Clinical trials: Enamel Hypomineralization
Molar-Incisor Hypomineralization (MIH)
Color Change and Desensitization of Molar Incisor Hypomineralization-Affected Enamel Using Biomimetic Nano-Hydroxyapatite Toothpaste
This clinical trial aims to evaluate if nano-hydroxyapatite (Nano-HA) toothpaste effectively treats children with Molar-Incisor Hypomineralization (MIH). It will also assess the safety of Nano-HA toothpaste.
- Trial name
- NCT07436039
- Testing
- Fluoridated Toothpaste, Nano-hydroxyapatite Toothpaste
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- King Abdulaziz University
Molar Incisor Hypomineralization
Change in OHRQOL Following Minimally Invasive Treatment of Anterior Teeth in Children With MIH
MIH is a prevalent developmental defect which has a negative impact on children's OHRQoL, especially when incisor opacities are present.
- Trial name
- NCT05727475
- Testing
- Minimal invasive restorative treatment, Fluoride gel application
- Where
- Jordan
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Molar Incisor Hypomineralization, Hypersensitivity
Intraosseous Local Anesthesia System in Children With Molar Incisor Hypomineralization
The goal of this clinical trial is to compare in effectiveness of intraosseous anesthesia and inferior alveolar block anesthesia in children with molar incisor hypomineralization (MIH).
- Conditions
- Molar Incisor Hypomineralization, Hypersensitivity, Composite Restoration
- Trial name
- NCT06461143
- Testing
- %4 articaine with 1:200 000 adrenaline
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Molar Incisor Hypomineralization, Hypersensitivity
The Desensitising Effect of Nanosilver Fluoride in Molar-Incisor Hypomineralisation
The aim of the current study is to assess the desensitising effect of nanosilver fluoride on first permanent molars (FPMs) in patients with MIH in comparison to low-level laser therapy.
- Trial name
- NCT06348849
- Testing
- Low-level laser therapy, Nanosilver fluoride
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Alexandria University
Dental Caries, Dental Fluorosis
Anticaries Potential and Fluorosis Risk From Different Fluoride Toothpastes
Fluoride toothpaste has been associated not only with declining dental caries prevalence but also with an increase in dental fluorosis.
- Trial name
- NCT01589991
- Testing
- Toothpaste
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Enamel Hypomineralization, Tooth Erosion
Hydroxyapatite Toothpastes and Enamel Remineralization:
This randomized controlled clinical trial aims to evaluate the efficacy of two commercially available toothpastes containing hydroxyapatite in the remineralization of early enamel lesions.
- Trial name
- HEREMI (NCT07069218)
- Testing
- Biorepair® Total Protection Plus Toothpaste, Bioniq® Toothpaste
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
Molar Incisor Hypomineralization
Educational Program to Improve Dental Interns, Knowledge ,Attitude and Awareness Toward Molar Incisor Hypo-mineralization.
This interventional, quasi experimental study aims to assess the effectiveness of an educational program on improving dental interns' knowledge, attitude and awareness regarding Molar-Incisor Hypo-mineralization (MIH).
- Trial name
- MIH (NCT07129720)
- Testing
- Educational Program on MIH
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Molar Incisor Hypomineralisation
Molar Incisor Hypomineralisation and Dental Anomalies
Background/study aim: Molar incisor hypomineralisation (MIH) is a common disorder of tooth development. Affected teeth have weak enamel and adult molars often require extensive treatment or even extraction.
- Trial name
- NCT05812690
- Testing
- This is a non intervention - observation only study
- Where
- United Kingdom
- Volunteers
- 1,279 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Dental Fluorosis
Clinical Severity of Dental Fluorosis and Associated Risk Factors Among a Group of Children in Rural Region, Dendera Center in Egypt
The goal of our observational study is evaluation of the clinical severity of dental fluorosis and associated risk factors among a group of children (8-12 years old) in a rural region, Dendera center, Egypt.
- Trial name
- NCT07138456
- Where
- Egypt
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- Cairo University
Molar-Incisor Hypomineralization (MIH), Masticatory Performance
Evaluation of Occlusal Force and Masticatory Function in Children With Molar-Incisor Hypomineralization
This study aims to evaluate right-left chewing balance and masticatory function in children with Molar-Incisor Hypomineralization (MIH) before and after restorative treatment.
