Clinical trials: Early Detection of Cancer
Cancer
Promoting Organizational Capacity to Implement Cancer Control Programs Among Latino Churches
This research study aims to develop an organizational-level intervention to enable communities to adopt, adapt, implement and sustain evidence-based interventions (EBIs) to address cancer disparities among Latinos.
- Trial name
- CRUZA (NCT01740219)
- Testing
- Capacity Enhancement, Standard Dissemination
- Where
- 3 sites in United States
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Prostate Cancer
Prostate Cancer IMAGing IN Early Detection (IMAGINED Trial)
The researchers hope to learn if specific types of MRI software and techniques can help improve early prostate cancer detection at time of a MRI-guided prostate biopsy.
- Trial name
- IMAGINED (NCT05882253)
- Testing
- Restricted Spectrum Imaging-Magnetic Resonance Imaging (RSI-MRI)
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- University of California, San Diego
Early Detection of Cancer
Strategic Targeting for Optimal Prevention of Cancer
The primary goal of the study is to record data over the observation period to evaluate the clinical benefit of using hereditary cancer genomic diagnostics to assess overall hereditary genetic cancer risk profile and to help…
- Trial name
- STOP-Cancer (NCT03897374)
- Testing
- Genetic Testing
- Where
- United States
- Volunteers
- 120,000 people
- Sponsor
- ClinLogic LLC
Breast Cancer, Cervical Cancer
Community Clinic Model to Improve Early Detection of Breast and Cervical Cancers in Kenya
Kenya has a high incidence of breast and cervical cancers, and most women are diagnosed with late-stage disease. The investigators will conduct a study to assess the effectiveness and cost-effectiveness of strategies to increase…
- Trial name
- C3Link (NCT06572774)
- Testing
- C3Link Strategies
- Where
- Kenya
- Volunteers
- 5,400 people, healthy volunteers welcome
- Sponsor
- Implenomics
Non Small Cell Lung Cancer
Detection of Circulating Tumor DNA After Stereotactic Ablative Radiotherapy in Patients With Unbiopsied Lung Tumors
The goal of this observational study is to determine if liquid biopsies from patients with stage I non-small cell lung cancer (NSCLC) can add to the diagnosis of a small lung cancer, or can better detect recurrent lung cancer…
- Trial name
- SABR-DETECT (NCT05921474)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
ER+ Breast Cancer, HER2-negative Breast Cancer
A Trial of Early Detection of Molecular Relapse With Circulating Tumour DNA Tracking and Treatment With Palbociclib Plus Fulvestrant Versus Standard Endocrine Therapy in Patients With ER Positive HER2 Negative Breast Cancer
Detection of molecular relapse with circulating tumour DNA analysis can identify which patients with ER positive breast cancer are relapsing on adjuvant endocrine therapy.
- Trial name
- TRAK-ER (NCT04985266)
- Testing
- Palbociclib 125Mg Tab, Fulvestrant injection, Tamoxifen
- Where
- 49 sites in France, United Kingdom
- Volunteers
- 1,100 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Gastric Cancer, Gastric Intestinal Metaplasia
Cytosponge for Gastric Intestinal Metaplasia
Gastric cancer has a very poor prognosis. The disease is often diagnosed at a late stage, when curative treatment options are limited or ineffective.
- Conditions
- Gastric Cancer, Gastric Intestinal Metaplasia, Gastric Atrophy
- Trial name
- CyGIM (NCT05657080)
- Testing
- Cytosponge-TFF3
- Where
- United Kingdom
- Volunteers
- 226 people
- Sponsor
- University of Cambridge
Detection Rate of SLN ; Accuracy Rate of Lymph Node Metastasis
Sentinel Lymph Node Navigation Surgery Using Near-infrared Imaging in Early Esophageal Cancer
The esophageal squamous cell carcinoma (ESCC) has high prevalence and mortality in China, which become a severe challenge for public health.
- Trial name
- NCT04173676
- Testing
- Indocyanine Green for Injection
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Cancer of Rectum
Peritoneal Microdialysis in Patients Undergoing Low Anterior Resection (LAR) for Recto-sigmoid Cancer
Anastomotic leakage is a serious complication after LAR with high morbidity and mortality rates. Early diagnosis and treatment is mandatory.
- Trial name
- NCT00271986
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Odense University Hospital
Medical Oncology, Cancer
Ezra Faster Scan Study
The Ezra Faster Scan study uses non-invasive magnetic resonance imaging (MRI) technology that can "visually" detect early and late-stage cancer, and other pathologies.
- Conditions
- Medical Oncology, Cancer, Healthy
- Trial name
- FasterScan (NCT05385718)
- Testing
- Magnetic Resonance Imaging
- Where
- 5 sites in United States
- Volunteers
- 694 people, healthy volunteers welcome
- Sponsor
- Ezra AI, Inc.
