Clinical trials: Elective
Cognitive Impairment, Postoperative Delirium
Cognitive Impairment Following Elective Spine Surgery
Older people are a rapidly growing proportion of the world's population and their number is expected to increase twofold by 2050.
- Conditions
- Cognitive Impairment, Postoperative Delirium, Spine Fusion
- Trial name
- CONFESS (NCT03486288)
- Where
- Germany
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Postoperative Pain
Dexmedetomidine Versus Clonidine for Transversus Abdominis Plane Block in Patients Undergoing Elective Caesarean Section
Aim to study the efficacy of co-administered Dexmedetomidine Or Clonidine with Bupivacaine and that of bupivacaine 0.25% alone for Transversus Abdominis Plane (TAP) Block for Postoperative Analgesia in Patients Undergoing…
- Trial name
- NCT03770013
- Testing
- bupivacaine, Dexmedetomidine, clonidine
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Aswan University Hospital
Complications; Cesarean Section
Control of Blood Loss During Caesarean Section
trial of 3 protocols to determine the best one to control blood loss during caesarean section
- Trial name
- NCT01412073
- Testing
- oxytocin, Misoprostol
- Where
- Egypt
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Cairo University
Opioid Use
Pregabalin Versus Gabapentin Opioid Sparing Effect in Discectomy
Pregabalin and gabapentin are both GABA analogue and their mechanism of action is not fully understood. Both drugs when given as a pre-emptive analgesia for spinal surgery were found to reduce intra-and postoperative opioid…
- Trial name
- NCT05539924
- Testing
- Pregabalin 150mg gabapentin 400mg
- Where
- Egypt
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Research Institute of Ophthalmology, Egypt
Chronic Disease, Old Age; Debility
CONNECARE-Assuta-Case Study 2
The European Union's Horizon 2020 project issued a Call for Action [1] in December 2013 to design, develop, disseminate and evaluate new IT technologies for use in integrative treatment processes, with emphasis on complex adult…
- Trial name
- NCT03327246
- Testing
- Connecare self managment system
- Volunteers
- 220 people
- Sponsor
- Assuta Medical Center
Perioperative Myocardial Infarction, Disability
TEAMS (Troponin Elevation After Major Surgery) Study
Background to main study question: Cardiac complications are a common cause of morbidity after non-cardiac surgery. Patients with perioperative myocardial injury (both MI, and lower levels of cardiac troponin elevation)…
- Trial name
- TEAMS (NCT02146560)
- Where
- Canada
- Volunteers
- 267 people
- Sponsor
- University Health Network, Toronto
Postoperative Pain
Efficacy of Intrathecal Clonidine Versus Neostigmine as Adjuvants to Bupivacaine on Postoperative Maternal and Fetal Outcomes After Elective Cesarean Section
The delivery of the infant into the arms of a conscious and pain free mother is one of the most exciting and rewarding moments in medicine.
- Trial name
- NCT05943613
- Testing
- Clonidine
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Assiut University
Post-Dural Puncture Headache
Effect of Intrathecal Neostigmine on Post-dural Puncture Headache.
Intravenous neostigmine was recently reported as an effective treatment for PDPH for parturients after intrathecal (IT) block which is postulated to be through its central effects on CSF secretion and cerebral vascular tone…
- Trial name
- NCT05289323
- Testing
- Neostigmine Methylsulfate, Dextrose 5%/Nacl 0.9% Inj
- Where
- Egypt
- Volunteers
- 722 people
- Sponsor
- Alexandria University
Hyperglycemia, Craniotomy
Impact of Severe Intraoperative Hyperglycemia on Infection Rate After Elective Intracranial Interventions
Severe intraoperative hyperglycemia (SIH) is recognized as one of the important risk factors for the increasing of the postoperative infections rate, which can negatively affect the final outcome of surgical treatment.
- Conditions
- Hyperglycemia, Craniotomy, Infection Post Op
- Trial name
- NCT04285359
- Testing
- Intracranial Interventions
- Where
- 2 sites in Italy, Russia
- Volunteers
- 514 people
- Sponsor
- Burdenko Neurosurgery Institute
Sedation During Spinal Anesthesia
Sedation During Spinal Anesthesia
Patients during spinal anesthesia should be sedated.
