Clinical trials: Dupuytren Contracture
Hand Surgery, Wrist Surgery
The Efficacy of Liposomal Bupivacaine in Ultrasound Guided Supraclavicular Nerve Blocks for Hand and Wrist Surgery
Patients undergoing hand, wrist, and elbow surgery may experience pain after surgery. The orthopedic surgeon may provide prescription pain medications after surgery to assist with pain control.
- Conditions
- Hand Surgery, Wrist Surgery, Elbow Surgery, Fracture Fixation
- Trial name
- NCT06806410
- Testing
- Liposomal bupivacaine (LB), Dexamethasone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- St. Luke's Hospital, Pennsylvania
Dupuytren Contracture, Disease Progression
Natural Disease Progress of Dupuytren Disease
Dupuytren disease (DD) is a progressive fibromatosis of the palmar fascias of the hand and fingers, which may lead to extension deficits of the fingers.
- Trial name
- DD (NCT01923103)
- Where
- Netherlands
- Volunteers
- 261 people
- Sponsor
- University Medical Center Groningen
Dupuytren's Contracture
DEPART Study at Yale
This is a randomized study to determine whether radiation therapy reduces the risk of progression / recurrence of Dupuytren's disease / contracture.
- Trial name
- Dupuytren's (NCT07661342)
- Testing
- Radiation Therapy
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- Yale University
Dupuytren Disease of Palm and Finger, With Contracture
Hand Therapy or Not Following Collagenase Treatment for Dupuytren's Contracture?
This study evaluates if hand therapy have an impact on the patients' preformance of and satisfaction with everyday activities or not following collagenase injection treatment for Dupuytren's contracture.
- Trial name
- NCT03580213
- Testing
- Hand therapy MCPJ affected, Hand therapy PIPJ affected
- Where
- Norway
- Volunteers
- 72 people
- Sponsor
- Haukeland University Hospital
Dupuytren Contracture
Dupuytren's Disease and Extracorporeal Shockwave Therapy (DupuyShock-2010)
Dupuytren's disease is a progressive disease due to unknown causal agents or genetics. Dupuytren's disease contains nodules and cords in the fascia as the epicenter of disease progression.
- Trial name
- DupuyShock (NCT01184586)
- Testing
- Intervention - ESWT Storz Duolith high energy
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Hannover Medical School
Dupuytren's Disease
Longterm Observational Study in Subjects Treated With AA4500 in AUX-CC-854, 856, 857, 858 & 859
The purpose of study AUX-CC-860 is to assess the durability of response of the AA4500 treatment regimen. This study will also evaluate long-term safety and progression of disease in joints.
- Trial name
- NCT00954746
- Where
- 39 sites in United States, Australia and 4 more
- Volunteers
- 645 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Dupuytren Contracture, Dupuytren Disease of Finger
Safety and Efficacy Study of Collagenase CNT201 Injection for Treatment of Dupuytren's Contracture
This trial is a multicenter, Phase 1/2, study to assess the safety, tolerability, efficacy, PK, and immunogenicity of CNT201 in adult participants with DC (Dupuytren's Contracture).
- Trial name
- NCT07640425
- Testing
- [Step1] CNT201 First-dose, [Step1] CNT201 Low-dose, [Step1] CNT201 Intermediate-dose
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- CONNEXT
Dupuytren Contracture
Collagenase and Needle Aponeurotomy: Single Modality Versus Combination Treatment for Dupuytren's Disease
Dupuytren's disease results in deformity of the hand and this can lead to trouble with daily activities. Treatment traditionally involves cutting out diseased tissue, however this can cause damage to important structures in the…
- Trial name
- NCT01776892
- Testing
- Collegenase injection, Needle aponeurotomy
- Where
- Canada
- Sponsor
- University of Alberta
Palmar Fibromatosis
Effect Of Extracorporeal Shock Wave Therapy On Ultrasonography Changes In Patients With Palmar Fibromatosis: A Randomized Controlled Trial
this study will be conducted to investigate the effect of extracorporeal shock wave therapy on ultrasonography chnges In patients with palmar fibromatosis
- Trial name
- ESWT (NCT06248866)
- Testing
- Extracorporeal Shock Wave Therapy, traditional treatment
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Dupuytren's Contracture
Efficacy and Safety of Xiaflex Injection for Treatment of Dupuytren's Contracture of the Thumb
This study will evaluate the efficacy and safety of clostridial collagenase injections for treatment of Dupuytren's contracture of the thumb and first web space.
