Clinical trials: Elderly
Elderly Immune System
Immune Response to High-Dose vs. Standard Dose Influenza Vaccine
This 5-year proposal is a randomized study of split-virus influenza vaccine (SVV) in a high-dose (HD) vs. standard-dose (SD) formulation in each of five influenza seasons to define the key determinants of vaccine-mediated…
- Trial name
- NCT02297542
- Testing
- Flu Vaccine
- Where
- 2 sites in United States, Canada
- Volunteers
- 393 people, healthy volunteers welcome
- Sponsor
- Health Sciences North Research Institute
Peripheral Neuropathies, Peripheral Neuropathy Due to Chemotherapy
Balance4Mobility: Effects of Walkasins Use in Individuals With Peripheral Neuropathy and Balance Problems
The goal of this clinical trial is to is to test whether Walkasins can help people with peripheral neuropathy maintain their balance better.
- Conditions
- Peripheral Neuropathies, Peripheral Neuropathy Due to Chemotherapy, Peripheral Neuropathy With Type 2 Diabetes, Balance Control in Elderly
- Trial name
- NCT06959277
- Testing
- Walkasins, Fall Prevention Training
- Where
- 6 sites in United States
- Volunteers
- 200 people
- Sponsor
- RxFunction Inc.
Sarcopenia in Elderly
Blood Flow Restriction Training in Acute Geriatric Rehabilitation
Background: Older adults have a reduced ability to build and maintain muscle mass due to age-related changes in the muscular system.
- Trial name
- NCT07291765
- Testing
- Stationary Bike + Blood-Flow-Restriction, Acute geriatric rehabilitation + No additional Intervention
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- University Hospital, Bonn
Fall Prevention in Healthy Aging, Fall
Effect of LiFE-SePBT on Postural Stability in Community-dwelling Older Adults: an Assessor-blinded Randomised Controlled Trial
This study is an assessor-blinded randomised controlled trial investigating the effects of combined Lifestyle-integrated Functional Exercise and Self-initiated Perturbation-based Balance Training (LiFE-SePBT) on postural…
- Conditions
- Fall Prevention in Healthy Aging, Fall, Fall Prevention Training, Postural Control
- Trial name
- LiFE-SePBT (NCT07842094)
- Testing
- Lifestyle-integrated Functional Exercise, Upper limb mobilisation and flexibility training
- Where
- Hong Kong
- Volunteers
- 44 people
- Sponsor
- The Hong Kong Polytechnic University
Sarcopenia in Elderly, Hospital Associated Disability
Preventing Hospital Associated Disability in Older Patients: Individualized Nutrition and Exercise Strategy
Aproximately a third of persons older than 70 years lose physical function and ability to take care of themselves during a stay at a hospital. This is associated to an increased risk of readmission and mortality.
- Conditions
- Sarcopenia in Elderly, Hospital Associated Disability, Malnutrition Elderly, Physical Function
- Trial name
- PrevHAD RCT (NCT07373587)
- Testing
- Exercise
- Where
- Denmark
- Volunteers
- 360 people
- Sponsor
- Bispebjerg Hospital
Elective Surgery, Frail Elderly
Hybrid III Trial of Automated Referral to Comprehensive Geriatric Assessment for Frail Older Surgical Patients
The goal of this observational study is to learn about automated referrals to Perioperative Optimization of Senior Health (POSH).
- Trial name
- NCT07836959
- Testing
- Automated referral, Usual Care Group
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Wisconsin, Madison
Healthy Elderly
Development of a Visual and Motion Dual-Mirror Robot-Assisted Upper Limb Training System
Stroke is a major cause of disability and death worldwide. It can also cause sensory, cognitive, and unilateral upper-limb motor impairments.
- Trial name
- NCT07821346
- Testing
- Robot-Mirror Therapy (RMT), Robot therapy (RT), Mirror Therapy (MT)
- Where
- Taiwan
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Primary Central Nervous System Lymphoma (PCNSL), Zanubrutinib
Zanubrutinib Plus Lenalidomide for Frail Elderly Patients With Newly Diagnosed PCNSL
This is a prospective, single-arm, phase II clinical study evaluating the efficacy and safety of Zanubrutinib (a BTK inhibitor) plus Lenalidomide (an immunomodulatory drug) in frail elderly patients with newly diagnosed primary…
- Conditions
- Primary Central Nervous System Lymphoma (PCNSL), Zanubrutinib, Lenalidomide, Frail Elderly
- Trial name
- NCT07839247
- Testing
- Zanubrutinib, Lenalidomide
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Xiaohui Ren
Dementia, Home Care for Elderly or Disabled Individuals
The Effectiveness of a Caregiver-Based Multicomponent Intervention to Prevent Pressure Ulcers in Home-Cared-For Individuals With Dementia
Introduction and Aim: Pressure ulcers are preventable complications that are common, particularly in individuals with dementia cared for at home, reducing quality of life and creating significant costs for the healthcare system.
- Conditions
- Dementia, Home Care for Elderly or Disabled Individuals, Decubitis Ulcer, Intervention
- Trial name
- NCT07843888
- Testing
- Pressure Injury Prevention Education
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Manisa Celal Bayar University
Sarcopenia, Sarcopenia in Elderly
Effects of Aquatic Exercise in Older Adults With Sarcopenia:A Randomized Trial
Sarcopenia is a geriatric syndrome characterized by age-related loss of skeletal muscle mass, strength, and physical performance, leading to increased risk of falls, functional decline, and reduced quality of life.
