Clinical trials: ECMO
Sickle Cell Disease, Cerebral Stroke
Cerebral Oxygen Metabolism in Children
The purpose of this research study is to better understand how blood flow and metabolism change can influence brain development in the early decades of life.
- Trial name
- COMIC (NCT04157179)
- Testing
- Carbon Dioxide
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Respiratory Distress Syndrome, Adult, Respiratory Insufficiency
Australia and New Zealand Adult Extracorporeal Membrane Oxygenation (ECMO) Audit 2005
Extracorporeal membrane oxygenation (ECMO) is a means of artificially performing the function of the human lung and/or heart outside the body.
- Conditions
- Respiratory Distress Syndrome, Adult, Respiratory Insufficiency, Shock, Cardiogenic
- Trial name
- NCT00157144
- Where
- Australia
- Sponsor
- Bayside Health
ARDS, Acute Respiratory Failure
Generating Evidence in ECMO Ventilation Strategies
The goal of this pilot clinical trial is to test if ICU level ventilator protocols are appropriate interventions to study differences in ventilator strategies for patients with acute respiratory failure supported by VV-ECMO.
- Trial name
- GENIE-Vent (NCT05708365)
- Testing
- Standard-Lung Protective Ventilation, Ultra-Lung Protective Ventilation
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Duke University
Diaphragm, Extracorporeal Membrane Oxygenation Complication
Evolution of Diaphragm Thickness Under Veno-arterial ECMO
The main objective is to evaluate the evolution of the thickness of the diaphragm (during the first week of treatment) by VA ECMO in the resuscitation patients.
- Trial name
- ATROPHY-ECMO (NCT04052230)
- Testing
- ultrasound measure
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Grenoble
Lung Transplantation, Extracorporeal Membrane Oxygenation (ECMO)
Prospective Observational Pilot Study of LMWH Versus UFH as ECMO Anticoagulation in Lung Transplantation
The aim of this observational pilot study is to evaluate the effectiveness and safety of low-molecular-weight heparin (LMWH) compared to unfractionated heparin (UFH) as anticoagulation in perioperative ECMO during bilateral lung…
- Conditions
- Lung Transplantation, Extracorporeal Membrane Oxygenation (ECMO), Anticoagulants and Bleeding Disorders
- Trial name
- LUX-ET-LT (NCT06868823)
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- University Hospital, Motol
ARDS, Human
Decrease of Lesions Induced by Mechanical Ventilation During ARDS
Modification of mechanically ventilated lesions by an ultra-protective multimodal strategy compared to a protective strategy in patients with veno-venous ECMO for severe ARDS.
- Trial name
- ECMO-VILI (NCT03918603)
- Testing
- ventral décubitus
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Out-of-Hospital Cardiac Arrest
Induced Hypothermia in Cardiac Arrest Patients Rescued by Extracorporeal Cardiopulmonary Resuscitation.
Background： Cardiopulmonary resuscitation (CPR) with closed-chest cardiac massage has been shown that survival to discharge rate is poor.
- Trial name
- NCT00965016
- Testing
- hypothermia
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Min-Sheng General Hospital
Cardiogenic Shock
CARDSUP - SWISS Circulatory Support Registry
The project's main goal is to collect baseline clinical and procedural data as well as to assess clinical outcomes for all patients undergoing ECMO or Impella implantation at all included sites.
- Trial name
- CARDSUP (NCT04117230)
- Where
- 5 sites in Switzerland
- Volunteers
- 1,500 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Ards, Mechanical Ventilation Pressure High
Prognostic Value of Respiratory System Compliance Under VV-ECMO on 180-day Mortality in COVID-19 ARDS.
Mortality of patients with COVID-19 associated acute respiratory distress syndrome (CARDS) treated with veno-venous extra-corporal membrane oxygenation (vv-ECMO) is increasing over time since the beginning of the COVID-19…
- Conditions
- Ards, Mechanical Ventilation Pressure High, Extracorporeal Membrane Oxygenation
- Trial name
- COMPLIECMO (NCT05341687)
- Testing
- No applicable
- Where
- France
- Volunteers
- 122 people
- Sponsor
- Central Hospital, Nancy, France
Respiratory Distress Syndrome
Place of ECMO in the Management of Severe Refractory ARDS Associated With Covid-19
Describe COVID-19 patients who are receiving ECMO-VV respiratory replacement and what happens to them.
- Trial name
- ECMO-COVID-19 (NCT04343404)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Cardiogenic Shock
A Study on the Effects of Left Ventricular Unloading in the Setting of VA ECMO Support
REMAP ECMO is a registry based platform in which multiple response adaptive randomized clinical trials (trial domains) will be embedded.
