Clinical trials: Edematous
Diabetic Retinopathy (DR), Center-Involved Diabetic Macular Edema (CI-DME)
RGX-314 Gene Therapy Administered in the Suprachoroidal Space for Participants With Diabetic Retinopathy (DR) With and Without Center Involved-Diabetic Macular Edema (CI-DME)
ABBV-RGX-314 is being developed as a novel, potential one-time gene therapy treatment for the treatment of Diabetic Retinopathy (DR) with and without Center-Involved Diabetic Macular Edema (CI-DME).
- Trial name
- ALTITUDE® (NCT04567550)
- Testing
- ABBV-RGX-314 Dose 1, ABBV-RGX-314 Dose 2, ABBV-RGX-314 Dose 3
- Where
- 25 sites in United States
- Volunteers
- 139 people
- Sponsor
- AbbVie
Cardiorenal Syndrome, Acute Kidney Injury
Effect on Kidney Function Recovery Guiding Decongestion With VExUS in Patients With Cardiorenal Syndrome 1
During cardiorenal syndrome type 1 (CRS1) vascular congestion is the major contributor to worsening renal function, but promoting decongestion with routine clinical evaluation is ineffective in some patients.
- Conditions
- Cardiorenal Syndrome, Acute Kidney Injury, Decompensated Heart Failure, Fluid Overload
- Trial name
- NCT05927285
- Testing
- Vexus, Control group
- Where
- Mexico
- Volunteers
- 140 people
- Sponsor
- Hospital Civil de Guadalajara
Diabetic Macular Edema
The Endurance 1 Trial
The Endurance Trial is a phase IV open label clinical study to assess the need for ongoing intravitreal aflibercept injections after the 3-year VISTA DME (VGFT-OD-1009) end-point.
- Trial name
- Endurance (NCT02297204)
- Testing
- Focal Laser Treatment, aflibercept 2.0 mg
- Volunteers
- 9 people
- Sponsor
- Northern California Retina Vitreous Associates
Renal Insufficiency, Chronic
Chlortalidone and Bumetanide in Advanced Chronic Kidney Disease: HEBE-CKD Trial
This study aims to demonstrate the possible benefit of a treatment based on double diuretic in patients with chronic kidney disease and severely impaired glomerular filtration rate.
- Trial name
- NCT03923933
- Testing
- Chlorthalidone, Bumetanide
- Where
- Mexico
- Volunteers
- 34 people
- Sponsor
- Hospital General de México Dr. Eduardo Liceaga
Amputation Stump, Peripheral Vascular Disease With Complications
Comparison Between Postoperative Tubular Dressing and a Vacuum Removable Rigid Dressing After Transtibial Amputation
Comparison of wound healing, edema level, knee range of motion, rate of revision post falls, device application time, time to prosthetic fit, and cost between postoperative soft dressing and a vacuum removable rigid dressing…
- Conditions
- Amputation Stump, Peripheral Vascular Disease With Complications, Edema Leg, Wound Healing Delayed
- Trial name
- EMPAR (NCT03948087)
- Testing
- Vacuum Removable Rigid Dressing (VRRD)
- Volunteers
- 100 people
- Sponsor
- Covenant Health, Canada
Diabetes Mellitus, Macular Edema
Clinical Trial on Alpha Lipoic Acid in Diabetic Macular Edema
To evaluate the effect of alpha lipoic acid (ALA) on the occurrence of diabetic macular edema.
- Trial name
- RETIPON (NCT01208948)
- Testing
- 1,2 dithiolane 3 valeric acid
- Where
- Germany
- Volunteers
- 520 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Glioma
Expression of ANXA2 in the Extracellular Space in the Microenvironment of Periumoral Edema Promotes Glioma Invasion
The prognostic value of ANXA2 expression in tumor tissue and PTBE was analyzed, so as to seek new therapies to inhibit glioma invasion and improve the prognosis of glioma patients
- Trial name
- NCT04953468
- Testing
- expression level of ANXA2 protein
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Peking University Third Hospital
Diabetic Macular Edema
A Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Participants With Diabetic Macular Edema
This study will evaluate the efficacy, safety, and pharmacokinetics of faricimab administered at 8-week intervals or as specified in the protocol following treatment initiation, compared with aflibercept once every 8 weeks (Q8W)…
- Trial name
- RHINE (NCT03622593)
- Testing
- Aflibercept, Faricimab
- Where
- 188 sites in United States, Argentina and 22 more
- Volunteers
- 951 people
- Sponsor
- Hoffmann-La Roche
Severe Diabetic Macular Oedema
Anti-vascular Endothelial Growth Factor (Anti-VEGF) Monotherapy vs Anti-VEGF Followed by Subthreshold Micropulse Laser for Treating Severe Diabetic Macular Oedema When the Central Retina Goes <400 Microns
The macula is the centre of the retina; it gives central sight, colour and fine detail. People with diabetes may develop diabetic macular oedema (DMO).
