Clinical trials: ECT
Electroconvulsive Therapy, Intravenous Ketamine
Electroconvulsive Therapy Versus Intravenous Ketamine in Treatment-Resistant Major Depressive Disorder
This study aimed to compare the efficacy, safety, and tolerability of electroconvulsive therapy (ECT) versus intravenous (IV) ketamine in adults with treatment-resistant major depressive disorder (TRD).
- Conditions
- Electroconvulsive Therapy, Intravenous Ketamine, Treatment-Resistant, Major Depressive Disorder
- Trial name
- NCT07526454
- Testing
- Electroconvulsive Therapy, Ketamine
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Tanta University
Electroconvulsive Therapy, Depression
Blood Biomarkers in Electroconvulsive Therapy
The present multi-disciplinary study will assess blood biomarkers to investigate putative mechanisms of action of ECT. Laboratory findings will be correlated to clinical parameters, cognitive measures and psychometric outcome…
- Conditions
- Electroconvulsive Therapy, Depression, Blood Biomarkers
- Trial name
- NCT05515159
- Testing
- electroconvulsive therapy
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Haukeland University Hospital
Primary Visceral Tumors of Any Histotype, Visceral Lesions
Electrochemotherapy (ECT) in Patients With Primary Visceral Tumors and/or Secondary Visceral Localizations, of Any Histotype
This is an monocenter, single arm, clinical investigation that evaluate the impact of the method on the objective response rate (ORR) of visceral lesions undergoing electrochemotherapy.
- Conditions
- Primary Visceral Tumors of Any Histotype, Visceral Lesions, Liver Cancer, Liver Metastasis Colon Cancer
- Trial name
- NCT06753136
- Testing
- percutaneous, laparoscopic or laparotomy lesion electrochemotherapy
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Istituto Oncologico Veneto IRCCS
Depression
Neurorestorative Effects of Electroconvulsive Therapy (ECT) in Patients With Severe Late Life Depression
To study the potential neurorestorative effects of electroconvulsive therapy (ECT) in depressed patients by measuring brain derived neurotrophic factor (BDNF) serum levels and hippocampal volumes in severely depressed patients…
- Trial name
- NCT02667353
- Testing
- ECT, Etomidate, Succinylcholine
- Volunteers
- 110 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Treatment Resistant Depression
Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy
Electroconvulsive therapy (ECT) alleviates treatment-resistant depression (TRD) through repeated generalized seizures. The goal of this study is to evaluate how ECT impacts sleep-wake regulation and efficiency of information…
- Trial name
- DNS-ECT (NCT05905705)
- Testing
- Electroencephalography (EEG), Quantitative Measurements of Sleep Microstructure
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Washington University School of Medicine
Depressive Disorder, Major
Randomised Controlled Trial of Electroconvulsive Therapy (ECT) in Relapse Prevention of Depression
The purpose of the study is to determine if continuation electroconvulsive therapy (ECT) is safe and effective in relapse prevention of depression.
- Trial name
- NCT00627887
- Testing
- Electroconvulsive therapy, venlafaxine, Lithium
- Where
- 4 sites in Sweden
- Volunteers
- 56 people
- Sponsor
- Örebro County Council
Epilepsy
Levetiracetam for Benign Rolandic Epilepsy
This study is designed to test if the language problems commonly seen in children with benign rolandic epilepsy would improve by switching anticonvulsants to levetiracetam.
- Trial name
- NCT00181116
- Testing
- Levetiracetam
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Johns Hopkins University
Electroconvulsive Therapy, Major Depressive Disorder
Impact of Covid-19 Pandemic on Patients Receiving Continuation or Maintenance Electroconvulsive Therapy
Electroconvulsive therapy is a safe and effective therapeutic strategy in patients with treatment resistant depression. As relapse after successful ECT is significant even with adequate pharmacological strategies, continuation…
- Conditions
- Electroconvulsive Therapy, Major Depressive Disorder, Covid-19
- Trial name
- COVID-M-ECT (NCT05633368)
- Testing
- Questionnaires
- Where
- 2 sites in Belgium
- Volunteers
- 47 people
- Sponsor
- University Hospital, Ghent
Dementia
Safety and Efficacy of Electroconvulsive Therapy (ECT) for Behavioural and Psychological Symptoms of Dementia (BPSD)
This is a prospective, open-label, observational study of the efficacy and safety of ECT for BPSD. There is no control or comparison group.
- Trial name
- ECTBPSD (NCT02969499)
- Where
- 3 sites in Canada
- Volunteers
- 33 people
- Sponsor
- University of British Columbia
Benign Epilepsy With Centrotemporal Spikes
18F-FDG PET Imaging Analysis of Antiepileptic Drug Response in BECTS
This original article is a novel investigation on the metabolic characteristics of different patterns of antiepileptic drug (AED) responses in benign epilepsy with centrotemporal spikes (BECTS) patients using 18F-FDG PET imaging.
