Clinical trials: Effects of Heat
Body Surface Cooling Methods
Cooling During Exercise in the Heat
The goal of this clinical trial is to compare the effectiveness of upper-body surface cooling with whole-body surface cooling on exercise performance while wearing firefighter clothing in the heat.
- Trial name
- NCT05890261
- Testing
- Cold water-perfused cooling garment
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Heart Failure With Preserved Ejection Fraction
Leg Heat Therapy in Heart Failure With Preserved Ejection Fraction
The objective of this pilot study is to establish evidence to support the validity of HT in improving skeletal muscle function and physical capacity of patients with HFpEF.
- Trial name
- NCT06388226
- Testing
- Leg heat therapy
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Indiana University
Venous Thrombosis Deep (Limbs), Venous Insufficiency (Chronic)(Peripheral)
Apixaban vs Rivaroxaban vs No Anticoagulant to Prevent EHIT After Great Saphenous Vein Laser Ablation
Endothermal heat-induced thrombosis (EHIT) is a thrombotic complication specific to endovenous thermal ablation of the great saphenous vein (GSV), for which no prophylactic regimen is standardized.
- Conditions
- Venous Thrombosis Deep (Limbs), Venous Insufficiency (Chronic)(Peripheral), Varicose Veins Leg, Venous Thrombosis
- Trial name
- NCT07699796
- Testing
- Apixaban, Rivaroxaban
- Where
- United States
- Volunteers
- 564 people
- Sponsor
- Heart, Artery, and Vein Center of Fresno
Heat Stress
Non-invasive Prediction of Thermal Strain in Healthy Male Adults
This is primarily an experimental study investigating methods of temperature measurement / heat strain detection. In the calibration study, there are different skin temperature sensor types, and in the prediction study there are…
- Trial name
- HUMONHEAT (NCT04650776)
- Testing
- Heat strain
- Where
- Switzerland
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Simon Annaheim
Hypothermia
Efficacy of Warming Garment in the Perioperative Period With Integrated Chemical Heat Packs to Maintain Normothermia
Efficacy of Stand-alone, Non-tethered, Self-applying Warming Garment in the Preoperative, Intraoperative and Postoperative Recovery Period; Using an Integrated Chemical Heat Pack Construction, With a View to Maintaining…
- Trial name
- NCT02905708
- Testing
- Air-Activated heating packs, Forced Air Warming Device
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Dr K Services PC
Food Hypersensitivity, Hypersensitivity
Peanut Allergy Vaccine Study in Healthy and Peanut-allergic Adults
The purpose of this study is to evaluate the safety and side effects of a study product that contains recombinant modified peanut proteins (EMP-123) in healthy and peanut-allergic participants. This is a first in human study.
- Conditions
- Food Hypersensitivity, Hypersensitivity, Immediate Hypersensitivity, Peanut Hypersensitivity
- Trial name
- NCT00850668
- Testing
- E. Coli-Encapsulated, Recombinant Modified Peanut Proteins Ara h 1, Ara h 2, and Ara h 3
- Where
- 2 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Allertein Therapeutics, LLC
Hepatocellular Carcinoma, Liver Neoplasms
A Study of ThermoDox™ in Combination With Radiofrequency Ablation (RFA) in Primary and Metastatic Tumors of the Liver
The purpose of this study is to determine the maximum tolerated dose (MTD) of ThermoDox when used in combination with radiofrequency ablation (RFA) in the treatment of primary and metastatic tumors of the liver.
- Trial name
- NCT00441376
- Testing
- ThermoDox
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Imunon
Previous Hamstring Injury
Effects of Warm up in Athletes With Previous Hamstring Injury
The objectives of this study is to determine the immediate and 10 minutes follow-up effects of a warm-up based on a continous run on a treadmill or the application of a hot-pack in athletes with previous hamstring injury.
- Trial name
- NCT03444285
- Testing
- Warm Up, Hot Pack
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- University of Extremadura
Elevated Blood Pressure
Post-exercise Hot Water Immersion to Improve Overnight Blood Pressure
The goal of this clinical trial is to test whether putting a participant's legs in a hot bath after exercise improves blood pressure in people with higher blood pressure. .
- Trial name
- ExHT (NCT06348225)
- Testing
- Exercise, Heat Therapy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Providence College
Healthy Volunteer Study
Dose Ranging Study of Intravenous Oxytocin for Analgesia to Heat Pain
This is a study of participants that will receive intravenous (IV) infusions of oxytocin (naturally occurring hormone that is made by the brain). In this study healthy participants will be recruited for the study.
