Clinical trials: Drug Interactions
HAART Non-Adherence, HIV
Cell Phone Reminders Intervention
This study will use a longitudinal, experimental design. Participants will be randomized to either the intervention or the control group.
- Conditions
- HAART Non-Adherence, HIV, HIV Infections
- Trial name
- NCT01049568
- Testing
- Cell Phone Intervention
- Where
- 5 sites in United States
- Volunteers
- 43 people
- Sponsor
- University of North Carolina, Chapel Hill
COVID-19
Host-pathogen Interactions, Immune Response, and Clinical Prognosis at COVID-19 - the CoVUm Trial
The project aims to clarify how immunity to SARS-CoV2 develops in humans and to investigate the possibility of finding patients with a particularly effective, neutralizing antibody response for future treatment.
- Trial name
- CoVUm (NCT04368013)
- Testing
- Extended sampling and procedures
- Where
- 4 sites in Sweden
- Volunteers
- 550 people
- Sponsor
- Johan Normark
Healthy Volunteers
Safety, Tolerability, and Pharmacokinetics (PK) of Single and Multiple Ascending Oral Doses of XEN1101.
The XEN1101 Phase 1 clinical trial is a randomized, double-blind, placebo-controlled study that will evaluate the safety, tolerability and PK of both single ascending doses (SAD) and multiple ascending doses (MAD) of XEN1101 in…
- Trial name
- NCT03340220
- Testing
- XPF-008, Microcrystalline Cellulose, XPF-010
- Where
- United Kingdom
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Xenon Pharmaceuticals Inc.
Healthy Volunteer
A Phase 1 Clinical Study in Healthy Volunteers to Investigate the Drug-drug Interaction Between Multiple Doses of RO7033877 and Multiple Doses of Colistin Methanesulfonate Sodium (CMS)
This single center, open-label, randomized study will investigate the drug-drug interaction potential between multiple doses of RO7033877 and multiple doses of colistin methanesulfonate sodium (CMS).
- Trial name
- NCT02156323
- Testing
- CMS, RO7033877, RO7033877 + CMS
- Where
- Netherlands
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Herbal Interaction
Chinese Medicine Zhengyi Prescription Tea Bag
Chinese herbal tea bags can adjust physiological functions, help protect power, and give positive energy to the body. This prescription not only focuses on regulating the patient's physical function, but also helps to enhance…
- Trial name
- NCT04702659
- Where
- Taiwan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Prostate Cancer Patients
Drug-drug Interaction of SHR3680 With Repaglinide and Bupropion
The DDI study had been designed to investigate the effect of SHR3680 on the pharmacokinetics of Repaglinide and Bupropion
- Trial name
- NCT04664725
- Testing
- Repaglinide, Bupropion and SHR3680
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
RSV Infection
Drug-Drug Interaction Study Between Fluconazole and EDP-938 in Healthy Subjects
A Non-Randomized, Open-Label, Drug-Drug Interaction Study to Evaluate the Effects of Fluconazole on the Pharmacokinetics and Safety of EDP-938 in Healthy Subjects
- Trial name
- NCT04871724
- Testing
- EDP-938, Fluconazole
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Enanta Pharmaceuticals, Inc
Kidney Transplant; Complications, Drug Interaction Food
Drug Interaction With Envarsus XR and Grapefruit Juice
Transplant patients must take lifelong immunosuppression in order to prevent rejection of their organ. Tacrolimus is the most widely used immnosuppressive agent.
- Trial name
- NCT03916380
- Testing
- Grapefruit Juice
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Shirley M. Tsunoda
Idiopathic Pulmonary Fibrosis
Study of Oral Epigallocatechin-3-gallate (EGCG) in IPF Patients
The primary purpose of this multi-center, double-blind, placebo-controlled, dose-ranging Phase I study is to assess the safety of a purified from green tea, EGCG, in patients with idiopathic pulmonary fibrosis (IPF) as a…
- Trial name
- NCT05195918
- Testing
- EGCG 300 mg + Nintedanib, EGCG 300 mg + Pirfenidone, EGCG 600 mg + Nintedanib
- Where
- 7 sites in United States
- Volunteers
- 50 people
- Sponsor
- Hal Chapman
Healthy
Drug-Drug Interaction Study in Health Adult Volunteers
The purpose of this study is to assess the effects of K-877 on the pharmacokinetics of digoxin in healthy adult volunteers.
- Trial name
- NCT02273986
- Testing
- Digoxin, K-877
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kowa Research Institute, Inc.
