Clinical trials: Dry Eye Syndrome
Evaporative Dry Eye Disease
Comparative Efficacy Study to Demonstrate the Non-inferiority of I-DROP® MGD Versus 2 Competitor Eye Drops in Managing Evaporative Dry Eye
A Pilot Comparative study between I-DROP MGD vs two commercially available lubricant eye drops for the management of evaporative dry eye
- Trial name
- NCT06686368
- Testing
- I-DROP MGD, Theloze Duo, Systane Complete PF
- Volunteers
- 60 people
- Sponsor
- I-MED Pharma
Dry Eye Disease
A Dose-Finding Study Comparing InSite Vision, Inc. 101 to Vehicle and DuraSite Alone for Dry Eye Disease
The purpose of this study is to evaluate the safety, tolerability, and efficacy in topical administration of differing dosing regimens of ISV-101 (Bromfenac in DuraSite® ophthalmic solution) compared to Vehicle and DuraSite alone.
- Trial name
- ISV-101 (NCT01478555)
- Testing
- ISV 101
- Sponsor
- Sun Pharmaceutical Industries Limited
Dry Eye, Dry Eye Syndromes
Tear Production by Nasal Neurostimulation Compared to Active Control
This crossover design study evaluates the effectiveness of the Oculeve Intranasal Neurostimulator comparing the effect of intranasal (active) versus extranasal (control) stimulation on tear production as measured by the Jones…
- Conditions
- Dry Eye, Dry Eye Syndromes, Keratoconjunctivitis Sicca
- Trial name
- NCT02970799
- Testing
- Intranasal Neurostimulator
- Volunteers
- 27 people
- Sponsor
- Oculeve, Inc.
Dry Eye Syndromes
Long Term Administration Study of OPC-12759 Ophthalmic Suspension
The purpose of this study is to evaluate safety and efficacy of OPC-12759 ophthalmic suspension during 52 weeks in dry eye patients
- Trial name
- NCT00818324
- Testing
- OPC-12759 Ophthalmic suspension
- Where
- 5 sites in Japan
- Volunteers
- 154 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Dry Eye Disease
Assessing Safety and Efficacy of DE-089 Ophthalmic Solution in Patients With Dry Eye Disease
The objective of this study is to assess safety and efficacy of DE-089 ophthalmic solution in patients with dry eye disease in Taiwan.
- Trial name
- NCT03216096
- Where
- 2 sites in Taiwan
- Volunteers
- 20 people
- Sponsor
- Santen Pharmaceutical Co., Ltd.
Dry Eye Syndrome
Sodium Hyaluronate Ophthalmic Solution, 0.18% for Treatment of Dry Eye Syndrome
The purpose of this study was to determine if Sodium Hyaluronate, 0.18% is effective in treating the signs and symptoms of dry eye disease.
- Trial name
- NCT01382225
- Testing
- Sodium Hyaluronate Ophthalmic Solution, 0.18%, Vehicle
- Volunteers
- 1,936 people
- Sponsor
- Alcon Research
Dry Eye
Oasys vs. Extreme H20 Xtra 59
To compare the performance of Oasys to Extreme H20 xtra 59 in dry eye contact lens pts who receive Restasis in 1 eye and vehicle (Endura) in the other eye.
- Trial name
- NCT00477763
- Testing
- Restasis, Refresh Endura
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Innovative Medical
Dry Eye Disease
In Vivo Confocal Microscopic Analysis of Corneal Nerve Changes After ProKera Slim® for Dry Eye
Prospective controlled pilot study to compare the outcome of ProKera® (PK) and conventional treatment in patients with moderate to severe Dry Eye Disease (DED)
- Trial name
- NCT02764814
- Testing
- Cryopreserved amniotic membrane
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- BioTissue Holdings, Inc
Sjogren Syndrome
Three-arm Study to Assess Efficacy and Safety of Ianalumab (VAY736) in Patients With Active Sjogren's Syndrome
A randomized, double-blind, placebo controlled, 3-arm multicenter phase 3 study to assess the efficacy and safety of ianalumab in patients with active Sjogren's syndrome (NEPTUNUS-2)
- Trial name
- NEPTUNUS-2 (NCT05349214)
- Testing
- VAY736
- Where
- 146 sites in United States, Argentina and 24 more
- Volunteers
- 506 people
- Sponsor
- Novartis Pharmaceuticals
Dry Eye Syndrome
A Multi-Center Study Subjects With Dry Eye Syndrome
This is a Phase 1b, multi-center, double-masked, randomized, placebo-controlled, parallel-group study designed to evaluate the safety and biological activity of two doses of EBI-005 ophthalmic solution versus placebo in subjects…
- Trial name
- EBI (NCT01745887)
- Testing
- EBI-005-2
- Where
- 8 sites in United States
- Volunteers
- 74 people
- Sponsor
- Eleven Biotherapeutics
Sjögren's Syndrome
A Study to Evaluate the Efficacy and Safety of VIB4920 in Participants With Sjögren's Syndrome
The purpose of the study is to evaluate the efficacy, safety, and tolerability of VIB4920 (formerly MEDI4920) in adult participants with Sjögren's Syndrome (SS).
