Clinical trials: ECMO
COVID-19 Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation Complication
Correlation Between PaCO2 and Respiratory Effort in Patients With COVID-19 With Extracorporeal Membrane Oxygenation
Excessive respiratory effort may cause self-inflicted lung injury (SILI) and inspiratory muscle injuries , stimulate desynchronization between the patient and ventilator , and worsen the perfusion of extrapulmonary organs .
- Conditions
- COVID-19 Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation Complication, Respiratory Effort-Related Arousal
- Trial name
- NCT05882474
- Testing
- PaCO2
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Peking Union Medical College Hospital
Acute Respiratory Distress Syndrome, Cardiogenic Shock
Study of Immunity Dysfunction Induced by Extracorporeal Assistance (ECMO / ECLS)
Study of immunosuppression biomarkers in patients with ARDS or cardiogenic shock with ECMO / ECLS, compared to patients with ARDS or cardiogenic shock without ECMO / ECLS
- Trial name
- IMPEC (NCT03262155)
- Testing
- Blood test
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Rennes University Hospital
Extracorporeal Membrane Oxygenation, Acute Respiratory Distress Syndrome
Reduction of Blood Recirculation in Veno-Venous ECMO
Blood which recirculates through the circuit of a veno-venous Extracorporeal Membrane Oxygenation (V-V ECMO) does not contribute to the systemic oxygenation of a patient on V-V ECMO and is called the recirculation fraction (Rf).
- Trial name
- NCT04754854
- Where
- Germany
- Volunteers
- 136 people
- Sponsor
- Charite University, Berlin, Germany
Acute Myocardial Infarction, Cardiogenic Shock
Extracorporeal Life Support in Cardiogenic Shock
The aim of the study is to examine whether treatment with extracorporeal life support (ECLS) in addition to revascularization with percutaneous coronary intervention (PCI) or alternatively coronary artery bypass grafting (CABG)…
- Trial name
- ECLS-SHOCK (NCT03637205)
- Testing
- ECLS insertion, Revascularisation and optimal medical treatment
- Where
- 46 sites in Germany, Slovenia
- Volunteers
- 420 people
- Sponsor
- Helios Health Institute GmbH
Respiratory Failure
Volatile Anesthetic Pharmacokinetics During Extracorporeal Membrane Oxygenation
The goal of this study is to design a pilot trial evaluating the safety, feasibility, pharmacokinetic modeling, and physiological effects of a volatile anesthetic, sevoflurane, directly administered in extracorporeal membrane…
- Trial name
- Vol-ECMO (NCT05680545)
- Testing
- Sevoflurane vaporized in ECMO machines
- Volunteers
- 10 people
- Sponsor
- University Health Network, Toronto
Extracorporeal Membrane Oxygenation
When Heparin Stopped for Anticoagulation During ECMO Decannulation
Heparin (regular or unfractionated heparin, not low molecular weight heparin) is given as a bolus (50-100 units per kilogram) at the time of extracorporeal membrane oxygenation(ECMO) cannulation, and by continuous infusion during…
- Trial name
- NCT05239637
- Testing
- Heparin stopped before ECMO decannulation, Heparin reduced after ECMO decannulation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital of Zhengzhou University
Carbon Dioxide
Validation of Continuous Transcutaneous Carbon Dioxide Monitoring in VA-ECMO Patients
Carbon dioxide in patients on veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is eliminated via respirator as well as via the oxygenator's membrane of the ECMO machine.
- Trial name
- NCT04445909
- Testing
- VA-ECMO
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
ARDS
Extracorporeal Membrane Oxygenation (ECMO) in Non-intubated Patients With Acute Respiratory Distress Syndrome (ARDS)
Proof-of-concept study addressing the feasibility of awake ECMO (v/v) in patients with acute respiratory failure
- Trial name
- NCT01669863
- Testing
- ECMO, ECMO in non-intubated patients
- Where
- Germany
- Volunteers
- 6 people
- Sponsor
- Hannover Medical School
Heart Disease, Lung Disease
Evaluating the Use of Thromboelastography (TEG) in Patient's Requiring Extracorporeal Membrane Oxygenation (ECMO)
This is a pilot study that seeks to evaluate the feasibility and safety of using a TEG algorithm in addition to traditional laboratory tests to guide transfusion and coagulation management of ECMO patients.
