Clinical trials: Early Lung Cancer
Lung Cancer (Diagnosis), Lobectomy
A Study to Explore the Early Subjective Evaluation and Objective Recovery in Lung Cancer Patients Undergoing Sublobar Resection Versus Lobectomy
The trial was designed as a single-center, non-interventional, prospective observational study to explore the role of a multimodal digital device in analyzing subjective and objective recovery in lung cancer patients undergoing…
- Conditions
- Lung Cancer (Diagnosis), Lobectomy, Sublobar Resection
- Trial name
- NCT07288710
- Where
- China
- Volunteers
- 316 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Lung Tumour, Lung Metastases
Study of Use of Paravertebral Blocks for Pain Relief in Video Assisted Lung Surgery
This project involves looking at the timing of providing pain relief for patients who are having lung surgery via the use of a small camera inserted into the chest with a scope (Video assisted thorascopy).
- Trial name
- ErLaPara (NCT01621698)
- Testing
- Early paravertebral block, Late Paravertebral block.
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University Hospitals Bristol and Weston NHS Foundation Trust
Lung Neoplasms
Hybrid APC Therapy in Early Central Lung Neoplasms
1.1 Aims：This cohort study aims to investigate the clinical value of Hybrid APC for treatment of early central lung neoplasms. 1.2 methods：A total of 30 patients with early central lung neoplasms will be included in this open…
- Trial name
- NCT03537378
- Testing
- Hybrid APC
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Jiayuan Sun
Non Small Cell Lung Cancer
A Exploratory Study of Nivolumab Monotherapy or in Combination With Nab-paclitaxel and Carboplatin in Early Stage NSCLC in China
Nivolumab (BMS-936558) is a fully human, IgG4 (kappa) isotype mAb that binds PD-1 on activated immune cells and disrupts engagement of the receptor with its ligands PD-L1 (B7 H1/CD274) and PD-L2 (B7-DC/CD273), thereby abrogating…
- Trial name
- NCT04015778
- Testing
- Nivolumab, carboplatin, nab-paclitaxel
- Where
- China
- Volunteers
- 316 people
- Sponsor
- Guangdong Association of Clinical Trials
Multiple Pulmonary Nodules
Neoadjuvant Immunotherapy in Early Stage Non-small-cell Lung Cancer Presenting as Synchronous Ground-glass Nodules
Neoadjuvant Immunotherapy in Early Stage Non-small-cell Lung Cancer Presenting as Synchronous Ground-glass Nodules: a pilot study
- Trial name
- NCT04047186
- Testing
- Tislelizumab Injection
- Where
- China
- Volunteers
- 12 people
- Sponsor
- XiangNing Fu
Cancer, Cardiovascular
Strategy for EArly Recognition of Cancer, COPD & Heart Failure in the Emergency Department
SEARCH-ED is a research study which is running in Emergency Department (ED) of the Queen Elizabeth University Hospital. The aim of the study is to find out if using a computer programme can help doctors diagnose heart and lung…
- Conditions
- Cancer, Cardiovascular, Respiratory
- Trial name
- SEARCH-ED (NCT07391280)
- Testing
- Harrison.ai Chest X-Ray Solution
- Where
- United Kingdom
- Volunteers
- 17,000 people
- Sponsor
- NHS Greater Glasgow and Clyde
Lung Cancer
Multinational Observational Study to Describe Diagnostic Stage Shift in Patients With Lung Cancer Using Medical Records
Multinational observational study to describe diagnostic stage shift in patients with lung cancer using medical records. Increased lung cancer screening programs and increased utilization of other screening modalities such as…
- Trial name
- DIASTAG (NCT06842056)
- Volunteers
- 3,000 people
- Sponsor
- AstraZeneca
Chemotherapy, Adjuvant, Lung Adenocarcinoma, Stage I
Surgery With or Without Chemotherapy for Stage I NSCLC With Micropapillary Component ≥ 20%
Randomized phase II trial aims to compare surgery with or without adjuvant chemotherapy in treating patients who are pathologically diagnosed as stage I lung adenocarcinoma with micropapillary component no less than 20%.
- Conditions
- Chemotherapy, Adjuvant, Lung Adenocarcinoma, Stage I, Treatment, Histological Type of Neoplasm
- Trial name
- NCT03351842
- Testing
- cis Platinum/Carboplatin, Pemetrexed Disodium, Undergo surgery
- Where
- China
- Volunteers
- 460 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Lung Cancer, Postoperative Pulmonary Complications
Structured Pulmonary Physiotherapy After Lung Cancer Surgery by Age Group
This ambispective observational cohort study aims to evaluate age-related differences in clinical outcomes among patients undergoing lung cancer surgery who received a structured comprehensive in-patient physiotherapy (CIPT)…
- Trial name
- NCT07441863
- Testing
- Comprehensive In-Patient Physiotherapy (CIPT) Program
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bezmialem Vakif University
Early Detection of Cancer, Lung Neoplasms
Evaluation of a Scalable Decision Support and Shared Decision Making Tool for Lung Cancer Screening
The purpose of this project is to increase appropriate low-dose computed tomography (LDCT) lung cancer screening through the development and wide dissemination of patient-centered clinical decision support (CDS) tools that (1)…
- Trial name
- NCT04498052
- Testing
- EHR-integrated Shared Decision Making Tool and Clinical Decision Support for Lung Cancer Screening
- Where
- United States
- Volunteers
- 1,855 people
- Sponsor
- University of Utah
Oncogene-addicted Non Small Cell Lung Cancer, Early-stage Operable Non Small Cell Lung Cancer
Feasibility Study of Tissue and Blood Collection in Oncogene-addicted and Neoadjuvantly Treated Non Small Cell Lung Cancer
This study aims to determine if it is feasible to collect samples of blood and viable lung cancer tissue in patients with either: Stage IV mutation-driven NSCLC Stage II-III NSCLC undergoing neoadjuvant immunotherapy prior to…
- Conditions
- Oncogene-addicted Non Small Cell Lung Cancer, Early-stage Operable Non Small Cell Lung Cancer, Non Small Cell Lung Cancer, Metastatic Non Small Cell Lung Cancer
- Trial name
- FeStival (NCT07008742)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Solid Tumor, Adult, Lung Adenocarcinoma
TP53 R248Q TCR-T Cell Therapy for Advanced Solid Tumor
To evaluate the safety and efficacy of T cell therapy with mutated TP53 R248Q specific TCR transduction in patients with advanced solid tumor expressing the TP53 R248Q mutation and the HLA-A*11:01 allele.