- Trial name
- SS (NCT04129164)
- Testing
- VIB4920
- Where
- 62 sites in United States, Argentina and 10 more
- Volunteers
- 183 people
- Sponsor
- Amgen
Dry Eye Disease, Dry Eye
Phase III Study of Topical Fibrinogen-Depleted Human Platelet Lysate Compared to Placebo for Moderate to Severe Dry Eye
Prospective, multicenter, randomized, vehicle-controlled, double-masked, study of CAM-101 topical ophthalmic solution compared to vehicle control followed by crossover to long-term follow-up open-label treatment with CAM-101 for…
- Conditions
- Dry Eye Disease, Dry Eye, Dry Eyes Chronic, Dry Eye Syndromes
- Trial name
- CAMOMILE-2 (NCT06903611)
- Testing
- CAM-101, Vehicle Control
- Volunteers
- 475 people, healthy volunteers welcome
- Sponsor
- Cambium Bio Limited
Dry Eye
Phase III Study of OT202 in Treating Moderate to Severe Dry Eye
This is a multicenter, randomized, double-blind, placebo-controlled Phase III clinical trial, enrolling 842 subjects with moderate to severe dry eye, who will be randomized at a 1:1 ratio to receive either 1% OT202 ophthalmic…
- Trial name
- NCT07740564
- Testing
- OT202 conc 1%
- Where
- 49 sites in China
- Volunteers
- 842 people
- Sponsor
- Ocumension Therapeutics (Suzhou) Co., Ltd
Sjogren Syndrome
Intra-Nasal Mechanical Stimulation (INMEST) as a Potential Treatment Method for Sjogren's Syndrome (SS)
The purpose of the study is to investigate the effect and safety of the Walther System delivering INMEST (intranasal mechanical stimulation) on people with Sjogren\'s syndrome.
- Trial name
- A-SS-001 (NCT06626477)
- Testing
- Intra nasal mechanical stimulation treatment (INMEST)
- Where
- Sweden
- Volunteers
- 26 people
- Sponsor
- Abilion Medical Systems AB
Moderate to Severe Dry Eye
A Study of the Efficacy and Safety of Cyclosporin Ophthalmic Gel in Subjects With Moderate to Severe Dry Eye Disease
This study is a multicenter, randomized, double-blind, placebo-controlled, superiority design Phase III clinical trial. The primary objective is to evaluate the efficacy and safety of cyclosporine ophthalmic gel versus placebo in…
- Trial name
- NCT06766357
- Testing
- Cyclosporine ophthalmic gel, Cyclosporine ophthalmic gel vehicle
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.
Dry Eye Syndrome, Myopia
Clinical Evaluation of a Daily Disposable Contact Lens in Symptomatic Weekly/Monthly Lens Wearers
The purpose of this study was to evaluate the reduction of contact lens-related dryness symptoms when symptomatic weekly/monthly contact lens wearers were switched to DAILIES® AquaComfort Plus® lenses for a two-week period using…
- Trial name
- NCT01614600
- Testing
- Nelfilcon A contact lenses
- Volunteers
- 88 people
- Sponsor
- Alcon Research
Treatment of Dry Eye Disease
Objective Measurements of Prolonged Effects of Restasis on Dry Eye Disease
We propose to investigate the response to Restasis, over a prolonged period of time in heavy computer users with dry eye disease.
- Trial name
- NCT00567177
- Testing
- Restasis, Refresh Plus
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Innovative Medical
Keratoconjunctivitis Sicca
Efficacy Study of Cyclosporine Ophthalmic Emulsion in Patients With Dry Eye Disease
This study will evaluate the efficacy of cyclosporine ophthalmic solution vs. other non-prescription treatments in patients with dry eye disease.
- Trial name
- NCT00717418
- Testing
- cyclosporine ophthalmic emulsion 0.05%, artificial tears
- Where
- United States
- Volunteers
- 781 people
- Sponsor
- Allergan
Dry Eye Syndrome
A Dose Ranging Study to Evaluate Safety and Efficacy of Bromfenac Ophthalmic Solution in Dry Eye Disease
A dose ranging study to evaluate safety and efficacy of bromfenac ophthalmic solution in dry eye disease.
- Trial name
- NCT01212471
- Testing
- Bromfenac Ophthalmic Solution A, Bromfenac Ophthalmic Solution B
- Where
- United States
- Volunteers
- 840 people
- Sponsor
- Bausch & Lomb Incorporated
Dry Eye Disease
Clinical Pharmacological Study of AL-43546 Ophthalmic Product in Subjects With Shortened Tear Film Break Up Time
The purpose of the study is to observe lacrimal fluid condition (tear film break-up time) chronologically after a single dose of AL-43546 ophthalmic products（0.15%, 0.25% and vehicle）and 0.1% sodium hyaluronate ophthalmic…
- Trial name
- NCT00760045
- Testing
- Hydroxypropyl Guar Galactomannan, 0.1% sodium hyaluronate ophthalmic solution
- Where
- Japan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alcon Research