Clinical trials: Drug Effect
HPV Knowledge
AI Chatbot Education for Improving HPV Knowledge Among University Students
Human papillomavirus (HPV) is one of the most common sexually transmitted infections worldwide and is associated with several cancers. Adequate knowledge about HPV and vaccination remains limited among university students.
- Trial name
- AIHPV (NCT07684378)
- Testing
- AI Chatbot-Based Education, Standard Written Education
- Where
- Cyprus
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Near East University, Turkey
Heart Failure With Reduced Ejection Fraction
A Study to Assess the Effect of Danicamtiv on the Drug Levels of Midazolam in Participants With Stable Heart Failure
The purpose of this study is assess the effect of danicamtiv, as an inducer on the drug levels of midazolam in participants with heart failure with reduced ejection fraction (HFrEF).
- Trial name
- NCT05952089
- Testing
- Danicamtiv, Midazolam
- Where
- 5 sites in United States
- Volunteers
- 13 people
- Sponsor
- Bristol-Myers Squibb
Prostatic Neoplasms
Drug-drug-interaction Study to Assess the Effect of Darolutamide on the Pharmacokinetics of Probe Substrates of CYP3A4 and P-gp in Healthy Male Volunteers
Evaluate the effect of darolutamide on the pharmacokinetics of a probe CYP3A4 substrate and Pgp substrate
- Trial name
- NCT03237416
- Testing
- Dabigatran etexilate, Midazolam, BAY1841788 (darolutamide)
- Where
- Germany
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Bayer
Drug Interactions
S(+)-Ibuprofen Effects on Asprin Treated Volunteers
The purpose of this clinical trial is to determine whether S(+)-ibuprofen affect the platelet inhibition under steady state acetylsalicylic acid conditions.
- Trial name
- NCT00442585
- Testing
- S(+)-ibuprofen
- Where
- Austria
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Gebro Pharma GmbH
Healthy Volunteers
A Study to Assess the Effect of Ketoconazole on the Pharmacokinetics of Abiraterone Following Administration of Abiraterone Acetate Tablets in Healthy Adult Men
The purpose of this study is to evaluate the pharmacokinetics, safety, and potential for drug-drug interactions when a strong inhibitor of CYP3A4 (ie, ketoconazole) is co-administered with abiraterone acetate in healthy adult men.
- Trial name
- NCT01588782
- Testing
- Period 1: Abiraterone, Period 2: Abiraterone/Ketoconazole
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Complex Dyslipidemia
A Observational Study to Evaluate Lipid-lowering Drug Its Effect on Parameters in Dyslipidemia of Type 2 Diabetes.
1. Target disease: Patients with combined dyslipidemia accompanied by type 2 diabetes who has done exogenous visit or hospitalization from Jan 2010 to June 2014. 2. Study objective: 1.
- Trial name
- NCT02382159
- Where
- South Korea
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Yooyoung Pharmaceutical Co., Ltd.
Drug Toxicity
Phase I Clinical Trial to Investigate the Safety, Tolerability, Pharmacokinetics of KD101 in Healthy Male Subjects
To Evaluate the safety and tolerability after KD101 single oral dosing in healthy male subjects To Evaluate the pharmacokinetic property after KD101 single oral dosing in healthy male subjects To Evaluate the effect of food on…
- Trial name
- NCT01979380
- Testing
- KD101
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kwang Dong Pharmaceutical co., ltd.
Infection, Human Immunodeficiency Virus
A Study to Evaluate the Effect of BMS-955176 on Pharmacokinetics of Dolutegravir and the Effect of Dolutegravir on the Pharmacokinetics of BMS-955176
The purpose of this study is to evaluate how BMS955176 affects pharmacokinetics (PK) of Dolutegravir (DTG) and also how DTG administration affects the PK of BMS955176
- Trial name
- NCT02715479
- Testing
- Dolutegravir, BMS955176
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Alcohol Use Disorder
Behavioral Effects of Drugs: Inpatient (36) (Alcohol, Duloxetine, and Methylphenidate)
This study will evaluate the behavioral effects of alcohol during maintenance on placebo, duloxetine, methylphenidate and duloxetine combined with methylphenidate using sophisticated human laboratory methods.
- Trial name
- BED[IN]:36 (NCT03575403)
- Testing
- Alcohol, Duloxetine (60 MG), Methylphenidate
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Craig Rush
ADHD
Single and Combined Effects of Behavioral, Academic, and Medication Treatments for ADHD in the Classroom
This study is the first to systematically evaluate the efficacy of single and combined academic accommodation, behavioral treatment, and medication treatment in a large sample of children with ADHD.
