Clinical trials: Endocarditis
Endocarditis Infective
Study of the Prognosis of Infectious Endocarditis (EPEI)
Infectious endocarditis (IE) is the localization and proliferation of blood-borne germs in the endocardium. It remains a complicated disease to manage due to its low incidence, diagnostic difficulties, the change in epidemiology…
- Trial name
- EPEI (NCT03211975)
- Testing
- To study the evolution of the prognosis of infectious endocarditis on native valves and on prostheses
- Where
- France
- Volunteers
- 645 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Infective Endocarditis
Evolution of the Profile of Infectious Endocarditis in France in 2008 (EI2008)
Infective endocarditis (IE) is a rare (30 cases / million / year in France) and serious (20 % of deaths during hospitalization) disease .
- Trial name
- EI2008 (NCT03295045)
- Volunteers
- 484 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Infective Endocarditis
Rifampin-free Regimen Versus Rifampin-containing Regimen in the Treatment of Staphylococcal Prosthetic Valve Endocarditis
The primary objective of this study is to demonstrate that a rifampin-free regimen is non-inferior to the rifampin-containing regimen in terms of all-cause mortality in staphylococcal prosthetic valve endocarditis within 6 months…
- Trial name
- RIFREE (NCT07345325)
- Testing
- Rifampin-free regimen, Rifampin containing regimen
- Where
- 31 sites in France
- Volunteers
- 422 people
- Sponsor
- Nantes University Hospital
Infective Endocarditis, End Stage Renal Disease
Incidence of Infective Endocarditis in End Stage Renal Disease Patients on Hemodialysis by Transesophageal Echocardiography in Assuit University Hospital
1. To detect in more detail the incidence of infective endocarditis in patients with end stage renal disease (ESRD) on hemodialysis. 2.
- Trial name
- NCT05692089
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Endocarditis, Acute Kidney Injury
Renal Tolerance of Amoxicillin and Cloxacillin Combination
2015 European Society of Cardiology Guidelines have proposed the combination of Ampicillin and Cloxacillin for initial empirical treatment of infective endocarditis in acute severely ill patients (before pathogen identification).
- Trial name
- Amox-Cloxa (NCT05142891)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Staphylococcus Aureus Bacteremia, Staphylococcus Aureus Endocarditis
Direct Lysis of Staph Aureus Resistant Pathogen Trial of Exebacase
The purpose of this superiority study is to evaluate the efficacy and safety of exebacase in addition to standard of care antibiotics (SoCA) compared with SoCA alone for the treatment of patients with Staphylococcus aureus (S.
- Trial name
- DISRUPT (NCT04160468)
- Testing
- Exebacase
- Where
- 55 sites in United States
- Volunteers
- 259 people
- Sponsor
- ContraFect
Infective Endocarditis
Autoantibodies and Clinical Symptoms in Infective Endocarditis Patients
The purpose is to evaluate autoantibodies in infective endocarditis patients before, at the beginning of treatment, and after the end of the treatment, and to correlate the autoantibodies in the presence of clinical symptoms.
- Trial name
- NCT00562653
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Staphylococcus Aureus Endocarditis, Staphylococcus Aureus Septicemia
Dabigatran vs. Oral Anti-Xa Inhibitors in S. Aureus Bacteremia
This is an open-label randomized controlled trial which will enroll patients with S. aureus bacteremia who are already taking oral anticoagulant medications (apixaban, edoxaban, or rivaroxaban) for an approved indication (stroke…
- Conditions
- Staphylococcus Aureus Endocarditis, Staphylococcus Aureus Septicemia, Staphylococcus Aureus Bacteremia, Staphylococcus Aureus Bloodstream Infection
- Trial name
- DABI-SNAP (NCT06650501)
- Testing
- Dabigatran, Apixaban, edoxaban
- Where
- 3 sites in Canada
- Volunteers
- 300 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Infectious Endocarditis
Hyperbaric Oxygen Treatment in Humans With Gram Positive Cocci Endocarditis
Infectious endocarditis (IE) is defined as an infection anywhere on the endocardium, most often localised to the cardiac valves. It is an infection with an increasing incidence and in Denmark with 6-700 new cases annually.
