Clinical trials: Electroconvulsive Therapy, open to volunteers
Depression - Major Depressive Disorder, Catatonia
Optimizing Stimulation Parameters for Electroconvulsive Therapy
The goal of this clinical trial is to improve how electroconvulsive therapy (ECT) stimulation settings are chosen. Researchers will use real-time brain monitoring to measure both seizures and a recently identified brain event…
- Trial name
- PRESTO (NCT07561307)
- Testing
- Electroconvulsive Therapy
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Pennsylvania
Hemodynamic Response
Demedetomidine and Remifentanil in Electroconvulsive Therapy (ECT)
Electroconvulsive therapy (ECT) is a treatment modality that induces therapeutic seizures through electrical stimulation for the management of certain psychiatric disorders.
- Trial name
- NCT07824817
- Testing
- Saline (0.9% NaCl), Dexmedetomidine, Remifentanil
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Inonu University
Depression - Major Depressive Disorder, Bipolar Disorder (BD)
Flumazenil for Benzodiazepine Reversal in Electroconvulsive Therapy
The goal of this study is to investigate whether administering flumazenil to reverse the effects of benzodiazepines and/or zopiclone during electroconvulsive therapy (ECT) can help reduce cognitive side effects without…
- Conditions
- Depression - Major Depressive Disorder, Bipolar Disorder (BD), Functional Magnetic Resonance Imaging (fMRI), Cognition
- Trial name
- FLEET (NCT07619092)
- Testing
- Flumazenil, Electroconvulsive therapy (ECT)
- Where
- Denmark
- Volunteers
- 145 people
- Sponsor
- Anders Jørgensen
Major Depression Moderate, Major Depression Severe
EEG Microstate Parameters and Neuroinflammatory Biomarkers in Patients With Treatment-Resistant Major Depressive Disorder Receiving ECT
This study aims to investigate the neurophysiological and inflammatory changes associated with electroconvulsive therapy (ECT) in patients diagnosed with Major Depressive Disorder who are resistant to at least two antidepressant…
- Conditions
- Major Depression Moderate, Major Depression Severe, Major Depression With Comorbid Anxiety Symptoms, Major Depression With Panic Attacks
- Trial name
- NCT07748091
- Testing
- Electroconvulsive Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Major Depressive Disorder, Treatment Resistant Depression
Ketamine Augmentation of ECT in Treatment-Resistant Depression
This is a randomized, double-blind, placebo-controlled phase 3 clinical trial evaluating the additive effect of intravenous ketamine in combination with electroconvulsive therapy (ECT) in patients with treatment-resistant major…
- Trial name
- Ketamina (NCT07088380)
- Testing
- Ketamine Hydrochloride
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Università Vita-Salute San Raffaele
Treatment Resistant Schizophrenia, Schizophrenia
Magnetic Seizure Therapy for Schizophrenia - Trial
This trial aims to assess the clinical effects and tolerability of Magnetic Seizure Therapy (MST) as an alternative to electroconvulsive therapy (ECT) for Treatment Resistant Schizophrenia (RS).
- Conditions
- Treatment Resistant Schizophrenia, Schizophrenia, Schizoaffective Disorder
- Trial name
- MAST (NCT06672588)
- Testing
- Magnetic Seizure Therapy (MST), Electroconvulsive Therapy (ECT)
- Where
- 2 sites in Canada
- Volunteers
- 80 people
- Sponsor
- Centre for Addiction and Mental Health
Major Depression
Individual Narratives of Stimulation (ECT and TMS)
Electroconvulsive therapy (ECT) and transcranial magnetic stimulation (TMS) are two evidence-based treatments for major depressive disorder.
- Trial name
- INSight (NCT07807930)
- Testing
- There is no intervention in this observation study (qualitative interviews about past treatment experiences)
- Where
- 2 sites in United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Nottingham
Major Depressive Disorder (MDD), Treatment Resistant Depression (TRD)
Electroconvulsive Therapy Augmented With Transcranial Magnetic Stimulation for Treatment Resistant Depression
The RTMSECT2 study was design to compare the application of electroconvulsive therapy augmented by transcranial magnetic stimulation.
- Trial name
- RMTSECT2 (NCT07324070)
- Testing
- Electroconvulsive therapy, Transcranial Magnetic Stimulation
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- Charles University, Czech Republic
Depressive Disorder, Major, Depression, Bipolar
Optimal Electrical Stimulus During Electroconvulsive Therapy
Synopsis Aim: The purpose of the study is to determine the stimulus of electrical current during electroconvulsive therapy (ECT) that produces the optimal balance between antidepressant effect and memory disturbance.
- Trial name
- NCT04057378
- Testing
- Electroconvulsive therapy
- Where
- Sweden
- Volunteers
- 800 people
- Sponsor
- Region Örebro County
Major Depressive Disorder (MDD)
Accelerated TMS for Treatment-Resistant ECT
This study investigates whether an additional treatment using transcranial magnetic stimulation (TMS) can help severely depressed patients who did not respond well to electroconvulsive therapy (ECT).