- Conditions
- Solid Tumor, Adult, Lung Adenocarcinoma, Pancreas Cancer, Colorectal Cancer
- Trial name
- NCT06619886
- Testing
- Autologous, engineered T Cells targeting TP53 R248Q
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Lung Cancer (NSCLC)
Sublobar Wedge Resection or Stereotactic Radiotherapy Treatment of High-risk Patients With Early-stage Lung Cancer
In low-risk patients with stage I non-small cell lung cancer (NSCLC) surgical treatment with an anatomical resection is currently the standard of care.
- Trial name
- STRADOS (NCT07432802)
- Testing
- Stereotactic radiation therapy intervention, Surgical intervention
- Where
- 4 sites in Denmark
- Volunteers
- 182 people
- Sponsor
- Aarhus University Hospital
Non Small Cell Lung Cancer
A Neoadjuvant Study of Nivolumab Plus Ipilimumab or Nivolumab Plus Chemotherapy Versus Chemotherapy Alone in Early Stage Non-Small Cell Lung Cancer (NSCLC)
The purpose of this neoadjuvant study is to compare nivolumab plus chemotherapy and chemotherapy alone in terms of safety and effectiveness, and to describe nivolumab plus ipilimumab's safety and effectiveness in treating…
- Trial name
- CheckMate 816 (NCT02998528)
- Testing
- Nivolumab, Cisplatin, Vinorelbine
- Where
- 138 sites in United States, Argentina and 13 more
- Volunteers
- 505 people
- Sponsor
- Bristol-Myers Squibb
Lung Cancer
Clinical and Molecular Staging of Lung Cancer Stages I and IIp
The classification of lung cancer (LC) according to the degree of anatomical extension (TNM) allows the estimation of the prognosis of the patient, although its accuracy is limited.
- Trial name
- NCT03286036
- Testing
- biomarkers
- Where
- 4 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Corporacion Parc Tauli
Cancer, Lung Cancer
The SUMMIT Study: A Cancer Screening Study
The SUMMIT Study will enrol 13,000 participants in order to investigate how cancer screening can be improved and delivered. The SUMMIT Study has two main aims: the first is to clinically validate a blood test for detecting…
- Trial name
- SUMMIT (NCT03934866)
- Testing
- Low Dose CT scan
- Where
- United Kingdom
- Volunteers
- 13,035 people, healthy volunteers welcome
- Sponsor
- University College, London
Peripheral Lung Tumor
Padeliporfin VTP Using Robotic Assisted Bronchoscopy in Peripheral Lung Cancer
Phase 1/1b, safety, feasibility, and light dose titration study followed by further study of therapeutic ablation effects. Patients with high risk of peripheral primary lung cancer, stage 1A1/1A2, for whom surgical treatment is…
- Trial name
- NCT05918783
- Testing
- Padeliporfin Vascular Targeted Photodynamic (VTP) therapy
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Impact Biotech Ltd
Non Small Cell Lung Cancer
Neoadjuvant Afatinib in Early Stage Non Small Cell Lung Cancer.
This is a multicenter, randomized, 1:1, non-comparative phase II trial. Patients with early stage NSCLC will be randomized between ARM A: neoadjuvant afatinib followed by surgery and ARM B: immediate surgery with curative intent.
- Trial name
- REMNANT (NCT02470065)
- Testing
- Afatinib, Immediate surgery
- Volunteers
- 38 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Lung Neoplasms, Early Diagnosis
Diagnosis of Individuals With Pulmonary Nodules by Different Bronchoscopy Combination
This study evaluates the value of different bronchoscopy combination for diagnosing peripheral pulmonary lesions suspected to be cancer.
- Conditions
- Lung Neoplasms, Early Diagnosis, Bronchoscopy
- Trial name
- NCT02268162
- Testing
- guiding equipments
- Where
- China
- Volunteers
- 3,228 people
- Sponsor
- Tang-Du Hospital
Pulmonary Nodule, Solitary, Pulmonary Nodule, Multiple
IDEAL: Artificial Intelligence and Big Data for Early Lung Cancer Diagnosis Study
This study aims to test the use of novel CT image analysis techniques to enable a better characterisation of small pulmonary nodules.
- Conditions
- Pulmonary Nodule, Solitary, Pulmonary Nodule, Multiple, Lung Cancer
- Trial name
- IDEAL (NCT03753724)
- Where
- 4 sites in United Kingdom
- Volunteers
- 1,293 people
- Sponsor
- University of Oxford