Clinical trials: Elective Surgical Procedures, Digestive System
Immunonutrition, Gastric Cancer
Effect of Preoperative Immunonutrition in Upper Digestive Tract
Randomized, double-blind, multicenter clinical trial that will evaluate the effects of immuno-nutrition in the preoperative period in patients with cancer of the upper digestive tract (esophagus, stomach, and pancreas).
- Conditions
- Immunonutrition, Gastric Cancer, Esophageal Cancer, Pancreas Cancer
- Trial name
- NCT04027088
- Testing
- Immunonutrition, Standard
- Where
- 2 sites in Spain
- Volunteers
- 178 people
- Sponsor
- Complexo Hospitalario Universitario de A Coruña
Colorectal Cancer, Intestinal Obstruction
Randomized Trial of Colonic Stents as a Bridge to Surgery
The objective of this randomized controlled trial was to evaluate the role colonic self-expanding metal stent (SEMS) placement as a bridge to surgery in patients with acute malignant left-sided colonic obstruction.
- Trial name
- NCT00758186
- Testing
- Emergency endoscopic colonic stenting, Emergency surgery
- Where
- Singapore
- Volunteers
- 40 people
- Sponsor
- Singapore General Hospital
Choledocholithiasis, Jaundice, Obstructive
Immediate vs. Elective Endoscopic Removal of Large CBD Stones in High-Risk Elderly Patients
The goal of this clinical trial is to compare two different approaches for removing large or multiple stones from the common bile duct in older adults with chronic diseases.
- Trial name
- NCT06948279
- Testing
- The endoscopic retrograde cholangiopancreatography (ERCP) with insertion of a plastic stent., The endoscopic retrograde cholangiopancreatography (ERCP) with immediate stone extraction attempts.
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- National Liver Institute, Egypt
Gastrointestinal Hemorrhage
Early Colonoscopy for Lower Gastrointestinal (GI) Bleeding
Study hypothesis is that performing early colonoscopy in patients who present to the hospital with lower GI bleeding improves their outcome.
- Trial name
- NCT01031342
- Testing
- Early colonoscopy, Elective colonoscopy
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Southern California
Postoperative Ileus, Laparoscopic Colectomy Without Stoma Formation
Does Caffeine Reduce Postoperative Bowel Paralysis After Elective Colectomy?
Postoperative bowel paralysis is common after abdominal operations, including colectomy. As a result, hospitalization may be prolonged leading to increased cost.
- Conditions
- Postoperative Ileus, Laparoscopic Colectomy Without Stoma Formation, Colorectal Neoplasm, Diverticulitis
- Trial name
- CaCo (NCT02510911)
- Testing
- Caffeine (100 mg), Caffeine (200 mg), corn starch (250 mg approx.)
- Where
- 2 sites in Switzerland
- Volunteers
- 60 people
- Sponsor
- Thomas Steffen
Cancer of Colon, Nutrition Related Cancer
Preoperative Immunonutrition in Patients Undergoing Elective Colorectal Surgery for Neoplasm
Enhanced Recovery After Surgery (ERAS) protocols were developed to standardize perioperative practice in colon surgery to reduce morbidity, improve recovery, and shorten length of stay (LOS).
- Trial name
- NCT05916001
- Testing
- Oral Impact Nestle, Colorectal surgery
- Volunteers
- 216 people
- Sponsor
- University of Roma La Sapienza
Complicated Diverticulitis, Acute Diverticulitis
AIDE: Decision Support for Anastomosis or Colostomy in Emergency Surgery for Complicated Acute Diverticulitis
The AIDE/OBS study is a multicenter, observational, non-interventional study designed to collect standardized clinical, radiological, intraoperative visual, and surgical reasoning data from adult patients undergoing non-elective…
- Conditions
- Complicated Diverticulitis, Acute Diverticulitis, Peritonitis, Perforated Diverticulitis
- Trial name
- AIDE/OBS/2025 (NCT07651072)
- Testing
- Primary anastomosis, Hartmann's procedure
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- IRCCS San Raffaele Roma
Pregnancy, Respiratory Aspiration of Gastric Contents
Gastric Emptying Following an Oral Carbohydrate Load in Women Admitted for Elective Cesarean Delivery
Because of the risk of pulmonary aspiration, patients are asked to comply with the fasting guidelines when they are scheduled for an elective cesarean section.
- Trial name
- NCT03593980
- Testing
- Cranberry juice
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Intestinal Neoplasm, Perioperative Care
Simvastatin in Colorectal Surgery
Statins (HMG-CoA reductase inhibitors) are a widely used class of cholesterol-lowering drugs that have an established role in the medical management of cardiovascular disease.
- Trial name
- StatCol (NCT00994903)
- Testing
- Simvastatin
- Where
- 3 sites in New Zealand
- Volunteers
- 132 people
- Sponsor
- University of Auckland, New Zealand
Urologic Diseases, Cardiovascular Diseases
Patient Empowerment for Major Surgery Preparation @ Home
Non-randomized monocentric open cohort study vs historical comparative group testing the efficacy of a multimodal prehabilitation program (based on physical activity, nutritional support and mental preparation) for unfit patients…
- Conditions
- Urologic Diseases, Cardiovascular Diseases, Thoracic Diseases, Orthopedic Disorder
- Trial name
- Paprika (NCT04190719)
- Testing
- multimodal prehabilitation
- Where
- France
- Volunteers
- 225 people
- Sponsor
- University Hospital, Grenoble
Cholecystolithiasis
Study on the Learning Curve for Fundus First With Ultrasonic Tissue Coagulation in Elective Cholecystectomy
The present study aims at analyzing the learning curve for fundus first with the ultrasonic tissue coagulation dissection technique in elective cholecystectomy.
