Clinical trials: E-cigarette
E-Cig Use
Responses to E-Cigarette Advertising
While conventional cigarette use continues to decline among youth and young adults, e-cigarette (EC) use is on the rise. The use of ECs during young adulthood, particularly 18 years of age, is especially alarming because it is…
- Trial name
- NCT04249219
- Testing
- Viewing e-cigarette ads
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Smoking
User Acceptability of a Nicotine Lactate Delivery System (P3L)
This study will provide an initial assessment of the acceptability of the Nicotine Lactate Delivery System (P3L) after ad libitum use and the ability of combustible cigarette (CC) smokers to use P3L to maintain their customary…
- Trial name
- NCT02643693
- Testing
- P3L, VUSE, CC
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Smoking, Nicotine Addiction
The END Perioperative Smoking Pilot Study
The purpose of this pilot randomized trial is to determine the feasibility of e-cigarettes and telephone counselling (compared to transdermal nicotine replacement and telephone counselling) as a harm-reduction tool that may lead…
- Conditions
- Smoking, Nicotine Addiction, Surgery
- Trial name
- NCT02482233
- Testing
- ENDD (NJOY), NRT (NicoDerm CQ), telephone counseling
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
Attentional Bias, Smoking Cues
Trial on the Effect of E-cigarette Advertising on Cigarette Perceptions in Adolescents
This research aims to investigate how exposure to advertising for Electronic Nicotine Delivery Systems (commonly called e-cigarettes) may lead to combustible smoking initiation in adolescents.
- Conditions
- Attentional Bias, Smoking Cues, Positive Perceptions About Cigarette Smoking, Social Norms
- Trial name
- NCT03786042
- Testing
- E-cigarette ad exposure, non e-cigarette TV commercials
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- Trustees of Dartmouth College
E Cig Use
Young Adult EC Use and Respiratory Outcomes
E-cigarette (EC) use continues to increase among youth, and EC may be detrimental to youth respiratory health. Public health officials and the Food and Drug Administration (FDA) can now regulate ECs.
- Trial name
- NCT04395274
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Healthy Volunteers
An Exploratory PET-study of Deposition, Disposition and Brain Uptake of [11C]Nicotine After Inhalation of 2 Nicotine Formulations Via the myBluTM E-cigarette in Smokers
This is a single-center, exploratory positron emission tomography (PET) study of deposition, disposition and brain uptake [11C]nicotine when given to smokers as two different formulations via mybluTM e-cigarette system.
- Trial name
- NCT04780815
- Testing
- myBluTM Formulation 1, myBluTM Formulation 2
- Where
- Sweden
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Imperial Brands PLC
Nicotine, Vaping
Reduced HPHC Exposure in Cigarette Smokers Switching to P4M3 Gen. 2.0 Compared to Continuing Smoking, or Smoking Abstinence
To demonstrate the reduction of Biomarkers of Exposure (BoExp) to selected harmful and potentially harmful constituents (HPHC) in smokers switching from cigarette (CIG) to P4M3, an Electronic Nicotine Delivery System (ENDS)…
- Conditions
- Nicotine, Vaping, Nicotine Vaping
- Trial name
- NCT05487456
- Testing
- P4M3 CA35, P4M3 CM35, CIG
- Where
- United Kingdom
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Electronic Cigarette Use
Effects of Electronic Cigarette Flavors on Abuse Liability in Smokers (P3-Taste)
The purpose of this study is to determine if abuse liability indices will be impacted by varying flavors and e-cigarette (ECIG) nicotine delivery capability (i.e., nicotine flux) among current combustible cigarette users.
- Trial name
- NCT05971823
- Testing
- Tobacco product administration and assessment
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Smoking, Asthma
E-cigarettes for Harm Reduction in Adults With Asthma
Smoking is the main cause of preventable disease and death in the US and impacts respiratory illnesses including COPD and asthma.