Early Gastric Cancer, Barrett Esophagus
Linked Color Imaging vs White Light Imaging for Detection of Gastric Cancer Precursors
This study aims to examine the use of Linked Color Imaging in detection of gastric cancer precursors, as well as oesophageal and duodenal lesions.
- Trial name
- NCT03990025
- Testing
- Linked Color Imaging, White Light Imaging
- Where
- 2 sites in Singapore
- Volunteers
- 90 people
- Sponsor
- Changi General Hospital
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Reproducibility and Accuracy of a Portable System for Early Detection of Cardiac Dysfunction in Childhood Cancer Survivors
The clinical trial compares the reproducibility and accuracy of cardiac tonometry-based portable systems that may detect early cardiac dysfunction (SphygmoCor® Xcel and Oscar 2™ ambulatory blood pressure monitor) at home and in…
- Trial name
- NCT05138991
- Testing
- Echocardiogram Recording, Questionnaire Administration, Stress Cardiac Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Cardiovascular Diseases
Early Detection of Imaging-derived Subclinical Cardiac Injuries
Breast cancer (BC) radiotherapy leads to incidental cardiac irradiation, resulting in an increased risk of various major cardiac events (MCEs).
- Trial name
- EMIRA (NCT03575650)
- Testing
- Cardiac imaging modalities
- Where
- Netherlands
- Volunteers
- 148 people
- Sponsor
- University Medical Center Groningen
Melanoma
Achieving Self-directed Integrated Cancer Aftercare (ASICA) in Melanoma
The ASICA study is looking at how the UK National Health Service (NHS) might use technology in the future to more effectively support people who have been treated for melanoma.
- Trial name
- ASICA (NCT03328247)
- Testing
- ASICA digital app
- Where
- 2 sites in United Kingdom
- Volunteers
- 240 people
- Sponsor
- University of Aberdeen
Chronic Hepatitis B
Follow-up Strategy of Chronic Hepatitis B for Early Detection and Diagnosis of Hepatocellular Carcinoma: A Randomized Control Trial
This study is a randomized control prospective study. The aim of this study is to establish an all-round and convenient follow-up strategy of Chronic Hepatitis B for early detection and diagnosis of Hepatocellular Carcinoma…
- Trial name
- NCT02817685
- Testing
- 3 months, 6 months, 3 month ultrasound(US)+3 month CT/MRI+3 month US+3 month CT/MRI
- Where
- China
- Volunteers
- 7,660 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Bladder Cancer
Analysis of Urinary Methylation Patterns Via Liquid Biopsy as an Early Diagnosis Tool
Multicenter, observational, prospective, biological pilot study on liquid biopsy, aimed at investigating methylation profiles in relation to the early diagnosis of bladder cancer, to validate the potential of commercially…
- Trial name
- NCT06878027
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Regina Elena Cancer Institute
Esophagogastroduodenoscopy
AQCS for Detection of Early Cancer and Precancerous Lesions on Upper Gastrointestinal Tract
The purpose of our study was to assess the performance of esophagogastroduodenoscopy automatic quality-control system in real-time quality control of EGD.
- Trial name
- NCT04720924
- Testing
- Computer-aided Real-time Automatic Quality-control System
- Where
- 6 sites in China
- Volunteers
- 1,840 people
- Sponsor
- Shandong University
Cervical Dysplasia, Vulvar Dysplasia
OCT-AF Imaging of Pre-cancers of Vulva and Cervix
The multimodal imaging technology, OCT-AFI, will be used to image sites on the cervix, the endocervical canal and vulva. The imaging probe is small enough, it can be inserted into the endocervical canal for imaging.
- Conditions
- Cervical Dysplasia, Vulvar Dysplasia, Precancerous Lesions, Vulvar Cancer
- Trial name
- NCT03285841
- Testing
- OCT-AFI
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- British Columbia Cancer Agency
Prostate Cancer
Detection of Minimal Residual Disease Post-prostatectomy
The clinical objective for this pilot study is to determine whether minimal residual disease (MRD) detection in high-risk prostate cancer, utilizing a custom-made prostate-specific circulating tumor DNA (ctDNA) panel, may lead to…
- Trial name
- MiRaDE (NCT07334275)
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Radboud University Medical Center
Breast Cancer
Breast MRI for Early Detection of Breast Cancer in Thuringia
Breast magnetic resonance imaging (MRI) has different diagnostic characteristics from conventional mammography and may detect breast cancers that are difficult to identify using mammography.
- Trial name
- NCT07881679
- Testing
- Breast MRI
- Where
- Germany
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Jena University Hospital