- Trial name
- NCT01265420
- Testing
- Injectable clostridial collagenase
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Indiana Hand to Shoulder Center
Palmar Fibromatosis
Effect of Transfer Energy Capacitive and Resistive Therapy on Palmar Fibromatosis
The objective of the present study is to explore the effect of Transfer Energy Capacitive and Resistive Therapy (TECAR) therapy on pain, range of motion (ROM) and hand function in dupuytren's contracture patients (palmar…
- Trial name
- NCT07443371
- Testing
- Transfer Energy Capacitive and Resistive (TECAR) therapy, Traditional therapy
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Cairo University
Dupuytren's Disease
Palmaris Longus Muscle and Dupuytren
Dupuytren disease is a medical condition characterized by the painless formation of nodules in the palm of the hand. Cords are formed on the palmar fascia, a connective tissue sheet in the palm of the hand.
- Trial name
- Palmaris (NCT06281509)
- Testing
- Non-invasive tests to determine the presence or absence of the palmaris longus tendon in both hands., Ultrasound
- Where
- Belgium
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dupuytren's Contracture
Collagenase Option for Reduction of Dupuytren's Contracture in Japan
To investigate the efficacy and safety of AK160 in patients with Dupuytren's Contracture. To determine plasma concentration after the first injection of AK160 in patients with Dupuytren's Contracture.
- Trial name
- CORD-J (NCT01588353)
- Testing
- Collagenase Clostridium Histolyticum
- Where
- 20 sites in Japan
- Volunteers
- 104 people
- Sponsor
- Asahi Kasei Therapeutics Corporation
Dupuytren Disease
Ultrasound Features of Dupuytren's Disease
Dupuytren's disease (DD) is a benign and progressive condition that affects the palmar aponeurosis with a very high global incidence.
- Trial name
- Micro in DD (NCT06956027)
- Testing
- Ultrasound assesment, ROM measurement
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dupuytren Contracture
The Effects of Prophylactic Limited Palmar Fasciectomy on Surgical Outcomes and Scarring
Research is instrumental for improving medical care and the patient experience. Finding new surgical techniques can create better outcomes and minimize recovery time and complications for patients.
- Trial name
- NCT03155854
- Testing
- Pretendinous cord excision, Division/manipulation of the cord
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Dupuytren's Contracture
AA4500 (XIAFLEX™, Proposed Name) in the Treatment of Dupuytren's Contracture
This was a Phase 3, double-blind, randomized, placebo-controlled study conducted in the United States. Subjects with a diagnosis of Dupuytren's contracture in a metacarpophalangeal (MP) or proximal interphalangeal (PIP) joint…
- Trial name
- CORD-I (NCT00528606)
- Testing
- collagenase clostridium histolyticum
- Where
- 15 sites in United States
- Volunteers
- 308 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Dupuytren's Disease
Collagenase in the Treatment of Dupuytrens Disease
The purpose of the study is to determine if collagenase will reduce the degree of contracture in the primary joint in subjects with Dupuytren's disease.
- Trial name
- NCT00260429
- Testing
- collagenase clostridium histolyticum
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Stony Brook University
Dupuytren Contracture, Dupuytren's Disease of Finger
Collagenase Injection vs Percutaneous Needle Aponeurotomy for Dupuytren's Disease
Dupuytren's disease is a non-curative, progressive disorder leading to function-impairing deformities of the hand. Although numerous treatments exist, the most common and widely accepted therapy is removal of diseased fascia.
- Trial name
- NCT03000114
- Testing
- Percutaneous Needle Aponeurotomy, XIAFLEX
- Where
- Canada
- Volunteers
- 334 people
- Sponsor
- University of Calgary
Dupuytren's Contracture
Administration of Two Injections for Multiple Dupuytren's Contractures
The objectives of this study are to assess the safety and efficacy of concurrent administration of two injections of AA4500 into the same hand of subjects with multiple Dupuytren's contractures caused by palpable cords.
- Trial name
- NCT01407068
- Testing
- AA4500 collagenase clostridium histolyticum
- Where
- 8 sites in United States, Australia
- Volunteers
- 60 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Dupuytren's Contracture
Health-Related Quality of Life in Patients With Dupuytren's Disease
Main Research Questions: We want to measure the change in quality of life in Dupuytren's disease patients who do and do not undergo surgery.
- Trial name
- NCT00468949
- Where
- Canada
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation