Clinical trials: Drugs, Non-Prescription, open to volunteers
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
SARS-CoV-2 Infection, Influenza A
Clinical Validation of an At-Home Flu A/B and COVID-19 Rapid Test
The study's primary objective is to evaluate the performance of the CorDx Tyfast Flu A/B \& COVID-19 At-Home Test for detecting SARS-CoV-2, Influenza A, and B in nasal samples collected by lay users, compared to 510(k)-cleared…
- Conditions
- SARS-CoV-2 Infection, Influenza A, Influenza B
- Trial name
- NCT07430410
- Testing
- CorDx Tyfast Flu A/B & COVID-19 At-Home Multiplex Rapid Test
- Volunteers
- 200 people
- Sponsor
- CorDx, Inc.
Hearing Loss, Hearing Aids
Innovations in Hearing Accessibility and Technology (IHAT) Study
The research will explore outcomes of different service delivery models of over-the-counter (OTC) hearing aids by comparing them to prescription hearing aids fitted by specialists in individuals with mild to moderate hearing…
- Conditions
- Hearing Loss, Hearing Aids, OTC Hearing Aids
- Trial name
- IHAT (NCT06689865)
- Testing
- HA-HCP, OTC-HCP, OTC-R
- Where
- 2 sites in United States
- Volunteers
- 280 people
- Sponsor
- University of Colorado, Denver
Hearing Loss, Mild Cognitive Impairment
OTC Hearing Aid and MCI
The goal of this study is to better understand if, in patients with mild to moderate hearing loss who are also experiencing mild cognitive impairment (MCI) or Alzheimer's disease and related dementias (ADRD), Over-the-Counter…
- Conditions
- Hearing Loss, Mild Cognitive Impairment, Alzheimer Disease and Related Dementias (ADRD)
- Trial name
- NCT06112860
- Testing
- Over the counter hearing aid, Communication Strategies Information/Counseling
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Northwestern University
SARS-CoV-2 Infection, Influenza A
Usability and Clinical Validation of the Flu A/B/COVID-19 + RSV Multiplex Rapid Test
This will be a prospective study for the clinical validation of the CorDx Tyfast Flu A/B/COVID-19 + RSV Multiplex Rapid Test for the qualitative detection and differentiation of SARS-CoV-2, Influenza A, Influenza B and RSV in AN…
- Conditions
- SARS-CoV-2 Infection, Influenza A, Influenza B, RSV
- Trial name
- CorDx 4in1 (NCT07875270)
- Testing
- Flu A/B/COVID-19 + RSV Multiplex Rapid Test
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- CorDx, Inc.
Insomnia, Insomnia Disorder
A SMART Approach to Evaluating the Benefits of Common Prescription and OTC Medications for Insomnia
The purpose of this study is to assess the relative effectiveness, safety, and durability of the most commonly used prescription (zolpidem, trazodone) and over-the-counter (OTC) (melatonin, diphenhydramine) medications for…
- Conditions
- Insomnia, Insomnia Disorder, Chronic Insomnia, Chronic Insomnia Disorder
- Trial name
- NCT07542756
- Testing
- Sleep Hygiene Education, Melatonin IR, 3 mg, Melatonin IR, 5 mg
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- University of Pennsylvania
Type 2 Diabetes, Non Insulin Dependent Diabetes
T2D Intermittent Nonprescription Sensors for Informed Glucose Health Tracking
The goal of this clinical trial is to learn if periodic use of over-the-counter continuous glucose monitoring (CGM) can support glucose management in people with type 2 diabetes not using insulin being treated in primary care…
- Trial name
- T2D INSIGHT (NCT07422831)
- Testing
- Periodic, over-the-counter continuous glucose monitoring
- Where
- United States
- Volunteers
- 188 people
- Sponsor
- University of Colorado, Denver
Dry Eye Disease (DED)
Randomized Single Center Study to Evaluate Tolerability, Symptoms, and Visual Functional Outcomes With the Use of OTC Lubricating Eye Drops in Subjects With Dry Eye Disease
A study to evaluate the effect of over- the- counter (OTC) lubricating eye drops on tolerability, symptoms and visual outcomes in patients with dry eye disease (DED)
- Trial name
- NCT07676084
- Testing
- Preservative Free Polyethylene glycol 400 0.25%, Propylene Glycol (0.6%), Carboxymethylcellulose sodium 0.5%, Glycerin 1.0%, Polysorbate 80 0.5%
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Andover Research Eye Institute
Drug Overdose
Social Network Overdose Prevention and Education Intervention
The purpose of this study is to test a social intervention focused on overdose prevention and care. In the investigators prior work, the investigators have shown that people who use opioids (PWUO) can be effective peer educators…
- Trial name
- NCT06327061
- Testing
- Network overdose prevention, Standard of care health education
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Crohn's Disease (CD), Dysmenorrhea Primary
Comparing Over the Counter Pain Medicines for Discomfort in Crohn's Disease (AVID-CD)
The purpose of this pilot study is to prepare for a larger study that will compare the effectiveness and safety of two common pain medications, ibuprofen and acetaminophen, to help treat period cramps in women with Crohn's…
- Trial name
- AVID-CD (NCT07337902)
- Testing
- Acetaminophen, Ibuprofen
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of North Carolina, Chapel Hill
Epidermis, Ultraviolet Exposure
A Clinical Study to Evaluate the Efficacy and SPF of Two Test Materials According to an Adaptation of the Guidelines of the FDA Sunscreen Drug Products for Over-the-Counter Human Use
Approximately 70 subjects (35 subjects per light and dark group) will be enrolled in this clinical study (to complete with a minimum of 10 subjects per skin type (I-VI) to assess the effects of known UV Radiation dosage on light…
- Trial name
- NCT07789639
- Testing
- Hybrid sunscreen, Chemical sunscreen, No sunscreen
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Good Molecules, LLC
Benign Prostatic Hyperplasia, Nocturia Associated With Nocturnal Polyuria
A Clinical Observation Study of a Chinese Patent Medicine Combined With Tamsulosin in Improving Sleep and Nocturia Symptoms After Enucleation of the Prostate
This study will test whether a traditional Chinese medicine called Lingze tablets, when added to the standard drug tamsulosin, can better improve sleep and nighttime urination problems in men after prostate surgery.
