Clinical trials: Drug Monitoring
Hypertension
The Effect of Timing of Antihypertensive Medication on Diurnal Fluctuations in Blood Pressure Using a Wearable Sensor With Continuous Monitoring
Minimal or absent of diurnal fluctuation in blood pressure, and specifically conditions in which BP values are elevated during the night compared to daytime (rather than "nighttime dipping"), are associated with higher rates of…
- Trial name
- ABPM (NCT04826250)
- Testing
- Timing of medication
- Where
- Israel
- Sponsor
- Tel Aviv University
Osteoarthritis, Rheumatoid Arthritis
The Standard Care Versus Celecoxib Outcome Trial
The Standard Care versus Celecoxib Outcome Trial (SCOT) is a large streamline safety study designed to compare the cardiovascular safety of celecoxib versus traditional non-selective Non Steroidal Anti-Inflammatory Drug (NSAID)…
- Trial name
- SCOTLSSS (NCT00447759)
- Testing
- Celecoxib, Diclofenac
- Where
- 10 sites in Denmark, Netherlands and 1 more
- Volunteers
- 7,297 people
- Sponsor
- University of Dundee
Safety
LabAlert: Enhancing Medication Safety Through Electronic Interventions to Improve Laboratory Monitoring
Errors and preventable adverse events associated with medication prescription and dispensing are common, and the difference between guideline recommendations and the actual frequency of laboratory monitoring is substantial.
- Trial name
- NCT00256386
- Testing
- Electronic Medical Record (EMR) to clinician's in-basket, Automated Voice Message (AVM) reminder to patient's phone, Pharmacy Team phone call-letter followup
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Kaiser Permanente
Non-Small Cell Lung Cancer (MeSH Term: Carcinoma, Non-Small-Cell Lung)
TailorDose Lung: Decentralized TDM of Taxanes and ALK Inhibitors Using Capillary Self-Sampling
This study will evaluate whether people with non-small cell lung cancer (NSCLC) can collect small blood samples themselves using a finger-prick sampling kit.
- Trial name
- TD-Lung (NCT07823725)
- Testing
- True Dose® Capillary Self-Sampling System
- Where
- 2 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska Institutet
Anesthesia
The Comparability of Bispectral Index and Neurosense During Anesthesia
The assessment of anesthesia depth was based, until recently, on the evolution of hemodynamic parameters. Nowadays it can be evaluated by several monitoring methods, derived from electroencephalogram analysis, namely the…
- Trial name
- NCT00910416
- Testing
- propofol, remifentanil, atracurium, propofol, remifentanil, atracurium, sevoflurane, EEG monitoring
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hopital Foch
Essential Hypertension
Home Blood Pressure in Hypertension Management
This is a prospective randomized study with two arms: the Conventional and Ambulatory blood pressure monitoring arm and the Home blood pressure monitoring arm.
- Trial name
- HBP10 (NCT00841308)
- Testing
- Decision to start and titrate drug treatment based only on home blood pressure monitoring
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- University of Athens
Sepsis, Critical Illness
Provider Perspectives on Beta-lactam Therapeutic Drug Monitoring Programs in the Critically Ill
The purpose of the study is to characterize various healthcare practitioners' perspectives on implementation of beta-lactam therapeutic drug monitoring in critical care practice.
- Trial name
- NCT04755777
- Where
- 3 sites in United States, Australia
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Alcohol Dependence, Drug Dependence
LINK: Aftercare Monitoring Project
The prevalence of substance use disorders (SUD) in the VA is rising, making SUD(s) among the most commonly diagnosed disorders in the VA.
- Trial name
- NCT00265512
- Testing
- Telephone Case Monitoring, Continuing Care as Usual
- Where
- 3 sites in United States
- Volunteers
- 667 people
- Sponsor
- VA Office of Research and Development
Breast Cancer Early Stage Breast Cancer (Stage 1-3), Endocrine Therapy
Symptom Monitoring Using Patient-Report to Improve Medication Use
This is an intervention targeting patients at risk for non-adherence to endocrine therapy after primary treatments for hormone-positive breast cancer.
- Trial name
- SyMPTOM (NCT06765707)
- Testing
- Pharmacist delivered symptom monitoring and management
- Where
- 3 sites in United States
- Volunteers
- 225 people
- Sponsor
- Medical College of Wisconsin
Intracranial Infection, Central Infection
Concentration Monitoring of Anti-infective Drugs in Human Cerebrospinal Fluid and Its Clinical Application
At least 50 patients with intracranial infection receiving anti-infective drugs such as vancomycin, meropenem, linezolid, cefoperazone sulbactam, ceftazidime and avibactam were included in each group for pharmacokinetic study…
- Trial name
- NCT06729619
- Testing
- The concentration of anti-infective drugs in blood and cerebrospinal fluid will be determined.
