Clinical trials: Early Cancer Detection
Colorectal Cancer
Increasing Colorectal Cancer (CRC) Screening Among Hispanic Primary Care Patients
This study is designed to test a standard mailed intervention (SI) versus a novel decision support and navigation intervention (DSNI).
- Trial name
- NCT02272244
- Testing
- Decision Support & Navigation, Standard
- Where
- 3 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Smoking Cessation
Tobacco Education and Lung Health Study (TEAL)
Primary Objective To compare two smoking cessation interventions among individuals undergoing lung cancer screening. Primary outcomes are: 3-month self-reported abstinence from cigarettes and 6-month self-reported and bioverified…
- Trial name
- TEAL (NCT06290869)
- Testing
- Phone-based Tobacco Treatment, Nicotine Replacement, and Stepped Care Intervention, E-Referral to the Tobacco Quitline
- Where
- United States
- Volunteers
- 1,188 people
- Sponsor
- Georgetown University
ER+ Breast Cancer, HER2-negative Breast Cancer
A Trial of Early Detection of Molecular Relapse With Circulating Tumour DNA Tracking and Treatment With Palbociclib Plus Fulvestrant Versus Standard Endocrine Therapy in Patients With ER Positive HER2 Negative Breast Cancer
Detection of molecular relapse with circulating tumour DNA analysis can identify which patients with ER positive breast cancer are relapsing on adjuvant endocrine therapy.
- Trial name
- TRAK-ER (NCT04985266)
- Testing
- Palbociclib 125Mg Tab, Fulvestrant injection, Tamoxifen
- Where
- 49 sites in France, United Kingdom
- Volunteers
- 1,100 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Patient Educational Materials
Patient Educational Materials for Prostate Cancer Screening
Although the harms of screening for prostate cancer with the prostate-specific antigen (PSA) test outweigh the benefits, 560,000 Ontario men undergo PSA screening each year.
- Trial name
- NCT03222466
- Testing
- Co-created PEM
- Where
- Canada
- Volunteers
- 573 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Breast Cancer Female, Health Knowledge, Attitudes, Practice
Faith in Action! A Church-Based Navigation Model to Increase Breast Cancer Screening in Korean Women
The purpose of this research is to develop a culturally adapted "Faith in Action!" curriculum to train lay health navigators to provide breast cancer screening navigation to Korean American women within faith-based settings and…
- Conditions
- Breast Cancer Female, Health Knowledge, Attitudes, Practice, Cancer Screening, Health Disparities
- Trial name
- NCT05298605
- Testing
- Faith in Action! Church-based Navigation Model, Control
- Where
- 2 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Smartphone Addiction
Short, Animated Storytelling (SAS) Videos to Reduce Smartphone Addiction in the US
This study will test the effect of exposure to short, animated storytelling videos on participants' perceived risk of smartphone overuse immediately after exposure, two weeks later and four weeks later.
- Trial name
- SAS (NCT06979856)
- Testing
- Short animated videos, Informational Control
- Where
- United States
- Volunteers
- 6,000 people
- Sponsor
- Stanford University
Non Small Cell Lung Cancer, Esophageal Cancer
Tumor Cell and DNA Detection in the Blood, Urine, and Bone Marrow
Patients with resectable solid primary cancers and even limited number of metastases are potentially curable. However, most patients develop recurrences despite surgery.
- Conditions
- Non Small Cell Lung Cancer, Esophageal Cancer, Gastric Cancer, Pancreatic Cancer
- Trial name
- NCT03551951
- Testing
- Test for circulating tumor cells, DNA alterations
- Where
- United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Ovarian Cancer
CA-125 in Screening Patients at High Risk for Ovarian Cancer
RATIONALE: Measuring levels of CA 125 in blood samples of women who have a high risk of developing ovarian cancer may help doctors detect cancer early and plan more effective treatment.
- Trial name
- NCT00080639
- Testing
- physiologic testing, study of high risk factors
- Where
- United States
- Sponsor
- University of Alabama at Birmingham
Bronchopulmonary Disease, Diagnoses Disease
Optimizing Bronchopulmonary Cancer Screening
The aim of this study is to evaluate the feasibility of performing a first screening for bronchopulmonary cancer by thoracic scanner in a French cohort within a dedicated, effective and structured network in the pilot centers…
- Trial name
- OPTI-DEPIST (NCT06439901)
- Testing
- Screening, Inclusion, Chest CTscan and follow-up
- Where
- 9 sites in France
- Volunteers
- 500 people
- Sponsor
- Institut Curie
Colorectal Cancer, Advanced Adenocarcinoma
Colorectal Cancer and Pre-Cancerous Adenoma Non-Invasive Detection Test Study
This study was a prospective analysis conducted by Geneoscopy Inc. to evaluate the ColoSense test, which is a multi-target stool RNA test for colorectal cancer screening.
