Clinical trials: Disorientation
Elderly, Hip Fracture Surgery
Dexmedetomidine Supplemented Analgesia and Delirium After Hip Fracture Surgery
Delirium is common in the elderly after hip fracture surgery, and is associated with worse outcomes. The investigators hypothesize that, for elderly patients after hip fracture surgery, dexmedetomidine supplemented analgesia can…
- Conditions
- Elderly, Hip Fracture Surgery, Patient-controlled Analgesia, Dexmedetomidine
- Trial name
- NCT04955249
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 67 people
- Sponsor
- Peking University First Hospital
Emergence Delirium
MELAtonin for Prevention of Postoperative Agitation and Emergence Delirium in Children
Postoperative agitation and emergence delirium describe a spectrum of symptoms of early postoperative negative behavior, in which the child experiences a variety of behavioral disturbances including crying, thrashing, and…
- Trial name
- MELA-PAED (NCT05541276)
- Testing
- Melatonin, Isotonic sodium chloride solution
- Where
- Denmark
- Volunteers
- 676 people
- Sponsor
- Arash Afshari
Magnesium, Emergence Delirium
Oral Versus Intravenous Magnesium on Emergence Delirium
This prospective randomized controlled study will be conducted to compare the effects of preoperative oral magnesium and intraoperative IV magnesium on the incidence and severity of emergence delirium in children undergoing…
- Conditions
- Magnesium, Emergence Delirium, Children, Adenotonsillectomy
- Trial name
- NCT07655817
- Testing
- Magnesium glycinate, Magnesium sulfate injection, Oral juice and intravenous saline
- Where
- Egypt
- Volunteers
- 360 people
- Sponsor
- Tanta University
Postoperative Delirium
Effects of Nutritional Support on Postoperative Delirium
This study is a prospective, single-center, randomized controlled trial to compare whether applying nutritional supplementation therapy before and after surgery in elderly patients aged 65 years or older undergoing non-cardiac…
- Trial name
- NCT06467552
- Testing
- control group, Nucare Curact group
- Where
- South Korea
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Delirium
Electroencephalography Guidance of Anesthesia
This study aims to determine whether, compared with usual anesthetic care, an electroencephalography-guided anesthesia protocol is effective at preventing postoperative delirium and its downstream effects, and improving…
- Trial name
- ENGAGES (NCT02241655)
- Testing
- a pragmatic EEG-guided anesthetic protocol
- Where
- United States
- Volunteers
- 1,400 people
- Sponsor
- Washington University School of Medicine
Cognitive Decline, Delirium
CITADEL: Effectiveness of CITicoline in Preventing Cognitive Decline After DELirium
The aim of this study is to assess whether citicoline (TRAUSAN), a neuroprotective agent involved in membrane phospholipid synthesis and neurotransmission, can prevent or attenuate cognitive decline in older adults who develop…
- Trial name
- CITADEL (NCT07804498)
- Testing
- Citicoline
- Where
- Italy
- Volunteers
- 122 people
- Sponsor
- University of Milano Bicocca
Post Operative Cognitive Dysfunction
Ketamine and Postoperative Cognitive Dysfunction
Over 30 million patients require a major surgery annually in the US alone and more than half of them are performed in patients over 60 years of age.
- Trial name
- POCK (NCT02892916)
- Testing
- Ketamine
- Where
- France
- Volunteers
- 307 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiratory Failure, Delirium
Delirium, Agitation/Sedation, Pain and Dyspnea in Respiratory Intensive Care Unit (NIVILIUM)
Non-Invasive Mechanical Ventilation (NIV) has been increasingly used in the treatment of acute respiratory failure. Notwithstanding failure rates still remains high, ranging from 5% to 60%.
- Conditions
- Respiratory Failure, Delirium, Agitation,Psychomotor, Pain
- Trial name
- NIVILIUM (NCT03880084)
- Testing
- Observation
- Where
- Italy
- Volunteers
- 92 people
- Sponsor
- University of Modena and Reggio Emilia
Abdominal Surgery
The Effect of Eye Mask and Music on Sleep Quality and Delirium in Patients Monitored in Intensive Care Unit
After abdominal surgery, most patients experience problems such as respiratory complications, surgical wound infection, cardiac problems, renal failure, delirium, and insomnia, along with surgical trauma and underlying…
- Trial name
- NCT06268158
- Testing
- Eye patch
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Emergence Delirium, Anesthesia; Adverse Effect
Language During Inhalational Induction
The aim of this study is to compare the impact of common (standard of care) language vs positive language used by clinicians during inhalational induction of anesthesia on anxiety and negative behaviors in children.
