Clinical trials: Dry Eye
Congenital Heart Block, Neonatal Lupus
Preventive IVIG Therapy for Congenital Heart Block
Neonatal lupus (NL) is the name given to a group of conditions that can affect the babies of mothers who have certain autoantibodies against components of the body's cells that are called SSA/Ro and SSB/La.
- Conditions
- Congenital Heart Block, Neonatal Lupus, Autoantibody-associated Heart Block
- Trial name
- PITCH (NCT00460928)
- Testing
- intravenous immune globulin (IVIG)
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- NYU Langone Health
Systemic Sclerosis (SSc), Rheumatoid Arthritis (RA)
A Study of BEN301 Injection in theTreatment of Autoimmune Diseases
The study aims to investigate the safety, tolerability, and preliminary clinical efficacy of BEN301 Injection in patients with autoimmune diseases.
- Conditions
- Systemic Sclerosis (SSc), Rheumatoid Arthritis (RA), Sjogren's Syndrome (SS), Idiopathic Inflammatory Myopathies(IIM)
- Trial name
- NCT07527936
- Testing
- Single administration of 1x10^8 viable CD4+ CAR+ Foxp3+ cells., Single administration of 3x10^8 viable CD4+ CAR+ Foxp3+ cells.
- Where
- China
- Volunteers
- 24 people
- Sponsor
- RenJi Hospital
Dry Eye, Contact Lens Complication
Effects of Supplementation With PUFAs and Antioxidants for Contact Lens Discomfort
HydroEye® is a dietary omega 3 fatty acid supplement that contains both EPA and DHA, as well as GLA and ALA in the form of black currant seed oil.
- Trial name
- NCT04163328
- Testing
- HydroEye®
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Alabama at Birmingham
Dry Eye Disease (DED) , Diabetic Macular Edema
Association Between Dry Eye Disease and Diabetic Macular Edema
This study evaluates the association between dry eye disease (DED) and diabetic macular edema (DME) in adult patients at the Ophthalmology Department, Faculty of Medicine, Sohag University.
- Trial name
- DED-DME (NCT07392307)
- Testing
- Dry Eye Disease Assessment
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Dry Eye, MGD-Meibomian Gland Dysfunction
Study on Prevention and Treatment of Dry Eye in Patients Using Glaucoma Drops
A multicenter randomized controlled trial on prevention and treatment of ocular surface injury and meibomian gland dysfunction in patients using anti-glaucoma eye drops.
- Trial name
- NCT03515187
- Testing
- 0.3% sodium hyaluronate ophthalmic solution, 0.1% sodium bromide solution, Meibomian gland massage
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Shenzhen Hospital of Southern Medical University
Dry Eye
Dry Eye Assessment and Management Study
The objective of the DREAM study is to evaluate the effectiveness and safety of supplementation with omega-3 fatty acids in relieving the symptoms of moderate to severe dry eye disease.
- Trial name
- DREAM (NCT02128763)
- Testing
- Omega-3 supplements
- Where
- 27 sites in United States
- Volunteers
- 535 people
- Sponsor
- University of Pennsylvania
Dry Eye, Cataract Surgery
Efficacy Evaluation of SYSTANE® ULTRA in Patients Scheduled for Cataract Surgery
The purpose of this study is to evaluate the effectiveness of FID 112903 (SYSTANE ULTRA® Lubricating Drops) plus standard of care to standard of care alone, in subjects with a history of intermittent eye irritation or dryness…
- Trial name
- NCT01199510
- Testing
- FID 112903 (SYSTANE® ULTRA Lubricant Eye Drops) plus standard of care, Standard of Care
- Volunteers
- 40 people
- Sponsor
- Alcon Research
Dry Eye
Long-term Effects of Acoltremon vs. Control in Dry Eye Disease
This is a prospective, longitudinal, single-center study designed to evaluate the long-term changes in symptoms and tear production in subjects with dry eye disease.
- Trial name
- NCT07659626
- Testing
- Acoltremon 0.003%, Refresh classic preservative free
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Eye Care Institute
Dry Eye Disease
A Trial to Assess the Safety and Efficacy of Subjects With Dry Eye Disease
A Randomized, Double-Masked, Vehicle-Controlled Parallel Group Clinical Trial to Assess Efficacy and Safety of 0.25% Reproxalap Ophthalmic Solution Compared to Vehicle in Subjects with Dry Eye Disease
- Trial name
- NCT06493604
- Testing
- Reproxalap Ophthalmic Solution (0.25%), Vehicle Ophthalmic Solution
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Aldeyra Therapeutics, Inc.