- Trial name
- REMAP ECMO (NCT05913622)
- Testing
- Intra-aortic balloon pump
- Where
- 14 sites in Belgium, Netherlands
- Volunteers
- 430 people
- Sponsor
- Erasmus Medical Center
Respiratory Failure
Lung Transplantation in Respiratory Failure Patients
Survival after cadaveric lung transplantation in recipients depended on ventilation support prior to transplantation has been reported to have relative high surgical mortality and morbidity rate.
- Trial name
- NCT00854165
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- National Taiwan University Hospital
Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation Complication
"Continuous Positive Airway Pressure on Venovenous extracorporeaL Membrane Oxygenation for Acute respIratory Distress syndrOme"
The CALMDOWN trial is a prospective, open-label, multicenter, comparative, controlled trial randomizing patients who received near apneic ventilation vs usual care on ECMO (ultra-protective lung ventilation).
- Trial name
- CALMDOWN (NCT06814340)
- Testing
- ECMO + near apneic ventilation, ECMO + ultra-protective lung ventilation
- Where
- 11 sites in France
- Volunteers
- 280 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Respiratory Distress Syndrome (ARDS), Extracorporeal Membrane Oxygenation
Personalized Ventilator Settings for Patients on ECMO
While mechanical ventilation can be used to sustain life in those with lung injury, it, can further worsen lung injury or prevent lung healing resulting in high morbidity and mortality as seen in Acute Respiratory Distress…
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Extracorporeal Membrane Oxygenation, Respiratory Failure Patients Treated With ECMO, Respiratory Failure, ICU
- Trial name
- PEEPECMO (NCT07673250)
- Testing
- Personalized Positive End-Expiratory Pressure (PEEP)
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of California, San Diego
ExtraCorporeal Life Support (ECLS), Wound Infection
Investigating the Impact of Cold Atmospheric Plasma Treatment on Wound Healing at Cannulation Sites in Patients Following Extracorporeal Life Support
This study aims to evaluate a new wound treatment called cold atmospheric plasma (CAP) for patients receiving extracorporeal life support (ECLS).
- Conditions
- ExtraCorporeal Life Support (ECLS), Wound Infection, Surgical Site Infection, Delayed Wound Healing
- Trial name
- NCT07501897
- Testing
- Cold Atmospheric Plasma (CAP) Therapy, Standard wound care
- Where
- Taiwan
- Volunteers
- 65 people
- Sponsor
- National Taiwan University Hospital
ECMO Treatment, ARDS
Hemodynamic Monitoring and Fluid Responsiveness in Venovenous Extracorporeal Membrane Oxygenation (VV ECMO) - "HemodynamECMOnitoring-VV Study"
In extracorporeal membrane oxygenation (ECMO), blood is drawn out of the body via tubes, oxygenated in an artificial lung; and then pumped back into the blood vessels.
- Conditions
- ECMO Treatment, ARDS, Pneumonia, Intensive Care
- Trial name
- NCT06593717
- Testing
- Transthoracic Echocardiography, Uncalibrated Pulse Contour Analysis, Transpulmonary Thermodilution/Calibrated Pulse Contour Analysis
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Drug Effect
PK/PD of the Sedatives, Analgesics and Antibiotics in Patients Receiving ECMO
It is a multi-center, open-label, observational study aimed to understand the pharmacokinetics and pharmacodynamics of the commonly used sedative, analgesic and antibiotic drugs in adult patients supported with extracorporeal…
- Trial name
- NCT03787550
- Testing
- The Sedatives, analgesics and antibiotics
- Where
- 3 sites in China
- Volunteers
- 36 people
- Sponsor
- Guangdong Provincial People's Hospital
Cardiac Arrest With Successful Resuscitation, Cardiac Arrest, Cause Unspecified
Optimization of Transport and Use of a Mobile ECMO Team in Patients With Sudden Cardiac Arrest in the Moravian-Silesian Region
This study evaluates the feasibility of implementing a mobile extracorporeal membrane oxygenation (ECMO) team and optimizing patient transport logistics.
- Trial name
- NCT07009652
- Testing
- Extracorporeal cardiopulmonary resuscitation (ECPR)
- Where
- 2 sites in Czechia
- Volunteers
- 100 people
- Sponsor
- University Hospital Ostrava
Cardiogenic Shock
Pharmacokinetic Modelling of Levosimendan in Adults
In the light of current knowledge of the PK of levosimendan and its use in ECMO weaning, deciphering the mechanisms of inter-individual variability in exposure and response to levosimendan appears essential in order to better…
- Trial name
- MILADECMO (NCT06993584)
- Testing
- Adult patients in cardiogenic shock
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Rouen
Complex High-risk and Indicated Patients
Long-term Outcomes of Patients Undergoing ECMO-assisted PCI
Evidence regarding the long-term outcomes of patients undergoing Veno-arterial extracorporeal membrane oxygenator (VA-ECMO) assisted percutaneous coronary intervention (PCI) and the impact of the operator experience is limited.
- Trial name
- NCT06713876
- Testing
- VA-ECMO-assisted PCI
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Ling Tao, MD, PhD