Clinical trials: Ejaculatory Dysfunction
Premature Ejaculation
TPTNS for Treating Patients With Premature Ejaculation
Background: Transcutaneous posterior tibial nerve stimulation is an effective therapy for controlling urinary incontinence. Premature ejaculation (PE) and urinary incontinence are anatomically and physio-pathologically similar.
- Trial name
- NCT03204890
- Testing
- Transcutaneous Posterior Tibial Nerve Stimulation
- Where
- Colombia
- Volunteers
- 26 people
- Sponsor
- Boston Medical Group
Premature Ejaculation
A Comparative Study of Selective Dorsal Neurectomy, Pulsed Radiofrequency Neuromodulation, and Intragranular Hyaluronic Acid Injection for Premature Ejaculation
The goal of this clinical trial is to evaluate the effectiveness and safety of three treatment methods for lifelong premature ejaculation (PE) in adult males.
- Trial name
- NCT06777199
- Testing
- Microscopic Selective Dorsal Neurectomy (SDN), Pulsed Radiofrequency (PRF) Nerve Ablation, Intraglanular Hyaluronic Acid (HA) Injection
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ahmed Hamdy Ahmed
Ejaculation
A Study of the Effectiveness and Safety of Dapoxetine in the Treatment of Men With Premature Ejaculation.
The primary purpose of the study is to demonstrate that dapoxetine can prolong intravaginal ejaculatory latency time (IELT) compared with placebo in men with premature ejaculation (PE).
- Trial name
- NCT00211107
- Testing
- Dapoxetine
- Volunteers
- 1,294 people
- Sponsor
- Alza Corporation, DE, USA
Erectile Dysfunction, Premature (Early) Ejaculation
Effectiveness of Pelvic Floor Therapy for the Management of Erectile Dysfunction and Premature Ejaculation.
The objective of this clinical trial is to evaluate the effectiveness of pelvic floor therapy for the management of erectile dysfunction and premature ejaculation in patients with erectile dysfunction and premature ejaculation.
- Conditions
- Erectile Dysfunction, Premature (Early) Ejaculation, Premature Ejaculation, Pelvic Floor; Weak
- Trial name
- NCT06425211
- Testing
- Therapeutic exercises, Perineal electromyographic biofeedback, Electrical stimulation
- Where
- Colombia
- Volunteers
- 66 people
- Sponsor
- Boston Medical Group
Premature Ejaculation
Proof of Mechanism in ELT
The purpose of this study is to determine if the administration of GSK958108 can delay ejaculation in patients with primary premature ejaculation as measured by the ejaculatory latency time (ELT) using the masturbation model and…
- Trial name
- PoM (NCT00861484)
- Testing
- GSK958108
- Where
- Italy
- Volunteers
- 33 people
- Sponsor
- GlaxoSmithKline
Prostate Hyperplasia, Transurethral Incision Of The Prostate
Ejaculatory Sparing Transurethral Incision Of The Prostate (ES-TUIP) Versus Conventional TUIP
In this study, Investigators planned to compare ejaculatory sparing and non-ejaculatory sparing (conventional) TUIP using both subjective and objective assessment tools for the degree of deobstruction.
- Conditions
- Prostate Hyperplasia, Transurethral Incision Of The Prostate, Ejaculatory Dysfunction
- Trial name
- NCT03176017
- Testing
- Ejaculatory sparing TUIP, Conventional TUIP
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Mansoura University
Ejaculatory Dysfunction
Exploration of eJaculatory Anatomy Concept Study (EJAC Study)
Ejaculatory dysfunctions (ED) are an important cause of postoperative dissatisfaction, which lead to a decrease in the intensity of orgasms in 50% of patients.
- Trial name
- NCT05650853
- Testing
- Transrectal ultrasound, Urethroscopy
- Where
- France
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Clinique Pasteur
Premature Ejaculation
Efficacy, Safety and Tolerability of PSD502 (a Topical Anesthetic) in the Treatment Premature Ejaculation
The purpose of this study is to evaluate the effectiveness, safety and tolerability of the investigational drug, PSD502 in subjects with premature ejaculation (PE) The study drug, PSD02, is a metered dose (measured dose), topical…
- Trial name
- NCT00556478
- Testing
- PSD502, contains a mixture of lidocaine and prilocaine
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- Plethora Solutions Ltd
Premature Ejaculation, Sexual Function Disturbances
The Effect of Behavioral Therapy Given to Men and Their Partners'
Premature ejaculation involves not only sexual problems but also relationship and communication difficulties, and behavioral approaches to the treatment of premature ejaculation are promising.
