Clinical trials: Drug-Induced Liver Injury
Drug Induced Liver Injury, Chronic Liver Disease
Efficacy of Plasmapheresis in Patients of Drug-Induced Liver Injury (DILI) With Underlying Chronic Liver Disease
DILI is an underdiagnosed and under appreciated causal or contributing factor to liver injury. DILI can mimics features of the entire spectrum of acute and chronic liver disease.
- Trial name
- NCT06797011
- Testing
- High volume Plasma Exchange, Standard Medical Treatment
- Where
- India
- Volunteers
- 96 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Drug-Induced Liver Injury
A Retrospective Study on Drug Induced Liver Injury in China
This is a multi-center, open-enrollment, retrospective, non-interventional epidemiologic study without any clinical treatment. Its primary objective is to understand 1) incidence of drug-induced liver injury, including incidences…
- Trial name
- DILI-R (NCT02407964)
- Where
- 371 sites in China
- Volunteers
- 15,000 people
- Sponsor
- Drug Induced Liver Disease Study Group
Chemotherapeutic Toxicity, Malignant Tumor
Serum miR-122 as a Real-time Detection Biomarker of Drug-induced Liver Injury by Chemotherapy
This is an open , multicenter, interventional clinical trial to conform the role of of miR-122 a real-time detection biomarker of drug-induced liver injury by chemotherapy.
- Conditions
- Chemotherapeutic Toxicity, Malignant Tumor, Liver Injury
- Trial name
- NCT03039062
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences
Liver Toxicity, Chemically-Induced
Livertoxcicity in Acute Leukemia Patients During Chemotherapy Treatment
Detection of hepatotoxcicity in acute leukemia and study the outcome of acute leukemia patients that suffer from hepatic toxiciyt
- Trial name
- NCT06383325
- Testing
- Chemotherapy
- Volunteers
- 70 people
- Sponsor
- Assiut University
Chronic Liver Disease, Non-Alcoholic Fatty Liver Disease
Ultrasound Method to Measure Fibrosis of the Liver in Children
HYPOTHESIS: The investigators hypothesize that sonoelastography (SE) provide accurate quantitative measurements that can be used to stage liver fibrosis in pediatric patients with chronic liver disease.
- Conditions
- Chronic Liver Disease, Non-Alcoholic Fatty Liver Disease, HCV Coinfection, HBV
- Trial name
- NCT02086708
- Testing
- Shear Wave sonoelastography
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Massachusetts General Hospital
Acute Drug Induced Liver Injury
Efficacy and Safety of Polyene Phosphatidylcholine in Treatment of Patients With Acute Drug-induced Liver Injury
The purpose of this study is to explore the efficacy and the safety of polyene phosphatidylcholine Injection in patients with acute drug-induced liver injury after 2-4 weeks of treatment.
- Trial name
- NCT04595916
- Testing
- Polyene phosphatidylcholine injection 930 mg QD, Magnesium Isoglycyrrhizinate injection 200 mg QD
- Where
- 9 sites in China
- Volunteers
- 73 people
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
Recurrent Drug-induced Liver Injury
Clinicopathological Features and Genetic Susceptibility Screening of Recurrent Drug-induced Liver Injury
The goal of this observational study is to screening for clinical, pathological and HLA features in patients with recurrent drug-induced liver injury.
- Trial name
- RDILI-GS (NCT06547229)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Friendship Hospital
Drug-Induced Liver Injury
Efficacy and Safety Study of Magnesium Isoglycyrrhizinate Injection in Subjects With Acute Drug-induced Liver Injury
The purpose of this study is to investigate the safety, effective dosage and treatment of Magnesium Isolycyrrhizinate Injection to cure the acute drug-induced liver injury compared with the Tiopronin Injection.
- Trial name
- NCT02734966
- Testing
- Magnesium Isoglycyrrhizinate Injection 100mg OD, Magnesium Isoglycyrrhizinate Injection 200mg OD, Tiopronin Injection
- Where
- 8 sites in China
- Volunteers
- 174 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Chronic Liver Disease
Efficacy and Safety of Plasma Exchange Compared to Standard Medical Therapy in Patients With Severe Drug Induced Liver Injury With or Without Underlying Chronic Liver Disease.
In this randomized study subject will be randomized into two groups Group A will receive Standard Medical Treatment (Albumin + High Caloric Diet) Group B will continue Standard Medical Treatment with High Volume Plasma Exchange.
- Trial name
- NCT04015570
- Testing
- High Volume Plasma Exchange, Standard Medical Treatment
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Drug-induced Liver Injury
Glucocorticosteroid Therapy on Drug-induced Liver Injury: a Prospective Non-randomized Concurrent Control Trial
The purpose of this study is to assess the safety and efficacy of glucocorticosteroid for treatment of drug-induced liver injury.
- Trial name
- NCT04553003
- Testing
- Glucocorticoids+hepatoprotectant, hepatoprotectant
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Li Yang
Alcohol-Related Liver Disease, Drug-Induced Liver Injury
Misocholic Tablets for Non-Viral Elevated Liver Enzymes
Elevated liver enzymes are common laboratory abnormalities that may result from alcohol-related liver disease, drug-induced liver injury, or non-alcoholic fatty liver disease (NAFLD).
