Clinical trials: Edema
Angio Edema
Evaluation of New Markers in Type 3 Angioedema
Angioedema is a common condition, with multiple etiologies. Type 3 angioedema is caused by an increase in kininogenase activity responsible for an increased production of bradykinin.
- Trial name
- NCT03917680
- Testing
- Factor XII dosage, p.Thr328Lys mutation detection, Videocapillaroscopy
- Where
- Belgium
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Brugmann University Hospital
Pregnancy Related, Hemorrhage
The Effect of Fluids on Aortic VTI During C-section
Pregnancy is associated with a myriad of physiologic changes, including expansion of blood volume, decrease in oncotic pressure, and increased cardiac output. The obstetric population is associated with intrapartum hemorrhage.
- Conditions
- Pregnancy Related, Hemorrhage, Fluid Overload, Labor Complication
- Trial name
- NCT04330742
- Testing
- lactated ringers
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Lymphedema, Upper Extremity Lymphedema
Comparison of Reliability, Time Cost, and Participant Comfort of Lymphedema Assessments in Upper Extremity
This study aims to evaluate and compare the measurement reliability, total time cost (preparation, acquisition, post-processing), and participant comfort of conventional limb volume measurement methods (water displacement…
- Conditions
- Lymphedema, Upper Extremity Lymphedema, Breast Cancer Related Lymphedema, Edema
- Trial name
- NCT07921290
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Postoperative Cognitive Impairment, Optic Nerve Sheath Edema
Effect of Different Ventilation Modes on POCD in Elderly Patients with Abdominal Wall Hernia
The purpose of this clinical trial is to understand the effect of different ventilation patterns during surgery on postoperative cognitive impairment in elderly patients with abdominal wall hernias.
- Trial name
- NCT06764745
- Testing
- PC Ventilation Modes, VC Ventilation Modes, PRVC Ventilation Modes
- Where
- China
- Volunteers
- 471 people, healthy volunteers welcome
- Sponsor
- Inner Mongolia University of Science and Technology
Atelectasis, Hypertension
Pulmonary Evaluation With Ultrasound in Different Levels of PEEP
Patients submitted to general anesthesia and artificial ventilation almost always develop pulmonary atelectasis, which can determine adverse consequences both intraoperatively and postoperatively.
- Conditions
- Atelectasis, Hypertension, Lung Edema
- Trial name
- EVALUS (NCT03211936)
- Testing
- PEEP TITRATED, Use ultrasound, Impedance tomography
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Impacted Mandibular Third Molar
Does Vitamin C Improve Postoperative Healing
This randomized, split-mouth clinical trial investigates the effect of oral vitamin C supplementation on postoperative recovery following the surgical extraction of impacted mandibular third molars.
- Trial name
- NCT07012564
- Testing
- Vitamin C
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Age-Related Macular Degeneration, Geographic Atrophy
Evaluation of the Precision of the Microperimetry Function of the Spectral OCT/SLO
To conduct a precision study to assess the microperimetry function of the Spectral OCT/SLO. The study will assess variability across measurements taken by three different operator-device configuration across clinical sites…
- Conditions
- Age-Related Macular Degeneration, Geographic Atrophy, Diabetic Retinopathy, Macular Edema
- Trial name
- NCT01692938
- Where
- 3 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Optos, PLC
Retinal Vein Occlusion (RVO), Macular Edema
Ozurdex Implant for Macular Edema After Treatment Failure With Anti-VEGF
To determine if Ozurdex implant can offer an effective treatment for macular edema associated with retinal vein occlusion when treatment with intravitreal Avastin, Lucentis, or Eylea have not demonstrated a significant response.
- Trial name
- NCT01946399
- Testing
- Ozurdex implant
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Retina Research Institute, LLC
Intravitreal Injection, Ocular Rinse
The Effect of Ocular Rinse Volume on Surface Irritation After Intravitreal Injections
This is the first randomized controlled trial looking into post-injection rinse volume of standard ophthalmic eyewash and its affect on patient comfort up to 72 hours after injections.