- Trial name
- NCT02887820
- Testing
- Thromboelastograph
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Stephen Esper
Septic Shock
Extracorporeal Cytokine Removal in Patients With Septic Shock in an Adult Intensive Care Unit
Goals Primary: compare changes in norepinephrine requirements before and after hemoperfusion (HP) treatment. Secondary: demonstrate the decrease in levels of IL-6 , assess the total and individual change of SEQUENTIAL ORGAN…
- Trial name
- NCT04231695
- Where
- Argentina
- Volunteers
- 20 people
- Sponsor
- Hospital Jose Maria Cullen
Cardiac Arrest
A Modified Delphi for ECPR Post Resuscitation Care
The objective of this study is to generate expert consensus statements on the management of out of hospital cardiac arrest (OHCA) patients treated with extracorporeal membrane oxygenation (ECMO) cardiopulmonary resuscitation…
- Trial name
- NCT06552312
- Testing
- Delphi Questionnaire
- Where
- Australia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sydney Local Health District
Bleeding Disorder
Recombinant vWF Concentrate and ECMO
Adult patients on extracoporeal membrane oxygenation (ECMO) frequently experience bleeding, which is in part caused by acquired von Willebrand syndrome (vWS).
- Trial name
- NCT06118372
- Testing
- Recombinant von Willebrand Factor
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Virginia
Critical Illness, Intensive Care Units
Characterising Changes in Muscle Quantity and Quality in Patients Requiring ECMO Oxygen During Critical Illness
This study will identify the changes in different muscles of patients receiving Extracorporeal Membrane Oxygenation (ECMO) during critical illness and admission to Intensive Care Unit (ICU).
- Conditions
- Critical Illness, Intensive Care Units, Extracorporeal Membrane Oxygenation
- Trial name
- ECMO USS (NCT02995811)
- Testing
- Observational Cohort
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
ARDS, Acute Lung Injury
Low Frequency, Ultra-low Tidal Volume Ventilation in Patients With ARDS and ECMO
The acute respiratory distress syndrome (ARDS) is the most severe form of respiratory failure, presented in 10% of all intensive care patients and carrying a high mortality rate.
- Conditions
- ARDS, Acute Lung Injury, Extracorporeal Membrane Oxygenation, Respiratory Distress Syndrome
- Trial name
- NCT03764319
- Testing
- Ultra-protective ventilator settings, Standard ventilator settings
- Where
- Austria
- Volunteers
- 44 people
- Sponsor
- Medical University of Vienna
ARDS (Acute Respiratory Distress Syndrome)
CUrrent Practices of Intensive Care for the Management of Acute Respiratory Distress Syndrome in EurOpe.
This study seeks to gain a comprehensive understanding of current ARDS management practices across European ICUs, with a particular focus on the use of LTV and PP therapy, which have been shown to improve outcomes in ARDS…
- Trial name
- CUPIDO (NCT06714201)
- Volunteers
- 100 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Acute Respiratory Failure, ECMO
Cardinality Matching Study of Early v.s. Delayed VV ECMO in Severe Respiratory Failure
Clinical reasoning and recent data suggest that early use of venovenous extracorporeal membrane oxygenation in refractory respiratory failure may confer a survival advantage.
- Trial name
- NCT03981393
- Volunteers
- 667 people
- Sponsor
- University of Cambridge
Acute Respiratory Distress Syndrome
Assessment of Cardiac Output in Patients With ARDS Implanted With Venous-venous ECMO.
In patients with severe acute respiratory distress syndrome, extracorporeal membrane oxygenation (ECMO), which also as known as extracorporeal life support, may be used.
- Trial name
- PiCCMO (NCT05164484)
- Testing
- Transpulmonary thermodilution
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Extracorporeal Membrane Oxygenation Complication, Outcome, Fatal
Therapy and Outcome of Prolonged Veno-venous ECMO Therapy of Critically Ill ARDS Patients.
In the context of the coronavirus (COVID-19) pandemic, healthcare systems worldwide faced an unprecedented shortage of severe ARDS.
- Trial name
- NCT05338593
- Testing
- Outcome
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Goethe University
Extracorporeal Membrane Oxygenation Complication, Acute Brain Injury
Assessing Brain Injury Using Portable Magnetic Resonance Imaging (MRI)
This study aims to assess the feasibility of assessing acute brain injury using a portable low field MRI in patients on ECMO.
- Trial name
- SAFE MRI (NCT05469139)
- Testing
- Portable MRI acquisition
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Johns Hopkins University
Cardiogenic Shock
Early Left Atrial Septostomy Versus Conventional Approach After Venoarterial Extracorporeal Membrane Oxygenation
The use of venoarterial-extracorporeal membrane oxygenation(VA-ECMO) was associated with lower in-hospital mortality in patients with cardiogenic shock. However, VA-ECMO has a deleterious effect for hemodynamics.
- Trial name
- EARLY-UNLOAD (NCT04775472)
- Testing
- Early left atrial septostomy within 12 hours after VA-ECMO implantation, Selective left atrial septostomy
- Where
- South Korea
- Volunteers
- 116 people
- Sponsor
- Chonnam National University Hospital