- Trial name
- NCT06324955
- Testing
- Standard/common language during induction, Positive language during induction
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Boston Children's Hospital
Preoperative Anxiety, Maladaptive Postoperative Behavior
Effects of Virtual Reality on Perioperative Pediatric Anxiety
This study evaluates the effect of virtual reality on anxiety levels in a pediatric surgical population. Half of participants will receive standard perioperative treatment, while the other half will receive additionally a virtual…
- Conditions
- Preoperative Anxiety, Maladaptive Postoperative Behavior, Emergence Delirium
- Trial name
- VIRTUALPED (NCT04043663)
- Testing
- Virtual Reality glasses, standard perioperative care without virtual reality program
- Where
- Spain
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Germans Trias i Pujol Hospital
Nervous System Diseases
Randomized, Double-blind, Placebo-controlled Trial of the Efficacy and Safety of Tianeptine in the Treatment of Covid Fog Symptoms in Patients After COVID-19.
COVID-19 is associated with a high risk of complications from the central nervous system. Syndrome of cognitive disorders- in terms of memory, attention or executive functions among COVID-19 convalescents is often called brain…
- Trial name
- COVMENT (NCT06012552)
- Testing
- Tianeptine
- Where
- Poland
- Volunteers
- 140 people
- Sponsor
- Military Institute od Medicine National Research Institute
Suspected Delirium After Elective or Emergency Heart Surgery, CAM-ICU Diagnosed Delirium
Evaluation if Physostigmine Reduces Symptoms in Patients Who Has Developed a Delirium in Intensive Care After a Surgery
Evaluation if physostigmine reduces symptoms in patients who has developed a delirium in Intensive care after a surgery
- Trial name
- NCT02216266
- Testing
- Physostigmine, Sodium Chloride solution
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- PD Dr. Bertram Scheller
Cardiac Surgery, Intraoperative Hemodynamic Instability
Impact of Intraoperative Hemodynamic Instability on Outcomes in Cardiac Surgery
Intraoperative hemodynamic instability (IOHI) is a common occurrence during cardiac surgery and is associated with organ hypoperfusion. However, the specific impact of IOHI on composite adverse outcomes remains unclear.
- Conditions
- Cardiac Surgery, Intraoperative Hemodynamic Instability, Postoperative Complication, Acute Kidney Injury
- Trial name
- NCT07324694
- Where
- Turkey (Türkiye)
- Volunteers
- 351 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Delirium
Non-Invasive Eye Tracking for the Diagnosis of Delirium on ICU
In this trial, the investigators seek to demonstrate the feasibility of a system in continuously detecting 'inattention' as a subset of CAM-ICU in a small representative sample of patients in the Intensive Care Unit (ICU) at…
- Trial name
- CONfuSED (NCT04589169)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Delirium, Encephalopathy
Study to Assess and Monitor Brain Activity
A mainstay in the diagnosis and care of hospitalized patients is the assessment of mental status. Changes in mental status can have broad clinical significance, and while some patients are admitted with mental status changes…
- Trial name
- SAMBA (NCT04602988)
- Testing
- EEG
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Massachusetts General Hospital
Postoperative Delirium
The Impact of the Implementation of BIS on the Incidence of Postoperative Delirium
This study will investigate the incidence of postoperative POD in patients undergoing non cardiac surgery under general anesthesia with and without the implementation of the BIS monitoring.T
- Trial name
- NCT04736303
- Testing
- BIS
- Where
- Greece
- Volunteers
- 1,400 people
- Sponsor
- University of Thessaly
Postoperative Complications, Hip Fracture
A Trial To Assess Risk of Delirium in Older Adults Undergoing Hip Fracture Surgery With Spinal or General Anesthesia
This pilot project will address the gaps in knowledge regarding the effect of anesthetic technique on the risk of delirium through an adequately-powered trial employing standardized regimens for treatment and outcome assessment…
- Conditions
- Postoperative Complications, Hip Fracture, Delirium
- Trial name
- NCT02190903
- Testing
- General endotracheal anesthesia, Regional (spinal) Anesthesia
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Pennsylvania
Postoperative Delirium (POD), Prostate Cancer
Preoperative Breathing Exercise Training and Postoperative Delirium After Robotic Radical Prostatectomy
Postoperative delirium is an acute and fluctuating disturbance in attention, awareness, and thinking that may occur after major surgery.
- Trial name
- NCT07766603
- Testing
- Preoperative Deep Breathing Exercise Training
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- ALİ DEMİRTAŞ
Critical Illness, Sleep Disturbance
Mobilisation in the EveNing to TreAt Delirium
Patients with severe illness require lifesaving treatment in intensive care units. Around a third of patients admitted to intensive care develop delirium. This is a severe state of confusion.
- Conditions
- Critical Illness, Sleep Disturbance, Mobility Limitation, Intensive Care Unit Delirium
- Trial name
- MENTAL (NCT05401461)
- Testing
- Evening mobilisation
- Where
- 2 sites in United Kingdom
- Volunteers
- 58 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust