Clinical trials: Emergency Abdominal Surgery
Laparotomy, Peritonitis
Standardized Perioperative Management of Patients Operated With Acute Abdominal Surgery in a High-risk Emergency Setting
The objective of the study is to handle patients with the need for an acute laparotomy according to a standardised perioperative protocol and to document the measurement as they are performed (i.e.
- Conditions
- Laparotomy, Peritonitis, Ileus, Perforated Bowel
- Trial name
- SMASH (NCT03549624)
- Testing
- Standardised protocol for the perioperative management in patients in need of an acute laparotomy
- Where
- Sweden
- Volunteers
- 1,435 people
- Sponsor
- Sahlgrenska University Hospital
Abdomen, Acute, Surgery--Complications
Survival After Emergency Laparotomy in Octogenarians
In this single-center retrospective study we wanted to investigate mortality and postoperative complications after emergency laparotomy performed in patients aged 80 years or above.
- Conditions
- Abdomen, Acute, Surgery--Complications, Postoperative Complications, Frailty
- Trial name
- NCT04176432
- Testing
- No intervention
- Volunteers
- 106 people
- Sponsor
- Haukeland University Hospital
Sepsis, Intra-Abdominal Infections
Gelaspan vs Crystalloid Therapy in Sepsis
The goal of this randomized clinical trial is to evaluate whether balanced gelatin solution is more effective and safe than balanced crystalloid solution for perioperative fluid management in adults with sepsis undergoing…
- Trial name
- SPACES (NCT07172451)
- Testing
- Balanced Gelatin Solution, Acetate Ringer's Solution
- Where
- 9 sites in China
- Volunteers
- 318 people
- Sponsor
- Shanghai Zhongshan Hospital
Abdominal Wall Defect, Abdominal Wall Hernia
The Efficacy and Security of the Small Stitch Technique in Emergency Surgery
This study evaluates the abdominal closure technique in emergency surgery. Half of participants will be perform the classic Large Stitch technique, while the other half will undergo the Small Stitch technique.
- Conditions
- Abdominal Wall Defect, Abdominal Wall Hernia, Eventration, Evisceration; Operation Wound
- Trial name
- STCU (NCT03765060)
- Testing
- Monomax® 2/0 HR26, Monomax® 1 HR48
- Where
- Spain
- Volunteers
- 105 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Emergency General Surgery Laparotomy
Surgical Apgar Score for Identifying Patients Who May Need Intensive Care After Emergency Abdominal Surgery
This prospective observational study will evaluate whether the Surgical Apgar Score can help identify patients who require direct admission to the intensive care unit after emergency abdominal surgery.
- Trial name
- SAS-ICU (NCT07814131)
- Where
- Pakistan
- Volunteers
- 77 people
- Sponsor
- King Edward Medical University
Surgical Wound Dehiscence
Prevention of Fascial Dehiscence With Prophylactic Onlay Mesh in Emergency Laparotomies
Facial dehiscence elicit high morbidity and mortality. This complication may arise in more than 8.5% of high-risk patients. Addressing risk factors and optimizing surgical technique are guarded as mainstay measures for…
- Trial name
- NCT03293862
- Testing
- prophylactic polypropilene mesh, Midline Fascial Closure, vacuum drainage system
- Where
- Brazil
- Volunteers
- 145 people
- Sponsor
- University of Sao Paulo General Hospital
Incisional Hernia After Midline Laparotomy, Emergency Abdominal Surgery
Prophylactic Mesh Reinforcement Versus Primary Closure After Emergency Midline Laparotomy (PREEMPT)
The PREEMPT trial is a multicenter randomized controlled trial comparing prophylactic onlay biosynthetic mesh reinforcement with primary suture closure in adult patients undergoing emergency midline laparotomy.
- Trial name
- PREEMPT (NCT07753551)
- Testing
- Prophylactic Biosynthetic Mesh Placement, Direct suture
- Where
- Italy
- Volunteers
- 189 people
- Sponsor
- University of Rome Tor Vergata
Emergency Inguinal Hernia Repair, Emergency Ventral Hernia Repair
Emergency Hernia Repair
Emergency hernia repairs are associated with significantly higher morbidity and mortality compared with elective hernia surgery.
- Trial name
- NCT07314398
- Testing
- Emergency hernia repair
- Volunteers
- 600 people
- Sponsor
- Oulu University Hospital
Hernia Incisional, Suture, Complication
DuraMesh Laparotomy Closure Following Trauma and Emergency Surgery
The proposed project aims to evaluate the safety of DuraMesh™ suture for laparotomy closure in an emergent setting, while also providing preliminary efficacy data with regard to incisional hernia prevention.
- Trial name
- NCT04312165
- Testing
- Duramesh Laparotomy Closure, Conventional suture closure
- Where
- 2 sites in United States
- Sponsor
- Uniformed Services University of the Health Sciences
Emergency General Surgery
STRATA: Surgical Treatment Using Robotic Approach in The Acute Abdomen
Robotic surgery in the UK is now widely used in elective procedures based on evidence that it can improve outcomes, with improved vision and precision for the surgeon resulting in better results and greater rates of minimally…
- Trial name
- STRATA (NCT07850401)
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- Portsmouth Hospitals NHS Trust
Diabetes (Insulin-requiring, Type 1 or Type 2)
Investigation of the Effectiveness of Prophylactic NPWT (ciNPWT) in High-risk Diabetic Patients With Acute Laparotomy Wounds
The aim of this study is to evaluate the effectiveness of prophylactic Negative Pressure Wound Therapy (NPWT) in patients with diabetes mellitus undergoing laparotomy who are at high risk for Surgical Site Infections (SSI).