- Trial name
- NCT07357324
- Testing
- Tamsulosin Hydrochloride Sustained-Release Capsules, Lingze Tablets
- Where
- China
- Volunteers
- 136 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Gender Incongruence, Gender Dysphoria
Sex Hormone Overdose and Misuse in Chinese Transgender and Gender Non-conforming Population
The investigators propose to investigate the definition of hormone overdose and misuse (HODM) in Chinese transgender and gender nonconforming population (TGNCs), address the incidence of HODM in Chinese TGNC population, related…
- Trial name
- HODMChina (NCT05583058)
- Testing
- Hormone Overdose and Misuse
- Where
- China
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Xiamen University
Community Pharmacy Services
Evaluation of the Effect of Consensus-based Protocols for the Treatment of Minor Ailments
Minor ailments are common, self-limited conditions unrelated to the patient's underlying health problems or adverse effects of their current medications.
- Trial name
- NCT06378099
- Testing
- Patient guided and followed by the pharmacist
- Where
- Colombia
- Volunteers
- 900 people
- Sponsor
- Universidad de Antioquia
Liver Diseases
DILIN - Prospective Study
The purpose of this study is to identify individuals who have suffered a liver injury arising as an idiosyncratic reaction to a prescription drug or a complementary and alternative medicine.
- Trial name
- NCT00345930
- Where
- 6 sites in United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Breastfeeding Education, Lactating Mother
Breastfeeding Advices on OTC Medicines With the Internet: What is the Best Medium
Pharmacotherapy for lactating women in Hungary presents a unique challenge. While certain medications may pose risks to the infant or reduce breast milk production, the unnecessary avoidance of treatment can also be harmful.
- Conditions
- Breastfeeding Education, Lactating Mother, Breastfeeding Mothers, Lactation
- Trial name
- LACT-ED (NCT06863597)
- Testing
- Video content, Written content, Podcast content
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Insomnia, Obesity
Qing-Xin-Jiao-Tai Decoction for Insomnia Comorbid With Obesity Presenting With Heart-Kidney Non-interaction Syndrome
This randomized, double-blind, placebo-controlled clinical trial aims to evaluate the efficacy of Qing-Xin-Jiao-Tai Decoction (QXJTD), a Traditional Chinese Medicine formula, in treating adults (aged 18-65) suffering from both…
- Trial name
- NCT07754383
- Testing
- Qingxin Jiaotai Decoction
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Fohow Pharmaceutical Group
Bilateral Hearing Loss, Health Services Research
Assessing Pharmacy Technician Educational Training for the Provision of Over-the-Counter Hearing Aids in Rural Alabama and Mississippi Pharmacies
Hearing loss is a major public health concern due to its negative association with emotional well-being, cognition, and physical ailments, such as diabetes.
- Trial name
- NCT06864273
- Testing
- Pharmacy Technician Educational Training
- Where
- 2 sites in United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Alabama, Tuscaloosa
Psoriasis
A Study to Evaluate the Impact of a Magnolia Officinalis Dietary Supplement on Immune Biomarkers in Subjects With Psoriasis
The goal of this clinical trial is to evaluate whether Viv, a consumer-grade dietary supplement derived from the Magnolia officinalis plant, has an effect on biomarkers of immune activity in adults with psoriasis.
- Trial name
- NCT07471048
- Testing
- Oral supplement containing 200mg Magnolia officinalis bark extract
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Sirt3 LLC