drugs, hydroxychloroquine (HCQ) and nelfinavir mesylate (NFV) will benefit ovarian cancer…
- Trial name
- NCT06971744
- Testing
- Hydroxychloroquine, Nelfinavir, Bevacizumab
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Medical University of South Carolina
Overweight and Obesity
UCSD Get Fit, Be Fit Study
The purpose of the Get Fit, Be Fit Study is to examine the effect of incorporating pistachios in an intensive 4-month cognitive-behavioral weight loss intervention in overweight and obese men and women, to examine effects on…
- Trial name
- NCT03387709
- Testing
- Pistachio-enriched diet, General dietary guidance diet
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Pancreas Cancer, Adenocarcinoma of the Pancreas
The HistoSonics Edison™ System for Treatment of Pancreatic Adenocarcinoma Using Histotripsy
The purpose of this trial is to evaluate the safety of the HistoSonics Edison System for the destruction of pancreatic adenocarcinomas using histotripsy.
- Conditions
- Pancreas Cancer, Adenocarcinoma of the Pancreas, Pancreatic Cancer, Tumor of Pancreas
- Trial name
- GANNON (NCT06282809)
- Testing
- HistoSonics Edison™ System for the treatment of pancreatic adenocarcinoma using histotripsy
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- HistoSonics, Inc.
Type 2 Diabetes Mellitus
Long-term Safety Study of Alogliptin Used in Combination With α-glucosidase Inhibitor in Participants With Type 2 Diabetes in Japan
The purpose of this study was to evaluate the long-term safety and efficacy of alogliptin and an α-glucosidase inhibitor administered once daily (QD) or three times daily (TID) for 40 consecutive weeks in participants who…
- Trial name
- NCT01263509
- Testing
- Alogliptin and voglibose
- Volunteers
- 179 people
- Sponsor
- Takeda
Healthy Subjects, Pharmacokinetics of ASP8232
A Study to Evaluate the Pharmacokinetics, Pharmacodynamics and Safety of ASP8232 in Subjects With Renal Impairment and in Type 2 Diabetes Mellitus Subjects With Chronic Kidney Disease
This study consists of two parts. Part 1 evaluates the effect of renal impairment on the PK and PD of a single dose of ASP8232. In addition, the safety and tolerability will be assessed.
- Conditions
- Healthy Subjects, Pharmacokinetics of ASP8232, Pharmacodynamics of ASP8232, Chronic Kidney Disease (CKD)
- Trial name
- NCT02218099
- Testing
- ASP8232
- Where
- 3 sites in Bulgaria, Moldova and 1 more
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Europe B.V.
Obesity, Diabetes
Effect of Pomegranate Extract Intake on Body Composition and Blood Pressure.
Pomegranate has gained widespread popularity since the health effects of the whole fruit, as well as its juices and extracts, have been studied in relation to a variety of chronic conditions such as hypertension, diabetes…
- Conditions
- Obesity, Diabetes, Cardiovascular Disease
- Trial name
- NCT02017132
- Testing
- Pomegranate extract
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Queen Margaret University
Pancreatic Neoplasms, Mediastinal Neoplasms
22G-Adapt Needle Biopsy Versus Fine-needle Aspiration in Endoscopic Ultrasound-guided Sampling of Solid Lesions
The investigators conduct a multicenter randomized controlled study to evaluate the diagnostic value and safety of 22G Adapt Aspiration puncture needle for histopathology of solid lesions.
- Conditions
- Pancreatic Neoplasms, Mediastinal Neoplasms, Abdominal Neoplasm, Excluding Pancreas Neoplasm
- Trial name
- NCT06563232
- Testing
- FNA group, Adapt FNB group
- Where
- China
- Volunteers
- 656 people
- Sponsor
- Huazhong University of Science and Technology
Ovarian Carcinoma, Fallopian Tube Carcinoma
NM32-2668 in Adult Patients With Selected Advanced Solid Tumors
This is a first-in-human, open-label, multi-center, Phase 1, dose-escalation study with expansion cohorts to evaluate NM32-2668 for safety and immunogenicity, to determine the maximal tolerated dose and recommended Phase 2 dose…
- Conditions
- Ovarian Carcinoma, Fallopian Tube Carcinoma, Peritoneal Carcinoma, Endometrial Cancer
- Trial name
- NCT06299163
- Testing
- NM32-2668
- Where
- 11 sites in United States
- Volunteers
- 11 people
- Sponsor
- Numab Therapeutics AG
Diabetes Mellitus, Type 2
A Single-dose Cross-over Study to Assess Direct and Indirect Effects of Dapagliflozin on Pancreatic Alpha and Beta Cells in Patients With Type 2 Diabetes
The purpose of this study is to evaluate if Dapagliflozin has direct effect on alpha cell glucagon release.
- Trial name
- NCT02765204
- Testing
- Dapagliflozin, Saxagliptin, Glucose
- Where
- Sweden
- Volunteers
- 15 people
- Sponsor
- Uppsala University
Diabetes Mellitus, Type 2
GliflOzin in eLderly Diabetic patiENts: A praGmatic Intraclass Evaluation Trial
Three SGLT2i were commercially available in Italy at the time the trial was designed: canagliflozin, dapagliflozin, and empagliflozin.
- Trial name
- GOLDEN-AGE (NCT04796428)
- Testing
- Canagliflozin, Dapagliflozin, Empagliflozin
- Volunteers
- 1,167 people
- Sponsor
- Center for Outcomes Research and Clinical Epidemiology, Italy