Clinical trials: E-cigarette Use
Nicotine Dependence, E-cigarette Use
Sex Differences in E-Cigarette Perception
This study examines differences between males and females in the appeal and addiction potential of menthol flavored e-cigarettes with and without nicotine.
- Trial name
- NCT07398976
- Testing
- Nicotine Level 1 (0mg/ml), Nicotine Level 2 (36mg/ml), Nicotine Level 3 (59mg/ml)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yale University
Tobacco Use, Cigarette Use
Responses of Adults Smoking Nondaily and Daily in the Experimental Tobacco Marketplace
The goal of this project is to learn about the potential impact of tobacco regulations that could affect the availability of tobacco products among adults who smoke nondaily and daily.
- Trial name
- NCT06988371
- Testing
- Reduced nicotine regulatory environment, Restriction on characterizing flavors in combustible nicotine products, Restriction on characterizing flavors in noncombustible nicotine products
- Where
- United States
- Volunteers
- 747 people, healthy volunteers welcome
- Sponsor
- Bethany Shorey Fennell, PhD
Implementation Science, Engagement, Patient
Parents Helping Parents for Youth Vaping Cessation
The goal of this randomized controlled study is to test if this new intervention works to help adolescents quit vaping. A key feature of the program is the use of peer support for parents, delivered by trained parent coaches.
- Conditions
- Implementation Science, Engagement, Patient, E Cigarette Use, Peer Support
- Trial name
- PhP-VX (NCT07207850)
- Testing
- Parents Helping Parents program
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Nebraska
Veterans, Tobacco Use Disorder
Varenicline for Smoking Reduction in Veterans Not Ready To Quit
In order to reduce the prevalence of cigarette smoking among Veterans, it is vital that healthcare providers offer effective tobacco treatment to all Veterans who smoke, including those not ready to make a quit attempt.
- Conditions
- Veterans, Tobacco Use Disorder, Cigarette Smoking, Tobacco Dependence
- Trial name
- NCT06966362
- Testing
- Motivation-Phase Varenicline, Motivation-Phase Nicotine Mini-Lozenge, Cessation-Phase Combination Nicotine Replacement Therapy (NRT)
- Where
- 4 sites in United States
- Volunteers
- 400 people
- Sponsor
- VA Office of Research and Development
Tobacco Use
Cardiovascular Effects of Very Low Nicotine Content Cigarettes
The study is measuring Cardiovascular effects of very low nicotine content cigarettes on daily and non-daily smokers
- Trial name
- CEV (NCT05707871)
- Testing
- SPECTRUM cigarettes, usual brand of Cigarettes
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Smoking, Smoking Cessation
A Study Evaluating the Use of an Indoor Air Quality Monitor to Promote a Smoke-free Home
The purpose of this study is to evaluate how using an indoor air quality monitor can promote a smoke-free home for cancer patients who are enrolled in MSK's Tobacco Treatment Program.
- Conditions
- Smoking, Smoking Cessation, Smoking Reduction, Smoking Habit
- Trial name
- NCT06693700
- Testing
- Indoor Air Quality Monitor AirGradient ONE
- Where
- 8 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Opioid Use Disorder, Tobacco Use Disorder
Deep Transcranial Magnetic Stimulation for Tobacco Cessation in Adults With Opioid Use Disorder
This pilot study will evaluate the use of deep transcranial magnetic stimulation (Deep TMS) to help adults with opioid use disorder (OUD) who are receiving medications for opioid use disorder (MOUD) such as buprenorphine or…
- Trial name
- NCT07770555
- Testing
- Deep TMS System With H4 Coil
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Payel Roy
Cigarette Smoking-Related Carcinoma, E-Cig Use
Carcinogen and Toxicant Exposure Among Young Adults Who Co-Use Cigarettes, E-cigarettes and Cannabis (Co-Tox Study)
This study evaluates the amount of nicotine, cannabis, and toxicants linked to the use of nicotine e-cigarette and/or cannabis products in the blood and urine of young adult users as well as the cannabis and nicotine use…
- Trial name
- NCT07167225
- Testing
- Effectiveness of different recruitment approaches, Choice of study completion locations, Cannabis Engagement Assessment
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
E Cigarette Use, Cessation, Tobacco
Evaluation of Dependence and Nicotine Replacement Therapy-Supported Cessation Efforts Among Regular Electronic Cigarette Use
This study aims to improve understanding of how people who use electronic cigarettes (ECIGs or e-cigarettes) respond when they try to stop using them and whether nicotine replacement therapy (NRT) can make that process easier.
- Conditions
- E Cigarette Use, Cessation, Tobacco, Cessation, Nicotine
- Trial name
- NCT07786896
- Testing
- Nicotine Replacement Therapies, Brief Behavioral Counseling
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- West Virginia University
Nicotine Dependence, Electronic Cigarette Use
Methadone-Maintained Smokers Switching to E-Cigarettes
Participants in this randomized clinical trial will be methadone-maintained smokers interested in switching to electronic cigarettes (ECs).
