Clinical trials: Dissection
Aortic Dissection
False Lumen Treatment for Prevention of Aortic Growth Using Shape Memory Polymer - First-in-Human Study
To determine the safety and feasibility of the investigational product to reduce aortic dissection false lumen perfusion.
- Trial name
- FLAGSHIP_NZL (NCT06550986)
- Testing
- False Lumen Embolization System, IMPEDE-FX RapidFill
- Where
- 2 sites in New Zealand
- Volunteers
- 30 people
- Sponsor
- Shape Memory Medical, Inc.
Type B Aortic Dissection
Evaluation of the GORE Conformable TAG® Thoracic Endoprosthesis for Treatment of Acute Complicated Type B Aortic Dissection
The primary objective of this study is to determine the safety and efficacy of the GORE Conformable TAG Thoracic Endoprosthesis (CTAG) for treatment of subjects with acute complicated type B aortic dissection.
- Trial name
- NCT00908388
- Testing
- GORE TAG® Thoracic Endoprosthesis
- Where
- 37 sites in United States
- Volunteers
- 50 people
- Sponsor
- W.L.Gore & Associates
Superficial Esophageal Cancer
A Study to Evaluate the Esophageal Stenosis Inhibition Effects of CLS2702C/CLS2702D After Endoscopic Submucosal Dissection (ESD) in Patients With Superficial Esophageal Cancer in the Steroid Administration Risk Group
The purpose of this study is to evaluate the efficacy and safety of esophageal epithelial regenerative treatment by the transplantation of the product, CLS2702C, to the esophageal wound site after extensive ESD for superficial…
- Trial name
- NCT04689594
- Testing
- CLS2702C/CLS2702D
- Where
- Japan
- Volunteers
- 1 people
- Sponsor
- CellSeed Inc.
Gastric Cancer
Effects of Ilaprazole on Ulcer Healing Rate and Prevention of Gastrointestinal Bleeding in the Patients Undergone ESD.
This study compared Ulcer healing rate of Ilaprazole 20mg or Rabeprazole 20mg in the patients undergone Endoscopic Submucosal Dissection for Gastric Adenoma or Early Gastric Cancer and investigated Prevention of gastrointestinal…
- Trial name
- NCT02638584
- Testing
- Ilaprazole, Rabeprazole
- Where
- South Korea
- Volunteers
- 176 people
- Sponsor
- Il-Yang Pharm. Co., Ltd.
Aortic Valve Disease, Ascending Aorta Abnormality
Valved Graft PMCF Study
Multicenter, global, prospective, non-randomized, interventional, post-market trial. All subjects enrolled will receive an Abbott Valved Graft device.
- Conditions
- Aortic Valve Disease, Ascending Aorta Abnormality, Aortic Dissection
- Trial name
- NCT04754217
- Testing
- VAVGJ, CAVGJ
- Where
- 25 sites in United States, Austria and 8 more
- Volunteers
- 260 people
- Sponsor
- Abbott Medical Devices
Aortic Arch Aneurysm, Aortic Arch Dissection
Clinical Study to Evaluate the Safety and Effectiveness of Arcevo LSA
The goal of this clinical trial is to learn if the Arcevo LSA stent graft can safely and effectively treat patients that have an acute or chronic aortic dissection and/or aneurysm that involves the aortic arch and the descending…
- Conditions
- Aortic Arch Aneurysm, Aortic Arch Dissection, Chronic Aortic Dissection, Acute Aortic Dissection
- Trial name
- ARTIZEN (NCT07089576)
- Testing
- Arcevo™ LSA Hybrid Stent Graft System
- Where
- 26 sites in United States, Germany and 1 more
- Volunteers
- 132 people
- Sponsor
- Artivion Inc.
Aortic Dissection, Aortic Aneurysm
PMCF Study in Patients With Acute or Chronic Aortic Dissection or Aortic Aneurysm Treated With E-vita OPEN NEO
The NEOS-APAC post-market clinical follow-up study is undertaken to demonstrate the safety and clinical performance of E-vita OPEN NEO in the treatment of aneurysm or dissection in the ascending aorta, aortic arch and descending…
- Trial name
- NEOS-APAC (NCT04986709)
- Testing
- Open repair
- Where
- 10 sites in Australia, Hong Kong and 4 more
- Volunteers
- 114 people
- Sponsor
- JOTEC GmbH
Vascular Ehlers-Danlos Syndrome
Investigate Efficacy, Safety, and Pharmacokinetics of Enzastaurin for the Prevention of Arterial Events in Patients With Vascular Ehlers-Danlos Syndrome.
The purpose of this study is to investigate the efficacy of enzastaurin compared to placebo in preventing arterial events (rupture, dissection, pseudoaneurysm, carotid-cavernous sinus fistula, or aneurysm, fatal or not) leading…
- Trial name
- PREVEnt (NCT05463679)
- Testing
- Enzastaurin
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- Aytu BioPharma, Inc.
Cancer, Malignant Melanoma
Effect of rIL-21 on Metastases in Lymph Nodes in Melanoma Skin Cancer
The trial is conducted in Europe. This trial aims for a comparison of the pathology in lymph nodes before and after the effect of recombinant interleukin-21 in patients with stage III melanoma
- Trial name
- NCT00601861
- Testing
- recombinant interleukin-21
- Where
- Germany
- Volunteers
- 1 people
- Sponsor
- Novo Nordisk A/S
Thoracic Aortic Dissection
Post-market Clinical Trial of the Dominus® Stent-Graft
Real-world clinical trial evidence post-market, evaluating the safety and efficacy of the Dominus® StentGraft Endoprosthesis in treating thoracic aortic diseases, following the Instructions for Use
- Trial name
- DominusPMCF (NCT06270537)
- Testing
- Stent-Graft Dominus® Endoprosthesis
- Where
- 3 sites in Brazil
- Volunteers
- 100 people
- Sponsor
- Braile Biomedica Ind. Com. e Repr. Ltda.
Aortic Dissection
False Lumen Treatment for Prevention of Aortic Growth Using Shape Memory Polymer - First-in-Human Study (FLAGSHIP_FRA)
To determine the safety and feasibility of investigational product to reduce aortic dissection false lumen perfusion.
- Trial name
- FLAGSHIP_FRA (NCT06740721)
- Testing
- False Lumen Embolization System, IMPEDE-FX RapidFill
- Volunteers
- 15 people
- Sponsor
- Shape Memory Medical, Inc.
Complex Aortic Aneurysms, Thoracoabdominal Aneurysm
Real-World Data Collection of GORE Devices Used In the Endovascular Treatment of Aortic Aneurysms Which Incorporate Visceral Arteries.
The registry population consists of patients presenting with complex aortic pathologies amenable to endovascular aortic repair that requires the incorporation of bridging stents to maintain visceral artery perfusion
- Conditions
- Complex Aortic Aneurysms, Thoracoabdominal Aneurysm, Fenestrated Endovascular Aortic Repair, Endovascular Aortic Repair
- Trial name
- ENVISION (NCT07480395)
- Where
- 26 sites in Austria, Denmark and 8 more
- Volunteers
- 400 people
- Sponsor
- W.L.Gore & Associates
Prostate Cancer
Pilot Study of 99mTc-MIP-1404 SPECT/CT Imaging in Men With Prostate Cancer Undergoing Prostatectomy and/or Pelvic Lymph Node Dissection
This is a single arm, open label study of up to 24 high risk prostate cancer patients scheduled for prostatectomy and/or pelvic lymph node dissection.
- Trial name
- NCT01572701
- Testing
- 99mTc-MIP-1404
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Molecular Insight Pharmaceuticals, Inc.
Rectal Adenoma, Rectal Polyp
Transanal Resection of Rectal Lesions With the ColubrisMX ELS System
This study is a prospective, single-arm, multi-center, open-label, staged clinical study. Overall Objective: 1. To evaluate the safety and effectiveness of the ELS System in subjects undergoing transanal endoluminal procedures in…
- Conditions
- Rectal Adenoma, Rectal Polyp, Rectal Lesion
- Trial name
- NCT04651764
- Testing
- ColubrisMX Endoluminal Surgical (ELS) System
- Where
- 3 sites in United States
- Volunteers
- 26 people
- Sponsor
- ColubrisMX
Aneurysm, Dissecting, Aortic Aneurysm
Study of the Influence of the Moon and Seasons On Outcomes Following Surgery To Repair Ascending Aortic Dissection
That the full-moon stage of the lunar cycle is associated with reduced mortality and shorter length of stay in patients undergoing repair of aortic dissection, after adjusting for seasonal effects, demographics and cardiovascular…
- Trial name
- ACS-MOON-1 (NCT02236923)
- Where
- United Kingdom
- Volunteers
- 2,684 people
- Sponsor
- 22EON
Aortic Diseases
INSTEAD Trial: INvestigation of STEnt Grafts in Patients With Type B Aortic Dissection
The objective of this study is to compare treatment with an endograft prothesis versus antihypertensive treatment in patients with a dissection of the thoracic aorta.
- Trial name
- INSTEAD (NCT00525356)
- Testing
- Medtronic Talent Stent-Graft-System
- Where
- Netherlands
- Volunteers
- 136 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Aortic Dissection Type B
Study of the RelayPro Thoracic Stent-Graft in Subjects With an Acute, Complicated Type B Aortic Dissection
This clinical trial is a prospective, multicenter, non-blinded, non-randomized study designed to assess the RelayPro thoracic endografts in the treatment of acute, complicated type B aortic dissection.
- Trial name
- NCT03033043
- Testing
- Relay Pro Stent-Graft
- Where
- 21 sites in United States
- Volunteers
- 56 people
- Sponsor
- Bolton Medical
Retinal Detachment, Achilles Tendon
A Study of Fluoroquinolones Exposure and Collagen-Related Serious Adverse Events
The purpose of this study is to evaluate whether there is an increased risk of achilles tendon rupture (ATR), retinal detachment (RD) or aortic aneurysm and dissection (AAD) following exposure to fluoroquinolone (FQ) or other…
- Conditions
- Retinal Detachment, Achilles Tendon, Aneurysm, Dissecting
- Trial name
- NCT03479736
- Testing
- Oral Fluoroquinolones (FQ), Other Antibiotics, Febrile Illness Not Treated with Antibiotics Will be Analyzed as an Exposure
- Where
- United States
- Volunteers
- 117,911 people
- Sponsor
- Janssen Research & Development, LLC
Aortic Dissection Type B
Safety and Efficacy Study of Fabulous Stent Graft System for Stanford B Aortic Dissection
A prospective, multi-center, objective performance criteria clinical trial to evaluate the safety and efficacy of Fabulous Stent Graft System manufactured by Hangzhou Endonom Medtech Co., Ltd. for Stanford B Aortic Dissection.
- Trial name
- NCT04918212
- Testing
- Fabulous Stent Graft System
- Where
- 24 sites in China
- Volunteers
- 148 people
- Sponsor
- Hangzhou Endonom Medtech Co., Ltd.
Aortic Diseases
Percutaneous Endovascular Arch Repair Trial (PEART) Study
This study is the feasible study on a new technique of ZIPPER aortic arch stentgraft system
- Trial name
- NCT05872282
- Testing
- ZIPPER aortic arch stentgraft system
- Where
- 3 sites in China
- Volunteers
- 24 people
- Sponsor
- Hangzhou Endonom Medtech Co., Ltd.