- Trial name
- NCT04357236
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Physiatrics, Electroconvulsive Therapy
Does Repetitive Electroconvulsive Therapies Affect Propofol Induction Dose ?
Electroconvulsive therapy has been used for many years for different types of physiatric diseases. General anesthesia is used during the procedure. Different anesthesiologists use different regimens.
- Trial name
- NCT02394847
- Testing
- propofol
- Volunteers
- 10 people
- Sponsor
- Ankara University
Depressive Disorder
Electroconvulsive Therapy and Concomitant Lithium in Depressive Disorder: A Pilot Study
Depression is a major psychiatric illness associated with significant morbidity and mortality. Electroconvulsive therapy (ECT) is the most effective treatment for depression and arguably the safest.
- Trial name
- ECT+LITHIUM (NCT05923476)
- Testing
- Lithium
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- Melbourne Health
Unipolar Depression
Effects of Electroconvulsive Therapy (ECT) on Serotonin-1A Receptor Binding
In treatment-resistant depression, electroconvulsive therapy (ECT) has been shown to effectively reduce depressive symptoms, though the underlying neurobiological mechanism is still unclear.
- Trial name
- NCT00922064
- Testing
- ECT
- Where
- Austria
- Volunteers
- 12 people
- Sponsor
- Medical University of Vienna
Depression
Clinical Outcomes With Electroconvulsive Therapy: Insights From Computational Modelling
This study will generate new information on how to optimise brain targets with ECT stimulation.
- Trial name
- NCT03297411
- Testing
- Brief Temporoparietal ECT, Ultrabrief Temporoparietal ECT, Brief Frontoparietal ECT
- Where
- Australia
- Volunteers
- 15 people
- Sponsor
- The University of New South Wales
Depression
Comparing the Effects of Four Types of Electroconvulsive Therapy on Mood and Thinking in People With Depression
This study will compare four types of electroconvulsive therapy to determine if they differ in their effects on mood, thinking, brain activity, and biochemistry in people with major depressive disorder.
- Trial name
- NCT00487500
- Testing
- Electroconvulsive Therapy (ECT)
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- New York State Psychiatric Institute
Mental Disorders
French Observatory of ElectroConvulsive Therapy (ECT)
Since the 30s, ECT has been a psychiatric treatment mainly used for drug-resistant depressive illnesses. Clinical studies have shown its therapeutic efficiency compared to standard treatments also in other psychiatric illnesses.
- Trial name
- NCT04477434
- Where
- 30 sites in France
- Volunteers
- 2,000 people
- Sponsor
- Centre Hospitalier Henri Laborit
Esketamine, ECT
Subanesthetic Esketamine in Modified ECT for Severe Depression in Adolescents: Clinical and Mechanistic Study
The study design was a randomized, double blind, parallel controlled trial.The goal of this clinical trial is to learn if esketamine-assisted modified electroconvulsive therapy (ESK-MECT) works to treat severe depression in…
- Conditions
- Esketamine, ECT, Depression, Adolescent
- Trial name
- NCT07247968
- Testing
- Esketamine injection group (0.25 mg/kg), Saline injection group (Consistent with esketamine injection volume)
- Where
- 2 sites in China
- Volunteers
- 220 people
- Sponsor
- Min Su
Depressive Disorder, Major, Bipolar Depression
Ketamine Versus Electroconvulsive Therapy in Depression
While there are effective treatments for depression available, some patients do not see results with these options. Often, these patients are referred to electroconvulsive therapy (ECT) which has drawbacks such as adverse side…
- Trial name
- NCT03674671
- Testing
- Intravenous Ketamine, Electroconvulsive Therapy
- Where
- 4 sites in Canada
- Volunteers
- 240 people
- Sponsor
- University of Ottawa
ECT, Anesthesia
Sevoflurane in Electroconvulsive Therapy
The purpose of the study was to investigate the effects of different doses of sevoflurane used in electroconvulsive therapy (ECT) on duration of seizure, hemodynamic response and recovery profiles
- Trial name
- NCT01905904
- Testing
- sevorane
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Inonu University
Depression
The Antidepressive Effect of rTMS as add-on to ECT
The aim of the present study is to investigate in which degree low frequency right prefrontal rTMS used ad add-on may potentiate the antidepressant effect of unilateral ECT and accelerate remission .
- Trial name
- TMS (NCT02123485)
- Testing
- Low frequency (1 hz) rTMS, as add-on to ECT
- Where
- Denmark
- Volunteers
- 35 people
- Sponsor
- University of Aarhus