Clinical trials: Electronic Cigarette Use, open to volunteers
Electronic Cigarette Use, Endothelial Dysfunction
Role of Inflammation in Vascular Phenotype Associated With E-cigarette Use
The use of electronic nicotine delivery systems, or e-cigarettes - colloquially referred to as "vaping" - in the United States has increased exponentially since their introduction to the US market in 2007.
- Conditions
- Electronic Cigarette Use, Endothelial Dysfunction, Inflammation
- Trial name
- NCT06489249
- Testing
- Salsalate 750 MG Oral Tablet [DISALCID]
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Tobacco Use Behavior, Nicotine Dependence Tobacco Product
§SMOKE Nicotine and Tobacco Youth Cohort
The §SMOKE Cohort Study aims to improve understanding of tobacco and nicotine use among adolescents and young adults in Denmark.
- Conditions
- Tobacco Use Behavior, Nicotine Dependence Tobacco Product, E-Cigarette Use, Smoking ( Cigarette)
- Trial name
- NCT07910331
- Where
- Denmark
- Volunteers
- 10,000 people
- Sponsor
- University of Southern Denmark
Electronic Nicotine Delivery Systems, Tobacco Products
Development of a Mobile Health Intervention for Electronic Cigarette Use Among Young Adults
Electronic Nicotine Delivery Systems (ENDS) use remains prevalent among young adults, and many have high interest in quitting, yet research on effective intervention is lacking.
- Conditions
- Electronic Nicotine Delivery Systems, Tobacco Products, Cigarette Smoking
- Trial name
- EQUIP (NCT06395415)
- Testing
- EQUIP, Standard Care
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Smoking, E-Cig Use
Clinical Alternatives for Reducing Harm Using E-cigarettes
For patients in cancer care, quitting smoking is critical, but a significant portion of patients in cancer care refuse all components of tobacco treatment, even when offered free of charge.
- Conditions
- Smoking, E-Cig Use, Oncology
- Trial name
- CARE (NCT07039292)
- Testing
- Harm Reduction (E-cigarette switching), Standard of Care
- Where
- United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Smoking, Smoking Behaviors
A Study to Assess Nicotine Uptake From Electronic Nicotine Delivery Systems
This will be an open-label, randomized, single-site, 8-way crossover study designed to evaluate plasma nicotine pharmacokinetic (PK) parameters and overall product liking (OPL) following an ad libitum use of Electronic Nicotine…
- Conditions
- Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
- Trial name
- NCT07323563
- Testing
- Product A, Product B, Product C
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Vaping, Addiction
The Use of tDCS for Vaping Reduction
Project Summary - tDCS for Vaping Reduction Background: While the prevalence of tobacco smoking has plateaued over the last several years, the prevalence of nicotine vaping (e-cigarettes) continues to increase exponentially in…
- Conditions
- Vaping, Addiction, Transcranial Direct Current Stimulation(tDCS)
- Trial name
- NCT06885606
- Testing
- Active tDCS
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre for Addiction and Mental Health
Addiction Nicotine
The CONQUER Trial - Cessation Of Nicotine, QUitting With E-cigarette Reduction
This clinical trial evaluates the VapeAway system, a novel, multi-modal intervention designed to address the multifaceted nature of vaping addiction.
- Trial name
- CONQUER (NCT07322432)
- Testing
- VapeAway filter system
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- VapeAway
Smoking Prevention and Control
Impact of Cigarette and E-cigarette Menthol Regulation on Current Smokers of Menthol Cigarettes
In a 2x2 design, current menthol smokers (N=240) will complete a baseline period before being assigned to a cigarette (menthol or non-menthol) and e-cigarette condition (menthol or tobacco-flavored e-liquid) and receiving a…
- Trial name
- NCT05896033
- Testing
- Non-Menthol Cigarettes, Tobacco Flavored E-cigarettes, Menthol Cigarettes
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Smoking, Smoking Behaviors
Abuse Liability for Eight Electronic Nicotine Products
This will be a randomized, open-label, 8-way crossover, single-site study designed to evaluate elements of abuse liability (AL), including subjective effects and physiological measures (pharmacodynamics [PD]), and plasma nicotine…
- Conditions
- Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
- Trial name
- NCT07323511
- Testing
- Product A, Product B, Product C
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
E-cigarette Use, Cigarette Smoking
Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers
This between-subjects study aims to evaluate whether e-cigarettes (ECIGS) versus oral nicotine pouches (ONPS) more readily substitute for combustible cigarettes among 200 cigarette smokers.
- Conditions
- E-cigarette Use, Cigarette Smoking, Harm Reduction, Tobacco Use
- Trial name
- NCT06372899
- Testing
- E-cigarettes, Oral nicotine pouches
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Electronic Cigarette Use
Effect of Menthol on ENDS Users' Addiction and Exposure
The use of electronic nicotine delivery systems (ENDS; e-cigarettes) has reached epidemic levels among young people in the United States (US).