- Trial name
- NCT05179421
- Testing
- Low dose oxytocin, High dose oxytocin
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Video Assisted Thoracic Surgery (VATS), Postoperative Complications
Clinical Effects of Intraoperative Heat and Moisture Exchange Systems During Thoracic Surgery: A Prospective Observational Cohort Study
General anesthesia with endotracheal intubation bypasses the physiological warming and humidification functions of the upper airway, allowing cold and dry gases to reach the lower respiratory tract.
- Conditions
- Video Assisted Thoracic Surgery (VATS), Postoperative Complications, Pulmonary Complications in Surgical Patients, Humidification
- Trial name
- NCT07729319
- Testing
- Active Heated Humidification, Heat and Moisture Exchanger
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Marmara University
Energy Metabolism
Lactate Profile and Fat Oxidation During Exercise
The goal of this clinical trial is to test whether changes in lactate kinetics during exercise (due to glycogen depletion or hyperthermia) alter the pattern of fat oxidation during a maximal incremental cycle ergometer test in…
- Trial name
- LacFat (NCT05703100)
- Testing
- Incremental exercise test, Incremental exercise test under hyperthermia, Incremental exercise test under glycogen depletion
- Where
- Spain
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Technical University of Madrid
Aging, Hyperthermia
Cardiovascular Responses to Heat Waves in the Elderly
The purpose of this study is to assess the cardiovascular responses of the elderly to heat wave conditions
- Trial name
- NCT04538144
- Testing
- Hot and Humid Trial, Hot and Dry Trial
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Body Temperature Changes
Cooling Vest May Reduce Heat Stress During Surgery
The investigators will propose a randomized cross-over trial using a uniform and strongly balanced 4-period design in which will include four operations for each surgeon.
- Trial name
- NCT04511208
- Testing
- Cooling Vest, Without cooling vest
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Rewarming by Shivering Heat Production Only, Rewarming by Arm and Leg Immersion in Warm Water
Hypothermia Rewarming With Distal Limb Warming
The study will compare the rewarming effectiveness of heat donation through the distal arms and legs during rewarming of mildly hypothermic subjects.
- Conditions
- Rewarming by Shivering Heat Production Only, Rewarming by Arm and Leg Immersion in Warm Water, Rewarming by Arm and Leg Exposure to Fluidotherapy
- Trial name
- NCT01827449
- Testing
- Fluidotherapy warming device
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Hypothermia, Trauma
Zero Heat Flux Temp Monitor on Discharge Hypothermia Among Trauma Patients (RUZIT Trial)
Hypothermia amongst trauma patients is a persistent problem that increases the relative risk of transfusion as well as morbidity and mortality.
- Conditions
- Hypothermia, Trauma, Temperature Change, Body
- Trial name
- RUZIT (NCT03313258)
- Testing
- Standard of Care Group, Active Warming Group
- Where
- Canada
- Sponsor
- Dr. Asim Alam
Healthy
Effects of Continuous Airway Pressure on the Ability to Heat and Humidify Air
We hypothesize that continuous positive pressure applied to the airway will decrease the ability of the nose to warm and humidify inspired air compared to zero or negative pressure.
- Trial name
- NCT00338403
- Testing
- Continuous positive airway pressure (CPAP) at -5, 0, 5 and 10 cm of water
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Low Birth Weight Baby, Small for Gestational Age (SGA)
Biological Impacts of Rising Temperatures on Maternal, Fetal, and Newborn Health: A Cohort Study (BIRTH Cohort)
The goal of this study is to learn how being exposed to high environmental temperatures during pregnancy affects the health of pregnant women and their babies.
- Conditions
- Low Birth Weight Baby, Small for Gestational Age (SGA), Preterm Birth, Pregnancy Complications
- Trial name
- BIRTH (NCT06957769)
- Testing
- heat stress
- Where
- 3 sites in Pakistan
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Syncope
Heat Stress and Volume Administration
Heat stress reduces the central blood volume and causes orthostatic intolerance. The hypothesis is that infusion of volume may reduce effects of orthostatic stress during heat stress.
- Trial name
- NCT00714766
- Testing
- Intravascular volume administration
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Heat Stress Disorders, Heat Stroke
Heat Strain Prevention in Elderly Agricultural Workers
The study explores a multi-component heat strain prevention program for older agricultural workers in response to climate change. It assesses hydration, rest breaks, reflective clothing, and shade provision.
- Conditions
- Heat Stress Disorders, Heat Stroke, Heat Exhaustion, Heat Cramps
- Trial name
- NCT06192069
- Testing
- Sustainable Heat Strain Prevention Program for Agricultural Elderly Workers (SHiP-AEW)
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Cairo University