Clinical trials: Electroconvulsive Therapy
Unipolar Depression, Bipolar Depression
Ketamine as an Augmentation Strategy for Electroconvulsive Therapy (ECT) in Depression
The study aims to compare outcomes of Electroconvulsive Therapy (ECT) using ketamine versus methohexital anesthesia in depressed patients.
- Trial name
- NCT01881763
- Testing
- Ketamine, Methohexital
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Northwell Health
Major Depressive Disorder
Electroconvulsive Therapy Amplitude Titration
This study is focused on advancing ECT treatment for older adults with depressive disorders by refining neuromodulation stimulus parameters to improve efficacy and cognitive safety.
- Trial name
- NCT04621786
- Testing
- Mecta Spectrum 5000Q paired with Soterix Medical 4X1 HD - ECT Multi-Channel Stimulation Interface
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of New Mexico
Major Depression
The Effect on Cognition of Terminating ECT Induced Seizures With Propofol
Participating subjects are those who are referred for electroconvulsive therapy (ECT) for severe depression who have agreed to the protocol. The control group receives ECT as usual.
- Trial name
- NCT00616759
- Testing
- electroconvulsive therapy, electroconvulsive therapy plus propofol, propofol
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Loma Linda University
Post-anesthesia Recovery, Orientation
Use of Ketamine vs Methohexital for Electroconvulsive Therapy (ECT) on Patient Recovery and Re-orientation Time
When undergoing ECT treatments, patient recovery time and re-orientation time may be shorter using ketamine for induction than using methohexital.
- Trial name
- NCT01567852
- Testing
- Ketamine, Methohexital
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of New Mexico
Neuromuscular Blockade
Comparison Of Rocuronium Reversal By Sugammadex To Succinylcholine For Electroconvulsive Therapy (ECT)
The investigators propose to compare the recovery of neuromuscular blockade from rocuronium reversal by sugammadex to succinylcholine in ECT.
- Trial name
- CRoSSECT (NCT03532178)
- Testing
- Group A. "Muscle relaxant #1": rocuronium + sugammadex; "Muscle relaxant #2": succinylcholine +saline, Group B. "Muscle relaxant #2": succinylcholine +saline; "Muscle relaxant #1": rocuronium + sugammadex;
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of California, San Francisco
Depression
Ketamine Anesthesia in Electroconvulsive Therapy
Does the use of ketamine as the anesthetic medication in electroconvulsive therapy (ECT) accelerate the antidepressant effect of ECT? The study hypothesis was that depressed subjects receiving ECT with ketamine as the anesthetic…
- Trial name
- NCT01367119
- Testing
- Ketamine, methohexital
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Mayo Clinic
Blood Pressure, Electroconvulsive Therapy
Pre-medication With Alfentanil vs Placebo During ECT
Hemodynamic changes associated with the conduct of electroconvulsive therapy may be minimized with the administration of alfentanil as part of their anesthetic regimen.
- Trial name
- NCT03359395
- Testing
- Alfentanil
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wake Forest University Health Sciences
MDD
Effect of Bupropion on Seizure Threshold in Depressed Patients
The purpose of the study is to examine the effect of bupropion on seizure threshold and duration in depressed patients receiving right unilateral ultra-brief electroconvulsive therapy (ECT).
- Trial name
- NCT03126682
- Testing
- Wellbutrin SR 300Mg Extended-Release Tablet
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Duke University
Catatonia
Prospective Treatment Study of Catatonia Patients
The purpose of this treatment study is to compare the effectiveness of different electrode placements used in Electroconvulsive Therapy (ECT) in the treatment of catatonia.
- Trial name
- NCT02734498
- Testing
- Electroconvulsive Treatment (ECT) Right Unilateral, Electroconvulsive Treatment (ECT) - Bilateral
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Wake Forest University Health Sciences
Depression
The Antidepressive Effect of rTMS as add-on to ECT
The aim of the present study is to investigate in which degree low frequency right prefrontal rTMS used ad add-on may potentiate the antidepressant effect of unilateral ECT and accelerate remission .
- Trial name
- TMS (NCT02123485)
- Testing
- Low frequency (1 hz) rTMS, as add-on to ECT
- Where
- Denmark
- Volunteers
- 35 people
- Sponsor
- University of Aarhus
Depression, Delirium
Cognitive Recovery After Electroconvulsive Therapy and General Anesthesia
This study is geared toward characterizing the recovery of brain activity and cognitive function following treatments of electroconvulsive therapy and ketamine general anesthesia.
- Conditions
- Depression, Delirium, Seizures, Cognitive Disorders
- Trial name
- RCC2 (NCT02761330)
- Testing
- Ketamine, Electroconvulsive Therapy
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Washington University School of Medicine
Dementia
Safety and Efficacy of Electroconvulsive Therapy (ECT) for Behavioural and Psychological Symptoms of Dementia (BPSD)
This is a prospective, open-label, observational study of the efficacy and safety of ECT for BPSD. There is no control or comparison group.
- Trial name
- ECTBPSD (NCT02969499)
- Where
- 3 sites in Canada
- Volunteers
- 33 people
- Sponsor
- University of British Columbia
Depression
Enhancing the Effectiveness of Electroconvulsive Therapy in Severe Depression
Electroconvulsive therapy (ECT) is the most powerful antidepressant treatment available and is often life-saving. There are concerns, however, that standard bitemporal ECT (the most commonly used form of ECT worldwide) causes…
- Trial name
- EFFECT-Dep (NCT01907217)
- Testing
- ECT Mecta 5000M, Methohexitone, Suxamethonium
- Where
- Ireland
- Volunteers
- 138 people
- Sponsor
- St Patrick's Hospital, Ireland