- Conditions
- Colorectal Cancer, Advanced Adenocarcinoma, Serrated Polyp
- Trial name
- CRC-PREVENT (NCT04739722)
- Testing
- ColoSense
- Where
- 2 sites in United States
- Volunteers
- 14,263 people, healthy volunteers welcome
- Sponsor
- Geneoscopy, Inc.
Colorectal Cancer
Increasing Colorectal Cancer Screening in African Americans
RATIONALE: Screening may help doctors find colorectal cancer sooner, when it may be easier to treat. Finding out what affects a patient's decision to undergo screening tests may help increase the number of patients who undergo…
- Trial name
- NCT00893295
- Testing
- informational intervention, medical chart review, screening questionnaire administration
- Where
- United States
- Volunteers
- 896 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Taurine in Cancer Colon
The Prospect of Using Serum Taurine Level as a Potential Biomarker for Early Detection of Colorectal Carcinoma and Its Correlation With Other Prognostic Markers
Serum taurine results in this study showed that, besides CRC biomarkers; it is most attractive, more precious and more accurate early biomarker for early detecting of any malignant change which may led to CRC by other mean it is…
- Trial name
- NCT04192539
- Testing
- Taurine
- Where
- Egypt
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Family History of Lung Cancer
LEGACY: Lung Cancer Screening in Individuals With a Lung Cancer Family History-Protocol B
This research is being done to determine if an image-based deep learning model (Sybil) can accurately predict the likelihood of future lung cancer based on chest computed tomography (CT) imaging from individuals with a family…
- Trial name
- NCT07600801
- Testing
- CT scan, Sybil
- Where
- United States
- Volunteers
- 2,250 people
- Sponsor
- Massachusetts General Hospital
Health Knowledge, Attitudes, Practice
PALS for Pap Smear Follow up
In this study, the researchers will utilize information gained from patient interviews about their knowledge of the cervical cancer screening and treatment process, and perceived barriers surrounding appropriate follow up, to…
- Trial name
- PALS (NCT04070534)
- Testing
- PALS
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Colorectal Cancer Screening
Information With or Without Numbers For Optimizing Reasoning About Medical Decisions
Experts believe that increasing the low uptake of screening for colorectal cancer (CRC) requires educating patients about all approved tests and helping them choose one that fits their preferences.
- Trial name
- INFORM (NCT02477553)
- Testing
- DA - Quantitative, DA - Verbal
- Where
- United States
- Volunteers
- 728 people
- Sponsor
- Indiana University
Colorectal Cancer
Promoting Veteran-Centered Colorectal Cancer Screening
Systematic efforts to improve colorectal cancer screening use in the VA Healthcare System have resulted in an increase in not only appropriate, but also inappropriate use of screening.
- Trial name
- PROM-IS (NCT02027545)
- Testing
- Decision Aid, Provider Education, Performance Measure Modification
- Where
- United States
- Volunteers
- 436 people
- Sponsor
- VA Office of Research and Development
Colorectal Cancer
Microbiome-based Diagnostic Tool for the Screening of Colorectal Cancer (GUILTI)
Colorectal cancer (CRC) is one of the most common cancer and cause of cancer death worldwide. Population-based screening programs for average risk populations have proven effective in reducing both incidence and mortality of CRC…
- Trial name
- GUILTI (NCT06738173)
- Testing
- Gut microbiome testing
- Where
- Italy
- Volunteers
- 1,202 people
- Sponsor
- Catholic University of the Sacred Heart
Prostate Cancer
Prostate Cancer IMAGing IN Early Detection (IMAGINED Trial)
The researchers hope to learn if specific types of MRI software and techniques can help improve early prostate cancer detection at time of a MRI-guided prostate biopsy.
- Trial name
- IMAGINED (NCT05882253)
- Testing
- Restricted Spectrum Imaging-Magnetic Resonance Imaging (RSI-MRI)
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- University of California, San Diego
Colorectal Cancer Screening
Cancer Screening; Access; Awareness; Navigation
To assess the feasibility and efficacy of community-based Colorectal Cancer (CRC) screening intervention in increasing CRC screening rates To evaluate individual-level knowledge related to CRC screening and risk factors To…
- Trial name
- NCT04131946
- Testing
- Community-Based (Intervention Arm)
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- University of Illinois at Chicago
Barrett Esophagus
Detection of Early Esophageal Cancer by NIR-FME.
To improve detection of esophageal (pre)malignant lesions during surveillance endoscopy of patients at risk of developing malignancies, for example in Barrett's Esophagus (BE), there is a need for better endoscopic visualization…
- Trial name
- ESCEND (NCT03877601)
- Testing
- Bevacizumab-IRDye800CW, Fluorescence endoscopy
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- University Medical Center Groningen