Clinical trials: Emergency Surgery
Emergencies, Surgery
Patient and Staff Experience of Ambulatory Emergency Care on the Surgical Admissions Unit (SAU)
Emergency ambulatory care ("day-case" care that does not involve staying in a hospital bed overnight) is now well-established for medical patients and is being used increasingly for surgical patients.
- Trial name
- NCT03514043
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University of Exeter
Surgical Site Infection (SSI)
Rationale of Subcutaneous Levofloxacin Infiltration as an Adjunct for Surgical Site Infection Prevention in Emergency Laparotomy
Surgical site infection (SSI) remains a major cause of postoperative morbidity following emergency laparotomy, particularly in contaminated and dirty/infected abdominal conditions.
- Trial name
- NCT07696819
- Testing
- Levofloxacin
- Where
- Bangladesh
- Volunteers
- 90 people
- Sponsor
- Sylhet M.A.G.Osmani Medical College
Secondary Peritonitis, Post-induction Hypotension
Low-dose Norepinephrine Infusion for Prevention of Post-induction Hypotension in Emergency Surgery for Peritonitis
This study tests whether giving a low-dose norepinephrine infusion just before induction of anesthesia can reduce low blood pressure during emergency surgery for peritonitis.
- Trial name
- NCT07529795
- Testing
- Norepinephrine (0.05 μg/kg/min)
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- Bach Mai Hospital
Surgical Wound Dehiscence
Prevention of Fascial Dehiscence With Prophylactic Onlay Mesh in Emergency Laparotomies
Facial dehiscence elicit high morbidity and mortality. This complication may arise in more than 8.5% of high-risk patients. Addressing risk factors and optimizing surgical technique are guarded as mainstay measures for…
- Trial name
- NCT03293862
- Testing
- prophylactic polypropilene mesh, Midline Fascial Closure, vacuum drainage system
- Where
- Brazil
- Volunteers
- 145 people
- Sponsor
- University of Sao Paulo General Hospital
Emergency Surgery
NLR and Emergency Surgery
In the immune system, it has been observed that the preoperative neutrophil-to-lymphocyte ratio (NLR) is an index that reflects the state of inflammation and oxidative stress.
- Trial name
- NCT06549101
- Where
- Chile
- Volunteers
- 851 people, healthy volunteers welcome
- Sponsor
- University of Chile
Pulmonary Aspiration, Emergency Surgery
Aspiration Risk Assessment by Gastric Ultrasound in eMErgency Surgery and ANesThetic Decision-making: The ARGUMENT Study
Pulmonary aspiration of gastric contents is a serious patient safety problem accounting for 50% of anesthesia-related mortality.
- Trial name
- NCT06303492
- Testing
- GUS
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Acute Abdomen
The Role of Laparoscopy in Upper Abdominal Surgical Emergencies in Adults: A Retrospective Observational Study.
Introduction Laparoscopy can be used to diagnose and treat the etiologies of acute abdominal pain. This study aimed to assess laparoscopy's effectiveness in upper gastrointestinal (G.I.T) emergencies regarding intra-and…
- Trial name
- NCT05591495
- Testing
- laparoscopy in upper abdominal surgical emergencies in adults
- Volunteers
- 215 people
- Sponsor
- Zagazig University
Laparotomy Closure After Abdominal Surgery
Comparing Delayed vs Primary Wound Closure After Emergency Laparotomy: Impact on Infection, Healing, and Hospital Stay
The purpose of this study is to find out which type of wound closure after emergency abdominal surgery leads to fewer wound infections and better recovery: closing the wound immediately after surgery (called primary closure) or…
- Trial name
- NCT07142395
- Testing
- Immediate skin closure, Delayed primary closure
- Where
- Pakistan
- Volunteers
- 82 people
- Sponsor
- Bkahtawar Amin Medical and Dental College Multan
Pregnancy Complications, Acute Appendicitis
Fetal Outcomes Among Pregnant Emergency General Surgery Patients
Approximately 1 in 500 pregnant women require non-obstetric surgery. Surgical care for the pregnant woman raises concern for complications adversely affecting pregnancy outcomes.
- Conditions
- Pregnancy Complications, Acute Appendicitis, Acute Cholecystitis, Biliary Pancreatitis
- Trial name
- NCT05085353
- Testing
- non-obstetric acute general surgical disease
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Methodist Health System
Frailty, Cardiac Surgery
SAGE-Heart : Senior Assessment fraGility and Post-opErative QALYs 1 Year After Emergency HEART Surgery for Patients Aged 75 and Older
The hypothesis is that the preoperative Clinical Frailty Score (CFS) is a predictive factor for a loss in quality-adjusted life years (QALYs) one year after emergency cardiac surgery under cardiopulmonary bypass (CPB) in patients…
- Conditions
- Frailty, Cardiac Surgery, QALYs
- Trial name
- SAGE-Heart (NCT07677319)
- Testing
- Phone Calls
- Where
- France
- Volunteers
- 265 people
- Sponsor
- University Hospital, Bordeaux
Pediatric Anesthesia, Emergence Delirium, Anesthesia
Impact of EEG-guided Sevofluorane on Opioid Consumption and Quality of Awakening
This prospective, randomized, single-blind, two-arm parallel-group clinical trial evaluates whether EEG-guided sevoflurane titration affects intraoperative opioid consumption and emergence quality in children undergoing painful…
- Conditions
- Pediatric Anesthesia, Emergence Delirium, Anesthesia, Postoperative Pain, Tonsillectomy
- Trial name
- NCT07714785
- Testing
- EEG-guided, Standard
- Where
- Chile
- Volunteers
- 50 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Digestive Emergency, New Pathway
Effectiveness of the RAUC Pathway in Reducing Unscheduled Hospitalizations After Emergency Digestive Surgery
The number of emergencies's visits (22 million visits in 2019 in France), the organization of emergencies and the sustainability of the current health system are threatened.
