Clinical trials: Effects of Heat
Physical Inactivity, Vascular Dysfunction
Heat Therapy During Reduced Physical Activity
The purpose of this randomized controlled trial is to determine whether daily Finnish dry sauna therapy attenuates the adverse cardiovascular, muscular, and metabolic effects of seven days of experimentally reduced physical…
- Conditions
- Physical Inactivity, Vascular Dysfunction, Skeletal Muscle Atrophy
- Trial name
- HEAT-RPA (NCT07847424)
- Testing
- Sauna, Reduced Physical Activity
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brigham Young University
GERD, Gastroesophageal Reflux Disease
Thread-Embedding Acupuncture as an Adjunct to Proton Pump Inhibitor Therapy for Gastroesophageal Reflux Disease
This study aims to evaluate the effectiveness of thread-embedding acupuncture combined with omeprazole in patients with gastroesophageal reflux disease (GERD) presenting with the traditional medicine pattern of Liver-Stomach…
- Trial name
- NCT07797959
- Testing
- Thread-Embedding Acupuncture
- Where
- Vietnam
- Volunteers
- 50 people
- Sponsor
- University of Science Ho Chi Minh City
Healthy
Is Nociceptive Processing Evoked by Heat Homeostatically Regulated: A Contact-heat Evoked Potentials Study
Homeostatic plasticity is a mechanism that stabilizes neuronal activity to prevent excessive nervous system excitability. This mechanism can be investigated in humans by applying two blocks of non-invasive brain stimulation, such…
- Trial name
- NCT06197529
- Testing
- Homeostatic Plasticity, Topical alone (Capsaicin 8% Patch)
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Body Temperature Changes, Heat Stress
Working in the Heat at Simulated Altitude: Effects of Normobaric Hypoxia on Physiological Strain
Extreme heat events are becoming more frequent, intense, and prolonged, increasing the risk of heat-related illness among workers performing physically demanding work in hot environments.
- Conditions
- Body Temperature Changes, Heat Stress, Heat Exposure, Heat Fatigue
- Trial name
- NCT07664462
- Testing
- Simulated Occupational heat exposure under normoxic conditions, Simulated Occupational heat exposure under hypoxic conditions
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Ottawa
Acute Exercise, Probiotics
Probiotic Supplementation and Exercise Performance in the Heat
Endurance athletes will be invited to participate in the following study. Subjects will visit the laboratory on three occasions, each time following an overnight fast.
- Trial name
- NCT05389033
- Testing
- Probiotic bacteria
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Hypertension
Heat Therapy and Omega 3 on Cardio-Metabolic Health
Currently, controlled studies are lacking which test the benefits of: 1) ω3 PUFA; and 2) heat therapy on improving vascular-metabolic-microbiota health in Hispanic American populations.
- Trial name
- NCT04051034
- Testing
- Omega 3
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Ischemic Stroke
Heat-clearing and Blood-activating Chinese Medicinal Components in Acute Cerebral Infarction
The present study is designed to confirm the therapeutic effects of heat-clearing and blood-activating Chinese medicinal components in treatment of Acute Cerebral Infarction (ACI) and to investigate the therapeutic mechanisms of…
- Trial name
- NCT02544087
- Testing
- Ixeris of sonchifolia Hance, Panax notoginseng saponins, Ixeris of sonchifolia Hance combined with Panax notoginseng saponins
- Where
- 4 sites in China
- Volunteers
- 120 people
- Sponsor
- Yunling Zhang
Healthy, Heat Stress, Exertional
Impact of Heat on Dual Task Performance
This study looks at how people response performing single and dual tasks (cognitive and motor) prior to and after a rapid heat stress that increased core temperature to 39C.
- Trial name
- NCT07629414
- Testing
- heat stress
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Acute Exercise, Heat Exposure
The Influence of Menthol Gel During Exercise With Heat
The purpose of this study is to examine the human thermoregulatory impact of applying a commercially available menthol gel (BioFreeze) to the skin prior to moderate intensity walking under heated conditions.
- Trial name
- NCT05302804
- Testing
- Menthol Gel, Control Gel
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Escherichia Coli Infection
Safety Study of Chimeric Vaccine to Prevent ETEC Diarrhea
The purpose of the study is to determine if immunization with a chimeric E. coli protein, dsc14CfaE-sCT2/LTB5, is safe and immunogenic when administered by vaccination under the skin.
