Clinical trials: ECT
Intrauterine Growth Restriction, Premature - Weight 1000g-2499g or Gestation of 28-37weeks
Influence of Intrauterine Growth Restriction on Amplitude-integrated EEG in Preterm Infants
Objective: The impact of intrauterine growth restriction (IUGR) on perinatal morbidity and long-term neurodevelopmental outcome has been published in numerous studies.
- Conditions
- Intrauterine Growth Restriction, Premature - Weight 1000g-2499g or Gestation of 28-37weeks, Neurodevelopmental Disorder, EEG; Spikes, Centrotemporal, Epilepsy of Childhood
- Trial name
- NCT01942525
- Testing
- aEEG
- Where
- Austria
- Volunteers
- 156 people
- Sponsor
- Medical University of Vienna
Retinitis Pigmentosa
A Study of Encapsulated Cell Technology (ECT) Implant for Participants With Early Stage Retinitis Pigmentosa
The purpose of this study is to look at the safety and effectiveness of CNTF implants on vision in persons with retinitis pigmentosa, Usher type II \& III, and Choroideremia.
- Trial name
- NCT00447980
- Testing
- NT-501
- Where
- 12 sites in United States
- Volunteers
- 73 people
- Sponsor
- Neurotech Pharmaceuticals
Depression, Mania
Impact of Closely Grouped, Iterative Exposures to Suxamethonium During ECT on the Sensitization to NMBA and the Development of Protective Antibodies
Acute per-anesthetic hypersensitivity reaction (HSA-PA) is a rapidly occurring systemic reaction following injection of a drug during anesthesia (mortality between 3 and 9%).
- Conditions
- Depression, Mania, Hallucinations
- Trial name
- SismoSens (NCT05210062)
- Testing
- Iterative exposure to suxamethonium during ECT sessions
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Depressive Disorder
The Effect of Transcranial Direct Current Stimulation on Cognitive Side Effects of Electroconvulsive Therapy
Electroconvulsive therapy (ECT) is an effective treatment for a variety of psychiatric disorders. However, despite continued advances in ECT technique, neurocognitive dysfunction continues to be a frequent adverse effect.
- Trial name
- NCT02897843
- Testing
- transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Northwell Health
Depression, Unipolar Depression
Confirmatory Efficacy and Safety Trial of Magnetic Seizure Therapy for Depression
This trial aims to assess the efficacy and tolerability of Magnetic Seizure Therapy (MST) as an alternative to electroconvulsive therapy (ECT) for depression.
- Conditions
- Depression, Unipolar Depression, Treatment Resistant Depression
- Trial name
- CREST-MST (NCT03191058)
- Testing
- Magnetic Seizure Therapy, Electroconvulsive Therapy
- Where
- 3 sites in United States, Canada
- Volunteers
- 239 people
- Sponsor
- University of Texas Southwestern Medical Center
Depression
tDCS in the Prevention of Relapse After Electroconvulsive Therapy
While electroconvulsive therapy (ECT) in major depression is effective, high relapse rates and cognitive side effects limit its long-term use.
- Trial name
- NCT02886858
- Testing
- Device : Transcranial direct current stimulation
- Where
- France
- Volunteers
- 1 people
- Sponsor
- Hôpital le Vinatier
Major Depressive Disorder
Continuation Electroconvulsive Therapy Vs Medication to Prevent Relapses in Patients With Major Depressive Disorder
The purpose of this study is to compare the safety and effectiveness of two treatments to prevent relapses in seriously ill patients with major depressive disorder (MDD) who have responded to electroconvulsive therapy (ECT).
- Trial name
- NCT00000375
- Testing
- Nortriptyline-lithium (NOR-Li), Bilateral electroconvulsive therapy (ECT), Continuation therapy
- Where
- United States
- Sponsor
- National Institute of Mental Health (NIMH)
Depression, Bipolar Depression
Efficacy of Convulsive Therapies During Continuation
This trial aims to assess the efficacy and tolerability of Magnetic Seizure Therapy (MST) and two different forms of electroconvulsive therapy (ECT) in sustaining response during and after a course of continuation treatment.