- Conditions
- Molar-Incisor Hypomineralization (MIH), Masticatory Performance, Occlusal Analysis, Chewing Function
- Trial name
- NCT07589179
- Testing
- Glass Hybrid Restorative Treatment
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Marmara University
Fluorosis, Dental
Nails and Teeth as Biomarkers of Fluoride Exposure
To determine fluoride concentration in fingernails and estimate if there is a correlation between fluoride concentration in fingernails and fluoride concentration in toothpaste used.
- Trial name
- NCT05442320
- Testing
- Biodent Toothpaste (Ilirija d.d., Ljubljana, Slovenia)
- Volunteers
- 342 people
- Sponsor
- University of Ljubljana
Pit and Fissure Sealants, Molar Incisor Hypomineralization
Clinical Evaluation of Two Different Pit and Fissure Sealants
It is planned to include girls and boys between the ages of 6-12 who apply to Başkent University Faculty of Dentistry, Pediatric Dentistry Clinic for routine dental examination.
- Trial name
- NCT06776471
- Testing
- Resin-based flowable filling material
- Where
- Turkey (Türkiye)
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Baskent University
Pain and Anxiety in Children With MIH
Preemptive Analgesia for Pain and Anxiety Control in Children With MIH
This randomized, triple-blinded clinical trial aims to evaluate the effect of preemptive analgesia using ibuprofen on pain perception and anxiety during restorative treatment of first permanent molars in children diagnosed with…
- Trial name
- NCT07374354
- Testing
- ibuprofen 100mg/ml oral suspension syrup
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- October University for Modern Sciences and Arts
Molar Hypomineralization, Incisor
Comparison of the Long-Term Success of Different CAD-CAM Blocks Used as Indirect Restorations in Molar Incisor Hypomineralized Teeth: A Split Mouth Study
This study is about the long-term survival success of different, externally prepared fillings (Indirect restoration, CAD-CAM blocks) used in teeth with reduced mineral structure, namely Molar Incisor Hypomineralization (MIH)…
- Trial name
- NCT07144605
- Testing
- CAD-CAM, indirect restorations
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Molar Incisor Hypomineralization
Prevalence of MIH Among Group of Egyptians Children Aged From 8 to 12 in Damietta
Assesment of the prevalence of molar incisor hypomineralization among a group of egyptian children aged from 8 to 12 years old in Damietta governate.
- Trial name
- NCT04410172
- Testing
- Mirror and prope
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Eman Zakaria Ali Hashem
Molar Incisor Hypomineralisation, Enamel Hypoplasia
Effect of Resin Infiltration on Hypersensitivity and Satisfaction in Children With Enamel Defects
This study evaluates the effect of resin infiltration on dental sensitivity, quality of life, and satisfaction in children aged 7-14 with enamel defects in their front teeth.
- Conditions
- Molar Incisor Hypomineralisation, Enamel Hypoplasia, Dental Hypersensitivity
- Trial name
- NCT07118111
- Testing
- Resin infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Gizem Tıraşçı
Hypomineralization of Enamel
PMCs as a Treatment of Children With HSPM Using the HT
Hypomineralised primary second molars are primary molars with a developmental disorder of the enamel. Preformed metal crowns already have good results for the treatment of caries on primary molars.
- Trial name
- NCT04265183
- Testing
- Placing preformed metal crowns using Hall technique.
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Molar Incisor Hypomineralisation
Intraosseous Anesthesia in MIH-Affected Teeth
Managing MIH-affected teeth is challenging due to inflammation, sensitivity, rapid caries development, and difficulty achieving anesthesia.
- Trial name
- IO-MIH (NCT07457450)
- Testing
- Intraosseous anesthesia., Local infiltration anesthesia
- Where
- Croatia
- Volunteers
- 50 people
- Sponsor
- University of Zagreb
Hypomineralization of Enamel
Prevalence of Hypomineralized Second Primary Molars In A Group of Egyptian Children
Aim of the study: This study aims to detect the prevalence of hypomineralized second primary molars and its association with hypomineralized primary canines in a group of Egyptian children.
- Trial name
- NCT06736535
- Volunteers
- 825 people
- Sponsor
- Cairo University
Molar Incisor Hypomineralization
Assessment of the Remineralization Efficacy of Vitamin D in the Treatment of MIH. In Vitro Study and In Situ Randomized Double-Blind Placebo Clinical Trial.
In child patients with molar incisor hypo mineralization, Will Vitamin D mouth wash offer more success for patients with MIH as regards better MIH TNI index, decrease plaque accumulation, more gingival health and less bleeding on…
- Trial name
- NCT06515548
- Testing
- Vitamin D3 mouth wash
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cairo University