Clinical trials: Early-onset Gastrointestinal Cancer, open to volunteers
Colorectal Cancer, Early Onset Colorectal Cancer
Exogenous and Endogenous Risk Factors for Early-onset Colorectal Cancer
An increase in early-onset colorectal cancers (eoCRC), defined as a CRC before 50 years, is confirmed globally. CRC pathogenesis has been associated with several risk factors (family history, germline pathogenic variants…
- Conditions
- Colorectal Cancer, Early Onset Colorectal Cancer, Diet Habit, Risk Reduction
- Trial name
- DEMETRA (NCT05732623)
- Testing
- Semi Quantitative Food Frequency Questionnaire (SQFFQ)
- Where
- 8 sites in United States, Finland and 4 more
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- San Raffaele University
Colorectal Cancer
A Comparative Study Between Early Onset Colorectal Cancer and Late Onset Colorectal Cancer Patients
This study aims to investigate the clinical, socioeconomic, behavioral, genetic, and molecular factors characterizing Early Onset Colorectal Cancer (EOCRC) patients compared with Late Onset Colorectal Cancer (LOCRC) patients
- Trial name
- EOrOS (NCT06326879)
- Testing
- No intervention
- Where
- Italy
- Volunteers
- 340 people
- Sponsor
- Istituto Clinico Humanitas
Colo-rectal Cancer
Early-Onset Colorectal Cancer: An Observational Retrospective and Prospective Multicenter Study
Observational, retrospective and prospective multicentric Italian study of patients diagnosed with colorectal cancer between age 18-40, aiming at underpinning the biology of vEO-CRC, including colibactin as well as a broader…
- Trial name
- HEBE (NCT06965335)
- Testing
- BIOLOGICAL STUDY aiming at describing clinicophatological features of EO-CRC vs SO-CRC
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Niguarda Hospital
Pancreatic Cancer, Pancreatic Neoplasms
A Pancreatic Cancer Screening Study in Individuals With New-Onset or Deteriorating Diabetes Mellitus
The main goal of this study is to explore the relationship between new-onset diabetes mellitus/deteriorating diabetes and a subsequent diagnosis of pancreatic cancer.
- Conditions
- Pancreatic Cancer, Pancreatic Neoplasms, Diabetes Mellitus
- Trial name
- PANDOME (NCT03937453)
- Testing
- MRI/MRCP
- Where
- 2 sites in United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Nuvance Health
Colorectal Cancer, Early Onset Colorectal Cancer
Multi-Center Study Protocol: Impact of Sarcopenia in Early-Onset Colorectal Cancer.
Sarcopenia's role in early-onset colorectal cancer (EOCRC), a subtype increasingly diagnosed in individuals under 50 years, has not yet been investigated according to recent literature.
- Conditions
- Colorectal Cancer, Early Onset Colorectal Cancer, Sarcopenia, Prognostic Factors
- Trial name
- ISoPECC (NCT06868095)
- Testing
- Surgical resection
- Volunteers
- 1,000 people
- Sponsor
- Instituto de Investigación Biomédica de Salamanca
Colorectal Cancer, Metastatic Colon Cancer
Exercise for Gut Microbiome in Patients With Young-Onset Colorectal Cancer Undergoing Chemotherapy: The COURAGE Trial
This research study is a randomized controlled trial that will observe changes in microbiome activity, changes in chemotherapy toxicity, and any changes in treatment outcomes between two groups of participants undergoing…
- Conditions
- Colorectal Cancer, Metastatic Colon Cancer, Metastatic Colorectal Cancer
- Trial name
- NCT06202183
- Testing
- Exercise Program
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Dana-Farber Cancer Institute
Gastric (Cardia, Body) Cancer, Stomach Adenocarcinoma
Neoadjuvant Nab-Paclitaxel Plus Oxaliplatin, S-1, and Sintilimab in Early-Onset Resectable Gastric Cancer
This study aims to evaluate the effectiveness and safety of a preoperative treatment (called neoadjuvant therapy) combining four drugs-nab-paclitaxel, oxaliplatin, S-1, and sintilimab-for patients with locally advanced…
- Conditions
- Gastric (Cardia, Body) Cancer, Stomach Adenocarcinoma, Locally Advanced
- Trial name
- YOUNG-NEOS (NCT07018063)
- Testing
- nab-paclitaxel, oxaliplatin, S-1
- Where
- China
- Volunteers
- 35 people
- Sponsor
- zhoujing
Early-onset Gastrointestinal Cancer
A Prospective Observational Study on of Early-Onset Gastrointestinal Cancer: From Tumor Features to Patient Lifestyle Habits
The YOGICO study aims to characterize the distinctive features of EoGI cancer through a holistic approach that integrates clinical and demographic data, tumor biological characteristics, and patient lifestyle habits
- Trial name
- YOGICO (NCT07479472)
- Testing
- to characterize the distinctive features of EO-GI cancer through a comprehensive approach that considers clinical and demographic factors, tumor features, and patient lifestyle habits
- Where
- 11 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Gruppo Oncologico Italiano di Ricerca Clinica
Colorectal Neoplasms, Mass Screening
Preventing Early-Onset Colorectal Cancer in the VA
Colorectal cancer is a leading cause of cancer death among Veterans. The starting age for colorectal cancer screening has been lowered from 50 to 45 years in response to the rising incidence of early-onset colorectal cancer…
- Trial name
- PRECISE (NCT07071454)
- Testing
- Patient intervention, PCP intervention
- Where
- United States
- Volunteers
- 536 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Colorectal Cancer
EOCRCPred: an AI Model to Predict Survival in EOCRC Patients After Surgery
The goal of this observational study is to develop a predictive model for overall survival in patients under the age of 50 who have undergone surgery for early-onset colorectal cancer (EOCRC).
