Clinical trials: Drug Use Disorder
Asthma
Automated Inhaler Monitoring for Asthma Medication Usage
The goal of this clinical trial is to evaluate the aflo™ digital platform's ability to improve inhaler use technique and asthma control for children, adolescents, and adults with uncontrolled asthma.
- Trial name
- AIM (NCT06825871)
- Testing
- Smart Inhaler Monitoring Platform for Asthma Management
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Boston Children's Hospital
Substance Use (Drugs, Alcohol)
Emergency Department-Substance Use Screening, Motivational Interviewing and Active Referral Targeting Substance Use Disorder and Overdose Prevention
The purpose of this research study is to learn if an emergency department screening and telehealth intervention reduces substance use among individuals receiving emergency department treatment at The Ohio State University Wexner…
- Trial name
- ED-SMART (NCT07527871)
- Testing
- ED-SMART intervention, Substance use information
- Where
- United States
- Volunteers
- 650 people
- Sponsor
- Purdue University
Chronic Kidney Disease (CKD)
Tamsulosin and the Risk of Serious Adverse Events
This is a population-based cohort study assessing whether initiating a higher dose of tamsulosin (0.8 mg/day) compared to a lower dose (0.4 mg/day) in older adults with advanced chronic kidney disease (CKD) (an estimated…
- Trial name
- NCT07274228
- Testing
- Tamsulosin
- Where
- Canada
- Volunteers
- 14,000 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Knee Injuries and Disorders, Hip Injuries and Disorders
Impact of Different Educational Approaches on Post-operative Opiate Utilization After Elective Lower Extremity Surgery
The purpose of this study is to evaluate the use of post-operative opioid use after two different educational interventions. The investigators will compare changes in pain, disability and sleep between groups 6 months after…
- Conditions
- Knee Injuries and Disorders, Hip Injuries and Disorders, Opiate Addiction
- Trial name
- OpiateLEO (NCT02997644)
- Testing
- Video Education, Usual Care Group
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Brooke Army Medical Center
Drug Abuse
General Well-being After Quitting Drug Use
The aim of this study is to investigate physical and physicosocial well-being after quitting drug use.
- Trial name
- NCT07641712
- Testing
- Physical well-being, Physico-social well-being
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Alanya Alaaddin Keykubat University
Substance Use Disorders
Exercise Training as Medicine for Substance Use Disorder Patients
This study compares the effects of high dose and low dose, high intensity, endurance training and strength training in substance use disorder patients.
- Trial name
- NCT04065334
- Testing
- High dose training, low dose training
- Where
- Norway
- Volunteers
- 171 people
- Sponsor
- St. Olavs Hospital
Ischemic Heart Disease
Patterns of Antiacids Use in Patients With IHD Admitted to Department of Internal Medicine
There is substantial, continuing, and unexplained rise in prescribing of proton pump inhibitors. It is unknown whether their use in practice has corresponded to their licensed indications.
- Trial name
- NCT00392964
- Where
- 2 sites in Israel
- Volunteers
- 1,200 people
- Sponsor
- Rambam Health Care Campus
Pulmonary Embolism
Does a Home-based Exercise Programme Affect Physical Capacity and Quality of Life in Patients With Pulmonary Embolism?
In a randomised design the study aims to investigate whether an intervention of 8 weeks home-based exercise in addition to usual care can positively influence the physical capacity, quality of life, sick leave and use of…
- Trial name
- NCT02684721
- Testing
- 8-week home-based exercise programme
- Where
- 3 sites in Denmark
- Volunteers
- 140 people
- Sponsor
- Central Jutland Regional Hospital
Breast Neoplasms
Delphinus SoftVue Prospective Case Collection - ARM 2
The SoftVue™ is a whole breast ultrasound system with an automated scanning curvilinear ring-array transducer that employs UST. It is currently cleared under FDA 510(k) K123209 and K142517 for use as both a B-mode ultrasonic…
- Trial name
- SV PCC ARM2 (NCT02977247)
- Testing
- Non-Interventional, Automated Whole Breast Ultrasound
- Where
- 10 sites in United States
- Volunteers
- 1,150 people
- Sponsor
- Delphinus Medical Technologies, Inc.
Cannabis Use Disorder
N-Acetylcysteine for Youth Cannabis Use Disorder
This is a 12-week randomized, placebo-controlled trial of N-acetylcysteine for cannabis use disorder (CUD) in youth (N=192). Participants will be randomized to double-blind NAC or PBO, yielding two equally-allocated treatment…
- Trial name
- NCT03055377
- Testing
- N-acetyl cysteine
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Medical University of South Carolina
Carcinoma, Hepatocellular
Nexavar Post-marketing Surveillance for Hepatocellular Carcinoma in Japan
This study is a regulatory post-marketing surveillance in Japan, and it is a local prospective and observational study of patients who have received Nexavar for unresectable hepatocellular carcinoma (HCC).