- Trial name
- NCT05964608
- Testing
- Behavioral Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- University of Gaziantep
Sexual Dysfunction
Treating Sexual Dysfunction From Selective Serotonin Reuptake Inhibitor (SSRI) Medication: a Study Comparing Requip CR to Placebo
Antidepressant medicines sometimes cause sexual side effects. The purpose of this study is to determine whether the sexual dysfunction sometimes caused by selective serotonin reuptake inhibitor (SSRI) antidepressant medications…
- Trial name
- NCT00334048
- Testing
- Ropinirole (Requip)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Healthy Male Volunteers
A Phase I Study to Investigate KH-001 in Healthy Males
This was a Phase I, first-in-human study of KH-001 besylate in healthy male participants, conducted to investigate the safety, tolerability and pharmacokinetics (PK) of the study drug.
- Trial name
- NCT07868237
- Testing
- KH-001 besylate
- Where
- United Kingdom
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Kadence Bio
Premature Ejaculation
A Phase 2 Study of On-demand Therapy With Clomipramine and Sildenafil Combination in Premature Ejaculation
The purpose of this study is to evaluate the safety and efficacy of on-demand therapy with CDFR0812-15/25mg and CDFR0812-15/50mg compared to on-demand therapy with single-drug administration of Clomipramine HCl 15mg in Korean…
- Trial name
- NCT02571101
- Testing
- CDFR0812-15/25mg, CDFR0812-15/50mg, Condencia
- Where
- 9 sites in South Korea
- Volunteers
- 297 people
- Sponsor
- CTC Bio, Inc.
Premature Ejaculatory Dysfunction
A Study to Characterize the Pharmacokinetics of DA-8031 in Healthy Male Subjects
This is a dose block-randomized, double-blind, placebo-controlled, single/multiple dosing, dose-escalation study. The study is designed to describe the relationship between multiple doses and pharmacokinetic parameters of DA-8031…
- Trial name
- NCT01104948
- Testing
- DA-8031
- Where
- South Korea
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Dong-A Pharmaceutical Co., Ltd.
Lidocaine Spray
Effectiveness and Tolerability of Lidocaine 5% Spray in Treatment of Lifelong Premature Ejaculation Patients.
This study aimed to appraise effectiveness and tolerability of lidocaine 5% spray in treatment of patients with premature ejaculation (PE).
- Trial name
- PE (NCT04062357)
- Testing
- Lidocaine 5% spray
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Sohag University
Depression, Erectile Dysfunction
Impact of Depression Severity on Sexual Dysfunction
Assess the relationship and the prevalence…" "To determine the prevalence of erectile dysfunction and premature ejaculation among depressed male patients and evaluate their association with depression severity."
- Conditions
- Depression, Erectile Dysfunction, Premature Ejaculation
- Trial name
- IODOEDPE (NCT07627477)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Premature (Early) Ejaculation
On-demand Silodosin 4mg vs Dapoxetine 60mg in Treatment of Primary Premature Ejaculation
Both Silodosin 4 mg and Dapoxetine 60 mg significantly improved IELT and sexual function scores in primary PE patients. However, Silodosin exhibited a more favorable tolerability profile with fewer side effects, making it a…
- Trial name
- NCT07081659
- Testing
- sildosin 4mg, dapoxetine 60mg
- Where
- Egypt
- Volunteers
- 95 people
- Sponsor
- Benha University
Premature Ejaculation, Stress
Clinical Study to Reduce Premature Ejaculation in Healthy Adult Men
The current study focuses on clinical validation of efficacy of nutraceutical product in management of male health. In healthy adult men with induced premature ejaculation, the introduction of these nutraceuticals has been…
- Trial name
- NCT06571318
- Testing
- Destress and Perform Capsule-U001, Destress and Perform Capsule-I001
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Herbolab India Pvt. Ltd.
Premature Ejaculation, Erectile Dysfunction
The Safety of Dapoxetine/Tadalafil Combination Therapy
The purpose of this study is to evaluate the safety and efficacy of Dapoxetine/Tadalafil 30/20 mg film-coated tablet in the treatment of men with premature ejaculation and erectile dysfunction.
- Conditions
- Premature Ejaculation, Erectile Dysfunction, Safety Issues
- Trial name
- NCT03177746
- Testing
- Dapoxetine/Tadalafil 30/20 mg film coated tablet
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Neutec Ar-Ge San ve Tic A.Ş
Obstetric Labour, Premature, Premature Ejaculation
A Study To Assess The Pharmacokinetics Of Different Modified Release Formulations Of GSK221149 In Healthy Adult Subjects
PreTerm Labor (prior to 37 weeks gestation) is the largest single cause of infant morbidity and mortality and is frequently associated with long-term disability. Oxytocin is a hormone produced by the body during labor.
- Trial name
- NCT00449709
- Testing
- GSK221149
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Premature Ejaculation
A Safety and Tolerability Study of Administration of PSD502
A Phase I, Single-Centre, Double-Blind, Randomised, Placebo-Controlled, Parallel Group, Pharmacokinetic and Safety Study to Evaluate Systemic Exposure and Local Vaginal Exposure to Lidocaine and Prilocaine and the Metabolites 2,6…
- Trial name
- NCT01183208
- Testing
- Intervention A, Intervention B, Intervention C
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Plethora Solutions Ltd