- Trial name
- NCT05338801
- Testing
- Menthol-flavored e-cigarette, Tobacco-flavored e-cigarette
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Florida International University
Vaping, E Cig Use
A Hybrid Program to Prevent Substance Use Risk Among Upper Elementary School Students Using a Positive Youth Development Approach
The goal of this randomized controlled trial is to evaluate a psychosocial school-based hybrid intervention which includes traditional classroom sessions and online e-learning modules to reduce risk of vaping and prescription…
- Conditions
- Vaping, E Cig Use, Prescription Drug Misuse
- Trial name
- NCT07162155
- Testing
- School-based Hybrid Intervention to Prevent Vaping and Prescription Drug Misuse
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Christopher Williams
Nicotine Addiction
Developing Evidence to Inform Regulatory Policy on Nicotine Content in E-Liquids
The goal of this observational study is to learn if electronic cigarette users who currently choose to use lower nicotine eliquids have reduced harm compared those who choose higher nicotine eliquids.
- Trial name
- NCT06619964
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Rochester Institute of Technology
E-cigarette Use, Cigarette Smoking Risk
An Online Intervention to Reduce E-cigarette Use and Cigarette Smoking Risk in Adolescents
The goal of this clinical trial is to learn if a brief digital intervention can reduce e-cigarette use and prevent cigarette smoking initiation in teenagers ages 12-17.
- Trial name
- NCT07624292
- Testing
- Virtual Intervention for Behavioral Empowerment (VIBE)
- Volunteers
- 150 people
- Sponsor
- University of Southern California
Cigarette Smoking-Related Carcinoma, E-Cig Use
Carcinogen and Toxicant Exposure Among Young Adults Who Co-Use Cigarettes, E-cigarettes and Cannabis (Co-Tox Study)
This study evaluates the amount of nicotine, cannabis, and toxicants linked to the use of nicotine e-cigarette and/or cannabis products in the blood and urine of young adult users as well as the cannabis and nicotine use…
- Trial name
- NCT07167225
- Testing
- Effectiveness of different recruitment approaches, Choice of study completion locations, Cannabis Engagement Assessment
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Electronic Cigarette Use
Developing and Testing Health Warning Labels on the ENDS Device
In this project, after systematically developing electronic nicotine delivery systems (ENDS) pictorial health warning labels (HWLs), a proven clinical lab model will be used to examine and test their effect when these are placed…
- Trial name
- NCT04907136
- Testing
- Preferred ENDS, Preferred ENDS with HWL
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Florida International University
E-cigarette Use, Substance Use
The Development and Evaluation of a Culturally Grounded ENDS Intervention for Rural Hawaiian Youth
The purpose of this research proposal is to develop and evaluate a culturally grounded, ENDS prevention intervention for rural Hawaiian youth. This will be accomplished through two specific aims.
- Trial name
- NCT06929520
- Testing
- ENDS Prevention Intervention (TBD)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Hawaii
Opioid Use Disorder, Cigarette Smoking
E-Cigarettes for Harm Reduction in Smokers With Opioid Use Disorder
The purpose of this an open-label, randomized controlled trial study is to compare the effectiveness of electronic cigarettes (e-cigarettes/e-cigs) versus telehealth motivational counseling with combination nicotine replacement…
- Trial name
- NCT05722561
- Testing
- Telehealth Motivational Counseling, Nicotine Replacement Product, National Institute on Drug Abuse (NIDA) Standardized Research Electronic Cigarette (SREC).
- Where
- 2 sites in United States
- Volunteers
- 302 people
- Sponsor
- NYU Langone Health
Tobacco Use, Electronic Cigarette Use
Just-in-Time Support for Smoking, Vaping, and Eating Urges During High-Stress Moments Among Gender and Sexual Minority Adults in Dhaka
Gender and sexual minority adults in Bangladesh experience high levels of stigma-related stress. Acute stress can trigger strong, affect-driven urges to smoke, vape, or engage in stress-attributed eating.
- Conditions
- Tobacco Use, Electronic Cigarette Use, Emotional Eating, Stress, Psychological
- Trial name
- NCT07746492
- Testing
- Just-in-Time Adaptive Support Message
- Where
- Bangladesh
- Volunteers
- 115 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Nicotine Dependence, Cigarettes
AI-Enhanced App-based Intervention for Adolescent E-cigarette Cessation
The goal of this quasi-experimental study is to test if a smartphone app can help adolescents aged 14-20 quit e-cigarettes. The main questions it aims to answer are: Can the app help adolescents manage cravings and increase their…
- Trial name
- NCT06965296
- Testing
- AI-enhanced smartphone app, AI-enhanced smartphone app, but with delayed access
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- State University of New York at Buffalo