- Trial name
- SHINE (NCT05206435)
- Testing
- Electronic Cigarette, Nicotine Lozenge
- Where
- United States
- Volunteers
- 183 people
- Sponsor
- Butler Hospital
Cigarette Smoking, Nicotine Dependence
Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches
Tobacco-free oral nicotine pouches (such as Zyn brand) are a less harmful alternative to cigarette smoking. Pouches, however, contain nicotine, and addictive substance that is not risk-free.
- Conditions
- Cigarette Smoking, Nicotine Dependence, Smoking Cessation
- Trial name
- Pack2Pouch (NCT06678789)
- Testing
- High Nicotine Dose, Low Nicotine Dose
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Electronic Cigarette Use
Assessing the Effect of Nicotine Reduction on ENDS User's Addiction and Exposures
The rapid increase of electronic nicotine delivery systems (ENDS) use by young people in the US and their potential to harm health, cause addiction, and serve as a risk for cigarette smoking or dual-use is alarming.
- Trial name
- NCT05205382
- Testing
- 5% nicotine (Partial Nicotine Reduction), 3% or 2.4% nicotine (Partial Nicotine Reduction), 5% nicotine (Total Nicotine Reduction)
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Florida International University
Cigarette Smoking, Nicotine Dependence
Effects of Very Low Nicotine Content Cigarettes Among Adults Who Smoke Daily in South Korea
The goal of this clinical trial is to learn how switching to very low nicotine content (VLNC) cigarettes affects smoking behavior and nicotine exposure among adults in South Korea who smoke conventional cigarettes daily.
- Trial name
- NCT07755891
- Testing
- SPECTRUM cigarettes
- Where
- South Korea
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Sung-il Cho
Nicotine Dependence, Cigarettes
AI-Enhanced App-based Intervention for Adolescent E-cigarette Cessation
The goal of this quasi-experimental study is to test if a smartphone app can help adolescents aged 14-20 quit e-cigarettes. The main questions it aims to answer are: Can the app help adolescents manage cravings and increase their…
- Trial name
- NCT06965296
- Testing
- AI-enhanced smartphone app, AI-enhanced smartphone app, but with delayed access
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- State University of New York at Buffalo
Tobacco Use, Electronic Cigarette Use
Just-in-Time Support for Smoking, Vaping, and Eating Urges During High-Stress Moments Among Gender and Sexual Minority Adults in Dhaka
Gender and sexual minority adults in Bangladesh experience high levels of stigma-related stress. Acute stress can trigger strong, affect-driven urges to smoke, vape, or engage in stress-attributed eating.
- Conditions
- Tobacco Use, Electronic Cigarette Use, Emotional Eating, Stress, Psychological
- Trial name
- NCT07746492
- Testing
- Just-in-Time Adaptive Support Message
- Where
- Bangladesh
- Volunteers
- 115 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Tobacco Use Disorder, Smoking Cessation
THCV Treatment for Smokers
This study will randomize 32 non-treatment-seeking individuals who smoke cigarettes daily into a randomized, crossover, double-blind, placebo-controlled study testing the safety, tolerability, and initial efficacy of…
- Trial name
- NCT07636356
- Testing
- Δ9-Tetrahydrocannabivarin (oral gummy)
- Volunteers
- 32 people
- Sponsor
- University of California, Los Angeles
Smoking Behaviors, Smoking ( Cigarette)
A Study to Assess Nicotine Uptake From Electronic Nicotine Delivery System Products
This will be a randomized, open-label, 8-way crossover, single-site study designed to evaluate elements of abuse liability (AL), including subjective effects and physiological measures (pharmacodynamics [PD]), and plasma nicotine…
- Conditions
- Smoking Behaviors, Smoking ( Cigarette), Tobacco Use
- Trial name
- NCT07739797
- Testing
- Golden Tobacco Chill 5% (4) 6.5W, Glacier Menthol 5% (4) 6.5W, Fresh Mint 5% (4) 6.5W
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
E-cigarette Use, Withdrawal
Evaluation of the Electronic Cigarette Withdrawal Syndrome
The goal of this project is to rigorously evaluate the nature of e-cigarette withdrawal in exclusive e-cigarette users during a monitored abstinence period and the role of nicotine in the expression of this withdrawal syndrome.
- Trial name
- NCT06066996
- Testing
- Transdermal Nicotine Patch
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Tobacco Use, Cigarette Smoking
Effects of Relighting on Smoke Toxicant Deliveries and Subjective Smoking Measures
Characterize effects of relighting on smoke toxicant deliveries and subjective smoking measures. This will be a within-subject comparison in a single experimental group of 30 smokers who report engaging in relighting behaviors.
- Conditions
- Tobacco Use, Cigarette Smoking, Nicotine Dependence
- Trial name
- NCT06295757
- Testing
- Cigarettes
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Tobacco Use Disorder
5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder
This is a multi-site, double-blind, randomized clinical trial of the 5-HT2A receptor agonist psilocybin for smoking cessation. Four sites with experience in conducting psilocybin research will be involved in this trial: Johns…
- Trial name
- NCT05452772
- Testing
- Psilocybin, Niacin
- Where
- 3 sites in United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University