- Conditions
- Alcohol-Related Liver Disease, Drug-Induced Liver Injury, Non-alcoholic Fatty Liver Disease
- Trial name
- NCT07833514
- Testing
- Misocholic Tab, Silymarin (Silybum marianum)
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- Hanoi Medical University
Drug Induced Liver Injury, Pruritus
Drug-induced Liver Injury: Itching Study
Idiosyncratic drug-induced liver injury (DILI) is an unpredictable adverse hepatic reaction to a medication used in its therapeutic dose.
- Trial name
- NCT06446609
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Nottingham
Chronic Liver Disease, Non-Alcoholic Fatty Liver Disease
Sonoelastography: Ultrasound Method to Measure Liver Fibrosis
HYPOTHESIS: The investigators hypothesize that sonoelastography (SE) will provide accurate quantitative measurements that can be used to stage liver fibrosis in patients with chronic liver disease. 1.
- Conditions
- Chronic Liver Disease, Non-Alcoholic Fatty Liver Disease, Hepatitis C Virus (HCV) Coinfection, Hepatitis B Virus (HBV)
- Trial name
- NCT01747772
- Testing
- Shear Wave Sonoelastography
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Massachusetts General Hospital
Tuberculosis, Tuberculous Meningitis
Leukotriene A4 Hydrolase Stratified Trial of Adjunctive Corticosteroids for HIV-uninfected Adults With Tuberculous Meningitis
The primary objective is to determine whether Leukotriene A4 hydrolase (LTA4H) genotype, defined at randomisation, determines dexamethasone's clinical effectiveness when added to the first 6-8 weeks of anti-tuberculosis treatment…
- Conditions
- Tuberculosis, Tuberculous Meningitis, Drug-Induced Liver Injury
- Trial name
- NCT03100786
- Testing
- Dexamethasone
- Where
- 3 sites in Vietnam
- Volunteers
- 702 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Liver Injury, Liver Injury, Drug-Induced
A Retrospective Study in Patients With Liver Injury After the Use of Novel Antineoplastic Agents
This is an open-enrollment, retrospective, observational study without interventions. Its primary objective is to understand 1) incidence of liver injury among all the hospitalized patient from participating centers after the…
- Trial name
- NCT06670391
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Drug Induced Liver Disease Study Group
Acute Alcoholic Hepatitis, Chemical and Drug Induced Liver Injury
Digoxin In Treatment of Alcohol Associated Hepatitis
Prospective, single center, open label, randomized controlled trial to explore whether digoxin treatment affects cytokine levels as biomarkers of inflammation in patients with acute alcohol associated hepatitis, digoxin…
- Conditions
- Acute Alcoholic Hepatitis, Chemical and Drug Induced Liver Injury, Alcohol-Induced Disorders, Steatohepatitis Caused by Ingestible Alcohol
- Trial name
- DIGIT-AlcHep (NCT05014087)
- Testing
- Intravenous digoxin
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Yale University
Drug Induced Liver Injury
Glucocorticoids for Acute Drug Induced Liver Injury With Hyperbilirubinemia
Drug-induced liver injury (DILI) can lead to potentially fatal complications, such as acute liver failure and even death. In clinical practice, glucocorticoids have been considered in some cases of DILI, especially patients with…
- Trial name
- NCT06922669
- Testing
- Methylprednisolone, Magnesium isoglycyrrhizinate, Glutathione
- Where
- China
- Volunteers
- 232 people
- Sponsor
- General Hospital of Shenyang Military Region
Chemical and Drug Induced Liver Injury
Hepatotoxicity of Antituberculosis Therapy (HAT) Study
Drug-induced liver injury (DILI) is a common side effect in antituberculosis therapy, which interuputs the treatment of TB and leads to a higher proportion of Multidrug-Resistence TB(MDR-TB).The study primalily aims to observe…
- Trial name
- HAT (NCT04159441)
- Testing
- None intervetion
- Volunteers
- 5,000 people
- Sponsor
- Huashan Hospital
Drug-induced Liver Injury
A Prognostic Model for Drug-induced Liver Injury in China
A prospective, multi-center, non-interventional cohort study is going to conduct to explore the clinical characteristics, culprit drug(s) or herb(s), outcomes and risk factors of Drug-induced liver injury (DILI) in China and…
- Trial name
- DILI-PM (NCT05060289)
- Where
- 13 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Beijing Friendship Hospital
Non Alcoholic Fatty Liver, Hepatitis B
Combi-elastography Assessment of Chronic Liver Disease Multi-center Study
HITACH developed a new combi-elastography imaging technology combines shear wave imaging and strain imaging technology. In the study, not only the F index which is related to the stage of liver fibrosis can be obtained, but also…
- Conditions
- Non Alcoholic Fatty Liver, Hepatitis B, Drug-induced Liver Injury
- Trial name
- NCT04625166
- Where
- China
- Volunteers
- 880 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital