Clinical trials: Elderly People
Adverse Effects
Effects of Discontinuation of Benzodiazepine-derivative Hypnotics on Cognitive and Motor Functions in Elderly Persons
Benzodiazepines (BZDs) have been reported to cause negative impacts on motor as well as cognitive functions, which in turn could result in lethal incidents including falls especially in the elderly.
- Trial name
- NCT00707915
- Testing
- Drug: Benzodiazepine (listed out below)
- Where
- Japan
- Volunteers
- 30 people
- Sponsor
- Minamihanno Hospital
Frail Elderly Persons
SUPPORT FOR FRAIL ELDERLY PERSONS - From Prevention to Palliation
The present study "Elderly person in the risk zone" form part of the research programme "Support for frail elderly persons - from prevention to palliation" (www.
- Trial name
- NCT00877058
- Testing
- preventive home visit, senior meetings
- Where
- Sweden
- Volunteers
- 459 people
- Sponsor
- Vardalinstitutet The Swedish Institute for Health Sciences
Cardiovascular Events
A Randomized Controlled Trial of Aliskiren in the Prevention of Major Cardiovascular Events in Elderly People
This study was planned to provide new information regarding the role of aliskiren (with or without additional therapy with a diuretic or a Calcium channel blockers (CCB)) in elderly individuals (≥ 65 years) with systolic blood…
- Trial name
- APOLLO (NCT01259297)
- Testing
- Aliskiren, Amlodipine, Hydrochlorothiazide (HCTZ)
- Where
- 185 sites in United States, Argentina and 16 more
- Volunteers
- 2,336 people
- Sponsor
- Novartis Pharmaceuticals
Influenza
Clinical Study of the Immunogenicity of GSK Biologicals' Influenza Vaccine GSK2186877A in People Aged 65 Years or Older
This clinical trial aims to study the immunogenicity of GSK Biologicals' influenza vaccine GSK2186877A in people aged 65 years or older.
- Trial name
- NCT00765076
- Testing
- GSK Biologicals' influenza vaccine GSK2186877A, GSK Biologicals' Fluarix
- Where
- 4 sites in United States, Spain
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Insulin Resistance, Obesity
Metformin Effect on Brain Function in Insulin Resistant Elderly People
Alzheimer's disease (AD) and other forms of dementia are rapidly increasing with the aging of the population, and show a clear preponderance among people with insulin resistance.
- Conditions
- Insulin Resistance, Obesity, Obesity, Abdominal
- Trial name
- NCT03733132
- Testing
- Metformin Hydrochloride
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Breast Cancer
A Study to Learn About Vepdegestrant When Given With PF-07220060 to People With Advanced or Metastatic Breast Cancer.
The purpose of this study is to learn about the safety and effects of giving vepdegestrant along with PF-07220060. Vepdegestrant is studied to see if it can be a possible treatment for advanced metastatic breast cancer.
- Trial name
- NCT06206837
- Testing
- vepdegestrant, PF-07220060
- Where
- 58 sites in United States, Belgium and 6 more
- Volunteers
- 71 people
- Sponsor
- Pfizer
Loneliness, Quality of Life
The Helping Older People Engage Project: Improving Social Well-Being in Later Life
Older adults who feel lonely carry increased risk for reduced quality of life, morbidity, and mortality. Volunteering is a promising intervention for reducing loneliness in later life.
- Trial name
- HOPE (NCT03343483)
- Testing
- Volunteering, Life Review
- Where
- United States
- Volunteers
- 291 people
- Sponsor
- University of Rochester
Dental Caries
Caries Prevention Effect of S-PRG Filler Incorporated in Denture Base Resins on Edentulous Elderly People
The purpose of this study is to determine whether a novel material of S-PRG fillers containing in a daily-used resin denture base and their capability of fluoride release and recharge to elevate the salivary fluoride level and…
- Trial name
- NCT02460562
- Testing
- S-PRG filler, PMMA resin
- Where
- 3 sites in Thailand
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Kritirat Kiatsirirote
Somatization Disorder
Assessment of Somatic Symptom in Chinese Community-Dwelling People
With the rapid aging and worsening psychological problems worldwide, the special focus on somatic symptom and other psychological diseases of the older population is needed.
