Clinical trials: Endocarditis Infective
Infective Endocarditis
Betalactam Pharmacokinetics in Endocarditis Patients
Infectious endocarditis (IE) is associated with mortality rates of 10-12%. Adequate antibiotic therapy is crucial for survival and is administered in high doses due to the severity of the disease.
- Trial name
- NCT04647331
- Where
- 4 sites in Sweden
- Volunteers
- 150 people
- Sponsor
- Uppsala University
Infective Endocarditis
Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus
Infective endocarditis (IE) is a serious infection with a significant burden for patients and hospitals (in France, median length of hospital stay = 43 days), partly due to the long duration of intravenous (IV) antibacterial…
- Trial name
- NCT02701595
- Testing
- Amoxicillin, Conventional IV treatment of streptococci/enterococci IE following European guidelines 2015 including amoxicillin, gentamicin, amicillin, vancomycin, penicillin G, ceftriaxone, netilmicin
- Where
- 45 sites in France
- Volunteers
- 324 people
- Sponsor
- University Hospital, Tours
Endocarditis Infective
Study of the Prognosis of Infectious Endocarditis (EPEI)
Infectious endocarditis (IE) is the localization and proliferation of blood-borne germs in the endocardium. It remains a complicated disease to manage due to its low incidence, diagnostic difficulties, the change in epidemiology…
- Trial name
- EPEI (NCT03211975)
- Testing
- To study the evolution of the prognosis of infectious endocarditis on native valves and on prostheses
- Where
- France
- Volunteers
- 645 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Infective Endocarditis
Hygiene and Bucco-dental Status of Patients With Oral Streptococcal Endocarditis
Infective endocarditis (IE) is a rare (30 cases / million / year in France) and serious disease (20 % of deaths during hospitalization and 40 % after 5 years).
- Trial name
- EI-DENTS (NCT03612245)
- Volunteers
- 403 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Infectious Disease, Endocarditis
Real-life Use of Cefazolin for the Treatment of Meticillin-susceptible Staphylococcal Infective Endocarditis: Comparison to a Treatment Cohort With Penicillin M
Retrospective, regional, multicenter study (including the Annecy-Genevois Hospital Center, the Chambéry Métropole Savoie Hospital Center, and the Grenoble University Hospital Center), comparing a cohort of patients treated with…
- Trial name
- CEFASTA (NCT05474118)
- Where
- France
- Volunteers
- 192 people
- Sponsor
- Centre Hospitalier Annecy Genevois
Endocarditis
Cardiac Computed Tomography (CT) Scan Compared to Transesophageal Echocardiogram (TEE) in Endocarditis
The purpose of this study is to assess the effectiveness of cardiac CT versus TEE in endocarditis patients.
- Trial name
- NCT00995384
- Testing
- CT Scan
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Corewell Health East
Infective Endocarditis
The Incidence, Clinical Characteristics and Outcome of Infective Endocarditis Among Intravenous Drug Abusers Versus Non-Drug Abusers.
We aim to describe the incidence of IVDA among patients presented with IE, describe their clinical, psychiatric and microbiological characteristics in comparison to non - IVDA, as well as the rate and types of complications and…
- Trial name
- NCT06194409
- Testing
- Echocardiography, Urine analysis , blood culture
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Assiut University
Infective Endocarditis (IE)
Impact of Clinical Care Pathway on Prognosis and Therapeutic Medical Care of Infective Endocarditis
Infective endocarditis (IE) is defined as a bacterial infection of the endocardium (inner surface of the heart), which may include one or more heart valves.
- Trial name
- NCT02856607
- Testing
- determine the prognosis of threated patients according to the clinical care pathway.
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Endocarditis Infective, Endocarditis Acute and Subacute
Endocarditis Clinical Awareness, Research, and Evaluation in Sweden
The goal of this observational study is to improve the understanding of infective endocarditis by investigating clinical characteristics, treatment strategies, and short- and long-term outcomes in patients diagnosed with…
- Conditions
- Endocarditis Infective, Endocarditis Acute and Subacute, Endocarditis, Bacterial, Endocarditis Acute
- Trial name
- ENDO-CARE (NCT07671118)
- Where
- Sweden
- Volunteers
- 22,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Prosthetic Valve Endocarditis
Prosthetic Valve Sweing Ring Injection by Antiboitics Can Affect the Rate of Postoperative Infective Endocarditis?
Follow-up of patients undergoing cardiac valve replacements with prosthetic valve after injection of sewing ring of prosthetic valve with aminoglycoside for prevention of infective endocarditis.
- Trial name
- NCT05455788
- Testing
- Aminoglycoside
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Assiut University
Infectious Endocarditis
Evaluation of an Antibiotic Regimen Pharmacokinetic Applicable to Enterococcus Faecalis Infective Endocarditis
The clinical trial is designed as a phase II, crossover clinical trial. It will be carried out in healthy volunteers, who will receive two different antibiotic regimen based on ceftriaxone.
