Clinical trials: Drowsiness
Carpal Tunnel Syndrome, Depressive Symptoms
The Relationship of Psychological Factors and Sleep Quality With the Severity of Carpal Tunnel Syndrome
The most common entrapment neuropathy symptoms, the diagnosis of CTS, is determined by examination findings and by means of the results of electro-diagnostic test.
- Conditions
- Carpal Tunnel Syndrome, Depressive Symptoms, Sleepiness, Anxiety
- Trial name
- NCT05047367
- Testing
- cross-sectional survey study
- Where
- Turkey (Türkiye)
- Volunteers
- 149 people
- Sponsor
- Cumhuriyet University
Narcolepsy, Narcolepsy Type 1
Narcolepsy Nightmare Study
The goal of this clinical trial is to test two behavioral treatments for nightmares in adults with narcolepsy. The main questions it aims to answer are: Is imagery rehearsal therapy (IRT) effective for narcolepsy-related…
- Conditions
- Narcolepsy, Narcolepsy Type 1, Narcolepsy With Cataplexy, Narcolepsy Type 2
- Trial name
- NCT05709873
- Testing
- Imagery rehearsal therapy, Targeted dream control
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Northwestern University
Intracerebral Hemorrhage
Safety of NXY-059 for the Treatment of Patients Who Have Suffered From a Stroke
This study will determine if NXY-059 is safe in patients with an acute stroke caused by bleeding in the central nervous system. The primary objective was to assess the safety and tolerability of NXY-059 compared to placebo.
- Trial name
- NCT00075959
- Testing
- NXY-059
- Where
- 64 sites in United States
- Volunteers
- 600 people
- Sponsor
- AstraZeneca
Hypersomnia
Disentangling the Role of Depression in Hypersomnia
Individuals who have disorders of hypersomnolence (excessive sleepiness) often report symptoms of depression. The goal of this study is to further understand of the relationship between depression and hypersomnia by examining…
- Trial name
- NCT05850676
- Testing
- Sleep study
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Pennsylvania
Narcolepsy Type 1, Narcolepsy Type 2
A Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia
Narcolepsy Type 1 (NT1), Narcolepsy Type 2 (NT2), and Idiopathic Hypersomnia (IH) are rare conditions that make people feel very sleepy during the day (often referred to as excessive daytime sleepiness [EDS]).
- Conditions
- Narcolepsy Type 1, Narcolepsy Type 2, Idiopathic Hypersomnia
- Trial name
- CRYSTAL-1 (NCT06752668)
- Testing
- ORX750
- Where
- 37 sites in United States, Canada and 3 more
- Volunteers
- 248 people
- Sponsor
- Centessa Pharmaceuticals (UK) Limited
Idiopathic Hypersomnia
Low Sodium Oxybate in Patients With Idiopathic Hypersomnia
Low sodium oxybate has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of idiopathic hypersomnia.
- Trial name
- NCT05837091
- Testing
- Low Sodium Oxybate, 24-hour polysomnography, Nextsense EEG earbuds
- Where
- 4 sites in United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Major Depression, Mental Health
Provigil in Conjunction With SSRIs for the Treatment of Mild or Moderate Depression With Attendant Symptoms of Sleepiness and Fatigue.
The main purpose of this study is to determine if Provigil® (modafinil) at a dose of 200 mg once daily is safe and effective for treating symptoms of sleepiness and fatigue associated with Major Depressive Disorder when added to…
- Trial name
- NCT00208715
- Testing
- Provigil
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- Emory University
Drowsiness, Sleep Deprivation
TESTING AN MTM THEORY-BASED INTERVENTION ON REDUCING DROWSY DRIVING BEHAVIOR, "STAY AWAKE, STAY ALIVE ©," AMONG COLLEGE STUDENTS
The goal of this randomized controlled educational study is to learn whether a structured, theory-based program can help reduce drowsy driving among college students (18 years and older) in Nevada.
- Conditions
- Drowsiness, Sleep Deprivation, Fatigue
- Trial name
- NCT07434921
- Testing
- MTM Theory based intervention, Standard AAA Knowledge based
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Las Vegas
Restless Legs Syndrome, Insomnia
Restless Legs Syndrome Exercise Intervention
A pilot study of an aerobic exercise intervention to moderate symptoms and improve sleep quality among patients with Restless Legs Syndrome (RLS).
- Trial name
- NCT00258492
- Testing
- Aerobic exercise
- Volunteers
- 30 people
- Sponsor
- Northeastern Ohio Universities College of Medicine
Sleep Deprivation, Sleep Hygiene
Breakthrough Anxiety and Sleep Evaluation Using Linked Devices and Smartphone Application Onar (BASEL)
Sleep is not simply the absence of wakefulness. Sleep is an active procedure, normally happening every night, and is absolutely vital. Good sleep is essential for our well-being.