- Trial name
- NCT01644565
- Testing
- Recombinant fimbrial adhesin dsc14CfaE-sCTA2/LTB5, Recombinant fimbrial adhesin dscCfaE, Modified E. coli heat labile enterotoxin LTR192G
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Enteral Nutrition, Gastrointestinal System--Abnormalities
Heat Application on Gastrointestinal System Functions
Complications related to the gastrointestinal system can occur in patients receiving enteral nutrition. These complications may include nausea, vomiting, diarrhea, constipation, decreased bowel sounds, abdominal distension…
- Trial name
- NCT06225687
- Testing
- Heat Application
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Resting Heart Rate, Blood Glucose Control
Assessing the Effects of Cool Roofs on Indoor Environments and Health in Colima, Mexico
Ambient air temperatures in Mexico have broken record highs in 2024. Solutions are needed to build heat resilience in communities and adapt to increasing heat from climate change.
- Conditions
- Resting Heart Rate, Blood Glucose Control, Depression, Heat-related Symptoms
- Trial name
- REFLECT (NCT06834893)
- Testing
- Cool roof
- Where
- Mexico
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Aditi Bunker
Malignant Melanoma
Study of Heat Shock Protein-Peptide Complex (HSPPC-96) Versus IL-2/DTIC for Stage IV Melanoma
The primary goal of this study is to determine if people with metastatic melanoma who receive Heat Shock Protein-Peptide Complex - 96 (HSPPC-96 or Oncophage) after surgery live longer than people who may or may not have surgery…
- Trial name
- NCT00039000
- Testing
- HSPPC-96 or Oncophage
- Where
- 77 sites in United States, Australia and 7 more
- Volunteers
- 350 people
- Sponsor
- Agenus Inc.
Melanoma Stage IV, Sarcoma
Heat Shock Protein (HSP) 70 to Quantify and Characterize Circulating Tumor Cells
This study investigates the ability of heat shock protein HSP70 to isolate and quantify circulating tumor cells (CTCs) in patients with advanced or metastatic tumors.
- Conditions
- Melanoma Stage IV, Sarcoma, Squamous Cell Carcinoma, Pancreatic Cancer Stage IV
- Trial name
- HSP70CTC (NCT04628806)
- Testing
- CTC isolation by HSP70
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Charite University, Berlin, Germany
Thermoregulation
Physiological Responses to Heat Stress During High-risk Events
Exertional heat stroke (EHS) affects ~500 Military Personnel and over 100 Soldiers every year, and it is believed that these numbers are underreported.
- Trial name
- NCT06907225
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Healthy Adults
Evaluation of RSB11-HI Postbiotic Supplementation for Supporting Weight Management, Metabolic Wellness, and Quality of Life in Healthy Adults
This randomized, double-blind, placebo-controlled clinical trial will evaluate the safety, tolerability, and efficacy of RSB11-HI, a heat-inactivated postbiotic, in healthy adults over an 8-week intervention period.
- Trial name
- NCT07788833
- Testing
- RSB11-HI Heat-Inactivated Postbiotic
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Able Biolabs, LLC
Liver Neoplasms, Neoplasm Metastasis
A Phase I Study of Isolated Hepatic Portal and Arterial Perfusion (IHP) With Escalating Dose Melphalan for Primary or Metastatic Unresectable Cancers of the Liver
Patients with unresectable primary or metastatic cancer confined to the liver will undergo a 1 hour hyperthermic isolated hepatic perfusion (IHP) via the portal vein and hepatic artery with escalating dose melphalan.
- Trial name
- NCT00001587
- Testing
- Isolated hepatic portal and arterial perfusion, Melphalan
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Psoriasis
Chinese Herbal Medicine for Psoriasis Vulgaris: a Real World Study
The purpose of this study is to establish a multi-center clinical registration platform, to form the real world evidence of New Blood Syndrome Theory intervention in psoriasis, and to evaluate the therapeutic advantages of New…
- Trial name
- NCT03942185
- Testing
- Oral Chinese Herbal Medicine of Clearing heat and Cooling blood therapy, Oral Chinese Herbal Medicine according with syndrome differentiation therapy, Oral Chinese Herbal Medicine of Promoting blood circulation and Removing blood stasis therapy
- Where
- 20 sites in China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Yueyang Integrated Medicine Hospital
DYSMENORRHEA
Heat Application on Depression, Anxiety, Menstrual Attitude and Dysmenorrhea
AIM: Establishing the effects of heat application on depression, anxiety, menstrual attitude and severity of dysmenorrhea. METHODS: This randomized controlled prospective experimental trial was conducted with 43 students who were…
- Trial name
- NCT04572555
- Testing
- Heat Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Balikesir University
Eyelid Diseases
Clinical Safety Study on an Eyelid Warming Device to Evaluate the Eyelid and Cornea Temperature in Healthy Volunteers
The eyelid warming device is designed to relieve the symptoms of dysfunction of the glands in the eyelids. Prospective, non comparative, open, monocentre study.
- Trial name
- NCT01086943
- Testing
- LT2420
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Laboratoires Thea