- Trial name
- NCT03681431
- Testing
- Ceftriaxone 4g/ 24h, Ceftriaxone 2g/ 12h
- Where
- Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Cardiac Implantable Electronic Device Infections, Infective Endocarditis
Oritavancin for CIED Infections With MDR Gram-positive Cocci
The study aimed to conduct a randomized, non-inferiority controlled trial to compare the short- and medium-term efficacy and safety of two antibiotic dosage regimens in cardiac implantable electronic devices (CIED) infections…
- Conditions
- Cardiac Implantable Electronic Device Infections, Infective Endocarditis, Multidrug-resistant Bacteria Screening, Gram Positive Bacterial Infection
- Trial name
- ORI-4-CIEDi (NCT07013552)
- Testing
- Administration of a single or repeated dose of a long half-life antibiotic - oritavancin, Administration of a repeated dose of a short half-life antibiotic - vancomycin
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Silesia
Infective Endocarditis, Endocarditis
Barts Endocarditis Research Registry
The Barts Endocarditis Research Registry is being set up to give a unique opportunity to assess the characteristics of Infective Endocarditis (IE) in our population cohort, the current use of imaging techniques, as well as the…
- Conditions
- Infective Endocarditis, Endocarditis, Endocarditis, Bacterial
- Trial name
- NCT06434012
- Testing
- registry
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Queen Mary University of London
Infective Endocarditis
Rationale, Design and Methods for the Early Surgery in Infective Endocarditis Study (ENDOVAL)
Background: Prognosis of infective endocarditis is poor and has remained steady over the last four decades. Several nonrandomized studies suggest that early surgery could improve prognosis.
- Trial name
- ENDOVAL (NCT00624091)
- Testing
- Cardiac surgery, State-to-the-art treatment
- Where
- Spain
- Volunteers
- 216 people
- Sponsor
- Instituto de Ciencias del Corazon
Infective Endocarditis
Contribution of PET/CT With Gallium 68 Citrate (68Ga-PET/CT) for the Diagnosis of Prosthetic Valve Infective Endocarditis
CiGal-EI-TEP is an exploratory study that aim to assess the diagnostic performance of 68Ga Positron emission tomography (PET) / Computed Tomography (CT) for the diagnosis of prosthetic valve infective endocarditis in comparison…
- Trial name
- CiGal-EI-TEP (NCT05446376)
- Testing
- 68Ga-citrate PET/CT
- Where
- France
- Volunteers
- 19 people
- Sponsor
- University Hospital, Bordeaux
Pacemaker Lead Dysfunction, Pacemaker Electrode Infection
Contemporary Transvenous Lead Extraction Outcomes
Presentation of procedural safety and outcomes data from a high volume TLE centre
- Conditions
- Pacemaker Lead Dysfunction, Pacemaker Electrode Infection, ICD, Endocarditis Infective
- Trial name
- TLE (NCT05037474)
- Testing
- TLE group
- Where
- Germany
- Volunteers
- 340 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Infective Endocarditis
Management of Anemia in Patients with EndocaRditis Infectious Candidates for Cardiac Surgery: the AMERICA Study
Infective endocarditis (EI) is an extremely serious disease requiring prolonged hospitalisation, complex management by multidisciplinary teams and high healthcare costs.
- Trial name
- AMERICA (NCT06583902)
- Testing
- Intravenous iron, Retrospective case-control analysis
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Infective Endocarditis
Detection of the Most Common Microorganism of Infective Endocarditis in Assiut University Hospital
Indocarditis is an endogenous infection acquired when organisms entering the blood stream establish on the heart valves, therefore, any bacteremia can potentially result in endocarditis.
- Trial name
- NCT03487653
- Testing
- microbiology:Blood culture and sensitvity test .Serology
- Volunteers
- 50 people
- Sponsor
- Safaa Samir
Endocarditis, Bacterial
How to Improve Diagnosis in Infective Endocarditis
The purpose is to exam prospective if simple clinical information in combination with a normal s-procalcitonin are sufficient for exclusion of infective endocarditis (IE).
- Trial name
- NCT00524212
- Where
- Denmark
- Volunteers
- 761 people
- Sponsor
- University of Aarhus
Infective Endocarditis, Native Valve Endocarditis
Impact of FDG-PET/CT on Management of Patients with Native Valve Infective Endocarditis
The proposed study is a multicentric prospective observational cohort study of patients with suspected NVE. The study population includes those with Possible IE according to the modified Duke criteria and investigated at one of…
- Trial name
- PET-NAVIE (NCT04792281)
- Where
- 6 sites in Canada
- Volunteers
- 97 people
- Sponsor
- Montreal Heart Institute