Clinical trials: Dry Eye Syndromes
Sjögren's Syndrome
A PHASE II PROSPECTIVE RANDOMIZED DOUBLE-MASKED CONTROLLED STUDY ASSESSING THE SAFETY & EFFICACY OF RHPRG4 (450 µG/ML RECOMBINANT HUMAN PROTEOGLYCAN 4) COMPARED TO VEHICLE FOR THE TREATMENT OF SJÖGREN'S RELATED DRY EYE DISEASE
rhPRG4-Sjögren's-002 is a prospective multi-center study conducted in Australia to evaluate the safety and efficacy of topically-applied rhPRG4 in subjects with Sjögren's related Dry Eye Disease.
- Trial name
- NCT07118241
- Testing
- Recombinant Human Proteoglycan 4, Vehicle Control
- Where
- 7 sites in Australia
- Volunteers
- 80 people
- Sponsor
- Lubris Bio Pty Ltd
Dry Eye Syndromes
Management of Signs and Symptoms Associated With Dry Eye Disease
A prospective randomized, and controlled study to compare the effectiveness of PROKERA® SLIM plus standard of care (SOC) in the PROKERA® SLIM Arm to SOC alone in the Control Arm.
- Trial name
- NCT04015219
- Testing
- Self retained cryopreserved amniotic membrane, lifitegrast ophthalmic solution
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- BioTissue Holdings, Inc
Dry Eye Syndrome
Phase II Study of DA-6034 Eye Drops in Dry Eye Syndrome
This study is to determine the efficacy and safety of 3% or 5% DA-6034 eye drops compared with placebo in dry eye syndrome.
- Trial name
- DES (NCT01670357)
- Testing
- DA-6034 3%, DA-6034 5%
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Dong-A ST Co., Ltd.
Healthy Individuals, Diabetes
Heidelberg In Vivo Confocal Microscopy to Evaluate the Ocular Surface Disorders of Healthy and Diseased Individuals
In vivo confocal microscopy (IVCM) has been used in clinical settings for more than 25 years, and is noninvasive, rapid and easily repeatable technique to investigate ocular surface disorders.
- Conditions
- Healthy Individuals, Diabetes, Hypertension, Fabry Disease
- Trial name
- NCT04025801
- Where
- Taiwan
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Dry Eye Syndromes
Efficacy of Lycium Barbarum Polysaccharide in Dry Eye Disease Management
The goal of this pilot clinical study is to learn if Lycium barbarum polysaccharide (LBP) supplementation helps manage dry eye disease in adults. It will also learn about the safety of LBP supplementation.
- Trial name
- NCT07842536
- Testing
- Lycium Barbarum Polysaccharide
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- The Hong Kong Polytechnic University
Diabetic Eye Problems
Diquafosol Ophthalmic Solution for Dry Eye Symptoms
Diquafosol ophthalmic solution (DQS) stimulates P2Y2 receptors on the ocular surface, which enhances mucin secretion from goblet cells.
- Trial name
- NCT04980144
- Testing
- 3% Diquafosol tetrasodium, 0.1% hyaluronate
- Where
- China
- Volunteers
- 101 people
- Sponsor
- He Eye Hospital
Dry Eye
Efficacy and Safety of SJP-0132 Eye Drops in Chinese Patients With Dry Eye Disease
This study will evaluate the safety and efficacy of SJP-0132 in Chinese Patients with Dry Eye. Patients will be randomly assigned to receive either SJP-0132 or placebo.
- Trial name
- NCT06717152
- Testing
- SJP-0132
- Where
- 35 sites in China
- Volunteers
- 427 people
- Sponsor
- Senju Pharmaceutical Science & Technology (Beijing) Co., Ltd.
Dry Eye Syndromes
Soothe Versus Refresh
To determine the ocular efficacy and safety of Soothe and Refresh Tears.
- Trial name
- NCT00284999
- Testing
- Soothe, Refresh Tears
- Where
- 3 sites in United States
- Volunteers
- 33 people
- Sponsor
- Pharmaceutical Research Network
Contact Lens Wearers With Dry Eye Syndrome
Efficacy of Cyclosporine Ophthalmic Emulsion in the Treatment of Dry Eye Syndrome in Contact Lens Wearers
Cyclosporine Ophthalmic Emulsion is currently used in the treatment of dry eye syndrome. Contact lens wearers frequently suffer from dry eye syndrome.
- Trial name
- NCT00335114
- Testing
- cyclosporine ophthalmic emulsion
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Primary Sjögren's Syndrome
Efficacy and Safety of S95011 in Primary Sjögren's Syndrome Patients
The purpose of this study is to assess the effect of multiple intravenous infusions of S95011 compared to placebo in reducing disease activity in patients with primary Sjögren's syndrome.