- Trial name
- NCT01411436
- Testing
- Sorafenib (Nexavar, BAY43-9006)
- Where
- Japan
- Volunteers
- 1,637 people
- Sponsor
- Bayer
Opioid-use Disorder
Mobile Medication Adherence Platform for Buprenorphine-Naloxone During Treatment of Opioid Use Disorder: Phase I Study
The investigators will conduct a phase I study involving 41 participants selected randomly among patients prescribed buprenorphine-naloxone for opioid misuse as a feasibility trial of the study of the Pillsy device.
- Trial name
- MAP4BUP (NCT04656899)
- Testing
- Reminders messages to improve adherence.
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Washington State University
Metastatic Hepatocellular Carcinoma, Advanced Liver Cancer
A Study of Vitamin C in the Treatment of Liver Cancer to Determine if it is Safe and Effective
This protocol is a phase I/II, study of ascorbic acid (AA) infusions combined with treatment with sorafenib versus treatment with sorafenib alone in subjects with metastatic hepatocellular carcinoma.
- Trial name
- NCT01754987
- Testing
- Ascorbic Acid + Sorafenib, Sorafenib
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Thomas Jefferson University
Lymphoma, Non-Hodgkin, Multiple Myeloma
TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer
The purpose of the study is to learn from the real world practice of prescribing targeted therapies to patients with advanced cancer whose tumor harbors a genomic variant known to be a drug target or to predict sensitivity to a…
- Conditions
- Lymphoma, Non-Hodgkin, Multiple Myeloma, Advanced Solid Tumors
- Trial name
- TAPUR (NCT02693535)
- Testing
- Sunitinib (CLOSED TO ENROLLMENT), Trastuzumab and Pertuzumab (CLOSED TO ENROLLMENT), Vemurafenib and Cobimetinib (CLOSED TO ENROLLMENT)
- Where
- 181 sites in United States, Puerto Rico
- Volunteers
- 4,200 people
- Sponsor
- American Society of Clinical Oncology
Substance Use Disorders
Enhancing Addiction Treatment Through Psychoeducation
Addiction is a brain disorder characterized by a broad range of both apparent and subtle cognitive impairments in attention, memory, executive functions, and decision-making.
- Trial name
- NCT07178158
- Testing
- Installing the Metacognium software app, Continue treatment as usual
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Virginia Commonwealth University
Delirium
Impact of Various Sedation Regimens on the Incidence of Delirium
Sedation drugs that are commonly used in ICU in treatment of ARDS, includes propofol, midazolam and dexmedetomidine . Among these, both dexmedetomidine and propofol have been reported to be used together with midazolam in ICU and…
- Trial name
- NCT02117726
- Testing
- Dexmedetomidine,midazolam, Propofol,midazolam
- Where
- 7 sites in China
- Volunteers
- 320 people
- Sponsor
- Shandong Provincial Hospital
Type 2 Diabetes Mellitus
Study to Test Use of a Decision Aid in a Clinical Visit to Help Patients Choose a Diabetes Medication
The goal of this study is to test the relative merits of a decision aid for diabetes medications that we have developed - Diabetes Medication Choice Cards- versus usual care in translating comparative effectiveness research (CER)…
- Trial name
- TRICEP (NCT01293578)
- Testing
- Diabetes Medication Choice Cards
- Where
- 6 sites in United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
PTSD, Anxiety
Exploring Medically Perceived Benefits, Use and Interest in Psychedelics and Cannabinoids
The primary objective of this study is to collect insights from first responders and military personnel on their need for, use of, and interest in physical and/or mental health medical marijuana or psychedelic-assisted therapy…
- Conditions
- PTSD, Anxiety, Anxiety Disorders, Depression
- Trial name
- EMPOWER (NCT04965740)
- Testing
- Cannabis
- Where
- Canada
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Empower Research Inc
Insomnia, Major Depression
Cortical GABA Concentrations in Insomnia
Disturbances in the amino acid neurotransmitter (AANt), gamma-amino butyric acid (GABA) function are hypothesized to contribute to the neurobiology of Major Depressive Disorder (MDD) and insomnia.
- Trial name
- NCT00765752
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Yale University
Apnea, Sleep Disorders
A Study to Learn About the Monthly Dosing Study Medicine Called Berobenatide in Adults With Breathing Problems During Sleep and Overweight or Obesity Who Use a Breathing Machine (PAP) (VESPER-OSA 1)
This study is being done to learn about the safety and effects of a study medicine called berobenatide (bear-oh-BEN-uh-tide). The study will see if berobenatide can help adults with breathing problems during sleep (obstructive…
- Conditions
- Apnea, Sleep Disorders, Overweight and/or Obesity
- Trial name
- NCT07823608
- Testing
- Berobenatide
- Where
- 6 sites in United States
- Volunteers
- 258 people
- Sponsor
- Pfizer