- Trial name
- NCT05469386
- Testing
- Methylphenidate Hydrochloride ER, Behavioral classroom, General Classroom
- Where
- 2 sites in United States
- Volunteers
- 288 people
- Sponsor
- Florida International University
Diabetes Mellitus, Gastroparesis
Drug Trial of Lixisenatide on Gastric Emptying and Blood Pressure Drops in Type 2 Diabetics and Healthy People
The purpose of this study is to determine the effects of the drug lixisenatide on blood sugar levels, stomach emptying, blood pressure and heart rate, release of gut hormones and blood flow in the gut after a glucose drink in…
- Trial name
- Lixi (NCT02308254)
- Testing
- Lixisenatide
- Where
- Australia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Royal Adelaide Hospital
Acute Coronary Syndrome
Clopidogrel Maintaining Dosage in Acute Coronary Syndrome After Drug Eluting Stent Implantation
In view of its safety profile and the results of clinical trials, clopidogrel has become the standard treatment for patients with acute coronary syndrome (ACS) and drug eluting stent(DES) implantation.
- Trial name
- NCT00404053
- Testing
- Clopidogrel
- Sponsor
- Shenyang Northern Hospital
COPD, COPD Exacerbation
Nurse-led COPD Self-management Intervention
Introduction: Chronic Obstructive Pulmonary Disease (COPD) disease highest mortality and morbidity of respiratory diseases that third cause of death in the world and Turkey.
- Trial name
- NCT04459546
- Testing
- patient education, training booklet, 3 months tele health
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Pamukkale University
Metabolism
Effect of Genetics on Metabolism of Efavirenz
This study will evaluate the effects of genetics on metabolism of the anti-HIV medicine efavirenz (Sustiva) and will see if Efavirenz interacts with bupropion (Zyban or Wellbutrin), a drug commonly used to treat depression and to…
- Trial name
- NCT00245986
- Testing
- Blood draw
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Schizophrenia
Therapeutic Drug Monitoring for Individualized Clozapine Therapy
The purpose of this study is to evaluate the factors affecting the occurrence of adverse drug reactions (glucose and lipid metabolism abnormality, changes in liver function index and sleeping tendency) and clinical effects in…
- Trial name
- NCT03523741
- Testing
- Clozapine
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Hospital
COVID-19
Effect of CytoSorb Adsorber on Hemodynamic and Immunological Parameters in Critical Ill Patients With COVID-19
This prospective randomized single Center study investigates to what extent the physical elimination of the inflammatory mediators using the CytoSorb adsorber reduces the morbidity of severely and critically ill patients with…
- Trial name
- CYTOCOV-19 (NCT04344080)
- Testing
- CytoSorb-Therapy
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Healthy
A Study to Learn if the Study Medicine Called Itraconazole and if Food Changes How the Body Processes the Other Study Medicine Called PF 07258669 in Older Adults or Healthy Adults
The purpose of this study is to learn how the medicine called itraconazole and food changes how the body processes another study medicine called PF-07258669 in older adults or healthy adults.
- Trial name
- NCT06706869
- Testing
- PF-07258669, Itraconazole
- Where
- 2 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Pfizer
Dyslipidemia, Diabetes
Meta-analyses of the Effect of Important Food Sources of Sugars on Cardiometabolic Risk Factors
Fructose-containing sugars have been implicated in the epidemics of obesity, diabetes and related cardiometabolic disorders. This view is supported by lower quality evidence from ecological observations, animal models, and select…
- Conditions
- Dyslipidemia, Diabetes, Prediabetes, Dysglycemia
- Trial name
- NCT02716870
- Testing
- Fructose-containing Sugars
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Stress Disorders, Post-Traumatic, Alcohol Abuse
Combined Treatment for Alcohol-Dependent Individuals With PTSD
This treatment intervention trial is designed for men and women with either alcohol misuse (e.g. hazardous or binge drinking) or alcohol use disorders (alcohol abuse or dependence) and comorbid PTSD.
- Conditions
- Stress Disorders, Post-Traumatic, Alcohol Abuse, Substance-Related Disorders
- Trial name
- NCT00262223
- Testing
- Seeking Safety, Sertraline
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- New York State Psychiatric Institute
Bipolar Disorder (BD), Suicidality
Neural Correlates of Ketamine's Anti-suicidal Effects in Bipolar Depression
Bipolar disorder is characterized by manic episodes and episodes of extreme depressive feelings, also known as bipolar depression (BD).
- Trial name
- DEEPP (NCT05177146)
- Testing
- Intravenous Ketamine (IV)
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Centre for Addiction and Mental Health