Clinical trials: Down Syndrome (DS), open to volunteers
B Acute Lymphoblastic Leukemia Associated With Down Syndrome, Down Syndrome
A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia
This study attempts to learn more about the health of persons with Down syndrome after treatment for acute leukemia. Children with Down syndrome are at increased risk for side effects during treatment for acute leukemia, but it…
- Conditions
- B Acute Lymphoblastic Leukemia Associated With Down Syndrome, Down Syndrome, Myeloid Leukemia Associated With Down Syndrome
- Trial name
- NCT05702645
- Testing
- Biospecimen Collection, Clinical Evaluation, Neurocognitive Assessment
- Where
- 73 sites in United States, Canada
- Volunteers
- 330 people
- Sponsor
- Children's Oncology Group
Down Syndrome (DS), Alzheimer's Disease (AD)
Adapting RDAD for DS
The goal of this clinical trial is to observe feasibility and initial efficacy of a remotely delivered exercise and dementia caregiving intervention in older adults with Down syndrome and their caregivers.
- Trial name
- CareFit DS/AD (NCT07425769)
- Testing
- Remote Exercise Sessions, Caregiver Education Sessions
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Kansas Medical Center
Obstructive Sleep Apnea, Down Syndrome
Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS)
The overall objective of this randomized clinical trial is to test the effectiveness of a personalized approach to the surgical treatment of OSA in children with Down syndrome (DS).The estimated prevalence of obstructive sleep…
- Trial name
- TOPS-DS (NCT05508971)
- Testing
- DISE-Directed Surgery, Adenotonsillectomy
- Where
- 7 sites in United States
- Volunteers
- 304 people
- Sponsor
- Oregon Health and Science University
Down Syndrome, Alzheimer Disease
Trial-Ready Cohort-Down Syndrome (TRC-DS)
The purpose of the Trial-Ready Cohort - Down Syndrome (TRC-DS) is to enroll 120 healthy adults with Down syndrome (DS), between the ages of 25-55, into a trial ready cohort (TRC), and up to 550 participants in total including…
- Conditions
- Down Syndrome, Alzheimer Disease, Dementia
- Trial name
- TRC-DS (NCT04165109)
- Where
- 22 sites in United States, France and 3 more
- Volunteers
- 550 people
- Sponsor
- University of Southern California
Intellectual Disabilities (F70-F79), Down Syndrome (DS)
Using Technologies to Promote HEalthy Lifestyles in Adolescents With Intellectual Disabilities
IDHEApp will implement various educational technology tools and work with the families, teachers and caregivers to increase physical activity (PA) and improve healthy eating.
- Conditions
- Intellectual Disabilities (F70-F79), Down Syndrome (DS), Autism Disorder
- Trial name
- IDHEAPP (NCT07101523)
- Testing
- mHealth
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- University of Seville
Down Syndrome (DS)
The Effect of the HEP Approach in Infants With Down Syndrome
This study evaluates the effect of the HEP (Homeostasis-Enrichment-Plasticity) approach on motor and sensory development in infants with Down syndrome.
- Trial name
- HEP-DS (NCT07163780)
- Testing
- HEP Intervention, Traditional Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Izgi Miray Demirbag
Down Syndrome
DS-Connect®: The Down Syndrome Registry
The goal of this study is to develop a registry for Down syndrome (DS) to facilitate research participation by individuals with Down syndrome.
- Trial name
- NCT01950624
- Where
- United States
- Volunteers
- 100,000 people
- Sponsor
- University of Colorado, Denver
Pediatric Obstructive Sleep Apnea, Down Syndrome (DS)
Pediatric Down Syndrome Post-Approval Study
The purpose of this Post Approval research study is to assess ongoing safety and effectiveness of the Inspire therapy in adolescents and young adults (age 13-18) with Down syndrome and severe sleep apnea.
- Trial name
- NCT06851338
- Testing
- Hypoglossal Nerve Stimulation
- Where
- 6 sites in United States
- Volunteers
- 60 people
- Sponsor
- Inspire Medical Systems, Inc.
Down Syndrome-Associated Alzheimer's Disease (DS-AD)
A Study to Evaluate Mivelsiran in Adult Participants With Early-Stage Down Syndrome-Associated Alzheimer's Disease (DS-AD)
The purpose of the study is to evaluate the effect of mivelsiran in adult participants with early-stage DS-AD and to characterize the safety, tolerability, and pharmacodynamics (PD) of mivelsiran.
