Clinical trials: Endocarditis, Bacterial, open to volunteers
Transcatheter Aortic Valve Implantation, Dental
Impact of Preoperative Dental Screening in Reducing Infective Endocarditis Risk in Transcatheter Aortic Valve Implantation Patients
In Odense University Hospital preoperative dental screening (PDS) protocol for patients treated with Transcatheter Aortic Valve Implantation (TAVI) was changed from mandatory to targeted PDS to between June 2023 to october 2023.
- Conditions
- Transcatheter Aortic Valve Implantation, Dental, Endocarditis
- Trial name
- DENTAVI (NCT06330766)
- Testing
- No preoperative dental screening
- Where
- Denmark
- Volunteers
- 1,000 people
- Sponsor
- Odense University Hospital
Intracardiac Thrombus, Intracardiac Mass
AngioVac Aspiration Therapy Registry
As a structured, multinational retrospective registry the AVATAR Registry addresses the following scientific aspects through systematic data collection, centralized quality control, and robust statistical analysis in patients…
- Conditions
- Intracardiac Thrombus, Intracardiac Mass, Intravascular Thrombosis, Vegetation; Heart
- Trial name
- AVATaR (NCT07769320)
- Testing
- Retrospective analysis of assigned treatment
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Charite University, Berlin, Germany
Endocarditis, Bacterial
New Treatment of Cardiac Device Infections; Immediate Reimplantation After Removal of Infected System
The goal of this randomized clinical trials is to ascertain the safety and efficacy of immediate reimplantation of cardiac electronic implantable devices in patients with endocarditis and device-infections, compared to standard…
- Trial name
- POET-PPM (NCT06250985)
- Testing
- Timing of reimplantation
- Where
- 5 sites in Denmark
- Volunteers
- 176 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Infective Endocarditis, Endocarditis
Barts Endocarditis Research Registry
The Barts Endocarditis Research Registry is being set up to give a unique opportunity to assess the characteristics of Infective Endocarditis (IE) in our population cohort, the current use of imaging techniques, as well as the…
- Conditions
- Infective Endocarditis, Endocarditis, Endocarditis, Bacterial
- Trial name
- NCT06434012
- Testing
- registry
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Queen Mary University of London
Endocarditis Infective, Endocarditis, Bacterial
Dalbavancin Therapy for Infective Endocarditis
This study compares two treatment strategies for antibiotic therapy in endocarditis. The aim of the study is to determine which treatment is more effective overall and better tolerated by patients.
- Trial name
- EndoDalba (NCT07699211)
- Testing
- Dalbavancin administration, Standard of Care (Investigator Choice)
- Where
- 9 sites in Germany
- Volunteers
- 184 people
- Sponsor
- Stefan Hagel
Infective Endocarditis, Cardiac Device Infection
Oritavancin for Treatment of Serious Cardiac Infections
Cardiac infections, including infective endocarditis and cardiovascular implantable electronic device infections, are associated with substantial morbidity and mortality and are commonly caused by gram-positive bacteria.
- Conditions
- Infective Endocarditis, Cardiac Device Infection, Gram-positive Bacterial Infections
- Trial name
- OSCAR (NCT07550595)
- Testing
- Oritavancin
- Where
- 3 sites in Australia
- Volunteers
- 20 people
- Sponsor
- Kirby Institute
Infective Endocarditis, Bacterial Infections
Healthrelated Quality of Life and Experiences of a Heart Rehabilitation Programme After Care for Infective Endocarditis.
How does health develop after Infective endocarditis (IE)? Can the health of patients with IE be improved by participation in the physical exercise training within cardiac rehabilitation program? Participants will: Answer…
- Conditions
- Infective Endocarditis, Bacterial Infections, Cardiac Rehabilitation, Patient Participation
- Trial name
- NCT06704048
- Testing
- Cardiac rehabilitation
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Region Halland
Endocarditis, Bacterial
Bacteriophages in Addition to Antibiotics for the Treatment of Patients With Infective Endocarditis
Infective endocarditis (IE) is an endocardial lesion caused by bacterial and/or fungal infection that most commonly affects the heart valves and/or the endocardium around implanted intracardiac devices.
- Trial name
- PHARAOH (NCT06870409)
- Testing
- Bacteriophage
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- University Clinical Hospital na V.V.Vinogradov (branch of RUDN university na Patrice Lumumba)
Cardiac Implantable Electronic Device Infections, Infective Endocarditis
Oritavancin for CIED Infections With MDR Gram-positive Cocci
The study aimed to conduct a randomized, non-inferiority controlled trial to compare the short- and medium-term efficacy and safety of two antibiotic dosage regimens in cardiac implantable electronic devices (CIED) infections…
- Conditions
- Cardiac Implantable Electronic Device Infections, Infective Endocarditis, Multidrug-resistant Bacteria Screening, Gram Positive Bacterial Infection
- Trial name
- ORI-4-CIEDi (NCT07013552)
- Testing
- Administration of a single or repeated dose of a long half-life antibiotic - oritavancin, Administration of a repeated dose of a short half-life antibiotic - vancomycin
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Silesia
Sepsis, Infective Endocarditis
Study of Leukocyte Immunophenotype and the Lipid Transport System as Predictive Biomarkers of Severe Bacterial Infections
Current study evaluates the relationship between cell immunity and lipid transport systems in patients with severe bacterial infections (on the model of pneumonia, infective endocarditis, sepsis) in order to develop new methods…
- Conditions
- Sepsis, Infective Endocarditis, Pneumonia, Bacterial
- Trial name
- NCT04178915
- Testing
- Bood leukocyte subsets, The cholesterol content of the cell membrane of T-cells and monocytes
- Where
- Belarus
- Volunteers
- 100 people
- Sponsor
- The Republican Research and Practical Center for Epidemiology and Microbiology
Bacterial Infections, Bone Diseases, Infectious
Fosfomycin I.v. for Treatment of Severely Infected Patients
The purpose of this European, multicentric, prospective, non-interventional study is to document and evaluate the efficacy and safety of the treatment of severely infected patients with intravenously administered fosfomycin…
- Conditions
- Bacterial Infections, Bone Diseases, Infectious, Osteomyelitis, Central Nervous System Bacterial Infections
- Trial name
- FORTRESS (NCT02979951)
- Where
- 50 sites in Austria, Germany and 3 more
- Volunteers
- 1,000 people
- Sponsor
- Infectopharm Arzneimittel GmbH
Endocarditis, Bacterial, Endocarditis
Effectiveness of Antibiotic Prophylaxis of Infective Endocarditis for Invasive Dental Procedures in Patients With Prosthetic Heart Valves and/or History of Infective Endocarditis
Infective endocarditis (IE) continues to cause serious morbidity and mortality. To reduce its incidence, antibiotic prophylaxis has been recommended before invasive dental procedures in patients with at risk predispositions.
- Conditions
- Endocarditis, Bacterial, Endocarditis, Endocarditis Acute and Subacute
- Trial name
- PROPHETS (NCT05613933)
- Testing
- Improved practices
- Volunteers
- 250,000 people
- Sponsor
- University Hospital, Bordeaux