- Conditions
- Intravitreal Injection, Ocular Rinse, Age-Related Macular Degeneration, Diabetic Macular Edema
- Trial name
- NCT05615805
- Testing
- OSDI questionnaire, SPEEDII questionnaire
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Cystoid Macular Edema Following Cataract Surgery
CME With Different Fluidic Parameters
Understanding and modulating fluid parameters is an important, but often overlooked aspect of phacoemulsification. In a previous study we compared the impact of using high fluid parameters versus low fluidic parameters on…
- Trial name
- NCT01385852
- Testing
- microcoaxial phacoemulsification
- Where
- India
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Iladevi Cataract and IOL Research Center
Venous Insufficiency
Non-Invasive Management of Chronic Venous Insufficiency
The purpose of this study is: -item one to use two new non-invasive technologies to evaluate scarring and swelling associated with chronic venous insufficiency.
- Trial name
- NCT00950378
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Utah
Diabetic Macular Edema
OCT-Based Screening for Early Retinal Changes in Asymptomatic Diabetic Patients
The goal of this observational study is to detect early retinal changes in people with diabetes who do not have visual symptoms.
- Trial name
- DREAM-OCT (NCT07232225)
- Testing
- Spectral Domain OCT Imaging
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cystoid Macular Edema After Phacoemulsification
Prophylactic Effect of Ketorolac Tromethamine on the Cystoid Macular Edema After Phacoemulsification in Diabetic Patients
The aim of the study is determining the prophylactic effect of ketorolac tromethamine drop 0.5% eye drop on the functional and anatomical ocular characteristics of the diabetic patients after the phacoemulsification surgery.
- Trial name
- NCT03551808
- Testing
- using of Ketorolac Tromethamine Eye Drop
- Where
- Iran
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Cellulite
Study Aimed at Evaluation of the Effectiveness and Tolerability of an Anti-cellulite Cream Medical Device
Post-marketing clinical study conducted on a CE medical device, named Defense Body, cellulite treatment, edematous fibrosclerotic panniculopathy (2nd and 3rd stage pathology), reducing draining cream-gel, to verify its…
- Trial name
- DEFBODY (NCT06348615)
- Testing
- Anti-cellulite cream-gel Medical Device (DEFBODY)
- Where
- Italy
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- ICIM International S.r.l.
Maxillary Diseases
Photobiomodulation Effects on Pain, Edema, Paresthesia and Bone Regeneration After Maxillar Surgical Disjunction
The objective of the present study will be to evaluate the efficacy of photobiomodulation (PBM) with LED in pain control, facial edema, paresthesia, bone repair and quality of life arising after maxillar surgical disjunction…
- Trial name
- NCT03814525
- Testing
- Photobiomodulation
- Where
- Brazil
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Macular Edema, Cystoid, Uveitis
Vascular Endothelial Growth Factor (VEGF) in Uveitis
This study will look for the presence in blood of a substance called vascular endothelial growth factor (VEGF) in patients with uveitis (eye inflammation).
- Trial name
- NCT00001738
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Diabetic Macular Edema, Cataract
Steroid vs. Anti-vascular Endothelial Growth Factor for Diabetic Macular Edema Prior to Phacoemulsification
The primary objective of this study is to compare the efficacy of antecedent intravitreal anti-vascular endothelial growth factor therapy vs.
- Trial name
- STAMP (NCT03832179)
- Testing
- Bevacizumab, Ranibizumab, Aflibercept
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Bay Area Retina Associates
Visual Impairment
Post-market Evaluation of OdySight App to Monitor Near Visual Acuity at Home (TIL002)
OdySight is a mobile application allowing self-testing of visual parameters including near visual acuity and communication of the data to an online dashboard to patient's doctors.
- Trial name
- TIL002 (NCT05510479)
- Testing
- Software as medical device
- Where
- 3 sites in France
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Tilak Healthcare
Edema Leg, Venous Insufficiency of Leg
Discovering the Effect of Venous Insufficiency on Nocturia (DEVINe)
Nocturia, or waking during the night to pass urine, is a multifactorial disease. An important cause of nocturia are peripheral edema due to accumulation of fluid in the lower limbs.
- Conditions
- Edema Leg, Venous Insufficiency of Leg, Nocturia, Bio-Impedance Measurements
- Trial name
- DEVINe Pilot (NCT03928197)
- Testing
- Tilt Test, Inbody S10, Tape measurements
- Where
- Belgium
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Diabetic Macular Edema
Identifying Patients With Unrecognized Treatable Diabetic Macular Edema
This trial will assess the incidence of new and/or undiagnosed diabetic macular edema (DME) in diabetic patients that undergo a DME screening exam.
- Trial name
- NCT01934920
- Where
- 2 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Elman Retina Group