- Trial name
- NCT07636811
- Testing
- Mivelsiran
- Where
- 10 sites in United States, Spain
- Volunteers
- 58 people
- Sponsor
- Alnylam Pharmaceuticals
Down Syndrome (DS)
NAD Augmentation to Prevent or Reverse Alzheimer's Disease in People With Down Syndrome
The aim of the study is to determine the safety and tolerability of different increasing doses of MIB-626 (a microcrystalline form of β nicotinamide mononucleotide; NMN) given daily for 28 consecutive days to adults with Down…
- Trial name
- NCT07278492
- Testing
- MIB-626
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Brigham and Women's Hospital
Down Syndrome (DS), Down Syndrome (Trisomy 21)
Amyloid Lowering for Alzheimer's in Down's With Donanemab Investigation
The goal of this clinical trial is to learn if donanemab can reduce levels of amyloid in the brain, and if donanemab is safe and well-tolerated in participants with Down syndrome.
- Conditions
- Down Syndrome (DS), Down Syndrome (Trisomy 21), Alzheimer Disease, Amyloid Beta Protein
- Trial name
- ALADDIN (NCT06911944)
- Testing
- Donanemab
- Volunteers
- 60 people
- Sponsor
- Michael Rafii, MD, PhD
AML (Acute Myelogenous Leukemia), Down Syndrome (DS)
The Efficacy of Therapy in Patients With Acute Myeloid Leukemia and Down Syndrome in Russia
This prospective non-randomized multicenter trial created based on protocol ML DS 2006 and aimed at standardization of current therapy approaches and creating a national network for diagnostic, treatment and monitoring of…
- Trial name
- AML-DS-2025 (NCT07232134)
- Testing
- 4 chemotherapy blocks: Course 1 AIE (cytarabine/idarubicin/etoposide), Course 2 AI (cytarabine/idarubicin), Course 3 HAD (high-dose cytarabine (1g)/daunorubicin), Course 4 HA (high-dose cytarabine).
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Down Syndrome
Physical Fitness in DS: A Comparison of Cuevas Medak and Rebound Exercises
This randomized clinical trial investigates the comparative effects of Cuevas Medak Exercises Vs Rebound Exercises on physical fitness in DS.
- Trial name
- DownSyndrome (NCT07248449)
- Testing
- Cuevas Medak Exercises
- Where
- Pakistan
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Down Syndrome, Down Syndrome (DS)
LEvetiracetam to Prevent Seizures in Symptomatic Alzheimer's Disease in Adults With Down Syndrome
The purpose of this study is to evaluate whether levetiracetam can prevent epileptic seizures in patients with Alzheimer's disease associated with Down syndrome.
- Conditions
- Down Syndrome, Down Syndrome (DS), Down Syndrome (Trisomy 21), Alzheimer Dementia
- Trial name
- LESS-AD (NCT07234695)
- Testing
- Levetiracetam 500mg
- Where
- 5 sites in Spain
- Volunteers
- 120 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Down Syndrome
Effects of Powerball in Children With Down Syndrome
This randomised clinical trial investigates the effects of powerball using static and dynamic surface on upper limb Endurance and coordination in children with Down Syndrome.
- Trial name
- NCT07244133
- Testing
- Power ball with static surface, Powerball with dynamic surface
- Where
- Pakistan
- Volunteers
- 28 people
- Sponsor
- Riphah International University
Down Syndrome (DS), Keratoconus
Compassionate Use Study of Epi-ON Corneal Collagen Crosslinking Performed Using UVA Exposure on Eyes With Ectatic Corneal Diseases for Subjects With Down Syndrome
The goal of this clinical trial is to study the effects of an experimental (not Food and Drug Administration (FDA)-approved) treatment called corneal crosslinking (CXL) for conditions in which the cornea becomes progressively…
- Conditions
- Down Syndrome (DS), Keratoconus, Pellucid Marginal Degeneration, Forme Fruste Keratoconus (FFK)
- Trial name
- NCT07135167
- Testing
- Epi-ON corneal cross-linking (CXL)
- Where
- 12 sites in United States
- Volunteers
- 225 people
- Sponsor
- Woolfson Eye Institute
Down Syndrome (DS)
Suspension Therapy Effects on Mobility and Balance in Down Syndrome
Down syndrome (DS) is one of the most common congenital disorders. Individuals with Down syndrome present with several impairments such as hypotonia, ligament laxity, decreased muscle strength, insufficient muscular…
- Trial name
- STOMP (NCT06748248)
- Testing
- suspension Therapy, Routine Treatment
- Where
- 2 sites in Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University