- Trial name
- LEFFE (NCT03154164)
- Testing
- Ultrasonic tissue coagulation dissection
- Where
- Sweden
- Volunteers
- 240 people
- Sponsor
- Karolinska Institutet
Cancer of Colon, Cancer of Rectum
Clinical Trial Comparing Standard Care Versus Prehabilitation in Patients Undergoing Cancer Surgery
To determine whether exercise and nutrition prehabilitation improves patient outcomes after cancer surgery
- Conditions
- Cancer of Colon, Cancer of Rectum, Liver Metastases
- Trial name
- SPECS (NCT04880772)
- Testing
- Prehabilitation
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- East Lancashire Hospitals NHS Trust
Colorectal Neoplasm, Circadian Rhythm Sleep Disorder
Sleep and Survival in Colorectal Cancer
Objective The objective of the current trial is to investigate the effect of perioperative sleep and circadian rhythm on the natural course of survival among patient diagnosed with colorectal cancer.
- Conditions
- Colorectal Neoplasm, Circadian Rhythm Sleep Disorder, Depression, Quality of Life
- Trial name
- NCT03254836
- Testing
- Standard of care
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Zealand University Hospital
Pulmonary Aspiration of Gastric Contents
Comparison of Different Preoperative Fasting Times in Pediatric Patients Undergoing Elective General Anaesthesia
Rationale of this study is to provide an evidence on minimal safe clear fluid fasting duration without the risk of aspiration of gastric contents during elective pediatric procedures under general anesthesia.
- Trial name
- NCT05922072
- Testing
- Nasogastric aspiration for measurement of Residual Gastric Volume, Nasogastric Aspiration for Measurement of Gastric pH
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- King Edward Medical University
Ileostomy - Stoma, Colorectal Surgery
Readmission and Dehydration Prevention in Patients With Elective Ileostomy
The goal of this prospective observational study is to evaluate the adherence to DRIP score calculation and the application rate of each proposed item to prevent dehydration and readmission in patients undergoing ileostomy…
- Conditions
- Ileostomy - Stoma, Colorectal Surgery, Dehydration
- Trial name
- PREDESTO (NCT06824623)
- Where
- 7 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Multidisciplinary Italian Study group for STOmas (MISSTO)
Gastric Emptying, Preoperative Care
Incidence of Stomach Fullness and Associated Factors in Elective Surgical Patients
The aim of this prospective, observational study is to evaluate the incidence of residual gastric content in elective surgical patients who adhered to preoperative fasting guidelines and to investigate associated patient-related…
- Conditions
- Gastric Emptying, Preoperative Care, Preoperative Fasting, Elective Surgical Procedures
- Trial name
- NCT06606782
- Where
- Turkey (Türkiye)
- Volunteers
- 404 people
- Sponsor
- Recep Tayyip Erdogan University
Upper Gastrointestinal Disorder
Performance Characteristics and Technical Outcomes of Single-use vs. Reusable Gastroscopes Evaluated in the OR
The goal of this clinical trial is to investigate whether single-use gastroscopes are as good as reusable gastroscopes when used in the operation theater in all patients where gastroscopy in the operation theater is indicated.
- Trial name
- NCT06581016
- Testing
- Ambu aScope Gastro, Ambu aScope Gastro Large, Diagnostic gastroscopes, Olympus
- Where
- Denmark
- Volunteers
- 700 people
- Sponsor
- Zealand University Hospital
Cesarean Section, Postoperative Nausea and Vomiting (PONV)
Restrictive vs Liberal Intraoperative Fluid Strategy and Postoperative Outcomes After Elective Cesarean Section
Spinal anesthesia for elective cesarean section is frequently associated with hemodynamic instability and postoperative complications such as postoperative nausea and vomiting (PONV) and delayed gastrointestinal recovery.
- Conditions
- Cesarean Section, Postoperative Nausea and Vomiting (PONV), Postdural Puncture Headache (PDPH), Postoperative Ileus
- Trial name
- NCT07440667
- Testing
- Restrictive intraoperative crystalloid fluid strategy (≤3 mL/kg/h), Liberal intraoperative crystalloid fluid strategy (>3 mL/kg/h)
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Nigde Omer Halisdemir University
Colorectal Neoplasms, Surgical Wound Infection
Reduction of Surgical Site Infections in Elective Colorectal Surgery After the Implementation of a Bundle of Care.
Background. The Nosocomial Infection Surveillance Program in Catalonia (VINCat) monitors SSI in elective colorectal surgery since 2007 in 56 hospitals (7.5 million population).
- Trial name
- NCT04129177
- Testing
- Implementation of a bundle of surgical infection preventive measures
- Where
- Spain
- Volunteers
- 12,000 people
- Sponsor
- Hospital de Granollers
Cervical Disc Herniation, Cervical Degenerative Disc Disease
Effect of Topical Corticosteroids on Dysphagia in Anterior Cervical Discectomy and Fusion
The purpose of this study is to determine what effect intraoperative topical steroids have on reducing swallowing difficulty following Anterior Cervical Discectomy and Fusion surgery.
- Conditions
- Cervical Disc Herniation, Cervical Degenerative Disc Disease, Cervical Spondylotic Myelopathy, Dysphagia
- Trial name
- NCT02539394
- Testing
- Methylprednisolone Acetate, Hemostatic Matrix Kit
- Volunteers
- 128 people
- Sponsor
- Hospital for Special Surgery, New York