Schizophrenia
Interactions of Fronto-Parietal High Frequency rTMS on Anterior Cingulate Cortex Activation in Schizophrenia
This will be a single site pilot study. 20 subjects with EPP (Early Phase Psychosis), defined as medical record documentation of the onset of clinically significant psychotic symptoms within the past 10 years, will be enrolled.
- Trial name
- rTMS-FPCC (NCT04309370)
- Testing
- 20 Hz rTMS
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Indiana University
Healthy
A Study of Lasmiditan in Healthy Volunteers
The main purpose of the study is to investigate the blood concentrations of dabigatran etexilate and rosuvastatin when taken alone compared to when taken together with lasmiditan in healthy participants.
- Trial name
- NCT04749914
- Testing
- Lasmiditan, Dabigatran Etexilate, Rosuvastatin
- Where
- Singapore
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Healthy Subjects, Pharmacokinetics of ASP015K
A Study to Evaluate the Effect of Verapamil on the Pharmacokinetics of ASP015K in Healthy Adult Subjects
The purpose of this study is to evaluate the effect of verapamil, a P-glycoprotein (P-gp) inhibitor, on the pharmacokinetics of ASP015K.
- Trial name
- NCT02111317
- Testing
- ASP015K, verapamil
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Global Development, Inc.
HIV-1 Infection, Tuberculosis
PK Study of Rifampicin Interactions With DMPA and Efavirenz in TB
This study was done to evaluate the effect of HIV and TB treatment on a commonly used birth control method. It enrolled women who were infected with HIV and TB and were taking efavirenz (EFV; Sustiva®; an anti-HIV medication)…
- Trial name
- PRIDE-HT (NCT02412436)
- Testing
- Depot medroxyprogesterone acetate
- Where
- 5 sites in Botswana, Kenya and 2 more
- Volunteers
- 62 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Drug Interaction
The Interaction of Herbs and Statins
This project includes two separate pharmacokinetic studies with simvastatin and rosuvastatin, respectively. Each study is an open-label, single-dose, randomized, three-phase (no herbs, with green tea, with soy isoflavones)…
- Trial name
- NCT05072405
- Testing
- Simvastatin 20 mg (Zocor®, MSD), rosuvastatin 10 mg (Crestor®, Astra Zeneca)
- Where
- Hong Kong
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Healthy; Adult; Volunteer; Colchicine; Pharmacokinetics; Diltiazem; Cytochrome p450 3A4; P-glycoprotein
Drug-Drug Interaction Study Between Colchicine and Diltiazem ER
Colchicine is a substrate for both cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp). Extended-release diltiazem (diltiazem ER) is a potent inhibitor of both CYP3A4 and P-gp.
- Trial name
- NCT00983372
- Testing
- Colchicine, Diltiazem ER
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mutual Pharmaceutical Company, Inc.
Inflammatory Bowel Disease
Interactions Between Immune Cells of Intestinal Mucosa or Peripheral Blood With the Extracellular Matrix in Inflammatory Bowel Disease (IBD)
The purpose of this study is to examine the effects of different environmental factors on immune cells in patients with IBD.
- Trial name
- IBD (NCT00915044)
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Healthy
Pharmacokinetic Drug Interaction Between Pregabalin and Thioctic Acid.
A randomized, open-label, six-sequence, three-period, three-treatment, multiple dosing clinical trial to investigate the pharmacokinetic drug interaction between Pregabalin and Thioctic acid after oral administration in healthy…
- Trial name
- NCT01808300
- Testing
- Pregabalin 300mg, Thioctic acid 600mg
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Unimed Pharmaceuticals
Cocaine Abuse, Cocaine-Related Disorders
Progesterone for the Treatment of Cocaine Dependence - 1
Past research has demonstrated that cocaine dependent women experience less severe responses to cocaine during the luteal phase of the menstrual cycle, when estrogen and progesterone concentrations are high.
- Trial name
- NCT00218257
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of Minnesota
Healthy Subjects
A Study to Evaluate Orally-Administered Oseltamivir and Intravenous Zanamivir in Healthy Subjects
This study is a 4 period study to see if there is any interaction between Orally-Administered Oseltamivir and Intravenous Zanamivir in Healthy Thai Adult Subjects
- Trial name
- NCT00540501
- Testing
- Oseltamivir and Intravenous Zanamivir
- Volunteers
- healthy volunteers welcome
- Sponsor
- GlaxoSmithKline