- Trial name
- NCT03133780
- Testing
- Ketamine, Midazolam
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Surgery, Intubation
Comparison of the I-gel Laryngeal Mask and the Classic Laryngeal Mask in Patients With a BMI>25
The intention of this study is to compare the performance of the single-use I-gel laryngeal mask with the classic laryngeal mask in 50 patients with a BMI>25 during elective surgery. Primary outcome is the leak pressure.
- Trial name
- NCT01003327
- Testing
- I-gel, LMA-Unique
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Vienna
Hyperlactatemia, Brain Tumor
Hyperlactatemia During and After Tumorcraniotomy
This study aims to investigate the association between hyperlactatemia and neurological disability, length-of-stay and mortality in patients who undergo tumorcraniotomy.
- Conditions
- Hyperlactatemia, Brain Tumor, Surgery, Anesthesia
- Trial name
- NCT04410315
- Testing
- Serum-lactate < 2,2 mmol/L, Serum-lactate >/= 2,2 mmol/L
- Where
- Denmark
- Volunteers
- 450 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
CGA
Preoperative Comprehensive Geriatric Assessment (CGA) and Postoperative Delirium
The purpose of this research is to find out the best way to reduce delirium in frail, older patients undergoing planned surgery. Delirium is a state of confusion and difficulty concentrating that is temporary.
- Trial name
- NCT07059585
- Testing
- CGA, control
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Miami
Head-and-neck Cancer, Carcinoma of Unknown Primary
Elective Mucosal Irradiation in Head-and-Neck Cancer of Unknown Primary
The optimal treatment of HNCUP remains controversial and lacks evidence from prospective randomized trials. The management of these patients relies primarily on surgery and radiotherapy.
- Trial name
- NCT02764216
- Testing
- Elective mucosal irradiaton
- Where
- 2 sites in China
- Volunteers
- 48 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Thyroidectomy, Oxidative Stress
Opioid-Free Versus Opioid-Based Anesthesia in Thyroid Surgery
This study will compare opioid-free anesthesia and opioid-based anesthesia in adult euthyroid patients undergoing elective thyroidectomy.
- Conditions
- Thyroidectomy, Oxidative Stress, Anesthesia
- Trial name
- OFA-OBA (NCT07864155)
- Testing
- Fentanyl (IV), Dexmedetomidine and lidocaine
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Malatya Egitim Ve Arastirma Hastanesi
Neuromuscular Blockade
Safety and Efficacy of HRS-9190 Compared to Rocuronium for Tracheal Intubation and Bolus Maintenance in Adults
The study will enroll adult patients scheduled for elective surgery requiring general anesthesia. Participants will be randomly assigned to receive either HRS-9190 for Injection or Rocuronium.
- Trial name
- NCT07746726
- Testing
- HRS-9190, Rocuronium
- Where
- 2 sites in China
- Volunteers
- 320 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
1 Fluid Management
Trial With Deltex Cardio in Elective Bowel Resection Patients
The purpose of this study is: To determine if the intraoperative fluid administration with the Deltex CardioQ esophageal Doppler will reduce the length of stay after elective bowel resection.
- Trial name
- NCT01244685
- Testing
- Deltex CardioQ Probe
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Stony Brook University
Anesthesia, Preoxygenation
Preoxygenation Before General Anesthesia
Rationale of the study: we aim to clarify the question (related to still unclear and not univocal response) about the protective or unnecessary role of preoxygenation in non-critically ill patients (otherwise with no high risk of…
- Trial name
- PREOX2018 (NCT03802643)
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- University of Parma
Anxiety
Elective Coronary Angiography and Anxiety Study
Anxiety will be assessed from two aspects, the somatic and emotional. ANGST aims to determine how anxiety correlates with psychological parameters (personality traits, coping strategies and depressive symptoms) and with the…
- Trial name
- ANGST (NCT02804009)
- Where
- Slovenia
- Volunteers
- 350 people
- Sponsor
- General and Teaching Hospital Celje
Wrist Blood Pressure Measurements, Anesthesia Resulting in Shivering
Wrist NIBP During Elective Cesarean Delivery
Blood pressure is typically measured with a non-invasive cuff placed on the upper arm. This cuff cannot take accurate measurements when the patient's arm is moving.
- Trial name
- NCT01677234
- Where
- Canada
- Volunteers
- 71 people
- Sponsor
- University of British Columbia