- Conditions
- Smoking, Asthma, Electronic Cigarette Use, Cigarette Smoking
- Trial name
- SWAP (NCT05278065)
- Testing
- Nicotine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Brown University
Pulmonary Disease, Chronic Obstructive, Cigarette Smoking
E-Visit for COPD and Smoking Cessation
The goal of this work is to develop, refine, and pilot test an electronic visit (e-visit) to: 1) deliver smoking cessation treatment to adults at risk for COPD and 2) to improve rates of COPD early detection and accurate…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Cigarette Smoking, Telemedicine
- Trial name
- NCT04155073
- Testing
- smoking cessation, early COPD detection, electronic visit, Treatment As Usual
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Medical University of South Carolina
Cigarette Smoking
E-Cigarettes and Financial Incentives to Promote Tobacco Harm Reduction Among Adults Accessing Shelter Services
This randomized controlled trial evaluated the feasibility and potential efficacy of 1) e-cigarette switching (EC) or 2) e-cigarette switching + financial incentives for combustible cigarette cessation (EC+FI)
- Trial name
- EXCHANGE (NCT03743532)
- Testing
- E-cigarette Switching, Financial Incentives
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Electronic Cigarette Use
The Impact of Oral Ethanol and Vaped Ethanol on the Evaluation of Impairment
The purpose of this research study is to determine if ethanol-containing e-cigarettes impact ethanol breath, blood or oral fluid tests, field sobriety tests, or other tests of sobriety.
- Trial name
- NCT04522973
- Testing
- Beverage with ethanol and E-cigarette liquid with ethanol, Beverage with ethanol and E-cigarette liquid without ethanol, Beverage without ethanol and E-cigarette liquid with ethanol
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Nicotine Dependence, E-Cig Use
Research and Innovation to Stop E-cigarette/Vaping in Young Adults
The aim of this study is to test intervention components to help young adults quit vaping. A 2x2 factorial design will be used where all participants receive quitline-delivered behavioral phone counseling, and components to be…
- Trial name
- (RISE) (NCT04974580)
- Testing
- Nicotine patch, Phone Counseling, Digital Coaching
- Where
- United States
- Volunteers
- 508 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Nicotine Use Disorder
Effects of E-cigarette Flavors on Youth TCORS 2.0
This study is an examination of the influence of sweet and cooling flavors on the appeal and abuse potential of nicotine-containing e-cigarettes among susceptible youth.
- Trial name
- NCT03634839
- Testing
- Flavoring Agents, Nicotine
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Yale University
Cigarette Smoking Behavior
Effects of Cigarette and E-cigarette Flavors on Substitutability in the ETM
In 2009, the FDA banned all flavored conventional cigarettes except menthol. While no such ban exists for e-cigarettes, proposals have emerged in several regions.
- Trial name
- NCT06910202
- Testing
- Manipulation of nicotine/tobacco product price and availability
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Virginia Polytechnic Institute and State University
Marijuana Dependence
Vaping THC From Electronic Cigarettes
This study aims to understand THC pharmacology and the safety of cannabis vaping, including the pharmacology and safety of co-administration of nicotine and THC.
- Trial name
- V-PAX (NCT02955329)
- Testing
- Nicotine, Cannabis, PAX Loose Leaf Vaporizer
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Nicotine Addiction, E-Cig Use
Sex Differences in E-cig Perception: Study 1
The primary objective is to examine the influence of sex on sensory effects, appeal, and reinforcing value of nicotine containing e-cigs in popular flavor components; sweet and cooling.
- Conditions
- Nicotine Addiction, E-Cig Use, Cigarette Smoking, Sex Differences
- Trial name
- NCT05432830
- Testing
- E-liquid Flavor 1, E-liquid Flavor 2, E-liquid Flavor 3
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Yale University
Health Behavior
Effects of Electronic Cigarettes on Nicotine Concentrations
This study will examine whether nicotine levels increase with electronic cigarettes. It will also examine whether electronic cigarettes alter lung function tests.
- Trial name
- ECIG (NCT01775787)
- Testing
- Nicotine with Tobacco Flavor and Tobacco & Menthol Flavor
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- UConn Health
Smoking, Healthy
In-vivo Effects of E-cigarette Aerosol on Innate Lung Host Defense
While e-cigs are commonly represented as safer alternatives to tobacco cigarettes, little is known regarding the health effects of their short- or long-term use.
- Trial name
- Cinimic (NCT03700892)
- Testing
- Cinnamaldehyde e-liquid, PG/VG e-liquid
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Tobacco Dependence
Does Switching to Nicotine Containing Electronic Cigarettes Reduce Health Risk Markers
The overall goal of this project is to understand the likely health effects of cigarette smokers switching to a Standardized Research Electronic Cigarette (SREC) and to assess the role of nicotine delivery on switching and…
- Trial name
- NCT03625986
- Testing
- Nicotine-Containing Electronic Cigarette, Non-Nicotine Electronic Cigarette
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center