- Trial name
- NCT07575958
- Testing
- Aquatic Exercise Program, Home Exercise Program
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Frail Elderly Syndrome, Surgery--Complications
Outcome of Very Old Patients Admitted for Elective Major Surgery, the Effect of Frailty
The aim of the study is to investigate the effect of frailty in patients ≥ 80 years admitted for elective major abdominal surgery.
- Trial name
- NCT03721471
- Testing
- Scoring of frailty
- Where
- Norway
- Volunteers
- 144 people
- Sponsor
- Haukeland University Hospital
Acute Pneumonia, Elderly Person
Aspirin in Acute Pneumonia in the Elderly: a Multicenter, Double-blind, Randomized, Placebo-controlled Trial.
Acute pneumonia is a very common disease, and one of the leading causes of hospitalization and death in France. Almost a century after the discovery of penicillin, no major breakthrough has significantly reduced pneumonia-related…
- Trial name
- ASPAPY (NCT06774846)
- Testing
- Acetylsalicylic acid/Aspirin (100 mg)
- Volunteers
- 600 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Frail Elderly, Fall Risk
Functional Changes and Fall Risk in Older Adults Participating in a Frailty Program
This prospective observational study aims to describe changes in physical function and fall risk in adults aged 70 years and older participating in a routine multicomponent frailty and falls prevention program in primary care.
- Trial name
- FRAIL-ALAMA (NCT07572851)
- Testing
- Multicomponent Exercise Program- 1 times per week., Multicomponent Exercise Program- 2 times per week.
- Where
- Spain
- Volunteers
- 56 people
- Sponsor
- University of Vigo
Balance Control in Elderly, Fall Prevention
Balance Workshops Focusing on Learning to Stand Up From the Floor for Older Adults Living at Home: A Pilot Study Sol'Up
Falls among older adults are a major public health issue, accounting for approximately 2 million incidents annually in France, resulting in more than 10,000 deaths and 130,000 hospitalizations.
- Trial name
- NCT07741513
- Testing
- Balance Workshops, "getting up from the floor" module
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Emile Roux
Glioma, Glioblastoma
Phase II Elderly/Frail Pts With Newly Diagnosed or Recurrent Malignant Glioma Treated With Cesium-131 GammaTile®
This is a phase 2, open-label clinical trial determining feasibility, safety, and tolerability of GammaTile® in elderly or frail subjects with newly diagnosed or recurrent malignant gliomas.
- Conditions
- Glioma, Glioblastoma, GBM, Glioma, Malignant
- Trial name
- ENDURANCE (NCT07821112)
- Testing
- GammaTile®
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Irvine
Sarcopenia in Elderly
Tai Chi Exercise to Improve Quality of Life and Depression in Elderly With Sarcopenia
This study aims to evaluate the effects of Tai Chi exercise on quality of life and depressive symptoms in elderly with sarcopenia.
- Trial name
- NCT07831356
- Testing
- Tai Chi Exercise, Elderly exercise (senam lansia)
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Hasanuddin University
Undernutrition of Elderly Peopole
Personalized Dietary Advice After Discharge From Hospital in Geriatrics: Factors Associated With Improved Nutritional Status and Autonomy
The purpose of this study is to identify the factors associated with the effectiveness of home dietary management in these elderly people returning home (personal home or independent residence) after hospitalization in acute…
- Trial name
- DIETADOM (NCT04016532)
- Testing
- Personalized dietary management at home
- Where
- France
- Volunteers
- 353 people
- Sponsor
- Gérond'if
Community-dwelling Older Adults, Neurocognitive Function of Elderly Patients
Modified Otago Exercise Program on Neurocognitive Level and Balance Parameters
This study examined the effect of an eight-week modified Otago Exercise Program on neurocognitive level and balance parameters in community-dwelling older adults.
- Conditions
- Community-dwelling Older Adults, Neurocognitive Function of Elderly Patients, Functional Mobility, Fall Prevention in Healthy Aging
- Trial name
- NCT07831174
- Testing
- Otago Exercise, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 87 people
- Sponsor
- Alanya Alaaddin Keykubat University
Sarcopenia in Elderly
RANK-ligand Inhibition to Combat Sarcopenia With Underlying Osteoporosis
The objective of this study was to conduct a randomized, double-blind, double-dummy active controlled trial to determine the efficacy of denosumab in treating sarcopenia with underlying osteoporosis.
- Trial name
- NCT06643780
- Testing
- Denosumab, Zolendronic Acid
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Prince of Wales Hospital, Shatin, Hong Kong
Diabetes Type 2, Frail Elderly Syndrome
Involvement of Muscle Mitochondrial Dysfunction in Frailty in Older Adults. Role of Exercise
This study aims to investigate the role of skeletal muscle mitochondrial dysfunction in the development of frailty in older adults and to evaluate whether a short-term, supervised resistance training intervention can improve…
- Conditions
- Diabetes Type 2, Frail Elderly Syndrome, Mitochondrial Function, Bioenergetics, Functionality
- Trial name
- MITOSTRENGTH (NCT07828847)
- Testing
- Short-duration resistance training
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia