Clinical trials: Effectiveness
Chronic Rhinosinusitis (Diagnosis)
Silver Nanoparticle Investigation for Treating Chronic Sinusitis
Chronic rhinosinusitis is a highly prevalent disease resulting in high economic burden. Effective therapeutic options are needed. Rhinosinusitis-related biofilms are a likely contributor to recalcitrant disease.
- Trial name
- SNITCH (NCT03243201)
- Testing
- Colloidal silver nanoparticles, Purified Water
- Volunteers
- healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Pregnancy
Duration of Use of Highly Effective Reversible Contraception
To assess the proportion of women who use HERC for ≥2 years of duration
- Trial name
- NCT02414919
- Testing
- Mirena (Levonorgestrel IUS, BAY86-5028), ParaGard, Implanon/Nexplanon
- Where
- United States
- Volunteers
- 13,880 people
- Sponsor
- Bayer
Opioid Induced Constipation (OIC)
A Phase 2, Double-Blind, Multiple-Dose Escalation Study to Evaluate NKTR-118 (Oral PEG-Naloxol) in Patients With Opioid-Induced Constipation (OIC)
Study (07-IN-NX003) is a Phase 2, multi-center, placebo-controlled, double-blind, randomized, dose-escalation trial. It is designed to investigate the safety, efficacy and tolerability of NKTR-118 (PEG-naloxol) in patients with…
- Trial name
- NCT00600119
- Testing
- NKTR-118
- Where
- 33 sites in United States
- Volunteers
- 207 people
- Sponsor
- AstraZeneca
Acute Gastroenteritis, Vomiting
Antiemetic Efficacy of Ondansetron Versus Metoclopramide
Acute gastroenteritis (GEA) is a public health problem at present, the main cause of vomiting and consultation in emergencies in children under 5 years.
- Trial name
- NCT02619201
- Testing
- Ondansetron, metoclopramide
- Volunteers
- 250 people
- Sponsor
- Hospital General Naval de Alta Especialidad - Escuela Medico Naval
Nasopharyngeal Carcinoma, Local Recurrence
MRG003 Induction and Capecitabine Maintenance With PD-1 in Locally Recurrent NPC
This study enrolls patients who have experienced local recurrence of nasopharyngeal carcinoma (NPC) with or without regional recurrence.
- Trial name
- NCT07331428
- Testing
- MRG003, Tislelizumab, Capecitabine
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Fujian Cancer Hospital
Digital Eye Strain (DES)
Efficacy of Investigator Product for the Amelioration of Digital Eye Strain in Children
Computer vision syndrome (CVS), also referred to as Digital eye strain (DES), is a group of eye and vision problems caused by prolonged use of electronic devices.
- Trial name
- DES (NCT06589128)
- Testing
- Astaxanthin Oral Capsule
- Where
- 2 sites in Malaysia
- Volunteers
- 70 people
- Sponsor
- Universiti Sains Malaysia
Parkinson Disease, Physical Inactivity
Integrating AI in Postural Rehabilitation for Parkinson's Disease
Postural abnormalities are highly disabling complications of Parkinson's disease (PD). These include camptocormia, anterocollis, and Pisa Syndrome (PS).
- Conditions
- Parkinson Disease, Physical Inactivity, Physical Disability, Pisa Syndrome
- Trial name
- NCT07010328
- Testing
- Neurorehabilitation, AI-based home rehabilitation for postural disorders
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Post Intensive Care Unit Syndrome
Self-care App for Family Members of ICU Patients.
Family members of critically ill (ICU) patients are at risk for developing significant symptoms of anxiety, depression, and post-traumatic stress during and after the ICU experience.
- Trial name
- NCT04316767
- Testing
- App Intervention
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Kent State University
Anxiety, Stress
A New Mindfulness Intervention Called Mindfulness Based Swinging Technique (MBST) for Women With Breast Cancer
It is hypothesised to find that the new mindfulness intervention of Mindfulness Based Swinging Technique (MBST) for Women With Breast Cancer is an effective therapeutic intervention to be applied in breast cancer population.
- Conditions
- Anxiety, Stress, Self Efficacy, Depression
- Trial name
- NCT03985267
- Testing
- Mindfulness based Swinging Effect Intervention
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 156 people
- Sponsor
- University of Barcelona
Peptic Ulcer Bleeding
Study to Evaluate Efficacy and Safety of Wound Dressing Solution Containing EGF in Patients With Peptic Ulcers Bleeding
This is a prospective, single-blinded, randomized study to evaluate the efficacy and safety of CEGP003 in patients with acute peptic ulcers bleeding, compared to endoscopic epinephrine injection therapy.
- Trial name
- CEGP003 (NCT03469167)
- Testing
- CEGP003, Injection Tx
- Volunteers
- 76 people
- Sponsor
- CGBio Inc.
Arthroplasty, Replacement, Knee, Knee Injuries
ALGRX 4975 After Total Knee Replacement
ALGRX 4975 or placebo will be dripped onto the cut muscles and soft tissues before the end of surgery for total replacement of the knee.
- Trial name
- NCT00132392
- Testing
- ALGRX 4975
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- AlgoRx Pharmaceuticals
Dermatitis, Contact, Dermatitis, Occupational
Efficacy of Glycerol, Two Topical Steroids, and a Topical Immune Modulator Against Skin Irritation
The purpose of this study is to compare the efficacy of glycerol ointment, triamcinolone acetonide ointment, clobetasol ointment and tacrolimus ointment on irritated skin in a cumulative skin irritation test model using healthy…
- Trial name
- WA+TR_1 (NCT00779792)
- Testing
- clobetasol, triamcinolone acetonide, tacrolimus
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Adolescent Idiopathic Scoliosis (AIS)
Open-label Placebo (COLP) for Pain in Adolescent Idiopathic Scoliosis (AIS) Surgery+Surgical Treatment of Idiopathic Scoliosis
This study aims to investigate the effects of conditioning with open-label placebos on standard postoperative treatment for patients undergoing surgery for idiopathic scoliosis in a randomized controlled, 6-week trial with 64 AIS…
- Trial name
- NCT06365892
- Testing
- Treatment as usual
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of California, San Francisco
Gaucher Disease, Type 1
A Study of Eliglustat Tartrate (Genz-112638) in Patients With Gaucher Disease Who Have Reached Therapeutic Goals With Enzyme Replacement Therapy (ENCORE)
This Phase 3 study was designed to confirm the efficacy and safety of eliglustat tartrate (Genz-112638) in participants with Gaucher disease type 1 who had reached therapeutic goals with enzyme replacement therapy (ERT).
- Trial name
- ENCORE (NCT00943111)
- Testing
- Eliglustat tartrate, Imiglucerase
- Where
- 34 sites in United States, Argentina and 10 more
- Volunteers
- 160 people
- Sponsor
- Genzyme, a Sanofi Company
Diabetes Mellitus Non Insulin Dependent Oral Agent Therapy
A Study to Evaluate the Efficacy and Safety of BRL 49653C in Non-insulin Dependent Diabetes
At least 30% of patients initially treated with sulphonylureas for NIDOM will have a poor response, and in the remaining 70% the subsequent failure rate is approximately 4% to 5% per year.
- Trial name
- NCT01706211
- Testing
- BRL 49653C
- Where
- Taiwan
- Volunteers
- 77 people
- Sponsor
- National Taiwan University Hospital
Congenital Heart Diseases
Ulinastatin Injection in in Pediatric Patients Undergoing Open Heart Surgery
1. Explore the efficacy of Ulinastatin use in improving post-operative pulmonary insufficiency and safety in pediatric patients undergoing scheduled CPB open heart surgery to treat Complex Congenital Heart Disease 2.
- Trial name
- NCT02527811
- Testing
- Ulinastatin
- Where
- 5 sites in China
- Volunteers
- 450 people
- Sponsor
- Techpool Bio-Pharma Co., Ltd.
Internet-based Intervention, Depression
Treatment Outcomes and Predictive Factors of the Effectiveness and Adherence of Moodpep: an Online Self-help Intervention for College Students With Depressive Symptoms
Depressive symptoms are prevalent among college students and often remain untreated. E-health interventions may help overcome treatment barriers by offering accessible and flexible support.
- Conditions
- Internet-based Intervention, Depression, Adherence, Predictors
- Trial name
- NCT07030244
- Testing
- Moodpep
- Where
- 2 sites in Netherlands
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- Universiteit Leiden
Infertility, IVF
Addition of Dydrogesterone to the Luteal Phase Support After Fresh Embryo Transfer
Randomized controlled study, open label to compare effectiveness of addition of dydrogesterone 20mg to the standard luteal phase support treatment after fresh embryos transfer.
- Trial name
- NCT04408144
- Testing
- Dydrogesterone 10mg Oral Tablet
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Laniado Hospital
Knee Osteoarthritis
Knee Osteoarthritis: Platelet Rich Plasma or Hyaluronic Acid
PURPOSE: To compare the effect of hyaluronic acid (HA) or platelet-rich plasma (PRP) on pain, physical function, quality of life and knee joint morphology in patients with knee osteoarthritis severity II-III.
- Trial name
- OA (NCT03801564)
- Testing
- Platelet Rich Plasma Treatment Group (PRP), Hyaluronic Acid Treatment Group (HA)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Antalya Training and Research Hospital
Retinal Vein Occlusion
To Study the Effectiveness and Safety of Niacin and a Topical Steroid Eye Drop to Treat Retinal Vein Occlusions
The purpose of this study is to determine whether Niacin, a B vitamin, may act as a vasodilator to encourage earlier formation of collateral blood vessels that may serve to bypass the obstructed vein in the eye.
- Trial name
- NCT00493064
- Testing
- Nicotinic acid, Prednisolone acetate
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Palo Alto Medical Foundation