Dry Eye
A Study to Evaluate the Performance and Safety of Artelac Rebalance® Versus Vismed in the Management of Dry Eye
The objective of this investigation is to show that the performance of Artelac Rebalance eye drops is non-inferior to that of Vismed eye drops in subjects with moderate to severe dry eye, and to assess the safety of Artelac…
- Trial name
- NCT01791426
- Testing
- Artelac Rebalance, Vismed
- Sponsor
- Bausch & Lomb Incorporated
Dry Eye
Perfluorohexyloctane Eye Drops vs. Sodium Hyaluronate for Video Display Terminal-Associated Dry Eye
This is a prospective, multicenter, open-label, randomized controlled trial designed to evaluate the efficacy and safety of perfluorohexyloctane (PFHO) eye drops (Hengqin®, Chengdu Shengdi Pharmaceutical Co., Ltd.) compared with…
- Trial name
- NCT07679685
- Testing
- 0.1% Sodium Hyaluronate Eye Drops, Perfluorohexyloctane Eye Drops (PFHO)
- Where
- 9 sites in China
- Volunteers
- 159 people
- Sponsor
- Beijing Tongren Hospital
Dry Eye Syndrome
Safety and Efficacy of BRM421 for Dry Eye Syndrome Treatment
The objective of this study is to compare the safety and efficacy of BRM421 Ophthalmic Solution to placebo for the treatment of the signs and symptoms of dry eye.
- Trial name
- NCT04343287
- Testing
- BRM421
- Where
- 4 sites in United States
- Volunteers
- 220 people
- Sponsor
- BRIM Biotechnology Inc.
Dry Eye Disease
Transcutaneous Auricular Vagus Nerve Stimulation in Dry Eye
Objective: To evaluate the effect of transcutaneous auricular vagus nerve stimulation (taVNS) for the patients with dry eye disease. Methods: The investigators enrolled 256 patients at Beijing Tongren Hospital.
- Trial name
- NCT06696625
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation, 0.1% sodium hyaluronate eye drop
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Beijing Tongren Hospital
Evaporative Dry Eye Disease
Comparative Efficacy Study to Demonstrate the Non-inferiority of I-DROP® MGD Versus 2 Competitor Eye Drops in Managing Evaporative Dry Eye
A Pilot Comparative study between I-DROP MGD vs two commercially available lubricant eye drops for the management of evaporative dry eye
- Trial name
- NCT06686368
- Testing
- I-DROP MGD, Theloze Duo, Systane Complete PF
- Volunteers
- 60 people
- Sponsor
- I-MED Pharma
Dry Eye Disease, Dry Eye
Efficacy of Lipid-containing Artificial Tears in the Treatment of Dry Eye
This clinical study involves patients with Dry Eye Disease (DED) who are visiting an ophthalmology outpatient clinic. Eligible participants must have an Ocular Surface Disease Index (OSDI) score ≥14 and <50, and at least one…
- Conditions
- Dry Eye Disease, Dry Eye, Dry Eye, Evaporative
- Trial name
- NCT06955585
- Testing
- Proluxx Artificial Tear Spray
- Where
- Croatia
- Volunteers
- 50 people
- Sponsor
- University Hospital Sestre Milosrdnice
AMD - Age-Related Macular Degeneration
Repeated Low-Level Red-Light Therapy in Dry Age-Related Macular Degeneration
This prospective, double-blind, randomized controlled trial aims to evaluate the efficacy and safety of repeated low-level red-light (RLRL) therapy in patients with dry age-related macular degeneration (AMD).
- Trial name
- NCT07409389
- Testing
- RLRL device
- Where
- China
- Volunteers
- 94 people
- Sponsor
- The Hong Kong Polytechnic University
Dry Eye, Neurotrophic Keratitis
DOMPE -MT Neurotrophic Keratitis
TITLE: Toyos Clinic / A Phase 4 Study to Assess Longer Duration of Treatment with Cenegermin in Moderate to Severe Dry Eye-Associated Neurotrophic Keratitis
- Trial name
- NCT06947850
- Testing
- Cenegermin Ophthalmic Solution [Oxervate]
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Toyos Clinic
Dry Eye Syndromes
Evaluation Of Vision Recovery And Comfort Index In Patients With Borderline/Mild Dry Eyes Undergoing FLACS With Premium IOL
This is a prospective, open-label, single-center, randomized, head-to-head, investigator-sponsored clinical study. It aims to investigate the vision recovery and patient comfort in borderline/mild dry eye disease patients…
- Trial name
- ENHANCE (NCT04863742)
- Testing
- Dextenza 0.4Mg Ophthalmic Insert, Prednisolone Acetate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Sight Medical Doctors PLLC
Dry Eye
Bilateral, Masked Comparison of PEG-400 Based Artificial Tear and Systane for the Treatment of Dry Eye Signs, Symptoms and Visual Quality
To evaluate and compare the effects of PEG-400 based artificial tear and Systane tears in mild-moderate dry eye patients. TBUT, Visual impact and subjective evaluations will be assessed in this month long trial.
- Trial name
- NCT00622037
- Testing
- PEG-400 based artificial tear, Systane
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Bp Consulting, Inc
Dry Eye
An 8-week Study to Evaluate Safety and Efficacy of NGF Eye Drops Solution Versus Vehicle in Patients With Dry Eye
The primary objective of this study was to assess the efficacy and safety of rhNGF when administered as eye drops to patients with dry eye The secondary objectives of this study were: To assess change from baseline in Symptom…
- Trial name
- NCT03019627
- Testing
- NGF, Vehicle
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Dompé Farmaceutici S.p.A