- Conditions
- Depression, Bipolar Depression, Unipolar Depression, Treatment Resistant Depression
- Trial name
- CORRECT-C (NCT03711019)
- Testing
- Magnetic Seizure Therapy (MST), RUL-UB ECT, Bitemporal ECT
- Where
- 3 sites in Canada
- Volunteers
- 106 people
- Sponsor
- Centre for Addiction and Mental Health
Dementia, Aggression
Study of Electroconvulsive Therapy (ECT) Treatment for Agitation and Aggression in Dementia
Agitation/aggression is one of the most common and serious behavioral complications of dementia. If the behavior is refractory to standard care (behavior approaches and off label use of psychotropic medications), other evidence…
- Conditions
- Dementia, Aggression, Agitation
- Trial name
- NCT01856010
- Testing
- ECT treatment, Standard Care (Non-ECT group)
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Pine Rest Christian Mental Health Services
Major Depressive Disorder (MDD)
Investigating Functional Changes in the Frontotemporal Cortex of Patients With Major Depressive Disorder Following Electroconvulsive Therapy or Magnetic Seizure Therapy Using Functional Near-infrared Spectroscopy (fNIRS)
Against the clinical backdrop of the growing global burden of neuropsychiatric disorders, the rapid rise in depression prevalence, and the frequent association of these conditions with cognitive impairment, this study highlights…
- Trial name
- NCT07533773
- Testing
- Electroconvulsive Therapy, Magnetic Seizure Therapy
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Anhui Medical University
Esketamine, ECT
The Effectiveness and Safety of Esketamine in Modified Electroconvulsive Therapy
A multicenter, randomized, controlled, single blind clinical trial on the efficacy and safety of esmketamine injection in electroconvulsive therapy Objective to evaluate the efficacy and safety of esmketamine injection in the…
- Conditions
- Esketamine, ECT, Depression
- Trial name
- NCT04777110
- Testing
- Esketamine, Saline
- Volunteers
- 396 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Electroconvulsive Therapy
Comparision of Motor Seizure Duration of Ketofol and Propofol for Electroconvulsive Therapy
Propofol is routinely used in our hospital for ECT. It causes hypotension and has anticonvulsant actions. Use of ketofol ( 1:1 combination of ketamine and propofol) during ECT can have longer seizure duration and better…
- Trial name
- NCT05408000
- Testing
- ketofol vs propofol
- Where
- Nepal
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Schizophrenia
Bifrontal and Bitemporal Electroconvulsive Therapy (ECT) in Treatment of Patients With Schizophrenia
Electroconvulsive therapy has been used in clinical practice since 1938, a number of randomized trials found significant differences favoring ECT in response rates between individuals with depression receiving real and sham ECT.
- Trial name
- ESBECT (NCT02511509)
- Testing
- Bifrontal electroconvulsive therapy, Bitemporal electroconvulsive therapy
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Lodz
Electroconvulsive Therapy Treated Patients
Neural Biomarkers of Electroconvulsive Therapy Response
In the proposed study, the investigators will utilize resting-state functional MRI (fMRI) and structural MRI-based electrical field modeling to study the effect of electroconvulsive therapy on human neural circuitry.
- Trial name
- NCT04763655
- Testing
- clinical and neuropsychological testing
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Northwell Health
Depression, Schizophrenia
Comparison of Propofol Target-Controlled Infusion Anesthesia and Bolus Injection in Electroconvulsive Therapy
Electroconvulsive therapy (ECT) serves as an effective adjuvant or alternative modality for major depressive disorder, schizophrenia, or bipolar affective disorder refractory to or contraindicated to psychopharmacological…
- Conditions
- Depression, Schizophrenia, Bipolar Disorder, Cognitive Dysfunction
- Trial name
- NCT03863925
- Testing
- Target controlled infusion, Schnider model, Bolus injection of Propofol
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Chang Gung Memorial Hospital
Treatment Resistant Depression (TRD)
Maintenance TMS in Treatment Resistant Depression
Electroconvulsive therapy (ECT) is one of the most efficacious treatments available for treatment-resistant depression (TRD). Although a maintenance ECT protocol exists, multiple barriers limit its use for long-term use.
- Trial name
- NCT06682299
- Testing
- Transmagnetic Stimulation, Electroconvulsive Therapy
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Austin Messner
Hypovolemic Shock, Blood Loss
PMZ-2010 (Centhaquine) as a Resuscitative Agent for Hypovolemic Shock
This is a prospective, multi-centric, randomized, double-blind, parallel, controlled phase-II efficacy clinical study of PMZ-2010 therapy in patients with hypovolemic shock. Centhaquine is highly safe and well tolerated.
- Trial name
- NCT04056065
- Testing
- Normal Saline, Centhaquine
- Where
- 7 sites in India
- Volunteers
- 50 people
- Sponsor
- Pharmazz, Inc.
Major Depressive Disorder
Optimisation of ECT Based on ASTI vs Narcotrend
The Electro-Convulsion-Therapy (ECT) is a well accepted treatment option in severe depression. The quality of ECT is evaluated basing on minimal seizure duration (>15sec), the sympathic response and the postictal EEG-suppression.
- Trial name
- NCT04657575
- Testing
- Narcotrend
- Where
- Austria
- Volunteers
- 31 people
- Sponsor
- Medical University Innsbruck
Schizophrenia
Electroencephalogram (EEG) and Electroconvulsive Therapy(ECT) Response in Schizophrenia
This study is designed to find quantitative Electroencephalogram(qEEG) biomarkers to predict Electroconvulsive Therapy(ECT) Response in Schizophrenia
- Trial name
- NCT04220099
- Testing
- Electroconvulsive therapy(ECT)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Mental Health Center
Schizophrenia, Bipolar Disorder
Longitudinal Effect of Electroconvulsive Therapy on Schizophrenia and Bipolar Disorder: a MRI Study
For more severe and treatment-resistant cases in schizophrenia and bipolar disorder, electroconvulsive therapy (ECT) is often very effective.
- Trial name
- NCT03651674
- Testing
- ECT treatment, Drug treatment
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Xidian University