Clinical trials: Drug Monitoring
Schizophrenia, Schizoaffective Disorder
Adherence in Patients Admitted to a Psychiatric Unit for Acute Psychosis: an Analysis of Serum Levels of Antipsychotics.
This is a screening study aimed at estimating the frequency of antipsychotic non-compliance in patients with a history of schizophrenia or other psychotic disorder admitted to an inpatient psychiatric unit.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
- Trial name
- NCT01786369
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Northwell Health
Type 2 Diabetes Mellitus
A Study to Compare the Use of Diabetes Treatment Support System (BAP0527 and Blood Glucose Meter) in Addition to Daily Practice and Treatment With Daily Practice and Treatment Alone in Patients With Type 2 Diabetes Mellitus
The subjects of this study are patients with type 2 diabetes mellitus. The patients take part in dietetic therapy and exercise therapy, and also receive diabetes education to improve lifestyle habits, but since diet and exercise…
- Trial name
- NCT06156696
- Testing
- BAP0527, Blood Glucose Meter
- Where
- Japan
- Volunteers
- 248 people
- Sponsor
- Astellas Pharma Inc
Renal Transplantation
Computer Guided Doing of Tacrolimus in Renal Transplantation
Dosing of tacrolimus is challenging due to the large inter-individual variation in its pharmacokinetics. The investigators have developed a pharmacokinetics population model that can be used to estimate individual doses of…
- Trial name
- OPTIMAL (NCT02010320)
- Testing
- Computer dosing, Standard dose determination
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- University of Oslo School of Pharmacy
Emergencies
The Greek Acute Dance Injuries Registry
Dance is a highly demanded physical activity with a high rate of acute and emergent events (AEE). No systematic prospective study has been conducted in any Greek population of dance students for the registration of the AEE and…
- Trial name
- GrADIR (NCT06220916)
- Testing
- Dance training in Classical Ballet and Contemporary Dance
- Where
- Greece
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Psoriasis Vulgaris
Proactive TDM Versus Standard Use of Biologics in Psoriasis
Biologics are effective agents for the treatment of psoriasis. The newest generation of biologics block interleukin 17 and 23. Physicians always prescribe these drugs in a fixed dose, but this may lead to under- and overdosing in…
- Trial name
- HELIOS (NCT06398106)
- Testing
- Proactive TDM-based dosing of secukinumab, Proactive TDM-based dosing of ixekizumab, Proactive TDM-based dosing of guselkumab
- Where
- 15 sites in Belgium
- Volunteers
- 210 people
- Sponsor
- University Hospital, Ghent
Melanoma (Skin)
Therapeutic Drug Monitoring of BRAF-mutated Advanced Melanoma
BRAF V600-mutant metastatic melanoma are commonly treated using a combination of anti-BRAF and anti-MEK tyrosine kinase inhibitors (TKIs).
- Trial name
- OPTIMEL (NCT03416933)
- Testing
- Blood sampling
- Where
- 4 sites in France
- Volunteers
- 35 people
- Sponsor
- Institut de Cancérologie de Lorraine
Rheumatoid Arthritis
Proactive Therapeutic Drug Monitoring Based Adalimumab Therapy Optimization in Patients With Rheumatoid Arthritis
Current standard of care of rheumatoid arthritis (RA) management includes a routine clinical assessment of disease activity to adjust therapy.
- Trial name
- TDM-RA (NCT05460390)
- Testing
- Therapeutic drug monitoring (TDM)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Boston Medical Center
Pneumonia, Sepsis
Therapeutic Drug Monitoring - Targeting IMproved Effectiveness
Severe infections can be caused by various organisms, such as bacteria or viruses, and lead to otherwise healthy people getting very unwell, sometimes needing treatment in hospital or even intensive care.
- Conditions
- Pneumonia, Sepsis, Infection, Bacterial
- Trial name
- TDM-TIME (NCT05971979)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Manchester University NHS Foundation Trust
Hospitalizations
Use of Wearables in Hospitalized General Medicine Patients
This study will focus to determine the usefulness of continuous monitoring and the role it would play in improving inpatient management.
- Trial name
- NCT03646435
- Testing
- Fitbit Charge 2
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Arterial Hypertension, Dyslipidemias
Study of Adherence to Antihypertensive Drugs and Statins by Hair Analysis
The problem of adherence to long-term therapies has been known for years and occurs substantially in all countries, although with greater severity in developing countries.
- Conditions
- Arterial Hypertension, Dyslipidemias, Antihypertensive Drugs, Statins
- Trial name
- INNOVA (NCT05347823)
- Testing
- Hair analysis for drug concentration
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Pharmacokinetics, Antibacterial Agents
Plasma Protein Binding and PK/PD of Total and Unbound Temocillin Non-ICU Patients
Multidrug resistance towards Gram-negative pathogens makes essential the re-examination of older compounds. Temocillin is a penicillin originally marketed in the 1980s but then largely abandoned.
- Conditions
- Pharmacokinetics, Antibacterial Agents, Infections, Bacterial, Infection
- Trial name
- TEMODELTA (NCT03557840)
- Testing
- temocillin
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Paul M. Tulkens
Clinical Deterioration, Hemodynamic Instability
Early Identification of Clinical Deterioration Using a Wearable Monitoring Device
This study aims to provide myriad of physiological parameters in patients admitted in an internal medicine department, and which are defined as being in an increased risk of clinical deterioration within the first 72-hours after…
- Trial name
- NCT04220359
- Testing
- non-invasive monitoring
- Where
- Israel
- Volunteers
- 410 people
- Sponsor
- Biobeat Technologies Ltd.