- Trial name
- NCT04815863
- Testing
- Assessment of somatic symptom disorder with SSS-CN, Assessment of depressive symptoms disorder with PHQ-9, Assessment of anxiety disorder with GAD-7
- Where
- 2 sites in China
- Volunteers
- 9,110 people
- Sponsor
- RenJi Hospital
Influenza
Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Influenza Vaccine, Fluarix®/Influsplit SSW® (2013/2014 Season), in Adults 18 Years of Age and Older
The purpose of this study is to assess, in adults 18 years of age and above, the immunogenicity and reactogenicity of the seasonal influenza vaccine, Fluarix/Influsplit SSW 2013/2014, containing the three vaccine influenza…
- Trial name
- NCT01884519
- Testing
- Fluarix/Influsplit SSW® (2013-2014 season)
- Where
- 4 sites in Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Diabetes Mellitus, Type 2
A Study to Test How Well Empagliflozin Works in Japanese People With Type 2 Diabetes Who Are Older Than 65 Years
This study is to assess the efficacy of empagliflozin 10 mg after 52 weeks compared to placebo in elderly patients with Type 2 diabetes mellitus (T2DM) and to explore if empagliflozin has any impact on patient physical condition…
- Trial name
- NCT04531462
- Testing
- Empagliflozin
- Where
- 18 sites in Japan
- Volunteers
- 129 people
- Sponsor
- Boehringer Ingelheim
Atopic Dermatitis
A Study to Learn About Abrocitinib Tablets in People With Atopic Dermatitis in India
The purpose of this clinical trial is to learn about the safety and how well the study medicine (called Abrocitinib) works for the potential treatment of moderate to severe Atopic Dermatitis (AD) in India.
- Trial name
- NCT05375929
- Testing
- Abrocitinib 100 mg, Abrocitinib 200 mg
- Where
- 15 sites in India
- Volunteers
- 200 people
- Sponsor
- Pfizer
Anorexia of Ageing
Impaired Regulation of Energy Balance in Elderly People (Balance Study)
Over the past century life expectancy has risen rapidly. As a result, the proportion of elderly people continues to grow. Elderly people probably have an impaired regulation of energy balance (energy intake versus energy…
- Trial name
- Balance (NCT00561145)
- Testing
- Energy restriction period
- Where
- Netherlands
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Cognitive Dysfunction
Postoperative Cognitive Dysfunction as Geriatric Syndrome
This study is testing cognitive function before and after the surgery, with patient's informed consent. Patients of interest are 65 year or older, undergoing surgery in general or regional anesthesia.
- Trial name
- NCT05648890
- Where
- Czechia
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Tomas Bata Hospital, Czech Republic
Nutritive Value
Nutritional Intake of "Finger-food" on Elderly People in Seniors's Resident
The undernourishment and the prevention of its risk at the elderly person in seniors's resident represent a major issue in public health.
- Trial name
- FIFO (NCT02925728)
- Testing
- Finger-Food, Without Finger-Food
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Frailty, Frail Elderly Syndrome
Education for Prevention and Treatment of Frailty
Frailty is a condition with a high prevalence in older adults, leading to higher vulnerability and increasing the risk of adverse health outcomes and disabilities.
- Trial name
- FRAGSALUD (NCT05610605)
- Testing
- Health intervention programme: FRAGSALUD
- Where
- Spain
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- University of Cadiz
Elderly People
Virtual Gait System Intervention in Older People
Previous studies have shown that the neuroplasticity of the residual corticospinal fibers, the motor cortex and the spinal neurons plays an important role in the spontaneous functional recovery of people with neurological or…
- Trial name
- NCT05273229
- Testing
- Virtual Gait, Physical exercise
- Where
- Spain
- Volunteers
- 38 people
- Sponsor
- University of Valencia
Friedreich Ataxia
A Study to Learn About the Effects and Safety of RTA 408 (Omaveloxolone) in People Aged 16 to 40 With Friedreich's Ataxia
In this study, researchers are learning more about RTA 408, also known as omaveloxolone, BIIB141, or SKYCLARYS®. The main goal of this study is to learn more about the safety of RTA 408 and how it affects physical effort…
- Trial name
- NCT02255435
- Testing
- Omaveloxolone Capsules, 2.5 mg, Omaveloxolone Capsules, 5 mg, Omaveloxolone Capsules, 10 mg
- Where
- 11 sites in United States, Australia and 3 more
- Volunteers
- 172 people
- Sponsor
- Biogen
Frail Elderly People
Continuum of Care for Frail Elderly People
The present study "Continuum of care for frail elderly people" form part of the research programme "Support for frail elderly persons - from prevention to palliation" (www.vardalinstitutet.net) which comprises research into three…
- Trial name
- NCT01260493
- Testing
- integrated health care chain
- Where
- Sweden
- Volunteers
- 181 people
- Sponsor
- Vardalinstitutet The Swedish Institute for Health Sciences
Hepatitis b
The Immunogenicity and Safety of 60mcg/30mcg Recombinant Hepatitis B Vaccines in People Who Failed to Respond to Routine Administration of Hepatitis B Vaccines
This study is an expanded Phase 2/Phase 3 clinical trial base on the safety data obtained from the phase 1 clinical trial. The purpose of this study is to further evaluate the immunogenicity and safety of 60mcg/30mcg recombinant…
- Trial name
- NCT01203319
- Testing
- 60mcg/1.0ml recombinant hepatitis B vaccine, 30mcg/1.0ml recombinant hepatitis B vaccine, 10mcg/1.0ml recombinant hepatitis B vaccine
- Volunteers
- 1,091 people
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention