Clinical trials: Diverticular Disease
Colonic Diverticula
Predictive Value of DICA in the Diverticular Disease of the Colon
The Diverticular Inflammation and Complication Assessment (DICA) is an endoscopic classification for diverticulosis and diverticular disease of the colon.
- Trial name
- NCT02758860
- Testing
- Colonoscopy
- Where
- 45 sites in Brazil, Italy and 5 more
- Volunteers
- 2,215 people
- Sponsor
- University of Roma La Sapienza
Diverticulitis
Is It So Hard To Predict Complicated Diverticulitis?
Is It So Hard To Predict Complicated Diverticulitis? Objective: Acute diverticulitis (AD) is a frequent cause of abdominal pain leading to emergency department visits.
- Trial name
- NCT07322926
- Where
- Turkey (Türkiye)
- Volunteers
- 101 people
- Sponsor
- Haydarpasa Numune Training and Research Hospital
Diverticular Disease of Colon, Colostomy Complication
Comparing Hartmann's Procedure and Primary Resection With Anastomosis in Hinchey III-IV Diverticulitis: Focus on Ostomy Closure and Long-Term Outcomes
Brief Summary This multicenter study compares the effectiveness of primary anastomosis with diverting loop ileostomy to Hartmann's procedure for managing perforated sigmoid diverticulitis in stable patients.
- Conditions
- Diverticular Disease of Colon, Colostomy Complication, Colostomy - Stoma
- Trial name
- ARES (NCT06794905)
- Volunteers
- 578 people
- Sponsor
- Azienda Sanitaria Locale Napoli 2 Nord
Colonic Cancer, Rectal Cancer
Transversus Abdominis Plane (TAP) Block for Postoperative Analgesia After Laparoscopic Colonic Resection
Laparoscopic (key-hole) large bowel resection is a minimally invasive procedure when compared to open large bowel resection, but is still associated with a significant amount of pain and discomfort.
- Conditions
- Colonic Cancer, Rectal Cancer, Colonic Diverticulum, Ulcerative Colitis
- Trial name
- NCT01339273
- Testing
- Ultrasound guided Transversus Abdominis Plane (TAP) bock, Local anaesthetic infiltration of laparoscopic port sites
- Where
- United Kingdom
- Volunteers
- 72 people
- Sponsor
- Oxford University Hospitals NHS Trust
Diverticulitis
Recurrence Following Nonoperative Management of 1st Episode of Hinchey II Diverticulitis
Patients will agree to be randomized to either surgery or observation following nonoperative management of a first episode of Hinchey II diverticulitis.
- Trial name
- NCT01986686
- Testing
- Colon resection
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Stony Brook University
Colorectal Cancer, Diverticular Diseases
Initial Safety of SFM Plus OTOLoc for Creating Side-to-side or End-to-side Colorectal Anastomoses
The primary objective of this trial is to investigate the safety and effectiveness of the Flexagon 25mm SFM system plus OTOLoc when used to create a side-to-side Ileo-colic, Colo-colonic and side-to-side or end-to-side colorectal…
- Trial name
- Colonic (NCT07276529)
- Testing
- Flexagon Self Forming Magnet Anastomosis Plus OTOLoc for Creating side-to-side Colon Anatomoses
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- GI Windows, Inc.
Diverticulitis, Colon Disease
Comparison of NOM for ACLD Between Medical and Surgical Ward
In Europe, patients with acute left colon diverticulitis (ALCD) are usually admitted to surgical wards even when only medical treatment is required.
- Conditions
- Diverticulitis, Colon Disease, Acute Diverticulitis
- Trial name
- NCT06265649
- Testing
- NOM
- Where
- Italy
- Volunteers
- 175 people
- Sponsor
- Ospedali Riuniti Trieste
Diverticulosis
Evaluate the Safety and Diagnostic Advantages of Tilt Down Verses Standard Horizontal Colonoscopy Positioning
A tortuous sigmoid colon makes colonoscopy difficult. The purpose of this study was to systematically evaluate the diagnostic utility and incidence of adverse events in women using standard horizontal compared to lateral tilt…
- Trial name
- CTDTTIE (NCT01815671)
- Testing
- colonoscopy in the lateral horizontal position
- Where
- United States
- Volunteers
- 173 people
- Sponsor
- Specialists in Gastroenterology, LLC
Colonic Neoplasms, Diverticulosis, Colonic
Interest of the Nefopam and PCA Morphine Combination for Postoperative Analgesia in Patients Undergoing Colon Surgery
This study analyses interest of iv nefopam in combination with paracetamol after major abdominal surgery because the effect of morphine-sparing is discussed when combined these agents.
- Trial name
- NEFOPAM (NCT03619538)
- Testing
- Nefopam, saline solution
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Zenker Diverticulum
Endoscopic Treatment of Zenker's Diverticulum (ZENKTUN)
Prospective comparative observational study in numerous reference centers in France, comparing Tunnelization (Z-POEM) versus Non-Tunnelization Techniques according to the usual practices.
- Trial name
- NCT06594718
- Testing
- Endoscopic diverticulotomy with Z-POEM, Endoscopic diverticulotomy using a non-tunnelization technique
- Volunteers
- 128 people
- Sponsor
- Société Française d'Endoscopie Digestive
Diverticular Disease of the Colon
Mesalazine and/or Lactobacillus Casei in the Diverticular Disease of the Colon
This is a multi-centre, randomised, double blind, double-dummy, parallel groups, placebo-controlled trial was conducted in a population of patients suffering from symptomatic uncomplicated diverticular disease in order to…
- Trial name
- NCT01534754
- Testing
- Mesalazine plus Lactobacillus casei, Mesalazine 800 mg, Lactobacillus casei
- Where
- 14 sites in Italy
- Volunteers
- 250 people
- Sponsor
- Hospital Cristo Re
Infertile Patients With Previous Live Birth
The Outcome and Influence Factors of Assisted Reproductive Therapy in Patients With Cesarean Scar Uterus.
Mode of delivery affects the success rate of assisted reproductive techniques (ART). In this case study, the investigators will evaluate changes in the bacterial ecology and inflammatory markers of the female uterus with…
- Trial name
- NCT04070222
- Testing
- Hysteroscopy
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Colon Cancer, Colon Diverticulosis
Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery
The General Objective of this study is to investigate the cost and efficacy of treating patients undergoing colorectal surgical resections with an opioid limited pain control regimen as part of an Enhanced Recovery After Surgery…
- Conditions
- Colon Cancer, Colon Diverticulosis, Colonic Neoplasms, Colonic Diverticulitis
- Trial name
- NCT02958566
- Testing
- Acetaminophen, Gabapentin, Orphenadrine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Illinois College of Medicine at Peoria
ColoRectal Cancer, Colonic Diverticulitis
Intraoperative Testing of Colorectal Anastomosis - Air or Water (Methylene Blue)?
A leak from a colorectal anastomosis is a post-operative complication surgeons fear the most, following colonic resection. Over the years, there have been multiple suggestions for intraoperative tests for the integrity of the…
- Conditions
- ColoRectal Cancer, Colonic Diverticulitis, Anastomotic Leak, Anastomotic Complication
- Trial name
- ITCORA (NCT03316677)
- Testing
- Intraoperative testing of colorectal anastomoses, Stapled colorectal anastomoses
- Volunteers
- 150 people
- Sponsor
- Meir Medical Center
Colonic Neoplasms, Colonic Diverticulosis
Outpatient Left Laparoscopic Colectomy
The success of the enhanced recovery program after surgery leads us to consider outpatient management of the colectomy. To this end, the investigators have designed an observational and prospective study of left laparoscopic…
- Trial name
- COATI (NCT04310839)
- Testing
- Colectomy
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Groupe Hospitalier de la Rochelle Ré Aunis
Appendicitis, Evidence of Cholecystectomy
Point of Care 3D Ultrasound for Various Applications: A Pilot Study
Summary 1. Purpose and Objective: The purpose of this study is to test the feasibility of rapid acquisition of point of care 3D ultrasound in obtaining abdominal and/or pelvic images.
- Conditions
- Appendicitis, Evidence of Cholecystectomy, Gallstones, Pregnancy, Ectopic
- Trial name
- NCT02831556
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Duke University
Peritonitis, Diverticulitis
Multicenter Study Comparing Morbidity and Quality of Life Associated in the Treatment by Surgical Resection and the Conservative Treatment, After Favorable Evolution of Purulent Peritonitis That Originates From Diverticulitis Treated by Mini-invasive Surgery
Sigmoid diverticular diseases is a pathologie frequent in patients above 60 years old. A person with diverticulosis may have few or no symptoms.
- Trial name
- SIGMOIDITE (NCT01837342)
- Testing
- Surgical reserction, Radiological percutaneous drainage and washing drainage
- Where
- 14 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Strasbourg, France
Diverticular Disease of Colon
Percutaneous Drainage Versus Antibiotic Therapy for Acute Diverticulitis With Abscess.
the management of diverticular abscesses is guided by consensus-based recommendations from the WSES guidelines, the American College of Physicians, and the American Gastroenterological Association, all of which acknowledge the…
- Trial name
- NCT07352605
- Testing
- Arm 1 (Control Arm) - Percutaneous drainage plus antibiotics: Image-guided (CT or ultrasound) percutaneous drainage performed within 48 hours of randomization with intravenous bro, Arm 2 (Experimental Arm) - Antibiotics alone: Intravenous broad-spectrum antibiotics: piperacillin-tazobactam 4 g/0.5 g q6h (dosage to be adjusted based on renal function) according to the recent lite
- Volunteers
- 50 people
- Sponsor
- Azienda Sanitaria di Firenze
Colorectal Cancer, Colorectal Neoplasms
Indocyanine Green Fluorescence Imaging in Prevention of Colorectal Anastomotic Leakage
This is a randomized, controlled, parallel, multicenter trial to determine the difference in post-operative anastomotic leakages in colorectal surgery, where anastomosis perfusion is evaluated using indocyanine green fluorescence…
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Gastrointestinal Cancer, Gastrointestinal Neoplasms
- Trial name
- ICG-COLORAL (NCT03602677)
- Testing
- ICG fluorescence imaging
- Where
- 2 sites in Finland
- Volunteers
- 1,062 people
- Sponsor
- Oulu University Hospital
Diverticulitis, Colonic, Therapy
Probiotic After Acute Colonic Diverticulitis
The goal of this observational study is to assess the efficacy and safety of the probiotic Escherichia coli Nissle 1917 (EcN®, Ca.Di.Group S.p.A) in the treatment of symptomatic patients after an episode of both complicated and…
- Trial name
- NCT06040515
- Testing
- Probiotic Formula
- Where
- 12 sites in Italy
- Volunteers
- 145 people
- Sponsor
- Erasmo Spaziani