Clinical trials: Drug Discontinuation
Proton Pump Inhibitor, Inappropriate Drug Use
Patient Journey Application for Discontinuing Inappropriate PPI Use: a Randomized Controlled Trial
Rationale/objective: This study hypothesizes that offering patient-tailored and dosed information on PPI discontinuation in patients with inappropriate chronic PPI use will result in an increased discontinuation rate when…
- Conditions
- Proton Pump Inhibitor, Inappropriate Drug Use, Discontinuation, E-health
- Trial name
- SUPPORT (NCT05348252)
- Testing
- Patient Journey App, Information folder
- Where
- Netherlands
- Volunteers
- 163 people
- Sponsor
- Radboud University Medical Center
Cognitive Behavioral Therapy, Obsessive-Compulsive Disorder
CBT Augmentation to Promote Medication Discontinuation in Pediatric OCD
The purpose of this study is to examine whether youth with OCD who benefit from CBT augmentation to SRI can discontinue their medication without relapse over 24 weeks.
- Conditions
- Cognitive Behavioral Therapy, Obsessive-Compulsive Disorder, Obsessive-Compulsive Disorder in Children, Obsessive-Compulsive Disorder in Adolescence
- Trial name
- NCT05609916
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Baylor College of Medicine
Auricular Fibrillation, Anticoagulant Drugs
Discontinuation for Oral Anticoagulants in Patients With Atrial Fibrillation
The purpose of this study is to compare the discontinuation rates for vitamin K antagonists and for direct oral anticoagulants during their first year
- Trial name
- NCT04133545
- Where
- Argentina
- Volunteers
- 360 people
- Sponsor
- Hospital Italiano de Buenos Aires
Healthy Subjects
Lung Bioavailability With Continuous or Discontinuous Nebulization
To compare the continuous and sicontinuous delivery of drug with AKITA.
- Trial name
- NCT01913184
- Testing
- AKITA
- Where
- Belgium
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Colorectal Neoplasms, Melanoma
A Rollover Study for Patients Who Received Tremelimumab in Other Protocols, to Allow the Patients Access to Tremelimumab Until This Agent Becomes Commercially Available or Development is Discontinued.
This study is intended to provide access to tremelimumab for patients who have previously received tremelimumab in a clinical trial.
- Conditions
- Colorectal Neoplasms, Melanoma, Prostatic Neoplasms, Renal Cell Carcinoma
- Trial name
- NCT00378482
- Testing
- CP-675,206 (Tremelimumab)
- Where
- 6 sites in United States, United Kingdom
- Volunteers
- 37 people
- Sponsor
- AstraZeneca
Epilepsy
Outcomes After Planned Discontinuation of AntiSeizure Medication
The main purpose of this study is to understand the effects of continuing versus discontinuing antiseizure medications after a period of seizure-freedom.
- Trial name
- STOP-ASM (NCT07750496)
- Testing
- Discontinue antiseizure medications
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Schizophrenia
Predictors of Functional Remission in Discharged Patients With Schizophrenia After Long-term Drug Discontinuation
Study objectives: 1. Describe the characteristics of discharged patients with schizophrenia achieving functional remission after drug discontinuation. 2.
- Trial name
- NCT05667961
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Shanghai Mental Health Center
Melanoma Stage IV, Melanoma Stage III
Safe Stop Ipilimumab-nivolumab (IPI-NIVO) Trial
Safe Stop IPI-NIVO Trial: Early discontinuation of nivolumab upon achieving a (confirmed) complete or partial response in patients with irresectable stage III or metastatic melanoma treated with first-line ipilimumab-nivolumab
- Conditions
- Melanoma Stage IV, Melanoma Stage III, Immunotherapy, Toxicity, Drug
- Trial name
- NCT05652673
- Testing
- nivolumab
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Erasmus Medical Center
Rheumatoid Arthritis
Screening for Flare After b/tsDMARD Discontinuation in Rheumatoid Arthritis
To evaluate whether stringent follow-up consisting of combined laboratory and ultrasound surveillance is superior to clinical monitoring alone to maintain clinical remission in rheumatoid arthritis.
- Trial name
- NCT05119452
- Testing
- Discontinuation of biological/targeted synthetic disease modifying anti-rheumatic drug (b/tsDMARD)
- Volunteers
- 85 people
- Sponsor
- Medical University of Vienna
Depressive Symptoms, Expectations
Disentangling Pharmacological and Expectation Effects in Antidepressant Discontinuation
Antidepressant medication is established as an evidence-based, guideline-recommended treatment for Major Depressive Disorders. In the past decades, prescriptions of antidepressant medication have markedly increased, with a…
- Conditions
- Depressive Symptoms, Expectations, Antidepressants
- Trial name
- PHEA (NCT05191277)
- Testing
- Treatment 'discontinuation of antidepressant medication', Treatment 'continuation of antidepressant medication', Expectation 'high'
- Where
- Germany
- Volunteers
- 56 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Chronic Pain, Opioid Pain Medication
Discontinuation From Chronic Opioid Therapy For Pain Using a Buprenorphine Taper
Chronic opioid therapy for pain can be associated with significant risks, and a significant number of patients maintained on chronic opioids have continued pain and/or poor functioning.