- Conditions
- Digestive Emergency, New Pathway, Connected Health
- Trial name
- RAUCAMIENS (NCT06769438)
- Testing
- ERAS, ROFIM, DEEPSEN
- Where
- 2 sites in France
- Volunteers
- 3,000 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Frail Elderly Syndrome, Emergencies
Frailty and Sarcopenia Outcomes in Emergency General Surgery
1. A retrospective scoping cohort review of adult patients undergoing emergency laparotomy/laparoscopy for acute gastrointestinal (GI) pathology who have had a CT scan of the abdomen(+/- pelvis).
- Conditions
- Frail Elderly Syndrome, Emergencies, Surgery, Sarcopenia
- Trial name
- FrOGS (NCT03534765)
- Testing
- CT abdomen +/- pelvis, Edmunton Frailty Score, Emergency laparotomy for general surgical pathology
- Where
- 10 sites in United Kingdom
- Volunteers
- 294 people
- Sponsor
- Yeovil District Hospital NHS Foundation Trust
Emergency Surgery, Acute Kidney Injury
Preoperative Hemoglobin and Acute Kidney Injury in Emergency Surgery
Optimization of hemoglobin levels for organ perfusion is essential, especially in critically ill patients. Although anemia is associated with severe organ failure, especially in coronary artery disease, the effects of blood…
- Conditions
- Emergency Surgery, Acute Kidney Injury, Hemoglobin
- Trial name
- NCT06857630
- Testing
- Observational
- Where
- Turkey (Türkiye)
- Volunteers
- 420 people
- Sponsor
- Samsun University
Abdominal Pain
Randomized Study Evaluating the Role of Surgeon-Performed Ultrasound in the Management of the Acute Abdomen
The purpose of this study is to evaluate whether surgeon-performed ultrasound as a supplement to clinical investigation when a patient presents with abdominal pain in the emergency department can improve the management of the…
- Trial name
- NCT00550511
- Testing
- Surgeon-performed ultrasound
- Volunteers
- 800 people
- Sponsor
- Karolinska Institutet
Emergency General Surgery
Anticoagulation in Emergency General Surgery
While DOACs are increasing in use in the EGS patient population, the risk of bleeding and the reversal of these agents to reduce hemorrhage is still evolving.
- Trial name
- NCT04216394
- Testing
- Emergency general surgery
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Methodist Health System
Emergencies, Quality of Life
Quality of Life and Persistent Pain 3 Months After Emergency Surgery Before and After a National Urgency Classification
The aim of this study is to evaluate the impact of implementing a national surgical emergency classification system in the emergency operating room in Nice on patients' quality of life and persistent pain 3 months after surgery.
- Conditions
- Emergencies, Quality of Life, Postoperative Pain
- Trial name
- NCT07819903
- Testing
- Usual-practice emergency-surgery triage, National surgical-emergency classification-based triage
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Surgery, Diverticulitis
Hartmann's Versus Primary Anastomosis in Left-sided Colon Perforation
The purpose of this multi-center randomized trial is to identify any differences in the complication rates of patients undergoing Hartmann's (end colostomy) versus Primary Anastomosis (with defunctioning ileostomy) for left-sided…
- Conditions
- Surgery, Diverticulitis, Neoplasms, Postoperative Complications
- Trial name
- ColonPerfRCT (NCT01233713)
- Testing
- Hartmann's operation, Primary anastomosis
- Where
- 4 sites in Switzerland
- Volunteers
- 62 people
- Sponsor
- University of Zurich
Acute High-risk Abdominal Surgery (AHA)
Early Mobilization Following Emergency Abdominal Surgery
Acute High-risk abdominal surgery (AHA) is associated with high mortality rates, multiple postoperative complications and prolonged duration of hospital admission.
- Trial name
- NCT03662932
- Testing
- Early intensive mobilization
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Morten Tange Kristensen PT, PhD
Mental Health
Surgeons' Mental Distress and Risks After Severe Complications Following Emergency Surgery
Surgeons experience higher levels of work stress, even under normal circumstances. Many can suffer from substantial levels of mental health issues, especially when faced with severe complications.
- Trial name
- NCT05864443
- Testing
- Severe complications following emergency surgery
- Volunteers
- 2,500 people
- Sponsor
- Shanghai Zhongshan Hospital