- Trial name
- A-TREC (NCT07115628)
- Testing
- Transcranial Magnetic Stimulation
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Universitair Ziekenhuis Brussel
Schizophrenia, Treatment Resistant Schizophrenia
Maintenance ElectroConvulsive Therapy in Clozapine RESISTant Schizophrenia - the MECT-RESIST Trial
Schizophrenia is one of the most severe and costliest mental disorders in terms of human suffering and societal expenditure. About 15-30% of patients do not respond to all known antipsychotics, including clozapine, the current…
- Trial name
- MECT-RESIST (NCT06456983)
- Testing
- maintenance electroconvulsive therapy (mECT)
- Where
- 14 sites in Germany
- Volunteers
- 140 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Treatment Resistant Depression, Ketamine
ECT with Ketamine Anesthesia Vs High Intensity Ketamine with ECT Rescue for Treatment-Resistant Depression
To determine if an high intensity ketamine with ECT rescue (HIKER) approach for treatment resistant depression will: 1) reduce patient suffering by hastening disease remission, 2) have fewer side effects, 3) reduce the need for…
- Trial name
- NCT03272698
- Testing
- Ketamine, ECT
- Where
- Canada
- Volunteers
- 62 people
- Sponsor
- University of Saskatchewan
Electroconvulsive Therapy (ECT), Electroconvulsive Therapy Cognitive Assessment (ECCA)
ECCA's Turkish Validity and Reliability Study and Comparison With Other Cognitive Assessment Tests
Electroconvulsive therapy (ECT) is one of the oldest biological treatment methods used in psychiatry, based on inducing widespread seizures in the brain with externally applied controlled electrical currents.
- Conditions
- Electroconvulsive Therapy (ECT), Electroconvulsive Therapy Cognitive Assessment (ECCA), Montreal Cognitive Assessment (MoCA), Turkish Adaptation
- Trial name
- NCT07527234
- Testing
- ElectroConvulsive Therapy Cognitive Assessment (ECCA)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Pamukkale University
Treatment Resistant Depression
Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy
Electroconvulsive therapy (ECT) alleviates treatment-resistant depression (TRD) through repeated generalized seizures. The goal of this study is to evaluate how ECT impacts sleep-wake regulation and efficiency of information…
- Trial name
- DNS-ECT (NCT05905705)
- Testing
- Electroencephalography (EEG), Quantitative Measurements of Sleep Microstructure
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Washington University School of Medicine
Major Depressive Disorder, Bipolar Disorder
Venous Tourniquet vs. Arterial Tourniquet for Seizure Monitoring in ECT
This prospective, open-label clinical trial aims to compare a novel "Venous Tourniquet with Regional Low-Dose Sugammadex" method against the gold standard "Arterial Tourniquet" (Isolated Forearm Technique - IFT) for monitoring…
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Schizophrenia
- Trial name
- NCT07534475
- Testing
- Device: Arterial Tourniquet, Device: Venous Tourniquet, Sugammadex
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Medipol University
Electroconvulsive Therapy, Depression
Blood Biomarkers in Electroconvulsive Therapy
The present multi-disciplinary study will assess blood biomarkers to investigate putative mechanisms of action of ECT. Laboratory findings will be correlated to clinical parameters, cognitive measures and psychometric outcome…
- Conditions
- Electroconvulsive Therapy, Depression, Blood Biomarkers
- Trial name
- NCT05515159
- Testing
- electroconvulsive therapy
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Haukeland University Hospital
Major Depressive Disorder (MDD)
Effectiveness of MST Versus ECT for Major Depressive Episode
Despite advancements in Magnetic Seizure Therapy (MST) and Electroconvulsive Therapy (ECT) for Major Depressive Disorder (MDD), there remains a need for further research to replicate clinical outcomes and understand the…
- Trial name
- NCT06409325
- Testing
- MST, ECT
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Shanghai Mental Health Center
Electroconvulsive Therapy, Knowledge, Attitudes, Practice
Development of Virtual Reality for Nursing Students: Electroconvulsive Therapy
Project: "Development of virtual reality for nursing students: ECT" For this project the researchers will adapte 'health belief model' as a core concept for developing knowledge, attitude and skills of nursing students to take…
- Trial name
- Experimental (NCT06980831)
- Testing
- ECT group
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Mae Fah Luang University
Depression
Changing Tactics? Optimizing ECT in Difficult-to-treat Depression
The goal of this randomized controlled trial is to address which treatment strategy (continue right unilateral (RUL) ECT or switch to bitemporal (BT) ECT speeds up recovery and has the least impact on memory function, in case of…
- Trial name
- ChaT (NCT05923801)
- Testing
- switch to BT electrode position, continue with RUL electrode position
- Where
- Belgium
- Volunteers
- 196 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Electroconvulsive Therapy, Major Depressive Disorder
Multimodal Clinical Study of Electroconvulsive Therapy and Magnetic Seizure Therapy
To compare the efficacy and tolerability of Electroconvulsive Therapy (ECT) and Magnetic Seizure Therapy (MST) in patients with major depressive disorder (MDD).
- Conditions
- Electroconvulsive Therapy, Major Depressive Disorder, Magnetic Seizure Therapy
- Trial name
- NCT07473648
- Testing
- Electroconvulsive Therapy, Magnetic Seizure Therapy
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Anhui Medical University