- Trial name
- DAME (NCT06985706)
- Testing
- Subthreshold Micropulse Laser (SML), Anti-VEGF Monotherapy (standard care)
- Where
- 22 sites in United Kingdom
- Volunteers
- 264 people
- Sponsor
- Belfast Health and Social Care Trust
Diabetic Macular Edema (DME), Diabetic Retinopathy
Corticosteroid for Diabetic Macular Edema (DME) Study
Our current goals include confirming inflammation mediators are biomarkers of DR and DME The Aim of this project is to measure aqueous PGE2 and inflammatory cytokines before and after treatment of DME with intravitreal…
- Trial name
- NCT07843849
- Testing
- Intravitreal dexamethasone implant
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Bone Marrow Edema
Evaluation of Subchondroplasty™ for Defects Associated With Bone Marrow Lesions
Studying long-term changes in a sub-set of patients who undergo the Subchondroplasty procedure including changes in pain, function, and overall health.
- Trial name
- SCP (NCT01621893)
- Testing
- Subchondroplasty
- Where
- 6 sites in United States
- Volunteers
- 70 people
- Sponsor
- Zimmer Biomet
Healthy Participants
A Study to Evaluate the Safety, Tolerability, Drug Levels, and Drug Effects of BMS-986308 in Healthy Participants
The purpose of this study is to evaluate the safety, tolerability, drug levels, and drug effects of BMS-986308 compared to placebo in healthy participants.
- Trial name
- NCT04763226
- Testing
- BMS-986308, Furosemide
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Diabetic Macular Edema
Predictors of Treatment Response to Aflibercept and Aqueous Cytokine Levels in Patients With Persistent Diabetic Macular Edema Following Treatment With Ranibizumab: An Interventional Prospective Study
Diabetic macular edema refers to swelling (fluid accumulation) in the center of the retina. The retina is like the film of a camera and is located in the back of the eye.
- Trial name
- NCT02651168
- Testing
- aflibercept
- Volunteers
- 50 people
- Sponsor
- Unity Health Toronto
Liver Transplant; Complications, Fluid Overload
Albumin Mass Balance in Liver Transplantation
This clinical observational cohort study assess the loss of albumin from blood circulation during and after liver transplantation by mass balance of albumin.
- Trial name
- NCT03441035
- Testing
- General anesthesia and surgery (liver transplantation)
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Ake Norberg
Central Retinal Vein Occlusion, Proliferative Diabetic Retinopathy
Impact of Intravitreal Aflibercept Injections on Capillary Non-Perfusion
The purpose of this study is to look at how effective, safe, and well tolerated Intravitreal Aflibercept Injection is in subjects with Central Retinal Vein Occlusion (CRVO) or Proliferative Diabetic Retinopathy (PDR).
- Trial name
- ANDROID (NCT01724554)
- Testing
- Intravitreal Aflibercept Injection
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Ophthalmic Consultants of Boston
Retinal Vein Occlusion
Ozurdex With Rescue Lucentis for Treating Macular Edema Secondary to Retinal Vein Occlusion
This study seeks to compare dexamethasone implant with rescue intravitreal ranibizumab to monthly intravitreal ranibizumab for the treatment of macular edema secondary to branch or central retinal vein occlusion.
- Trial name
- NCT01581151
- Testing
- Dexamethasone intravitreal implant, Monthly Ranibizumab
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Brian Burke, MPH
Orofacial Pain, Orofacial Edema
Evaluation of Dental Emergency Treatments During COVID19 Crisis
"For 12 years, the odontology service of the Pitié-Salpêtrière hospital group (GHPS) has been responsible for day and night dental emergency care.
- Conditions
- Orofacial Pain, Orofacial Edema, Dental Trauma, Oral Infection
- Trial name
- URGDENTCOVID (NCT04354272)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 499 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
DME, Diabetic Macular Edema
Study of CU06-1004 in Patients With Daibetic Macular Edema
This phase 2b trial is a randomized, double-masked, parallel-group, multi-center study in approximately 156 patients with Diabetic Macular Edema to evaluate the efficacy and safety of CU06-1004 orally administered once daily for…
- Conditions
- DME, Diabetic Macular Edema, Diabetic Macular Edema (DME)
- Trial name
- NCT07459829
- Testing
- CU06-1004
- Volunteers
- 156 people
- Sponsor
- Curacle Co., Ltd.
Edema, Tonsillar Surgery Complications
Submucosal Dexamethasone After Tonsillectomy
In this prospective controlled study, 74 adults undergoing elective bilateral tonsillectomy for recurrent tonsillitis were consecutively enrolled and sequentially assigned in a 1:1 ratio to receive either local submucosal…
- Trial name
- NCT03079453
- Testing
- Dexamethasone, Normal Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Bezmialem Vakif University
Diabetes Mellitus, Macular Edema
Intravitreal Aflibercept Injection in Vision Impairment Due to DME
To determine the efficacy of intravitreally (IVT) administered VEGF Trap-Eye on the best-corrected visual acuity (BCVA) assessed by the early treatment diabetic retinopathy study (ETDRS) chart in subjects with diabetic macular…
- Trial name
- VIVID-DME (NCT01331681)
- Testing
- VEGF Trap-Eye (BAY86-5321), Macular Laser Photocoagulation (Control)
- Where
- 73 sites in Australia, Austria and 9 more
- Volunteers
- 406 people
- Sponsor
- Bayer