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xueyan Cui
Transpulmonary Pressure, Pressure.Rate Product
Measuring Lung Pressures in Critically Ill Children Who Are on Mechanical Ventilation
Typically doctors adjust the settings on the ventilator to ensure that children receive enough help to decrease the work they perform to breathe, receive enough oxygen through the machine to pass into the blood and to the organs…
- Conditions
- Transpulmonary Pressure, Pressure.Rate Product, Guide to Mechanical Ventilator Management, Extubation Readiness
- Trial name
- NCT02354365
- Testing
- Transpulmonary Pressure measurement
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Children's Hospital Los Angeles
Type 2 Diabetes Mellitus, Hypertension
Technology-augmented Self-monitoring Model Among Patients With Type 2 Diabetes and Hypertension
Objective: To develop and evaluate a technology-augmented self-monitoring model using a randomized controlled trial to demonstrate whether patients with co-morbid type 2 diabetes mellitus and hypertension can improve their…
- Trial name
- NCT02799953
- Testing
- Technology-based self-management model
- Where
- China
- Volunteers
- 299 people
- Sponsor
- The University of Hong Kong
Duchenne Muscular Dystrophy (DMD)
E-monitoring of PULMonary Function in Patients With Duchenne Muscular Dystrophy at Home"
Duchenne muscular dystrophy (DMD) is the most common, progressive, irreversible muscular dystrophy. The pulmonary function is crucial for the duration of life in this disease.
- Trial name
- E-PULMoDMD (NCT05516745)
- Testing
- AioCare spirometer, telerehabiliation of the respiratory system
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Medical University of Gdansk
Type 2 Diabetes Mellitus (T2DM)
Precision Lifestyle Interventions Guided by Continuous Glucose Monitoring: Impact on Glycemic Outcomes in Type 2 Diabetes Mellitus
This study is an interventional research. Through scientific evaluation, it explores the effect of precise lifestyle intervention based on CGM data on the control of chronic type 2 diabetes mellitus.
- Trial name
- NCT06960512
- Testing
- Precision Lifestyle Intervention (PLI) group
- Volunteers
- 200 people
- Sponsor
- He Eye Hospital
Rheumatoid Arthritis, Spondyloarthritis
The Norwegian Drug Monitoring Study
Infliximab and other TNF-inhibitors have revolutionised the treatment of several immunological inflammatory diseases. Still, more than half of the patients either do not respond sufficiently to infliximab therapy or loose…
- Conditions
- Rheumatoid Arthritis, Spondyloarthritis, Ankylosing Spondylitis, Crohn Disease
- Trial name
- NOR-DRUM (NCT03074656)
- Testing
- Therapeutic drug monitoring, Standard care
- Where
- 21 sites in Norway
- Volunteers
- 611 people
- Sponsor
- Diakonhjemmet Hospital
SANZ®KINGWILL Combined With CGM Equipment in GDM Patients, GLUCERNA SR® Combined With CGM Equipment in GDM Patients
Nutrition Product Combine With Continuous Glucose Monitoring in Gestational Diabetes Mellitus Patients
A prospective, multicenter, randomized controlled trial including about 60 Gestational Diabetes Mellitus patients (GDM) in Beijing will be included to evaluate the effectiveness and safety of nutrition product (SANZ®KINGWILL) in…
- Trial name
- NCT04368741
- Testing
- SANZ®KINGWILL, GLUCERNA SR®
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Epilepsy
Birth Defects Associated With Exposure to Lamotrigine in Pregnancy (EUROCAT)
In 2007 a case control study was completed within the EUROCAT European network of congenital anomaly registers to test the hypothesis that first trimester lamotrigine monotherapy exposure is associated with an increased risk of…
- Trial name
- NCT01055327
- Testing
- Lamotrigine monotherapy, No anti-epileptic drug exposure, Non lamotrigine anti-epileptic drug monotherapy
- Volunteers
- 1 people
- Sponsor
- GlaxoSmithKline
Asthma
Monitoring of Patients With Asthma Performed by a Clinical Pharmacist Using a Mobile Application
Asthma is a chronic inflammatory disease that affects the lungs. In Brazil it is responsible for about 4 to 8 deaths per day. Pharmacotherapeutic follow-up programs for people with asthma have a positive impact on treatment…
- Trial name
- NCT05503342
- Testing
- Mobile Application, Asthma control assessment
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Rafael Stelmach
Respiratory Disease
A Pilot Study to Assess the Suitability of the HealthBeacon Injection Care Management System (ICMS) as a Remote Therapeutic Monitoring (RTM) Device
This goal of this study is to assess the suitability of the HealthBeacon Injection Care Management System (ICMS) as a Remote Therapeutic Monitoring (RTM) device for patients on injectable medications in the home-setting, for the…
- Trial name
- NCT05592769
- Testing
- HealthBeacon Injection Care Management System (ICMS)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- HealthBeacon Plc
ARDS, Sepsis
Drug Monitoring of Antibiotics in Critical Care Patients
Infections are critical factors for the survival of critically ill patients. A broad, high-dose and early initial therapy of antibiotics is of particular relevance.
- Trial name
- DRAK (NCT01793012)
- Where
- Germany
- Volunteers
- 186 people
- Sponsor
- Ludwig-Maximilians - University of Munich