- Conditions
- Sleep Deprivation, Sleep Hygiene, Sleepiness, Sleep Driving
- Trial name
- BASEL (NCT06027047)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Raivotech
Obstructive Sleep Apnea (OSA), Excessive Daytime Sleepiness
SLEEPINESS - a Search for a Biomarker of Excessive Daytime Sleepiness in Severe Obstructive Sleep Apnoea - An Explorative Study
Study aim: This study aims to use a new brainwave monitoring device that meassure brainwaves 24 hours a day to create better understanding of sleep-wake interplay as a biomarker for excessive daytime sleepiness because of…
- Trial name
- NCT06711159
- Testing
- continuous positive airway pressure
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Zealand University Hospital
Narcolepsy, Cataplexy
Cardiovascular Variability and Heart Rate Arousal Response in Idiopathic Hypersomnia
Autonomic nervous system dysfunction has been described in narcolepsy with cataplexy affecting the sympathetic function. In this study the investigators analyzed whether altered diurnal and nocturnal cardiovascular control is…
- Trial name
- NCT02913651
- Testing
- Polysomnography
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Dementia With Lewy Bodies
"Pilot Study of Armodafinil in Patients With Dementia With Lewy Bodies"
This research study is to examine the effects of the study medication Armodafinil in patients with dementia with Lewy bodies (DLB).
- Trial name
- NCT01023672
- Testing
- Armodafinil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Sleep Deprivation
EEG Analysis for the Objective Assessment of Drowsiness
The objective of this clinical study is to develop solutions for the evaluation and management of drowsiness, based on 2 EEG sensors only, aiming at reducing the risk of accidents related to secondary hypersomnolence (sleepiness…
- Trial name
- MEEGASAFE (NCT05453643)
- Testing
- sleep deprivation patterns
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Physip S.A
Sleep Deprivation, Sleepiness
Metabolomics-based Sleepiness Markers
Estimating that people sleep on average up to two hours less over the last decades, sleepiness and fatigue need to be considered as significant societal problems of the modern world.
- Conditions
- Sleep Deprivation, Sleepiness, Insufficient Sleep Syndrome
- Trial name
- ME-SMART (NCT05585515)
- Testing
- Sleep deprivation, Sleep restriction
- Where
- Switzerland
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Narcolepsy, Excessive Sleepiness
Study Assessing Effects of JZP-110 on Driving Performance in the Treatment of Excessive Sleepiness in Narcolepsy
This trial is a randomized, double-blind, placebo-controlled, crossover study to evaluate the effect of JZP-110 on driving performance in subjects with excessive sleepiness due to narcolepsy.
- Trial name
- NCT02806908
- Testing
- JZP-110
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- Jazz Pharmaceuticals
Chronic Fatigue, Breast Cancer
Acupressure for Persistent Cancer Related Fatigue
There are over 2 million breast cancer survivors today. Persistent Cancer-Related fatigue (PCRF), a state of being tired or weary, is one of the most common and distressing symptoms experienced by breast cancer (BC) survivors.
- Conditions
- Chronic Fatigue, Breast Cancer, Sleepiness
- Trial name
- AcuCrft (NCT01281904)
- Testing
- Relaxation Acupressure, Stimulating Acupressure
- Where
- United States
- Volunteers
- 288 people
- Sponsor
- University of Michigan
Narcolepsy
Discovering Factors in Narcolepsy Patients' Clinical Research Experiences
An observational trial can provide a platform for patients to share experiences and perspectives on living with narcolepsy, which can inform the development of new treatments and support programs.
- Trial name
- NCT05870735
- Volunteers
- 500 people
- Sponsor
- Power Life Sciences Inc.
Sleep
Investigating Preferred Nap Schedules for Adolescents
The aim of this study is to examine the neurobehavioural responses to two successive cycles of sleep manipulation nights and recovery nights in adolescents, and to determine the benefits of napping on cognitive performance…
- Trial name
- NFS5 (NCT04044885)
- Testing
- Nap
- Where
- Singapore
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School
Narcolepsy, Excessive Daytime Sleepiness
Four-week Study of the Safety and Efficacy of NLS-2 (Mazindol Extended Release) in the Treatment of Narcolepsy
This is a double-blind, randomized, placebo-controlled, multicenter trial of NLS-2 in adult patients with narcolepsy. The study will enroll approximately 60 patients and eligible patients will be treated to receive either NLS-2…
- Conditions
- Narcolepsy, Excessive Daytime Sleepiness, Cataplexy Narcolepsy
- Trial name
- NCT04923594
- Testing
- mazindol extended release
- Where
- 22 sites in United States
- Volunteers
- 67 people
- Sponsor
- NLS Pharmaceutics