- Trial name
- ENDOHOT (NCT04691440)
- Testing
- Hyperbaric oxygen
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Ole Hyldegaard
Infective Endocarditis
Prospective Cohort Study of Patients With Infective Endocarditis at Pitié-Salpêtrière Hospital
Infective endocarditis (IE) is a severe condition associated with high mortality. Due to the relative low prevalence of IE, prospective data are lacking and current guidelines are mostly based on expert consensus with low level…
- Trial name
- EIPSL (NCT04992923)
- Where
- France
- Volunteers
- 700 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Staphylococcus Aureus Endocarditis, Prosthetic Valve Endocarditis
Adjunctive Rifampin for the Treatment of Prosthetic Valve Endocarditis Due to S. Aureus
This is a sub-study of the S. aureus Network Adaptive Platform (SNAP) trial (NCT05137119) wherein we will evaluate whether not giving rifampin in patients with probable or definite prosthetic valve endocarditis due to S.
- Trial name
- RIFA-SNAP (NCT07253688)
- Testing
- Rifampin, No rifampin
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Todd C. Lee MD MPH FIDSA
Staphylococcus Aureus, Bacteremia
Echocardiography Versus no Echocardiography in S. Aureus Bacteraemia and VIRSTA Score < 3
Staphylococcus aureus is the most frequent cause of both healthcare-associated and community-acquired bloodstream infections worldwide.
- Conditions
- Staphylococcus Aureus, Bacteremia, Infective Endocarditis
- Trial name
- VIRSTA-VAL (NCT06457386)
- Testing
- systematic echocardiography, no echocardiography arm
- Where
- France
- Volunteers
- 700 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infective Endocarditis
Endocarditis Registry of the University Hospital of Cologne (ER-UHC)
As recommended in the Guidelines on the prevention, diagnosis, and treatment of infective endocarditis (IE) patients with IE should be evaluated and managed by a multispecialty team including an cardiologist, infectious disease…
- Trial name
- NCT02388893
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University of Cologne
Bacteremia, Endocarditis
Retrospective Evaluation of Safety and Efficacy of Daptomycin Used in Patients With Serious Gram-positive Infections
Before Daptomycin (Cubicin ®) approved by the U.S. FDA in 2003, There were large-scale clinical trials conducted that included more than 1,000 subjects and than Daptomycin got complicated skin and soft tissue infections (CSSSI)…
- Conditions
- Bacteremia, Endocarditis, Serious Gram-positive Infections
- Trial name
- NCT01301638
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Far Eastern Memorial Hospital
Acute Kidney Injury
The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery
The purpose of study is to test whether perioperative sodium bicarbonate infusion can prevent acute kidney injury following open heart surgery in infective endocarditis patients.
- Trial name
- NCT01920126
- Testing
- sodium bicarbonate, Saline
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Yonsei University
Infective Endocarditis, Microbiology
Etiologic Diagnosis Algorithm in Infective Endocarditis
The goal of this study is to evaluate the impact of a diagnostic algorithm combining culture-based and molecular methods on the frequency of etiotropic antibiotic therapy prescription within 14 days of diagnosis of infective…
- Trial name
- NCT07682389
- Testing
- Molecular tests (PCR, sequencing), Standard Clinical Practice
- Where
- 3 sites in Russia
- Volunteers
- 128 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Infective Endocarditis
Characterization of RadiOlabeled Tracer Uptake Pattern in Noninfected Transcatheter Aortic Valves.
Therefore, the objective of the study is to characterize the pattern of radiolabeled tracer (18F-FDG) uptake in noninfected transcatheter heart valves in early follow-up after transcatheter aortic valve replacement (TAVR).
- Trial name
- COUNT (NCT03683355)
- Testing
- 18F-FDG PET/CT
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
Infective Endocarditis (IE)
Outcomes of Surgical Treatment in Patients With Infective Endocarditis
Infective endocarditis (IE) is a severe disease associated with significant morbidity and mortality despite advances in antimicrobial therapy and cardiac surgery.
- Trial name
- ETCEI (NCT07529730)
- Testing
- Data collection
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Infective Endocarditis
Characteristics of Infective Endocarditis in East China
This was a retrospective observational study of consecutive cases of definite or possible infective endocarditis (IE) as per the modified Duke criteria between January 2008 and December 2015, which was performed at the Second…
- Trial name
- NCT04977518
- Testing
- no intervention
- Volunteers
- 183 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Infective Endocarditis
Early Clinical, Laboratory and Microbiological Predictors of Treatment Outcomes in Infective Endocaridtis
The investigators conduct a prospective observational study on consecutive patients being admitted to a tertiary care-centre with infective endocarditis.
- Trial name
- CRP-IE (NCT02466139)
- Volunteers
- 102 people
- Sponsor
- Government Medical College, Kozhikode