- Trial name
- NCT06690606
- Where
- 2 sites in China
- Volunteers
- 250 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Colorectal Cancer
Early-Onset Colorectal Cancer Patients Too Young for Screening
This is a population-based retrospective study using the Surveillance, Epidemiology, and End Results (SEER) registry and National Cancer Data Base (NCDB) to look at colorectal cancer (CRC) patients younger than 35 and comparing…
- Trial name
- NCT07559825
- Testing
- Colorectal cancer
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Methodist Health System
Colorectal Cancer (CRC), Microbiome
CARE-CRC: Microbiome Insights and Correlations for Risk and Outcomes in Colorectal Cancer
Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths globally, with increasing incidence rates. While predominantly affecting older adults, CRC cases among individuals under 50 (early-onset CRC, or EoCRC)…
- Conditions
- Colorectal Cancer (CRC), Microbiome, Early Onset Colorectal Cancer
- Trial name
- CARE-CRC (NCT06734156)
- Testing
- No intervention: observational study
- Where
- 2 sites in Portugal
- Volunteers
- 400 people
- Sponsor
- Gulbenkian Institute for Molecular Medicine
Colorectal Cancer, Colorectal Neoplasms
Early Onset Colorectal Cancer Detection
Colorectal cancer (CRC) once predominantly affected older individuals, but in recent years has witnessed a progressive increase in incidence among young adults.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Adenocarcinoma, Colorectal Cancer Stage I
- Trial name
- ENCODE (NCT06342401)
- Testing
- ENCODE
- Where
- 13 sites in United States, Italy and 2 more
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Colorectal Cancer, Inflammation
Reducing Metabolic Dysregulation in Dyads
This study is a 6-month randomized controlled trail of diet modification designed to reduce chronic inflammation and reverse metabolic dysfunction among obese individuals with one or more polyps found at a colonoscopy screening.
- Conditions
- Colorectal Cancer, Inflammation, Nutrition Related Cancer
- Trial name
- REMEDY (NCT06117241)
- Testing
- IMAGINE HEALTHY
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Lynch Syndrome
Study Aiming to Test Whether Non-invasive Liquid Biopsies Can Safely Reduce Invasive Surveillance Methods in Lynch Syndrome
Lynch syndrome is an inherited genetic predisposition that increases the risk of developing several types of cancer, particularly colon and rectal cancers (colorectal cancer), as well as cancer of the uterine lining (endometrial…
- Trial name
- PREDI-LYNCH (NCT07360834)
- Testing
- INVITRO DIAGNOSTIC TESTS AND COLONOSCOPY
- Where
- 9 sites in Croatia, Czechia and 7 more
- Volunteers
- 2,000 people
- Sponsor
- UNICANCER
Colorectal Cancer Prevention, Colorectal Adenoma
Pathways, Risk Factors, and mOleculeS to Prevent Early-onset Colorectal Tumors
This research study is an open-label Phase 1 Exploratory/Pilot clinical trial to measure the effects of the incretin mimetic, tirzepatide, on tissue, urine, blood, and microbiome biomarkers associated with colorectal cancer risk…
- Trial name
- PROSPECT (NCT07095517)
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Colorectal Cancer, Colorectal Neoplasms
Changes in Reproductive and Sexual Health in People With Early Onset Colorectal Cancer
The purpose of this study is to find out how cancer treatments (chemotherapy and/or radiation therapy) affect reproductive and sexual health in people with early onset colorectal cancer.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Carcinoma
- Trial name
- NCT04812912
- Testing
- Hormone biomarker analysis, QoL Questionnaires
- Where
- 7 sites in United States
- Volunteers
- 120 people
- Sponsor
- Memorial Sloan Kettering Cancer Center