- Trial name
- NCT02737826
- Testing
- Buprenorphine Initiation - Phase I, Gabapentin + Buprenorphine - Phase II, Buprenorphine taper - Phase II
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Medical University of South Carolina
Palliative Medicine, Cardiovascular Disease
Statin Discontinuation in Advanced Illness
The purpose of this study is to determine if there is a difference in survival rate at 60 days after enrollment between patients with advanced life-limiting illness for whom statins are discontinued vs.
- Trial name
- NCT01415934
- Testing
- discontinue statins
- Where
- 15 sites in United States
- Volunteers
- 381 people
- Sponsor
- University of Colorado, Denver
Pain, Chronic, Pain, Medication
Paracetamol Discontinuation in the Elderly After Long-term Consumption
To investigate if long-term treatment of paracetamol can be discontinued without no worsening on pain, health-related quality-of-life and level of function compared to continuing paracetamol treatment in patients aged 65 years or…
- Conditions
- Pain, Chronic, Pain, Medication, Pain, Discontinuation
- Trial name
- PARADISE (NCT04523740)
- Testing
- Paracetamol
- Where
- Denmark
- Volunteers
- 98 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Human Immunodeficiency Virus
Triumeq As an Integrase Single Tablet Regimen in People With HIV Who Inject Drugs
The purpose of this study is to assess the tolerability, adherence and efficacy of single tablet dolutegravir/abacavir/lamivudine antiretroviral therapy in people living with HIV with a history of injection drug use (IDU)…
- Trial name
- TAISTR (NCT02659761)
- Testing
- dolutegravir/abacavir/lamivudine
- Where
- Ireland
- Volunteers
- 33 people
- Sponsor
- University College Dublin
Chronic Coronary Syndrome
Drug-Coated Balloon Versus Drug-Eluting Stent for Treatment of De-Novo Coronary Lesions in Patients With High Bleeding Risk-2
A prospective, multi-center, open-label, randomized controlled, and superiority trial. The trial will compare clinical outcomes between discontinuation of antiplatelet agent and continuation of antiplatelet agent in HBR patients…
- Trial name
- DCB-HBR-2 (NCT06742931)
- Testing
- Discontinuation of antiplatelet agent group, Continuation of antiplatelet agent group
- Where
- 18 sites in South Korea
- Volunteers
- 1,200 people
- Sponsor
- Samsung Medical Center
Acquired Brain Injury
Transition From Pediatric to Adult Care in Young Adults With Acquired Brain Injury
This retrospective, single-center observational study evaluates young adults with acquired brain injury who attended a joint pediatric-adult Physical and Rehabilitation Medicine transition consultation at Hôpitaux Paris Est…
- Trial name
- NEURO-TEA (NCT07881042)
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Hopitaux de Saint-Maurice
Metastatic Breast Cancer
The CDK4/6 Inhibitor Dosing Knowledge (CDK) Study
The purpose of this study is to generate evidence on an alternative dosing strategy for CDK4/6 inhibitors to help more patients with Metastatic Breast Cancer (MBC) (age ≥ 60 years) tolerate side effects and stay on treatment…
- Trial name
- NCT06377852
- Testing
- Palbociclib 125mg, Ribociclib 600mg, Ribociclib
- Where
- 88 sites in United States
- Volunteers
- 500 people
- Sponsor
- American Society of Clinical Oncology
HIV Infections
Effectiveness of Interleukin-2 (IL-2) Plus Anti-HIV Therapy in HIV-Positive Patients
The purpose of this study is to find out if the immune systems of HIV-positive patients can be improved by treatment with anti-HIV medications plus interleukin-2 (IL-2) in the early stages of HIV infection.
- Trial name
- NCT00001131
- Testing
- Aldesleukin, HAART
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chronic Insomnia
Facilitation of Zolpidem (≥10 mg) Discontinuation Through Use of Ramelteon in Subjects With Chronic Insomnia
The purpose of this study is to assess whether ramelteon, once daily (QD), can facilitate the discontinuation of zolpidem in subjects with chronic insomnia.
- Trial name
- NCT00492232
- Testing
- Ramelteon and zolpidem
- Where
- 41 sites in United States
- Volunteers
- 135 people
- Sponsor
- Takeda
Schizophrenia
Pragmatic RCT Comparing Aripiprazole, Olanzapine and Haloperidol in the Treatment of Schizophrenia
The GiSAS study is a multi-centre randomized clinical trial that will involve about 80 italian community psychiatric services in Italy and will recruit 800 patients affected by schizophrenia.
- Trial name
- GiSAS (NCT01052389)
- Testing
- Aripiprazole, Olanzapine, Haloperidol
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Mario Negri Institute for Pharmacological Research