- Trial name
- NCT07392853
- Testing
- Prophylactic/Incisional Negative Pressure Wound Therapy
- Where
- Hungary
- Volunteers
- 110 people
- Sponsor
- Semmelweis University
Surgical Site Infection, Length of Stay
Prevena to Prevent Surgical Site Infection After Emergency Abdominal Laparotomy
Post-operative wound complications in abdominal surgery have a major impact on patient outcomes and the real impact of Closed incision negative pressure therapy (CINVt) is not clear in the literature moreover concerning its…
- Conditions
- Surgical Site Infection, Length of Stay, Seroma, Hematoma
- Trial name
- CiPNT/SSI (NCT04496180)
- Testing
- Closed incision negative pressure therapy versus standard dressing after emergency abdominal laparotomies
- Volunteers
- 334 people
- Sponsor
- University Hospital, Geneva
Chronic Postoperative Pain
Persistent Postoperative Pain After Major Emergency Abdominal Surgery
Perioperative pain is one of the most significant complaints and problems for patients undergoing major open surgery. Pain after surgery carry an abundance of consequences such as reduced mobilization, reduced nutrition intake…
- Trial name
- NCT04508465
- Where
- Denmark
- Volunteers
- 110 people
- Sponsor
- Zealand University Hospital
Emergency Abdominal Surgery, Opioid Sparing Anaesthesia
Effect of Opioid-sparing Anesthesia on Quality of Recovery After Emergency Laparotomy
Opioids are widely used during anesthesia for pain control, but they cause many side effects-such as nausea, constipation, respiratory depression, dependence, and delayed recovery.
- Trial name
- NCT07262242
- Testing
- Lidocaine (drug), Fentanyl (IV)
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Cairo University
Emergency Laparotomy, Intestinal Obstruction
Enhanced Recovery Versus Standard Care After Emergency Abdominal Surgery in Patients Requiring Emergency Laparotomy
This study aims to compare an Enhanced Recovery After Surgery (ERAS) protocol with conventional postoperative care in adults undergoing emergency laparotomy for intestinal obstruction or intestinal perforation.
- Conditions
- Emergency Laparotomy, Intestinal Obstruction, Intestinal Perforation, Enhanced Recovery After Surgery (ERAS) Protocol
- Trial name
- NCT07650461
- Testing
- Enhanced Recovery After Surgery, Conventional Postoperative Care
- Where
- Pakistan
- Volunteers
- 102 people
- Sponsor
- Recep Tayyip Erdogan Hospital Pakistan - Muzaffargarh
Suture Techniques, Wound Closure Techniques
Small Bites Vs Large Bites Abdominal Midline Incisional Closure
The goal of this trial is to compare the effectiveness of small bite versus large bite abdominal incision closure in emergency settings. It will also evaluate the safety and outcomes of each technique.
- Conditions
- Suture Techniques, Wound Closure Techniques, Laparotomy/Standerds, Surgical Wound Dehiscence
- Trial name
- NCT07154277
- Testing
- Small bite closure, Large bite closure
- Where
- Pakistan
- Volunteers
- 200 people
- Sponsor
- Dow University of Health Sciences
Open Abdomen
An Adhesion Reduction Plan in the Management of the Surgical Open Abdomen
The purpose of this study is to determine whether an adhesion reduction plan, consisting of early adhesion prevention and application of a bioresorbable membrane is effective in reducing the severity of adhesions and the…
- Trial name
- NCT01010464
- Testing
- Adhesion Reduction Plan
- Where
- United States
- Sponsor
- University of Maryland, Baltimore
Surgery--Complications, Abdomen Disease
Use of Wearables for Early Detection of Complications After Major Acute Abdominal Surgery
The purpose of the study is to investigate whether glucose profile, sleep disturbances and heart rate variability measured with wearable devices is associated with postoperative recovery and complications within 30 days after…
- Trial name
- NCT04257344
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Zealand University Hospital
Laparotomy Closure After Abdominal Surgery
Comparing Delayed vs Primary Wound Closure After Emergency Laparotomy: Impact on Infection, Healing, and Hospital Stay
The purpose of this study is to find out which type of wound closure after emergency abdominal surgery leads to fewer wound infections and better recovery: closing the wound immediately after surgery (called primary closure) or…
- Trial name
- NCT07142395
- Testing
- Immediate skin closure, Delayed primary closure
- Where
- Pakistan
- Volunteers
- 82 people
- Sponsor
- Bkahtawar Amin Medical and Dental College Multan
Emergency Abdominal Surgery
Physiotherapy After Emergency Laparotomy in the Elderly
Emergency laparotomy is associated with high postoperative morbidity and mortality. This risk is particularly high among elderly patients, who often present with reduced physiological reserve, frailty, and multimorbidity.
- Trial name
- NCT07504185
- Testing
- Experimental (Structured postoperative physiotherapy), Standard postoperative care
- Where
- Cyprus
- Volunteers
- 250 people
- Sponsor
- University of Cyprus