- Trial name
- NCT04605978
- Testing
- S95011 concentrate for solution for infusion
- Where
- 19 sites in United States, Australia and 5 more
- Volunteers
- 48 people
- Sponsor
- Institut de Recherches Internationales Servier
Dry Eye
Intracanalicular Dexamethasone Insert for the Treatment of Inflammation and Discomfort in Dry Eye Disease (DEcIDED)
This prospective, single-center, randomized, double-masked, parallel comparison, sponsored study seeks to investigate the efficacy of Intracanalicular dexamethasone Insert (IDI) on ameliorating the signs and symptoms of dry eye…
- Trial name
- DEcIDED (NCT04527887)
- Testing
- Dextenza (IDI) (Sustained Release Dexamethasone), (0.4 mg), ProLong™ collagen plugs
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Tufts Medical Center
Dry Eye Syndrome
Safety and Efficacy of BRM421 for Dry Eye Syndrome Treatment
The objective of this study is to compare the safety and efficacy of BRM421 Ophthalmic Solution to placebo for the treatment of the signs and symptoms of dry eye.
- Trial name
- NCT04343287
- Testing
- BRM421
- Where
- 4 sites in United States
- Volunteers
- 220 people
- Sponsor
- BRIM Biotechnology Inc.
Dry Eye Syndromes
The Effect of Punctal Plugs on Tear Volume and Osmolality
The purpose of this study is to evaluate the role of tear volume in discomfort and dryness sensations during contact lens wear, and the possible influence on osmolality and ocular surface sensitivity.
- Trial name
- NCT00372034
- Testing
- Temporary Collagen Inserts
- Where
- Australia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The University of New South Wales
Dry Eye
Ocular Effects of Scleral Lens Wear on Dry Eye Patients
The purpose of this study is to investigate the effects of scleral contact lens wear on a DE population using coated (Hydra-PEG) and uncoated (control) lenses.
- Trial name
- NCT05079321
- Testing
- Hydra-PEG, Uncoated
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Dry Eye
Study to Evaluate the Efficacy of SDP-4 in Subjects With Dry Eye Disease (DED) (SDP-4-CS202)
SDP-4-CS202 is a Phase 2, multicenter, double-masked, randomized, vehicle-controlled, parallel group study designed to evaluate the ocular efficacy of SDP-4 ophthalmic solution in subjects with moderate to severe dry eye disease…
- Trial name
- NCT04535947
- Testing
- Vehicle, SDP-4 Ophthalmic Solution (1.0%)
- Where
- 5 sites in United States
- Volunteers
- 153 people
- Sponsor
- Silk Technologies, Ltd.
Dry Eye Disease
Examining the Clinical Characteristics, Treatment Patterns, Real-world Effectiveness, and Healthcare Resource Utilization of Patients With Dry Eye Disease
A prospective, non- interventional, observational, non-comparative, longitudinal cohort study design will be used to address the objectives of this study using data collected through a healthcare.
- Trial name
- NCT05857748
- Testing
- lifitegrast
- Sponsor
- Novartis Pharmaceuticals
Dry Eye Syndrome, Photophobia
Functional MRI Study of Cortical Modifications to Light Stimulation in Patients With Photophobia
Photophobia is a common and disabling symptom in patient with dry eye syndrome. The aim of this study is tried to better understand this complain analyzing brain activation during a luminous stimulation to highlight modification…
- Trial name
- NCT03464357
- Testing
- fMRI
- Where
- France
- Volunteers
- 16 people
- Sponsor
- University Hospital, Toulouse
Sjögren, Sjögren Syndrome
Pelvic Floor Exercises in Patients With Sjögren's
When the literature is examined, the positive effects of pelvic floor exercises on sexual functions have been supported by studies.
- Trial name
- NCT05079581
- Testing
- Pelvic floor exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Akdeniz University
Eye Diseases
Collection of Ocular Surface Impressions Cytology of the Living Eye From Patients With Dry Eyes or Limbal Stem Cell Deficiency.
In order to develop innovative biomarkers for the diagnosis of two ocular surface pathologies, Dry Syndrome (DS) and Limbic Stem Cell Deficiency (LSCD), human cells from the ocular surface will be collected in order to test these…
- Trial name
- ESSO (NCT06255301)
- Testing
- EYEPRIM
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Dry Eye Syndrome
Influence of Lachrymal Substitutes on Tear Film Thickness in Patients With Moderate Dry Eye Syndrome
Dry eye syndrome is a highly prevalent ocular disease with an increasing incidence in the elderly population. Topically administered lubricants are the basis for treatment of this disease.
- Trial name
- NCT01864330
- Testing
- Thealoz Duo®, Hyabak®, Hydrabak®
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Medical University of Vienna